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Precise Distinctions between Very Immature T-linegae and NK-lineage Neoplasms

Research Project

Project/Area Number 09672357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKobe University

Principal Investigator

TATSUMI Eiji  International Center for Medical Research, Kobe University Associate Professor, 医学部, 助教授 (20192172)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsT-ALL / LBL / NK (natural killer) / preT alpha (pre T-cell receptor alpha) / LBL / NK(Natural Killer) / preTCill receptor α(pTα) / ナチュラル・モラ- / ALL(AcnteLympboblustic Lcukemia) / LBL(Lymphoblastic Lymphoma) / pre-T-cell-α受容体
Research Abstract

Important works (Blood 82 : 207,1993 ; Am J Hematol 45 : 150,1994 ; ibid 45 : 310,199 4 ; ibid 49 : 6.1995) have been done by our group regarding phenptypic and gene ana Lysis of T-cell neoplasms derived from immature stages, T-ALL/LBL.It was strongly suspected that CD7+CD2+ subset of pro-thymic stage, which had been regarded as a subset of very immature T-lineage, seemed to be derived from an very immature stage of NK-lineage (Blood 89 : 4665,1997). The detailed research of this CD7+CD2+ subgroup is the major goal of this research. However, the incidence of this subgroup has been so low compared with CD7+CD5+ group that any such fresh case has not been encountered during the research peripod. (During writing this report, one case has been experiences, and the investigation is now going on.)
The distribution of the expression of preTalpha (pre T-cell receptor alpha) has been studied in 10 TCRalpha_beta expressing T-ALL/LBL cell lines, 3 TCRgamma_delta expressing T-ALL/LBL cell lines and a mature NK cell line, YT.
[1] After expressing TCRalpha chain, enough amount of preTalpha is expressed.
[2] In the 3 TCRgamma_delta expressing T-ALL/LBL cell lines, which have the monoclonal rearrangement of TCR beta gene, preTalpha are unexpectedly expressed.
These two are quite new observations.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Nakamura F.Tatsumi E et al: "Acute lymphoblastic leukemia/Lymphoblastic lymphpoma of natural killer(NK)lineage:Quest for another NK-lineage neoplasm." Blood(Letter to the Editor). 89(4). 4665-4666 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hasegawa D,Tatsumi E et al: "Evaluation of the serum Fas ligand in patients with, hemophagocytic syndrome and Diamod-Blackfan anemis." Blood. 91(8). 2793-2799 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sano K, Tatsumi E et al: "Translocation(10;12)(q24;q15)in a T-cell lymphoblastic lymphoma with myeloid hyperplasia." Cacer Genet Gytogenet. 105(6). 168-171 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mizuki M,Tatsumi E et al: "Phenotypic heterogeneity of Cd4+ CD8+ double positive chronic T lymphoid leukemia." Leukemia. 12(4). 499-504 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura F,Tatsumi E,Kawano S,Tani A,Kumagai S.: "Acute lymphoblastic leukemia/Lymphoblastic lymphpoma of natural killer (NK) lineage : Quest for another NK-lineage neoplasm." Blood (Letter to the editor). 89. 4665-4666 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hasegawa D,Kojima S,TatsumiE,Kosaak Y,Nakamura H,Sako M,Osugi Y,Nagata S,Sano K: "Evaluation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamod-Blackfan anemis" Blood. 91. 2793-2799 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sano K,Goji J,Kosaka Y,Nakamura H,Nakamura F,Tatsumi E: "Translocation (10 ; 12) (q24 ; q15) in a T-cell lymphoblastic lymphoma with myeloid hyperplasia" Cancer Cytogenetics and Cytogenetics. 105. 168-171 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mizuki M,Tagawa S,Machii T,Shibano M,tatsumi E,Tsubaki K,Tako H,Yokohama A,Nojima J,Hirota T,Kitani T: "Phenotypic heterogeneity of Cd4+ CD8+ double positive chronic T lymphoid leukemia" Leukemia. 12. 499-504 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hasegawa D, Tatsumi E et al: "Evaluation of the serum Fas ligand in patients with, hemophagocytic syndrome and Diamod-Blackfan anemis." Blood. 91(8). 2793-2799 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sano K, Tatsumi E et al: "Translocation (10;12)(q24;q15) in a T-cell lymphoblastic lymphoma with myeloid hyperplasia." Caha.Genet Cytogonet. 105(6). 168-171 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mizuki M, Tatsumi E et al: "Phenotypic heterogeneity of Cd_<4+> CD_<8+> double positive chronic T lymphoid leukemia." Lenkemia. 12(4). 499-504 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakamura F, Tatsumi E et al: "Acute lymphoblastic leukenia/Lymphoblascic lymphoma(LBL)of natural Killesa(NK)lineage : Ouect for another NK lineage Neopiacb" Blood. 89. 4665-4666 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 巽英二 他: "前胸腺(初期胸腺)段階由来のT-ALL LBLの中のCO7^+2^+群が未分化NK腫瘍を含む可能性" 臨床病理. 45(補). 226項 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hasegawa D, Tatswmi E 他: "Evaluation of serum Fas ligand in patienes with hemophago cytic syndrome" Blood. 91(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sagawa K, Tatsumi E 他: "Monoclonal Antibodies (MCS-1 and MCS-2) reacloe With Myeloid leukemia cells" Kurume Med J. 42. 177-185 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 巽英二, 大野仁嗣: "本部のバ-キットリンパ腫の第8番染色体切断点" 日本臨床. 55. 429-435 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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