| Project/Area Number |
09672362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
NISHIMURA Masato KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, DEPARTMENT OF CLINICAI AND LABORATORY MEDICINE, ASSOCIATE PROFESSOR, 臨床検査医学, 講師 (50218202)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Chlamydia pneumoniae / hypertension / infection / 動脈硬化 / 冠動脈硬化 / PTCA / ステント / 再狭窄 / 血管内膜肥厚 / 大動脈瘤 / PCR / 血管 |
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| Research Abstract |
To determine whether Chlamydia pneumoniae (C. pneumoniae) infection is associated with hypertension in Japanese adults, we measured serum levels of IgA (a marker of reinfection) and of IgG (a marker of previous infection) antibodies to C. pneumoniae by enzyme-linked immunosorbent assay in 112 adults including normotensive and untreated hypertensive subjects and in 117 hypertensive subjects who had been receiving treatment for over three years. In 112 adults, positivity rate for IgA was lower (P < 0.01)in hypertensive than in normotensive or borderline hypertensive subjects. Positivity rates for IgA and IgG together, which indicate persistent infection of C. pneumoniae, were lower (P <0.01) in hypertensive than in normotensive subjects. IgA levels were inversely correlated with systolic blood pressure (r=0.530, P=0.0001) and with diastolic blood pressure (r=0.398, P=0.0001). In the 117 hypertensive subjects treated with medication, positivity rate for IgA was lower (P <0.01) in subjects with poor control than in those with good control. Positivity rates for IgA and IgG together were lower (P <0.01) in the poor control group than in the good or fair control groups. IgA levels were correlated inversely with systolic and diastolic blood pressure. In both 112 adults and 117 hypertensive patients, levels of systolic or diastolic blood pressure are inversely associated with positivity rates for IgA and IgG together in multiple logistic regression analysis. The results suggest an inverse relationship between high blood pressure and C. pneumoniae infection in Japanese adults.
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