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CLINICAL LABORATORY ASSESSMENT OF EFFECTS OF VASCULAR INFECTION OF CHLAMYDIA PNEUMONIAE ON THE OCCURRENCE AND PROGRESSION OF ATHEROSCLEROSIS

Research Project

Project/Area Number 09672362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKYOTO PREFECTURAL UNIVERSITY OF MEDICINE

Principal Investigator

NISHIMURA Masato  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, DEPARTMENT OF CLINICAI AND LABORATORY MEDICINE, ASSOCIATE PROFESSOR, 臨床検査医学, 講師 (50218202)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
KeywordsChlamydia pneumoniae / hypertension / infection / 動脈硬化 / 冠動脈硬化 / PTCA / ステント / 再狭窄 / 血管内膜肥厚 / 大動脈瘤 / PCR / 血管
Research Abstract

To determine whether Chlamydia pneumoniae (C. pneumoniae) infection is associated with hypertension in Japanese adults, we measured serum levels of IgA (a marker of reinfection) and of IgG (a marker of previous infection) antibodies to C. pneumoniae by enzyme-linked immunosorbent assay in 112 adults including normotensive and untreated hypertensive subjects and in 117 hypertensive subjects who had been receiving treatment for over three years. In 112 adults, positivity rate for IgA was lower (P < 0.01)in hypertensive than in normotensive or borderline hypertensive subjects. Positivity rates for IgA and IgG together, which indicate persistent infection of C. pneumoniae, were lower (P <0.01) in hypertensive than in normotensive subjects. IgA levels were inversely correlated with systolic blood pressure (r=0.530, P=0.0001) and with diastolic blood pressure (r=0.398, P=0.0001). In the 117 hypertensive subjects treated with medication, positivity rate for IgA was lower (P <0.01) in subjects with poor control than in those with good control. Positivity rates for IgA and IgG together were lower (P <0.01) in the poor control group than in the good or fair control groups. IgA levels were correlated inversely with systolic and diastolic blood pressure. In both 112 adults and 117 hypertensive patients, levels of systolic or diastolic blood pressure are inversely associated with positivity rates for IgA and IgG together in multiple logistic regression analysis. The results suggest an inverse relationship between high blood pressure and C. pneumoniae infection in Japanese adults.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 西村眞人, 他: "Inverse association of Chlamydia pneumoniae infection with high blood pressure in Japanese adults."American Journal of Hypertension. 14. 20-26 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masato Nishimura, Masaji Ushiyama, Akira Nanbu: "Inverse association of chlamydia pneumoniae infection with high blood pressure in Japanese adults"American Journal of Hypertension. 14. 20-26 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inoue, N., Nishimura, M., et al: "Association Between Infection with Chlamydia Pneumoniae and the Risk of In-stent Restenosis." Circulation. 98(17)(abstract). I-435 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inoue, N., Nishimura, M., et al: "The Infection of Chlamydia Pneumoniae Accelerates Neointimal Hyperplasia Associated with In-stent Restenosis." Journal of the American College of Cardiology. 33(2)(abstract). 59A (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 西村眞人、他: "冠動脈硬化の危険因子としてのクラミジア・ニュモニエ感染" 生物資料分析. 22(1). 30 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura, M., et al: "Increased Serum Concentrations of Human Hepatocyte Growth Factor in Proliferative Diabetic Retinopathy." Journal of Clinical Endocrinology & Metabolism. 83(1). 195-198 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura, M., et al: "Serum Hepatocyte Growth Factor As a Possible Indicator of Vascular Lesions." Journal of Clinical Endocrinology & Metabolism. (発表予定). (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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