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Epidemiologic study on methicillin-resistant S.aureus in the medical center

Research Project

Project/Area Number 09672364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionJUTENDO UNIVERSITY

Principal Investigator

IGARI Jun  Juntendo University, School of Medicine, Professor, 医学部, 教授 (20053100)

Co-Investigator(Kenkyū-buntansha) TABE Yoko  Juntendo University, School of Medicine, Assistant Professor, 医学部, 講師 (70306968)
西園寺 克  順天堂大学, 医学部, 講師 (60138344)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
KeywordsNICU / MRSA / PFGL / genotyping / phenotyping / フェノタイプ / SmaI / SstII / パルスフィールドゲル電気泳動法 / genotyping / phenotyping
Research Abstract

This study was conducted to know the distribution of methicillin-resistant S.aureus(MRSA) in the neonatal intensive care unit(NICU).
We investigated MRSA carriers of medical staffs(7 medical doctors and 21 nurses) and 30 neonatal patients between May 1995 and January 1999. We studied the genotyping of isolated MRSA strains by pulsed-field gel electrophoresis(PFGL) using the macrorestriction enzyme, SmaI and the phenotyping by antibiotic resistant patterns as well.
The antibiotic drups were vancomycin, oxacillin, ampicillin, cefazolin, cefmetazole, imipenem, gentamicin, minocycline, ofloxacin and clindamycin and the minimal inhibitory concentration(MIC) was measured by the broth microdilution method according to the guideline of NCCLS.
The MRSA was isolated 21 strains from 17 nurses, 7 strains from 8 doctors and 49 strains from 30 patiants. In genotyping, all isolates except one isolate from a patient showed the same major type which was divides 6 subtypes.
The phenotype had 4 types.
The result of the genotyping study indicated that tile Same origin MRSA distributed in NICU.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (1 results)

All Other

All Publications (1 results)

  • [Publications] 田部陽子, 猪狩 淳: "特別養護老人ホーム入所者のMRSA保菌状況の経時的変化に関する検討" 環境感染. Vol.12,No3. 206-210 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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