| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Research Abstract |
The purpose of this study was to examine the effect of daily physical activity, muscle thickness and urinary excretion of free-deoxypyridinoline (free-Dpyr) on bone mineral density (BMD) and the prevention of fracture in middle-aged and elderly women. In these cross-sectional and longitudinal studies, we measured the BMD in the lumbar spine and the femur using dual X-ray absorptiometry with Hologic's QDR-1500 and that in the calcaneus using single X-ray absorptiometry with Osteon's Osteoanalyzer and the femoral muscle thickness using ultrasonography and urinary excretion of free-Dpyr (ELISAmethod). In addition, we evaluated the relationship between BMD and daily physical activity in healthy middle-aged and elderly women. The following results wereobtained. In 1997, the BMD in the lumbar spine, the calcaneus and the femur showed a negative correlation with age. In particular, those in the calcaneus, the femoral neck and ward's triangle showed significant correlations. Moreover, the femoral muscle thickness showed a significant negative correlation with age. In 1998, the change in the BMD and muscle thickness over a 1-year period was significantly decreased. However, values of free-Dpyr were slightly higher than those of the initial value. In addition, subjects who exercised regularly had significantly higher BMD than those who did not.
The results suggested that combining the measurement of BMD and bone resorptionmarker (free-Dpyr), in addition to establishing daily physical activity routinesand promoting muscle mass, are useful to improve the assessment of bone health and the risk of fracture in women. Moreover, physical activity and exercise may beimportant factors in preventing loss of muscle mass and strength.
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