| Project/Area Number |
09680535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | Chiba Institute of Technology (1998)
Nippon Medical School (1997) |
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Principal Investigator |
IINO Masaaki Chiba Institute of Technology, Precision Engineering, Associate Proffesor, 工学部, 助教授 (00182999)
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| Co-Investigator(Kenkyū-buntansha) |
OKUDA Yuichi Tokyo Institute of Technology, Applied Physics, Proffesor, 大学院・理工学研究科, 教授 (50135670)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | erythrocyte sedimentation rate / erythrocyte aggregation / effect of strong magnetic field / anisotropic diamagnetism of biomembrane |
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| Research Abstract |
A magnetic field of 6.3 T in the vertical direction slightly enhanced erythrocyte sedimentation rate (ESR), which was consistent with an effect on magnetic cell orientation. On the other hand, the magnetic field greatly enhanced ESR in plasma. Some examinations indicated that the magnetic field increased cell aggregation and thereby enhanced ESR in plasma. In order to quantify the determinants of the magnetic increase in aggregation, magnetic effects of the membrane-plasma protein interaction an d the hydrodynamics of hemoglobin molecules were studied, but in vain. In order to qualitatively specify a major determinant of the magnetic increase in aggregation, dependencies of ESR on osmolality have been measured under the magnetic field (submitted to Bioelectromagnetics). Even at a hypotonic osmolality an increase in ESR due to aggregation was observed in plasma solution as compared with that without aggregation in saline solution. The magnetic field, however, did not enhanced ESR at hypotonic osmolality, when the cell shape was isotropic sphere (so called spherocyte). A possible determinant that can work even for isotropic erythrocytes was denied. it was concluded that the major determinant can work only for anisotropic erythrocytes and is a magnetic field induced increase in an inter-membrane adhesive area due to magnetic orientation of anisotropic erythrocytes.
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