| Project/Area Number |
09680565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAMOTO Yorihiro The University of Tokyo, Research Center for Advanced Science and Technology, Assoc.Prof., 先端科学技術研究センター, 助教授 (60134475)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | vitamin E / salmon / oxidative stress / antioxidant / antioxidant activity / cold temperature |
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| Research Abstract |
We have isolated a new a-tocomonoenol from the lipophilic fraction of salmon eggs which has an unusual methylene unsatutation at the terminal phytyl chain of ubiquitous alpha-tocopherol (alpha-Toc). This marine-derived tocopherol (MDT) was found at high ratio with alpha-Toc in phytoplankton and zooplankton samples captured in the cold-water environment of the North Pacific Ocean (Hokkaido Sea) and our finding that aquaculutured salmon fed with a MDT-free diet had little MDT suggest that MDT is trophically acquired from natural phytoplankton production in the cold-water food-chain. We found little difference in the antioxidant activity between MDT and alpha-Toc in vitro, but observed higher activity for MDT in fish oil at 0ﾟC.Similarly, we found that MDT performed better than alpha-Toc in viscous, cholesterol-incorporated liposomal membranes than in cholestrol-free liposome. Our results suggest that MDT may provide an important physiological advantage in antioxidant functions of cold-water marine organisms.
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