| Project/Area Number |
09680575
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
IGUCHI Kazuo Tokyo Univ.of Pharm.& Life Sci., School of Life Sci., Professor, 生命科学部, 教授 (50057345)
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| Co-Investigator(Kenkyū-buntansha) |
IWASHIMA Makoto Tokyo Univ.of Pharm.& Life Sci., School of Life Sci., Assistant, 生命科学部, 助手 (20266901)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Marine Natural Product / Prostanoid / Soft Coral / Clavularia viridis / Clavulone / Structure Determination / Biological Activity / Symbiotic Micro Organism |
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| Research Abstract |
During the course of our investigation to find new marine prostanoids from the Okinawan soft coral, eight new prostanoids and six new steroids were isolated from the methanol extract of Clavularia viridis. Their structures were determined based on the results of spectroscopic analysis. The absolute configurations of the compound 1 (clavulolactone I), 2 (4-epiclavulone II), and 3 (4-epiclavulone Ill) were confirmed by chemical conversions from the corresponding clavulones. The novel prostanoid-related compounds 4 and 5 (clavirin A and B) consist of 17 carbons, containing the terminal aldehyde on the shorter alpha-side chain. The chiral center on C-7 in both compounds were independently determined by the stereoselective total syntheses from 4-hydroxy-2-cyclopentenone. The prostanoid-related compound 6 (clavucyclin) also posseses a novel unique structure, such as tricycic 5-5-4 ring systems. The total synthesis of 6 is currently carried out in our laboratory using the same synthetic intermediate of 4 and 5. We are investigating not only the bioactivities of all new compounds, particularly cytotoxic, antitumor, and enzyme-inhibition activities, but the interaction betwen the host C.viridis and symbiotic algae (zooxanthella).
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