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Anti-carcinogenic constituents of Shouseiryu-to prescription and its components

Research Project

Project/Area Number 09680580
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioorganic chemistry
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

KONOSHIMA Takao  Kyoto Pharmaceutical University, Department of Pharmacy, Associate Professor, 薬学部, 助教授 (80121557)

Co-Investigator(Kenkyū-buntansha) TOKUDA Harukuni  Kyoto Prefectural University of Medicine Department of Medicine, Research Instru, 医学部, 助手 (60111960)
TAKASAKI Midori  Kyoto Pharmaceutical University, Department of Pharmacy, Research Instructor, 薬学部, 助手 (10179434)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsShouseiryu-to / Anti-carcinogenesis / Asiasarum plant / lignan / asarinin / anti-tumor-promoter / anti-tumor-initiator / NO
Research Abstract

To search for possible cancer chemopreventive agents, many K.ampo-prescriptions were assayed by primary screening indicated by inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation in vitro. Of these prescriptions, Shouseiryu-to exhibited the significant inhibitory effects on EBV-EA activation, and exhibited strong anti-tumor-promoting activities on mouse skin and pulmonary two-stage carcinogenesis tests using TPA and glycerol, respectively, as promoters. Futher, this prescription showed the strong anti-tumor-initiating activity on mouse skin carcinogenesis induced by the NO donor. Searching for the active constituents of Shouseiryu-to, each component (eight crude drugs) of this prescription was assayed using EBV-EA activation test. Two lignans, asarinin and xanthoxyilol, were isolated from the MeOH extract of root of Asiasarum plant as the active constituents, and these lignans showed significant inhibitory effects on the two-stage carcino- genesis test in vivo. On the other hand, although these lignans were not isolated from the water extract of this crude drug alone but isolated from the water decoction of Shouseiryu-to prescription. Therefore, these lipophilic lignans could not extracted with water from single crude drug, but extracted from Kampo-prescription consisited with plural components.
From these results, it was concluded that Shouseiryu-to might be valuable for anticarcinogenesis agents (chemopreventive agents) and one of the active compounds was the lignan.
As a continuation of these studies, other crude drugs and folk medicines were investigated, and the anti-carcinogenic activities of several compounds were also reported.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Midori Takasaki: "Inhibitory effects of Shouseiryu-to on two-stage carcinogenesis II. Anti-tumor-promoting activities of lignans from Asiasarum heterotropeides." Biol.Pharm.Bull.20. 776-780 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Konoshima: "Anti-tumor-promoting activities of isoflavonoids from Wistaria brachybotry's" Biol.Pharm.Bull.20. 865-868 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Konoshima: "Anti-tumor-promoting activity of majonoside R2 from Vietnamese ginseng Panax vietnamensis Ha et Grushv." Biol.Pharm.Bull.21. 834-838 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tenji Konishi: "Anti-tumor-promoting activity of diterpenes from Excoecaria agallocha" Biol.Pharm.Bull.21. 993-996 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 安田一郎: "細辛に含まれる抗発癌プロモーター作用物質とその含量による品質評価" 東京都立衛生研究所年報. 49. 48-53 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Konoshima: "Food Factors for Cancer Prevention" Springer(Tokyo), 684 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Midori Takasaki et al.: "Inhibitory effects of Shouseiryu-to on two-stage carcinogenesis.II.Anti-tumor-promoting activities of lignans from Asiasarum heterotropoides var.mandshuricum." Biol.Pharm.Bull.20(No.7). 776-780 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Konoshima et al.: "Anti-tumor-promoting activities of isoflavonoids from Wistaria brachybotrys." Biol.Pharm.Bull.20(No.8). 865-868 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Konoshima et al.: "Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis Ha et Grushv." Biol.Pharm.Bull.21(No.8). 834-838 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tenji Konishi et al.: "Anti-tumor-promoting activity of diterpenes from Excoecaria agallocha" Biol.Pharm.Bull.21(No.9). 993-996 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ichiro Yasuda et al.: "Anti-tumor-promoting principles in Asiasarum root and the evaluation on their contents" Ann.Rep.Tokyo Metr.Res.Lab.P.H.49. 48-53 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Konoshima et al.: "Food Factors for Cancer Prevention."(eds.H.Ohigashi et al). (Pub.by)Springer, 235-240(684) (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Konoshima: "Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng,Panax vietnumensis Ha et Grushv" Biol.Pharm.Bull.21(8). 834-838 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tenji Konishi: "Anti-tumor-promoting activity of diterpenes from Excoecaria agallocha" Biol.Pharm.Bull.21(9). 993-996 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 安田一郎: "細辛に含まれる抗発癌プロモーター作用物質とその含量による品質評価" 東京都立衛生研究所年報. 49. 48-53 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Midori Takasaki: "Inhibitory Effects of Shouseiryu-to on Two-Stage Carcinogenesis.II.Anti-tumor-promoting Activities of Lignans from Asiasarum heterotropoides Var.mandshricum" Biol.Pharm.Bull.20(7). 776-780 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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