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Research on a novel endogenous catecholamine, 6-nitronorepinephrine

Research Project

Project/Area Number 09680771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTeikyo University

Principal Investigator

NAKAKI Toshio  Teikyo University, School of Medicine Department of Pharmacology, Assistant Professor, 医学部, 助教授 (30164148)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsnitric oxide / catecholamine / blood vessels / catalase / hydrogen peroxide / カタラーゼ / スーパーオキシド / NO
Research Abstract

Vasoactivities of 6-nitronorepineplirine were investigated using rat aorta. 6-Nitronorepinephrine (>100 muM) caused dose-dependent contraction in both endothelium-intact and -denuded aorta, although the latter showed greater contraction than the former. Prazosin (>3 nM), an alpha_1-adrenoceptor antagonist, attenuated significantly the 6- nitronorepinephrine-induced contractions, thereby suggesting the alpha_1-adrenoceptor involvement. Aortic rings prepared from reserpine-pretreated rats showed the 6-nitronorepinephrine-induced a contraction tothe extent similar to those from untreated rats, suggesting that endogenous norepinephrine does not play a role in the 6-nitronorepinephrine-induced contraction. 6-Nitronorepinephrine (>10 muM) potentiated norepinephrine-induced contraction only in the presence of endothelium. The augmentation was attenuated by catalase (1,200U/ml). H_2O_2 (10-300 muM) augmented the norepinephrine-induced contraction only in the endothelium-intact rat aortic rings. 6-Nitronorepinephrine attenuated significantly acetyicholine-induced relaxation. Catalase prevented the 6-nitronorepinephrine-induced inhibition of the acetylcholine-induced relaxation. These results suggest that 6-nitronorepinephrine has a weak txi-adrenoceptor agonistic property and that the endothelium-dependent potentiation by 6-nitronorepinephrine of the norepinephrine-induced contraction is mediated through production of H_20_2. Roles of superoxide in the formation of 6-nitronorepinephrine and distribution of the amine in the brain are being currently investigated.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Nakaki, T.: "Endothelium-independent and-dependent vasoactivity of 6-nitronorepinephrine" Eur J Pharmacol. 357. 193-197 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 中木, 敏夫: "生体内ニトロ化, ニトロソ化, ニトロシル化による機能修飾" 日本薬理学雑誌. 112. 161-168 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 中木 敏夫: "高血圧とNO" 臨床神経科学. 16. 90-93 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 中木, 敏夫: "血管トーヌスに対する柴胡加竜骨牡蛎湯の内皮依存性および非依存性作用" Progress in Medicine. 18. 710-714 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 中木, 敏夫: "呼吸器疾患治療薬" 臨床看護. 24. 786-792 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 鈴木, 映二: "向精神薬投与による脳内インターロイキン-1βとインターロイキン受容体アンタゴニストのmRNA濃度の変化" 精神薬療基金研究年報. 29. 201-207 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki, T., Fujii, T., Suzuki, E.and Shintani, F.: "Endothelium-independent and -dependent vasoactivity of 6-nitronorepinephrine." Eur.J.Pharmacol.357. 193-197 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki, T.and Fujii, T.: "Biological significance of nitration, nitrosation and nitrosylation in vivo." Jpn.J.Pharmacol.112. 161-168 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki, T.: "Hypertension and NO." Clinical Neuroscience. 16. 90-93 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki, T.: "Endothelium-dependent and -independent vasoactivities of a Japanese Kampo medicine." Progress in Medicine. 18. 710-714 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki, T.: "Drugs used for the treatment of pulmonary diseases." Jpn J Clin Nurs Month. 24. 786-792 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, E.: "Chronic treatment with various psychotropics elevates mRNA levels of both interleukin-1b and interleukin-1 receptor antagonist in the rat brain." Ann Rep Pharmacopsychiat Res Found. 29. 201-207 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki, T.: Medical Pharmacology.Chugai Igakusha, Tokyo, 562 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki, T.: Cardiovascular Diseases and NO.Kinpodo, Tokyo, 210 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaki,T.: "Endothelium-independent and-dependent vasoactivity of 6-nitronorepinephrine" Eur J Pharmacol. 357. 193-197 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中木敏夫: "生体内ニトロ化、ニトロソ化、ニトロシル化におる機能修飾" 日本薬理学雑誌. 112. 161-168 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中木敏夫: "高血圧とNO" 臨床神経科学. 16. 90-93 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中木敏夫: "血管トーヌスに対する柴胡加竜骨牡蛎湯の内皮依存性および非依存性作用" Progress in Medicine. 18. 710-714 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中木敏夫: "呼吸器疾患治療薬" 臨床看護. 24. 786-792 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 鈴木映二: "向精神薬投与によるラット脳内インターロイキン-1βとインターロイキン-1受容体アンタゴニストのmRNA濃度の変化" 精神薬療基金研究年報. 29. 201-207 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中木敏夫: "医系薬理学" 中外医学社, 562 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中木敏夫: "心血管病態とNO" 金芳堂, 210 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中木 敏夫: "一酸化窒素の生体内標的分子と機能" 帝京医学雑誌. 20. 413-421 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中木 敏夫: "NO吸入療法" 呼吸と循環. 45. 671-677 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakaki,T.: "Nitric oxide and neurodegenerative diseases" Current Topics in Pharmacology. 3. 157-163 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki,E.: "Dexamethason and nitric oxide synthase gene expression in brain" J.Psychiat.Neurosci.22. 105-110 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakaki,T.: "Nitric oxide synthase-mediated formation of Dioactive 6-nitronorepinephrine identified in mammalian brain" Neurochem.Res.22. 850-851 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishimura,Y.: "Oxygen Homeostasis and its Dynamics" Springer, 620 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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