| Project/Area Number |
09680797
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAMADA Yoshitaka Dept.of Anatomy & Neuroboil., Kyoto Prefectural University of Medicine, Research Associate, 医学部, 助手 (60254364)
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| Co-Investigator(Kenkyū-buntansha) |
IIJIMA Norio Dept.of Anatomy & Neuroboil., Kyoto Prefectural University of Medicine, Research, 医学部, 助手 (00285248)
IBATA Yasuhiko Dept.of Anatomy & Neuroboil., Kyoto Prefectural University of Medicine, Professo, 医学部, 教授 (10079684)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | suprachiasmatic nucleus / ptotic stimulation / hypothalamus / circadian rhythm / astrocyte / optic nerve / サーカデイアンリズム / 生体リズム / 神経内分泌 / Immediate early gene / VIPニューロン / 一酸化窒素 |
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| Research Abstract |
(1) Photic induction of NGFI-A gene expression was investigated in the SCN using in situ hybridization histochemistry. The broadness of NGFI-A mRNA and c-fos mRNA expression after photic stimulation were different. And NGFI-A gene induced in these cells of the SCN including VIP neurons are considered to be involved in circadian entrainment by light (Brain Res., 1997). (2) According to aging, the expression of VIP mRNA in the SCN was markedly decreased and their rhythm was disappeared (Neurosci.Lett., 1997). (3) The retinal projections to gastrin-releasing peptide (GRP) neurons in the SCN were investigated. The photic information is considered to be directly input from the optic nerve to GRP neurons and GRP neurons may be involved in circadian entrainment by light (NeuroReport 1997). (4) To explore the effect of photic stimulation in the astroglial elements in the hypothalamus, GFAP-like immunoreactive elements in the SCN and median eminence was investigated morphologically (Brain Res.Bull, 1998 ; Acta Histocem.Cytochem., 1998).
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