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Role of the cerebellar floccular lobe and vermis in vertical smooth pursuit eye movement

Research Project

Project/Area Number 09680806
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

FUKUSHIMA Kikuro  School of Med., Hokkaido Univ.Professor, 医学部, 教授 (70091486)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsMonkey / Direction tuning / Smooth pursuit / Vertical vestibulo-ocular reflex / Cerebellar floccular lobe / Vermis / Gaze velocity / Purkinje cell
Research Abstract

To understand how the floccular lobe is involved in vertical smooth pursuit and vestibulo-ocular reflex (VOR), we examined simple-spike activity of 58 vertical Purkinje (P-) cells. Vertical gaze velocity (VG) P-cells constituted only a minority of vertical P-cells (19%). Other P-cells that responded during pitch VOR suppression were classified as eye and head velocity (V E/H) P-cells (48%), regardless of the synergy of their response direction during pursuit and VOR suppression. Vertical P-cells that did not respond during pitch VOR suppression but responded during rotation in vertical planes other than pitch were classified as off-pitch V E/H P-cells (33%). The mean eye-velocity and eye-position sensitivities of the 3 types of vertical P-cells were similar. Maximal vestibular activation directions (MADs) were examined during VOR suppression by applying vertical whole body rotation with the monkeys oriented in different vertical planes. The MADs for VGP- and V E/H P-cells with eye and … More vestibular sensitivity in the same direction were distributed near the pitch plane, suggesting convergence of bilateral anterior canal inputs. In contrast, MADs of off-pitch V E/ HP-cells and V E/H P-cells with oppositely directed eye and vestibular sensitivity were shifted towards the roll plane, suggesting convergence of anterior and posterior canal inputs of the same side. Unlike horizontal GP-cells, the modulation of many V G and V E/H P-cells when the target was fixed in space (pitch VOR x1) was not well predicted by the linear addition of their modulations during vertical pursuit and pitch VOR suppression. These results indicate that the populations of vertical and horizontal eye-movement P-cells in the floccular lobe have markedly different discharge properties. Recordings in the cerebellar vermis using identical paradigms revealed many G P-cells with oblique preferred directions. These results suggest that these two structures are involved in different kinds of processing of vestibular-oculomotor interactions. Less

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Fukushima K: "Cortico-vestibular interactions : anatomy, electrophysiology and functional considerations." Exp Brain Res. 117. 1-16 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka M: "Slow eye movement evoked by suden appearance of a stationary visual stimulus observed in a step-ramp pursuit task in monkey." Neurosci Res. 29. 93-98 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki Y: "Stability of ocular counterrolling and Listings plane during static roll tilts." Invest Ophthalmol Visual Sci. 38. 2103-2111 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohashi T: "Ocular tilt reaction with vertical eye movement palsy caused by localized unilateral midbrain lesion." J Neuro-Ophthalmology. 18. 40-42 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kaneko CRS: "Discharge characteristics of vestibular saccade neurons in alert monkeys." J Neurophysiol.79. 835-847 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka M: "Neuronal responses related to smooth pursuit eye movements in the periarcuate cortical area of monkeys." Exp Brain Res. 142. 92-98 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka M: "Latency of saccades during smooth pursuit eye movements in man : directional symmetries." J Neurophysiol.80. 28-47 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato T: "Latency of cross-axis vestibulo-ocular reflex induced by pursuit training in monkeys." Neurosci Res. 33. 65-70 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukushima K: "Cross axis VOR induced by pursuit training in monkeys : further properties of adaptive responses." Arch.ital.Biol. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukushima K: "Vestibular-pursuit interactions : gaze velocity and target velocity signals in the monkey frontal eye fields." NY Acad Sci. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukushima K: "Cortico-vestibular interactions : anatomy, electrophysiology and functional considerations" Exp Brain Res. 117. 1-16 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka M: "Slow eye movement evoked by sudden appearance of a stationary visual stimulus observed in a step-ramp pursuit task in monkey" Neurosci Res. 29. 93-98 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki Y: "Stability of ocular counterrolling and Listings plane during static roll tilts." Invest Ophthalmol Visual Sci. 38. 2103-2111 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohashi T: "Ocular tilt reaction with vertical eye movement palsy caused by localized unilateral midbrain lesion" J Neuro-Ophthalmology. 18. 40-42 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kaneko CRS: "Discharge characteristics of vestibular saccade neurons in alert monkeys." J Neurophysiol. 79. 835-847 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka M: "Latency of saccades during smooth pursuit eye movements in man : directional symmetries" Exp Brain Res. 142. 92-98 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka M: "Neuronal responses related to smooth pursuit eye movements in the periarcuate cortical area of monkeys." J Neurophysiol. 80. 28-47 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato T: "Latency of cross-axis vestibulo-ocular reflex induced by pursuit training in monkeys." Neurosci Res. 33. 65-70 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukushima K: "Cross axis VOR induced by pursuit training in monkeys : further properties of adaptive responses." Arch.ital.Biol.(in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukushima K: "Vestibular-pursuit interactions : gaze velocity and target velocity signals in the monkey frontal eye fields" NY Acad Sci. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kaneko CRS: "Discharge characteristics of vestibular saccade neurons in alert monkeys." J Neurophysiol. 79. 835-847 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka M: "Neuronal responses related to smooth pursuit eye movements in the periarcuate cortical area of monkeys." J Neurophysiol. 80. 28-47 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka M: "Latency of saccades during smooth pursuit eye movements in man : directional symmetries." Exp Brain Res. 142. 92-98 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohashi T: "Ocular tilt reaction with vertical eye movement palsy caused by localized unilateral midbrain lesion." J Neuro-Ophthalmology. 18. 40-42 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sato T: "Latency of cross-axis vesubuio-ocular reflex induced by pursuit training in monkeys." Neurosci Res. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukushima K: "Cross axis VOR induced by pursuit training in monkeys : further properties of adaptive responses." Arch.ital.Biol. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukushima K: "Cortico-vestibular interactions : anatomy,electrophysiology and functional considerations" Experimental Brain Research. 117. 1-16 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka M: "Slow eye movement evoked by sudden appearance of a stationary visual stimulus observed in a step-ramp pursuit task in monkey" Neuroscience Research. 29. 93-98 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki Y: "Stability of ocular counterrolling and Listings plane during static roll titls" Invest Ophthalmol Visual Sci. 38. 2103-2111 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 福島菊郎: "いわゆる眼球運動における"神経積分器"について" Equilibrium Research. 56. 14-33 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kaneko CRS: "Discharge characteristics of vestibular saccade neurons in alert monkeys" Journal of Neurophysiology. 79. 835-847 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka M: "Latency of saccades during smooth pursuit eye movements in man : directional symmetries" Experimental Brain Research. (in press). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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