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Feedback and feedforward neural control of muscle glucose uptake during contraction

Research Project

Project/Area Number 09680839
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

NAKAMURA Takao  Res.Inst.for Electro.Sci., Hokkaido Univ., Assoc.Prof., 電子科学研究所, 助教授 (00142654)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Yoshiko  Res.Inst.for Electro.Sci., Hokkaido Univ., Assist.Prof., 電子科学研究所, 助手 (50230313)
HARA Tsutomu  Sch.of Med., Aichi Medical Univ., Lect., 医学部, 講師 (00198889)
KUSUNOKI Masataka  Sch.of Med., Aichi Medical Univ., Lect., 医学部, 講師 (80214956)
KAWAHARA Koichi  Res.Inst.for Electro.Sci., Hokkaido Univ., Prof., 電子科学研究所, 教授 (20125397)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsfeedback control / feedforward control / the central nervous system / muscle contraction / muscle glucose uptake / muscle sympathetic nerve / microneurogram / 運動
Research Abstract

To clarify a possibility of muscle sympathetic (MS) nervous system (MSNS) as an efferent path of neurally controlled muscle glucose uptake (MGU) system during contraction, microneurographic technique has been tested in the sciatic nerve of anesthetized rats. After surgical methodology has been established and the location of MS fibers in the nerve bundle has been clarified, in the supine position, multi-fiber MSNA and blood glucose level (BG) were measured at rest as well as during induced muscle contraction in the ipsilateral hindlimb. To our best knowledge, this was the first case that the microneurography was used for the measurement of MS nerve activity (MSNA) in small animals. The data was stored in a data recorder, and analyzed off-line with a personal computer system. A criteria to identify MSNA have been established, MSNA was evaluated with conventional methods including the integrated neurogram, and a novel method using continuous wavelet transform has been developed for detecting action potentials. Results showed that the BG decreased during muscle contraction and that it was accompanied with an enhancement of MSNA, suggesting the MSNS is the efferent path in the neural feedback control system of MGU.
To approach the central feedforward control system, rat heads were fixed in a stereotactic frame, and methodology has been established to record MSNA in the prone position by microneurography. As a candidate of the control center in the central nervous system, neural signal in the ventromedial hypothalamus nuclei (VMH) has been tried to find out with a tungsten microelectrode, because VMH is believed to affect MGU at rest. However, it has not been established well yet to identify the location of or signal from VMH, It is considered to be necessary to develop new methods, including Fos method for example, to identify them in the future projects.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 下野真博、他: "末梢筋収縮時糖代謝亢進に伴う筋交感神経活動の変化" 電子情報通信学会技術報告. MBE97-29. 31-34 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Involvement of the nervous system in the control of glucose uptake in contracting hindlimb muscle in the rat." Hormone and Metabolic Research. 29. 593-598 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nakamura, et al.: "Possibility of the nervous system as one of the non-insulin mediated controllers for muscle glucose uptake." Proc.9th ICBME. 731-732 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Hara, et al.: "A lipoprotein lipase activator, NO-1886, improves endothelium-dependent relaxation of rat aorta associated with aging." Eur.J.Pharmacol.350. 75-79 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 楠正隆、他: "医工学治療からみた未来の医療機器に望むこと" BME. 12. 14-19 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 中村孝夫、他: "マイクロニューログラム法によるラット座骨神経内交感神経活動の計測" 第13回生体生理工学シンポジウム論文集. 31-34 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Shimono, T.Nakamura, K.Kawahara, M.Kusunoki and T.Hara: "Muscle sympathetic nerve activity (MSNA) during increase of glucose uptake in contracting peripheral muscle" Technical Report of IEICE. MBE97-29. 31-34 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nakamura, K.Kawahara, M.Kusunoki, T.Hara and I.Minejima: "Involvement of the nervous system in the control of glucose uptake in contracting hindlimb muscle in the rat." Horm.Metab.Res. 29. 593-598 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nakamura, K.Kawahara, M.Kusunoki, M.Shimono, T.Hara and I.Minejima: "Possibility of the nervous system as one of the non-insulin mediated controllers for muscle glucose uptake" Proc.9th ICBME. 731-732 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Hara, M.Kusunoki, K.Tsutsumi, K.Okada, S.Sakamoto, M.Ohnaka, T.Nakamura, T.Miyata, K.Nakayama, A.Fukatsu, K.Kato, S.Kakumu and Y.Nakaya: "A lipoprotein lipase activator, NO-1886, improves endothelium-dependent relaxation of rat aorta associated with aging" Eur.J.Pharmacol. 350. 75-79 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Kusunoki, H.Mizuno, T.Nakamura, T.Hara, F.Sakakibara, Y.Fukuzawa, T.Suga and S.Kakumu: "Medical equipment for future biomedical therapy" BME. 12. 14-19 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Nakamura, M.Kusunoki, T.Hara, H.Komori and K.Kawahara: "Sympathetic nerve activity in the rat sciatic nerve measured by microneurography" Proc.13th Symp.Biol.Physiol.Eng.31-34 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Hara,et al.: "A lipoprotein lipase activator,NO-1886,improves endothelium-dependent relaxation of rat aorta associated with aging." Eur.J.Pharmacol.350. 75-79 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 楠正隆、他: "医工学治療からみた未来の医療機器に望むこと" BME. 12. 14-19 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中村孝夫、他: "マイクロニューログラム法によるラツト座骨神経内交感神経活動の計測" 第13回生体生理工学シンポジウム論文集. 31-34 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中村孝夫、他: "収縮時末梢筋の糖取込み亢進に伴う筋交感神経活動の変化" 自律神経. 35. 226 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Nakamura,et al.: "Microneurography for the measurement of muscle sympathetic activity in the sciatic nerve of anesthetized rats." Proc.4th Cong.FAOPS and 2nd Cong.FAONS. 213 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Kusunoki,et al.: "Eicosapentaenoic acid ameliorates insulin resistance,but increases muscle triglyceride in OLETF rats." Diabetologia. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 下野真博、他: "末梢筋収縮時糖代謝亢進に伴う筋交感神経活動の変化" 電子情報通信学会技術報告. BME97-29. 31-34 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Nakamura, et al.: "Involvement of the nervous system in the control of glucose uptake in contracting hindlimb muscle in the rat." Hormone and Metabolic Research. 29. 593-598 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Nakamura, et al.: "Muscle sympathetic nerve activity (MSNA) changes concomitantly with temporary decrease in blood glucose during muscle contraction in rats." J.of Autonomic Nervous System.65. 92- (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中村孝夫、他: "収縮開始時の末梢筋糖吸収亢進に伴う筋交感神経活動の変化" 第12回生体・生理工学シンポジウム論文集. 273-276 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Nakamura, et al.: "Possibility of the nervous system as one of the non-insulin mediated controllers for muscle glucose uptake." Proc.9th ICBME. 731-732 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中村孝夫、他: "末梢筋収縮時糖代謝の神経制御に関する研究" 電子科学研究. 5. 92-93 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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