| Project/Area Number |
09680841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
YOSHIZAWA Makoto Grad.Sch.of Eng., Tohoku Univ., Assoc.Prof., 大学院・工学研究科, 助教授 (60166931)
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| Co-Investigator(Kenkyū-buntansha) |
YAMBE Tomoyuki Inst.of Development, Aging and Cancer, Tohoku University, Assoc.Prof., 大学院・加齢医学研究所, 助教授 (70241578)
ABE Ken-ichi Grad.Sch.of Eng., Tohoku Univ., Prof., 大学院・工学研究科, 教授 (70005403)
NITTA Shin-ichi Inst.of Development, Aging and Cancer, Tohoku University, Prof., 大学院・加齢医学研究所, 教授 (90101138)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | Emax / maximum ventricular elastance / estimation / low-invasive / assisted circulation / cardiac function / Ees / inverse problem / E_<max> |
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| Research Abstract |
The maximum ventricular elastance (Emax) will be a good quantitative index for weaning the patient from the ventricular assist device if the Emax can be obtained low-invasively. The purpose of this research was to develop a method for estimating the Emax beat-to-beat and less-invasively.
First, it was formulated that the process for estimating the Emax is a kind of inverse problem. This leaded to an algorithm for estimating the Emax beat-to-beat on the basis of only two measurements : ventricular pressure and ventricular volume or aortic flow.
Second, the algorithm was implemented on a personal computer system to calculate Emax in a real-time fashion.
Third, the animal experiments using goats were carried out in many situations with change in preload and afterload or with injections for changing cardiac function. The data obtained from the experiments)showed that the correlation coefficient of the Emax between the proposed method and the traditional method was about 0.9. This indicates that the proposed method is sufficiently useful for monitoring cardiac function. Furthermore, it could be shown that the proposed method is superior to the traditional methods because the estimation error can be evaluated quantitatively as an error with respect to the intercept of the end-systolic pressure volume regression line.
To apply the proposed method to actual clinical settings, the proposed method must be further improved so that another less-invasive information like aortic pressure instead of ventricular pressure can be used for estimating the Emax.
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