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Development of Three Dimensional Tissue Elasticity Imaging -Acoustic Palpation- System based on Combined Autocorrelation

Research Project

Project/Area Number 09680844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIINA Tsuyoshi  Institute of Information Sciences and Electronics, University of Tsukuba Associate Professor, 電子・情報工学系, 助教授 (40192603)

Co-Investigator(Kenkyū-buntansha) UENO Ei  Institute of Clinical Medicine, University of Tsukuba Lecturer, 臨床医学系, 講師 (90150614)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsUltrasonic biomedical measurement / Ultrasonic tissue characterization / Tissue strain image / Tissue elasticity image / Quantification of palpation / 3-D ultrasound / Autocorrelation method / Medical diagnosis systems / 組織弾性率 / 超音波による触診 / 実時間処理 / 三次元計測
Research Abstract

The variation of elastic properties of tissues have much relation to the pathological condition. Therefore, the image of strain distribution when static compression is applied are proven to be useful for detecting the disease tissue based on the difference of tissue elastic properties though it is more qualitative but easier to detect than elastic modulus distribution.
So far, many approaches to obtain strain image from echo signals have been proposed. However, most methods are based on the spatial correlation technique and do not suit for real-time processing since they require much computation time. Although alternative approach, that is, a phase tracking method can realize the rapid detection of strain, it does not work a large displacement required for the high SN ratio of strain image. Therefore, we developed a new technique for tissue elasticity imaging from the viewpoint of the feasibility. The proposed approach referred to as the combined autocorrelation method has a merit of ob … More taining high quality strain image with real-time processing and being applicable to a large displacement.
On the other hand, some approach for elasticity imaging are investigated for the purpose of obtaining more quantitative properties of tissues. However, in order to simplify the estimation problem, many approaches for estimating elastic modulus distribution.are based on 2-D model, for example, plane stress distribution or plane strain distribution, which is not always satisfied for actual tissues. Therefore, we have developed a method of estimating the elastic modulus under more practical conditon based on a 3-D tissue model.
Numeric simulation and phantom experiment demonstrated that the method has a higher capability of reconstructing the image of tissue strain distribution in practical condition as compared with conventional spatial correlation method. Moreover, image of elastic modulus distribution was also obtained by estimating stress distribution using 3-D.tissue model. Measurement of breast tumor specimen is performed by the proposed method so that the obtained strain image clearly detected the harder tumor lesions which were vague in B-mode image. Moreover, the results indicated the possibility of extracting the pathological characteristic of tumor to be useful for discrimination of tumor type. These validate the feasibility of the proposed method for clinical application. Less

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 椎名 毅: "複合自己相関法による実時間 Tissue Elasticity Imaging" Journal of Medical Ultrasound. 26巻,2号 (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Yamakawa: "Tissue Elasticity Reconstruction based on 3-D Finite Element Model" Japanese Journal of Applied Physics. 38巻 1-5B号 (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Shiina: "A New Imaging Technique of 3-D Velocity Vector Distribution using 2-D Phased Array Probe" 1998 IEEE International Ultrasonic Symposium Proceedings. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Nitta: "Tissue Elasticity Imaging based on Combined Autocorrelation Method and 3-D Tissue Model" 1998 IEEE International Ultrasonic Symposium Proceedings. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Nitta: "Real-Time Three-Dimensional Velocity Vector Measurement using the Weighted Phase Gradient Method" Japanese Journal of Applied Physics. 37巻,1-5B号. 3058-3063 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 椎名 毅: "超音波による組織弾性の画像化-Tissue Elasticity Imaging-" Medical Imaging Technology. 16巻,4号. 351-352 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.SHIINA: ""Rral-Time Tissue Elasticity Imaging Based on Combined Autocorrelation Method"" Journal of Medical Ultrasound. Vol.26, No.2 (to be published). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Yamakawa: ""Tissue Elasticity Reconstruction based on 3-D Finite Element Model"" Japanese Journal of Applied Physics. Vol.38, Part1, No.5B (to be published). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Shiina: ""A New Imaging Technique of 3-D Velocity Vector Distribution using 2-D Phased Array Probe"" 1998 IEEE International Ultrasonic Symposium Proceedings. (to be published). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Nitta: ""Tissue Elasticity Imaging based on Combined Autocorrelation Method and 3-D Tissue Model"" 1998 IEEE International Ultrasonic Symposium Proceedings. (to be published). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Nitta: ""Real-Time Three-Dimensional Velocity Vector Measurement using the Weighted Phase Gradient Method"" Japanese Journal of Applied Physics. Vol.37, Part1, No.5B. 3058-3063 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naotaka Nitta: "Real-Time Three-Dimensional Velocity Vector Measurement Using Weighted Phase Gradient Method" Jpn.J.Appl.Phys.37 Part.I. 3058-3063 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山川 誠: "超音波による3次元組織弾性率分布推定法の検討" 医用電子と生体工学. 36巻 特別号. 663-664 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 椎名 毅: "超音波による組織弾性の画像化" Medical Imaging Technology. 16巻4号. 351-352 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 椎名 毅: "Elasticity Imagingによる腫瘍鑑別の基礎的検討" J.Med.Ultrasonics. 25巻4号. 237 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山川 誠: "3次元組織モデルによる弾性率分布の再構成" 電気学会 医用生体工学研究会試料. MBE-98-2. 9-12 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 椎名 毅: "複合自己相関法による実時間Tissue Elasticity Imaging" J.Med.Ultrasonics. 26巻2号(掲載予定). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 新田尚隆: "Combined Autocorrelation法を用いた乳房腫瘍の弾性特性の画像化" Journal of Medical Ultrasonics. 24巻,9号. 496-496 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 椎名 毅: "重み付き位相勾配法による3次元速度ベクトル計測法" 電子情報通信学会技術報告. US97-70. 63-67 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 新田尚隆: "超音波によるリアルタイム組織歪み計測法の検討" 医用電子と生体工学. 35巻秋期特別号. 96-96 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 椎名 毅: "Combined autocorrelation法による組織歪み分布計測" Journal of Medical Ultrasonics. 24巻,3号. 343-343 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 新田尚隆: "重み付き位相勾配法による三次元速度ベクトル空間分布の実時間計測" 第18回超音波エレクトロニクスの基礎と応用に関するシンポジウム講演予稿集. 239-240 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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