| Project/Area Number |
09680852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
IKEDA Noboru (1998) Kyoto University, Orthopaedic Surgery, Assistant, 医学研究科, 助手 (10273442)
川那辺 圭一 (1997) 京都大学, 医学研究科, 助手 (20273451)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi Kyoto University, Orthopaedic Surgery, Professor, 医学研究科, 教授 (10201675)
池田 登 京都大学, 医学研究科, 助手 (10273442)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Bioactive bone cement / Segmental bone defect |
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| Research Abstract |
We have developed a bioactive bone cement (BABC) which consists of spatite and wollastonite containing glass-ceramic (AW-GC) powder and bisphenol-A-glycidyl dimethacrylate (Bis-GMA)-based resin, In the present study, the effectiveness of the BABC for repair of segmental bone defects under load-bearing conditions was examined using a rabbit-tibia model. Polymethylmethacrylate (PMMA) bone cement was used as a control. A 15-mm-length of bone was resected from the middle of the shaft of the tibia, and the tibia was fixed by two Kirschner wires. The defects were replaced by cement. Each cement was used in 12 rabbits, with six rabbits each being killed at 12 and 25 weeks after surgery and the tibia containing the bone cement was excised and tension-tested. At both the intervals studied, the failure loads of the BABC were significantly higher than those of the PMMA cement. There was no significant change between the failure loads at 12 and 25 weeks for either cement. The BABC was in direct contact with bone, whereas soft tissue was observed between cement and bone in all PMMA cement specimens. Results indicated that the BABC was useful as a bone substitute under load-bearing conditions.
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