| Project/Area Number |
09832009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
咀嚼
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| Research Institution | Shimane Medical University |
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Principal Investigator |
TSUMORI Toshiko Shimane Med.Univ., Depat.Anaromy, Assistant Prof., 医学部, 助手 (30217377)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Yukihiko Shimane Med.Univ., Depat.Anaromy, Professor, 医学部, 教授 (30174501)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | substantia nigra pars reticulata / parafascicular thalamic nucleus / striatum / lateral agranular cortex / 外側無顆粒性皮質 / 大脳皮質 / 大脳基底核 / 視床 / 黒質 / 顎運動 |
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| Research Abstract |
We have already indicated that the dorsolateral part of the substabtia nigra pars reticulata (SNr), which is one of the major output nuclei of the basal ganglia, plays an important role in the control of jaw movement. The rostroventral part of the lateral agranular cortex (AGi) and the ventrolateral part of the striatum have been known as the area involved in the control of orofacial movement, In the present study, we examined the possible pathways from the dorsolateral part of the SNr to the rostroventral part of the AGl and the ventrolateral part of the striatum relayed by the thalamus using a combined anterograde and retrograde tracing technique.
We first showed that the dorsolateral part of the SNr sent projection fibers to the ventrolateral part of the parafascicular thalamic nucleus (PE). Secondly, we indicated the overlapping distributions of the nigral fibers and the PF neurons projecting to the rostroventral part of the AGl or to the ventrolateral part of the striatum in the ventrolateral part of the PF.This part of the PF contained not only some neurons projecting to the rostroventral part of the AGl, but also many neurons projecting to the ventrolateral part of the striatum. The nigral axon terminals made symmetrical synaptic contacts with the soma and dendrites of the PF neurons projecting to the AGl or to the striatum. Thus, the SNr-PF-AGl and SNr-PF-striatal pathways revealed by the present study may be involved in the control mechanism of orofacial motor functions.
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