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がん患者への精神医学的介入に関する神経精神免疫学的研究

Research Project

Project/Area Number 09877183
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionHiroshima University

Principal Investigator

山脇 成人  広島大学, 医学部, 教授 (40230601)

Co-Investigator(Kenkyū-buntansha) 加賀谷 有行  広島大学, 医学部, 助手 (60274065)
堀口 淳  広島大学, 医学部, 助教授 (90136317)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Keywordsがん患者 / QOL / 不安・抑うつ / 精神医学的介入 / コーピング / 家族機能 / 精神免疫 / がん / 精神症状 / 神経精神免疫
Research Abstract

本研究では、がん患者への精神医学的介入が患者のQOLおよび予後に及ぼす影響について検討し、以下のような結果を得た。
1. 術後の乳癌患者227例について、がんリハビリ評価システム(Cancer Rehabi1itation Examination System:CARES)を用いて術後1年目のQOL予測因子について検討した結果、感情状態の評価尺度(Profile of Mood State:POMS)とリンパ節転移が術後の不良なQOLの予測因子となりうることが示された。
2. 再発リスクの高い乳癌患者126例にグループ精神療法に関して調査した結果、興味あり106例(84,1%)、うち53例が参加意思ありで、高いニーズが示された。参加意思あり群の背景因子として、強い不安、抑うつが関連していた。実際にグループ療法を実施できた10例の分析から、日本人用のグループ療法プログラムを作成し、その妥当性を検討した。
3. 乳癌患者18例について、がんに対するコーピングスタイルの評価尺度(Mental Adjustment to Cancer Scale;MAC)、感情状態の評価尺度(POMS)を、また患者の同居家族全員に対して、家族機能の評価尺度(FAD)を用いて評価し、それぞれの相関を検討した結果、FADとMAC・POMSには高い相関性があり、患者のコーピングや感情状態に家族機能が密接に関与することが確認され、限られた医療資源の中で患者のQOLを向上させるためには、家族の効率的な関与が必要であり、その支持体制の確立が重要であると考えられた。
精神医学的介入と免疫マーカー(NK細胞活性、TNF活性など)との関連は今回の研究では確認できなかったが、精神医学的介入はがん患者のQOL向上に有用であることが示された。

Report

(2 results)
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Okamoto, Y.: "Trazodone in the treatment of delirium." J Clinical Psychopharmacology. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Akechi, T.: "Fatigue and its associated factors in ambulatory cancer patients-A preliminary study-" Journal of Pain and Symptom Management. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Hayashi, T.: "Neuroleptics with differential affinity at dopamine D2 receptors and sigma receptors affect differentially the N-methyl-D-aspartate-induced in crease in intracellular calcium concentration : Involvement of protein kinase." SYNAPSE. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Akechi, T.: "Predictors of patients' mental adjustment to cancer : patient characteristics and social support." British Journal of Cancer. 77. 2381-2385 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akechi, T.: "Predictive factors for psychological distress in ambulatory lung cancer patients." Support Care Cancer. 6. 281-286 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zensho, H.: "Heat shock protein 72 restores cyclic AMP accumulation after haeat shock in N18TG2 cells." Brain Research. 790. 278-283 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takebayashi, M.: "Plasma dehydroepiandrosterone sulfate in unipolar major depresion." Journal of Neural Transmission. 105. 537-542 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takabayashi, M.: "Differential regulation by pregnenolone sulfate of intracellular Ca^<2+> increase by amino acids in primary cultured rat cortical neurons." Neurochemistry International. 32. 205-211 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mori, T.: "Two cases of steroid psychosis induced after steroid pulse therapy." International Clinical Psychopharmacology. 13. 47 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tawara, Y.: "Lipopolysaccharide regulates both serotonin- and thrombin-induced intracellular calcium mobilization in rat C6 glioma cells : possible involvement of nitric oxide synthase-mediated pathway." Journal of Neuroscience Research. 51. 517-525 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamawaki, S.: "Intracellular calcium signaling systems in the pathophysiology of affective disorders" Life Sciences. 62. 1665-1670 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Uchitomi, Y.: "Positive influence of a liaison programme on the rate of psychiatric consultation referrals for cancer patients." Psychiatry adn Clinical Neurosciences. 52. 275-278 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 佐伯俊成: "家族のストレス" Current Therapy. 16. 59-62 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 新野秀人: "癌性疼痛の治療・-癌性疼痛の心理的援助-" The Pain. 10. 1-2 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamawaki, S.: "Calcium Ion Modulators : The New Wave of Psychotropic Drugs" Intracellular calcium signaling systems in the pathophysiology of affective disorders., 11 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okamura, H.: "Current Perspectives and Future Directons in Palliative Medicine" Depression in patients with advanced cancer., 10 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山脇成人: "疼痛コントロールのABC" 心理療法, 1 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 皆川英明: "コンサルテーション・リエゾン精神医療" 終末期がん患者のせん妄, 11 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Kugaya: "Modulation of endothelin-induced intracellular Ca^<2+>mobilization by interleukin-1β and lipopolysaccharide in C6 rat glioma cells." Neuropeptides. 31.2. 187-192 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Kagaya: "Plasma levels of cyclic GMP,immune parameters and depressive status during interferon therapy:A prospective study in Japan." Neuropsychobiology. 35.3. 128-131 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山脇成人: "がん患者の精神症状・心理状態とその対応" 綜合臨床. 46.10. 2593-2594 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Tawara: "Lipopolysaccharide regulates both serotonin-and thrombin-induced intracellular calcium mobilization in rat C6 glioma cells:possible involvement of nitric oxide synthase-mediated pathway" Journal of Neuroscience Research. in press.

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Akechi: "Predictors of patients'mental adjustment to cancer:fighting stirit versus helplesness/hopelessness" Life Science. in press.

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Yamawaki: "Intracellular calcium signaling systems in the pathophysiology of affective disorders." Life Science. in press.

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Kagaya: "Signal Transduction in affective Disorders" Springer-Verlag, 150 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Yamawaki: "Ca Ion Modulators:New Wave of Psychotropic Drugs in Japan" Gordon Science,

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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