感染症と免疫病の分子生物学と医学

• Project/Area Number: 09CE2007
• Research Category: Grant-in-Aid for COE Research
• Allocation Type: Single-year Grants
• Research Institution: Osaka University
• Principal Investigator: 山西 弘一 (2003) 大阪大学, 医学系研究科, 教授 (10029811); 岸本 忠三 (1997-2002) 大阪大学, 医学系研究科, 総長 (10093402)
• Co-Investigator(Kenkyū-buntansha): 審良 静男 大阪大学, 微生物病研究所, 教授 (50192919) ; 菊谷 仁 大阪大学, 微生物病研究所, 教授 (80161412) ; 木下 タロウ 大阪大学, 微生物病研究所, 教授 (10153165) ; 山西 弘一 大阪大学, 医学系研究科, 教授 (10029811) ; 清野 宏 大阪大学, 微生物病研究所, 教授 (10271032)
• Project Period (FY): 1997 – 2003
• Project Status: Completed (Fiscal Year 2003)
• Budget Amount: ¥2,712,000,000 (Direct Cost: ¥2,565,000,000、Indirect Cost: ¥147,000,000); Fiscal Year 2003: ¥390,000,000 (Direct Cost: ¥300,000,000、Indirect Cost: ¥90,000,000); Fiscal Year 2002: ¥247,000,000 (Direct Cost: ¥190,000,000、Indirect Cost: ¥57,000,000); Fiscal Year 2001: ¥470,000,000 (Direct Cost: ¥470,000,000); Fiscal Year 2000: ¥370,000,000 (Direct Cost: ¥370,000,000); Fiscal Year 1999: ¥435,000,000 (Direct Cost: ¥435,000,000); Fiscal Year 1998: ¥410,000,000 (Direct Cost: ¥410,000,000); Fiscal Year 1997: ¥390,000,000 (Direct Cost: ¥390,000,000)
• Keywords: GPIアンカー / PIG-V / Sema4A / sema6D / TLR / MyD88非依存症性経路 / gH-gL-gO / LANA / 感染症 / 免疫病 / サイトカイン / 自然免疫 / ヒトヘルペスウイルス6 / セマフォリン / Toll様レセプター / 粘膜免疫 / インターロイキン6 / ヒトヘルペルウイルス6 / CD40 / ヒトヘルペスウイルス

Research Abstract

(木下)1.ヒトのGPIアンカー生合成遺伝子群の解明に関し、PIG-Vが第2のマンノース転移酵素であること、PIG-Wがイノシトールへのアシル転移酵素であること、PGAP1がイノシトール・デアシラーゼであることを証明した。これにより、GPIアンカーが小胞体膜の細胞質側から内腔側へフリップするステップを除き、生合成の全ステップに働く遺伝子群が解明された。2.睡眠病トリパノソーマのGPIアンカー生合成遺伝子群の解明に関し、アンカーをタンパク質に付加するGPIトランスアミダーゼにヒトには存在しない2つのタンパク質(TTA1,TTA2)が必須であることを見いだした。これらのタンパク質は、睡眠病治療薬の標的に適している。
(菊谷)これまでクラスIVセマフォリンSema4AがTIM2を介してT細胞を刺激することを報告してきたが、本年度はSema4A欠損マウスを作成し、その解析からSema4Aが抗原特異的T細胞の分化、特にTh1細胞に必須であることを示した。また、新規クラスVIセマファリンSema6Dをクローニングし、Sema6Dがその受容体Plexin-A1を介して心内皮細胞の遊走を調節し、心臓形態形成に必須の役割を果たすことを明らかにした。さらに、Sema6Dは免疫系においても樹状細胞のサイトカイン産生を誘導するなどの生物活性を有することが明らかになった。
(審良)Toll Like Receptor(TLR)を介した細胞内シグナル伝達では、全てのTLRの炎症性サイトカインの誘導に必須のMyD88依存性経路と、TLR3,4を介しInterfron(IFN)-β,IFN誘導性遺伝子を誘導するMyD88非依存性経路が存在する。MyD88と同じTIRドメインを持つアダプター群のノックアウトマウスの作製、解析を行った。TIRAPはTLR2,4を介したMyD88依存性経路に関与していた。データベースから同定したTRIFはTLR3,4を介するMyD88非依存性経路に、TRAMはTLR4を介するMyD88依存性経路にだけかかわるアダプターであることを明らかにした。TLRを介したシグナルはアダプター群が制御しその特異性も規定していることがわかった。
(山西)1.ヒトヘルペスウイルス7(HHV7)U12遺伝子が機能的なβケモカインレセプターであることを明らかにした。これによりU12遺伝子産物が何らかのかたちで病態発症にかかわっていることが示唆された。ヒトヘルペスウイルス6(HHV6)variant AのgH-gL-gQがCD46と相互作用すること、HHV6 A U100遺伝子産物がgH-gLコンプレックスの形成因子の一つになっていることなどが明らかになった。Variant Aとvariant Bではウイルス粒子膜分子の形成が異なっており、これが感染細胞の特異性を決めているものと思われる。2.カポジ肉腫関連ヘルペスウイルス(KSHV)では、前初期遺伝子RTAがアポトーシスインデューサーであるにも関わらず、感染細胞ではXIAPの発現上昇によりこの機能が阻止されることを明らかにした。この機構にはORF57遺伝子産物と宿主細胞因子PCBP1が相互作用することにより、XIAP遺伝子のIRESの機能を上昇させることが主な理由であることを突き止めた。潜伏感染状態はウイルス遺伝子latency associated nuclear antigen(LANA)がヒストンメチラーゼSUV39H1と相互作用し、ゲノムをヘテロクロマチン化することにより誘導され、このことが潜伏感染での遺伝子発現プロファイルに強く関わっていることを明らかにした。

Research Products

• [Publications] Toyofuku, T., et al.: "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with Off-Track and vascular endothelial growth factor receptor type 2."Genes.Develp. (In press). (2004)
• [Publications] Tanaka, S., et al.: "Inositol-deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p."J.Biol.Chem. (In press). (2004)
• [Publications] Nishimura, J., et al.: "Clinical course and flow cytometric analysis of PNH in the USA and Japan."Medicin. (In press). (2004)
• [Publications] Campos, M.A., et al.: "Impaired production of proinflammatory cytokines and host resistance to acute infection with trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88."J.Immunol.. 172. 1711-1718 (2004)
• [Publications] Inoue, H., et al.: "Role of STAT3 in regulation of hepatic gluconegenic genes and carbohydrate metabolism in vivo."Nat.Med.. (In press). (2004)
• [Publications] Sasaki, H., et al.: "Gamma interferom (IFN-g) and IFN-g-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resoption in vivo."Clin.Diagn.Lab.Immunol.. 11. 106-110 (2004)
• [Publications] Into, T., et al.: "Stimulation of human Toll-like receptor (TLR)2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apopototic cell death after NF-kB activation."Cell Microbiol.. 6. 187-199 (2004)
• [Publications] Hokuto, I., et al.: "Stat-3 is required for pulmonary homeostasis during hyperxja."J.Clin.Invest.. 113. 28-37 (2004)
• [Publications] Yamamoto, M., et al.: "TIR domain-containing adaptors define the specificity of TLR signalin."Mol.Immunol.. 40. 861-868 (2004)
• [Publications] Wan, J., et al.: "Z. Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1."Mol.Cell.Biol.. 24. 192-199 (2004)
• [Publications] Serbina, N.V., et al.: "E.G. Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection."Immunity.. 19. 891-901 (2004)
• [Publications] Fujimoto, M., et al.: "Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases."Int Immunol.. 16(2). 303-314 (2004)
• [Publications] Ito, H., et al.: "A Pilot Randomized Trial of a Human Anti-Interleukin-6 Receptor Monoclonal Antibody in Active Crohn's Disease."Gastroenterol.. (In press). (2004)
• [Publications] Sugawara, I., et al.: "Mycobacterial Infection in MyD88-Deficient Mice."Microbiol Immunol.. 47. 841-847 (2003)
• [Publications] Misra, A., et al.: "Functional significance of toll-like receptor-2 mediated signaling in the heart following acute ischemia/infarction."J Am Coll Cardiol.. 41(6 Suppl B). 372 (2003)
• [Publications] Iiyama, R., et al.: "Normal Development of the Gut-Associated Lymphoid Tissue Except Peyer's Patch in MyD88-Deficient Mice."Scand J Immunol. 58. 620-627 (2003)
• [Publications] Matsukawa, A., et al.: "Aberrant Inflammation and Lethality to Septic Peritonitis in Mice Lacking STAT3 in Macrophages and Neutrophils."J Immunol.. 171. 6198-6205 (2003)
• [Publications] Joosten, L.A., et al.: "W.B. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation : critical role of myeloid differentiation actor 88."J Immunol.. 171. 6145-6153 (2003)
• [Publications] Suzuki, N., et al.: "IL-1R-Associated Kinase 4 Is Required for Lipopolysaccharide-Induced Activation of APC."J Immunol.. 171. 6065-6071 (2003)
• [Publications] Akira, S., et al.: "Toll-like receptors and their signaling mechanisms."Scand J Infect Dis.. 33. 555-562 (2003)
• [Publications] Schirmbeck, R., et al.: "Antigenic Epitopes Fused to gationic Peptide Bound to Oligonucleotides Facilitate Toll-Like Receptor 9-Dependent, but CD4(+) T Cell Help-Independent, Priming of CD8(+)T Cells."J Immunol.. 171. 5198-5207 (2003)
• [Publications] Heil, F., et al.: "The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7,8 and 9 subfamily."Eur J Immunol.. 33. 2987-2997 (2003)
• [Publications] Yamamoto, M., et al.: "TRAM is specifically involved in thte Toll-like receptor 4-mediated MyD88-independent signaling pathway."Nat.Immunol.. 1144-1150 (2003)
• [Publications] Krug, A., et al.: "Herpes simplex virus type 1 (HSV-1) activates murine Natural Interferon-Producing cells (IPC) through Toll-Like Receptor 9."Blood.. (In press). (2003)
• [Publications] Takahashi, K., et al.: "X-ray crystal structure of IRF-3 and its functional Implications."Nat Struct Biol.. 10. 922-927 (2003)
• [Publications] Sato, S., et al.: "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-Binding kinase 1, and activates two distinct transcription factors, NF-kappaB and IFN-regulatory factor-3, in the Toll-like receptor signaling."J Immunol.. 171. 4304-4310 (2003)
• [Publications] Haga, S., et al.: "Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms."J.Clin Invest.. 112. 989-998 (2003)
• [Publications] Shi, S., et al.: "MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yetMediates Few Responses to Mycobacterium tuberculosis."J Exp Med.. 198. 987-998 (2003)
• [Publications] Weijer, S., et al.: "Interleukin-18 Facilitates the Early Antimicrobial Host Response to Escherichia coli Peritonitis."Infect Immun. 71. 5488-5497 (2003)
• [Publications] Cheng, F., et al.: "A critical role for stat3 signaling in immune tolerance."Immunity.. 19. 425-436 (2003)
• [Publications] Kariyone, A., et al.: "Immunogenicity of Peptide-25 of Ag85 in Th1 development : role of IFN-g."Int.Immunol.. 15. 1183-1194 (2003)
• [Publications] Heli, F., et al.: "The Toll-like receptor 7(TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7,8,and 9 sub family."Eur.J.Immmunol.. 2987-2997 (2003)
• [Publications] Honda, K., et al.: "Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection."Proc Natl Acad Sci USA.. 10872-10877 (2003)
• [Publications] Zhang, J.H., et al.: "Analysis of crytokine regulators inducing interferon production by mmouse uterine natural killer cells."Biol.Of Reproduction.. 69. 404-411 (2003)
• [Publications] Goldstein, D.R., et al.: "Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection."J.Clin.Invest.. 111. 1571-1578 (2003)
• [Publications] Kaisho, T., et al.: "Regulation of dendritic cell function through Toll-like receptors."Curr.Mol.Med.. 3. 373-385 (2003)
• [Publications] Akira, S., et al.: "Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling."J.Infect.Dis. 15:Suppl2. S356-S363 (2003)
• [Publications] Kojima, E., et al.: "The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress : elucidation by GADD34-deficient mice."FASEB J.. 17. 1573-1575 (2003)
• [Publications] Jouault, T., et al.: "Candida albicans phospholipomannan is sensed through toll-like receptors."J.Infect.Dis.. 188. 165-172 (2003)
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• [Publications] Sugawara, I., et al.: "Mycobacterial infection in TLR2 and TLR6 knockout mice."Microbial.Immunol.. 47. 327-336 (2003)
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• [Publications] Tamai, R., et al.: "Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monoeytic THP-1 cells is accompanied by up-regulation of CD14,Toll-like receptor 4,MD-2 and MyD88 expression."J.Endotoxin Res. 9. 145-153 (2003)
• [Publications] Kawai, T., et al.: "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains."Mol.Cell.Biol.. 23. 6174-6186 (2003)
• [Publications] Lund, J., et al.: "Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells."J.Exp.Med.. 198. 513-520 (2003)
• [Publications] Ebisuno, Y., et al.: "Cutting edge : The B cell chemokine CXC chemokine ligand 13/B lymphocyte chemoattractant is expressed in the high endothelial venules If lymph nodes and Payer's patches and affects B cell trafficking across high endothelial venuls."J.Immunol.. 15. 1642-1646 (2003)
• [Publications] Kuwata, H., et al.: "IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages."Blood. 102. 4123-4129 (2003)
• [Publications] Marr, K.A., et al.: "Conrad Liles, W.Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens."Infect.Immunol.. 71. 5280-5286 (2003)
• [Publications] Takagi, H., et al.: "Contrasting action of IL-12 and II-18 in the development of dextran sodium sulphate colitis in mice."Scand J.Gastroenterol. 838. 837-844 (2003)
• [Publications] Shibue, T., et al.: "Integral role of Noxa in p53-mediated apoptotic response."Genes Dev.. 17. 2233-2248 (2003)
• [Publications] Tsutui, H., et al.: "IL-18 and IL-18 receptor knockout mice."Contemporary Immunol : Cytokine knockouts, 2^<nd> Edition. 303-322 (2003)
• [Publications] Uehori, J., et al.: "Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Macobacterium bovis bacillus calmette-guerin peptidoglycan."Infect.Immunol.. 4238-4249 (2003)
• [Publications] Yamamoto, M., et al.: "Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway."Science. 640-643 (2003)
• [Publications] Maruoka O., et al.: "Leptin-induced transactivation of NPY gene promotoer mediated by JAK1,JAK2 and STAT3 in the neural cell lines."Neurochem Int.. 42. 591-601 (2003)
• [Publications] Yasukawa, H., et al.: "IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages."Nature Immunol.. 4. 551-556 (2003)
• [Publications] Liu, N., et al.: "CpG directly induces T-bet expression and inhibits Igγ1 and Igε switching in B cells."Nature Immunol.. 4. 687-693 (2003)
• [Publications] Akira.S., et al.: "Role of adapters in Toll-like receptor signaling."Biochem.Soc.Trans.. 31. 637-642 (2003)
• [Publications] Kaisho, T., et al.: "Regulation of dendritic cell function through Toll-like receptors."Curr.Mol.Med. 3. 373-385 (2003)
• [Publications] Yokozeki, H., et al.: "Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice."Clin.Exp.Immunol.. 132. 385-392 (2003)
• [Publications] Akira, S., et al.: "Myelold differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling."J.Infect.Dis.. 187:Suppl2. S356-S363 (2003)
• [Publications] Okamoto, M., et al.: "Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432."J.Natl.Cancer Inst.. 95. 316-326 (2003)
• [Publications] Prinz, M., et al.: "Prion pathogenesis in the absence of Toll-like receptor signaling."EMBO Rep.. 4. 195-199 (2003)
• [Publications] Takeda, K., et al.: "Toll receptors and pathogen resistance."Cell Microbiol.. 5. 143-153 (2003)
• [Publications] Hazeki, K., et al.: "Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and-independent pathways."J.Immunol.. 33. 740-747 (2003)
• [Publications] Hemmi, H., et al.: "The roles of Toll-like receptor 9,MyD88,and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets."J.Immunol.. 170. 3059-3064 (2003)
• [Publications] Akira, S., et al.: "Mammalian Toll-like receptors."Curr.Opin.Immunol.. 15. 238 (2003)
• [Publications] Schultz, M., et al.: "Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa."Infect.Immun.. 71. 1630-1634 (2003)
• [Publications] Edwards A., et al.: "Toll-like receptor expression in murine DC subsets : lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines."Eur J.Immunol.. 33. 827-833 (2003)
• [Publications] Kruzik, S.R., et al.: "Activation and regulation of Toll-like receptors 2 and 1 in human leprosy."Nature.. 9. 525-532 (2003)
• [Publications] Takeda, K., et al.: "Recognition of lipopeptides by Toll-like receptors.J.Endotoxin Res."J.Endotoxin Res. 8. 459-463 (2003)
• [Publications] Datta, S., et al.: "A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells."J.Immunol.. 170. 4102-4110 (2003)
• [Publications] Yazawa, N., et al.: "CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes."Blood.. (In press). (2003)
• [Publications] Ganter, B.N., et al.: "Collaborative induction of inflammatory resposes by Dection-1 and toll-like receptor 2."J.Exp.Med.. 197. 1107-1117 (2003)
• [Publications] Kobayashi, M., et al.: "Toll-like receptor-dependent production of IL-12p40 causes choronic enterocolitis in myeloid cell-specific Stat3-deficient mice."J.Clin.Invest.. 111. 1297-1308 (2003)
• [Publications] Zwijnenburg, P.J., et al.: "Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis."J.Nueroimmunol.. 138. 31-37 (2003)
• [Publications] Goldstein, D.R., et al.: "Crinical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograht rejection."J.Clin.Invest.. 111. 1571-1578 (2003)
• [Publications] Yasukawa, H., et al.: "IL-6 induces an anti-infllamatory response in the absence of SOCS3 in macrophages."Nat.Immunol.. 4. 551-556 (2003)
• [Publications] Hong, Y., et al.: "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins."Mol.Biol.Cell. 14. 1780-1789 (2003)
• [Publications] Ohishi, K., et al.: "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins."J.Biol.Chem.. 278. 13959-13967 (2003)
• [Publications] Murakami, Y., et al.: "PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor."Mol.Biol.Cell. 14. 4285-4295 (2003)
• [Publications] Nagamune, K., et al.: "GPI transamidase of Trypanosoma brucei has two novel (TTA1 and TTA2) and three common subunits."Proc.Natl.Acad.Sci.USA. 100. 10682-10687 (2003)
• [Publications] Inoue, N., et al.: "Molecular genetics of paroxysmal nocturnal hemoglobinuria."Int.J.Hematol.. 77. 107-112 (2003)
• [Publications] Kumanogoh, A., et al.: "Roles of the semaphorin family in immune regulation."Adv.Immunol.. 81. 173-198 (2003)
• [Publications] Stratmann, T., et al.: "Susceptible MHC alleles, not background genes, select and autoimmune T cell reactivity."J.Glin.Invest.. 112. 902-914 (2003)
• [Publications] Moreau-Fauvarque., et al.: "The transmembrane semaphorin Sema4D/CD100,and inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion."J.Neurosci.. 23. 9229-9239 (2003)
• [Publications] Kumanogoh., et al.: "Immune semaphorins : a New area of semaphore research."J.Cell.Sci.. 116. 3463-3479 (2003)
• [Publications] Ishida, I., et al.: "Involvement of CD100,a lymphocyte semaphorin, in the activation of the human immune system via CD72 : implications for the regulation of immune and inflammatory responses."Int.Immunol.. 15. 1027-1034 (2003)
• [Publications] Takahashi, H., et al.: "Increased susceptibility to airway responses in CD40-deficient mice."Clin.Exp.Immunol.. 133. 22-29 (2003)
• [Publications] Kikutani, H, et al.: "Semaphorins in interactions between T cells and antigen-presenting cells."Nat Rev Immunol.. 31. 159-167 (2003)
• [Publications] Suzuki, K., et al.: "CD100/Sema4D, a lymphocyte semaphorin involved in the regulation of humoral and cellular immune responses."Cytokine Growth Factor Rev.. 14. 17-24 (2003)
• [Publications] Mori, Y., et al.: "The Human Herpesvirus 6 U100 Gene Product Is the Third Component of the gH-gL Glycoprotein Complex on the Viral Envelope."J Virol.. 77. 2452-2458 (2003)
• [Publications] Amo, K., et al.: "Human herpesvirus 6B infection of the large intestine of patients with diarrhea."Clin Infect Dis. 36. 120-123 (2003)
• [Publications] Mori, Y., et al.: "Human Herpesvirus 6 Variant A Glycoprotein H-Glycoprotein L-Glycoprotein.Q Complex Associates with Human CD46."J Virol.. 77. 4992-4999 (2003)
• [Publications] Kondo, K., et al.: "Recognition of a novel stage of betaherpesvirus latency in human herpesvirus 6."J Virol.. 77. 2258-2264 (2003)
• [Publications] Nakano, K., et al.: "Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded vMIP-I and vMIP-II induce signal transduction and chemotaxis in monocytic cells."Arch Virol.. 148. 871-890 (2003)
• [Publications] Kondo, K., et al.: "Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency."J Virol.. 77. 10719-10724 (2003)
• [Publications] Nakano, K., et al.: "Human herpesvirus 7 open reading frame U12 encodes a functional beta-chemokine receptor."J Virol.. 77. 8108-8115 (2003)
• [Publications] Nishimura, K., et al.: "A viral transcriptional activator of Kaposi's sarcoma-associated herpesvirus (KSHV) induces apoptosis, which is blocked in KSHV-infected cells."Virology. 316. 64-74 (2003)
• [Publications] Lufting, M., et al.: "Epstein-Barr virus latent membrane protein1 activation of NF-kB through IRAK1 and TRAF6."Proc.Natl.Acad.Scit.USA. 15595-15600 (2003)
• [Publications] 岸本 忠三: "Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats"J.Hepatology. 34. 884-888 (2002)
• [Publications] 岸本 忠三: "A regulatory role for SOCS-1 in T helper polarization in vivo"Int. Immunol.. 14. 1343-1350 (2002)
• [Publications] 岸本 忠三: "Expression of the suppressor of cytokine signaling-5 (SOCS-5) negatively regulates IL-4 dependent STAT6 activation and Th2 differentiation"Proc. Natl. Acad. Sci. USA.. 99. 13003-13008 (2002)
• [Publications] 岸本 忠三: "SOCS-1 participates in negative regulation of LPS responses"Immunity. 17. 677-687 (2002)
• [Publications] 山西 弘一: "Recognition of a novel stage of betaherpesvirus latency in humanherpesvirus 6"J Virol. 77(3). 2258-2264 (2003)
• [Publications] 山西 弘一: "The Human Herpesvirus 6 U100 Gene Product Is the Third Component of the gH-gL Glycoprotein Complex on the Viral Envelope"J Virol. 77(4). 2452-2458 (2003)
• [Publications] 山西 弘一: "Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription factor activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism"J Virol. 76(23). 12044-12054 (2002)
• [Publications] 木下 タロウ: "Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum α-toxin"EMBO J.. 21. 5047-5056 (2002)
• [Publications] 木下 タロウ: "Inefficient response of T lymphocytes to glycosylphosphatidylinositol-negative cells : implications for paroxysmal nocturnal hemoglobinuria"Blood. 100. 4116-4122 (2002)
• [Publications] 木下 タロウ: "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins"Mol. Biol. Cell. (in press). (2003)
• [Publications] 菊谷 仁: "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2"Nature. 419. 629-633 (2002)
• [Publications] 菊谷 仁: "Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clones"Int. Immunol.. 14. 1439-1447 (2002)
• [Publications] 菊谷 仁: "Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells"J. Immunol.. 169. 1175-1181 (2002)
• [Publications] 審良 静男: "Essential role for TIRAP in activation of the signaling cascade shared by TLR2 and TLR4"Nature. 420. 324-329 (2002)
• [Publications] 審良 静男: "A novel Toll/IL-1 receptor domain-containing adaptor that preferentially activates the IFN-β promoter in the Toll-like receptor signaling"J. Immunol.. 169. 6668-6672 (2002)
• [Publications] 審良 静男: "Cutting Edge : Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins"J. Immunol.. 169. 10-14 (2002)
• [Publications] Kawazoe, Y., Akira, S, Kishimoto, T.et al.: "SOCS-1/SOCS-1 family proteins inhibit insulin signal transduction pathway through modulating IRS-1 phosphorylation"J. Exp. Med.. 193. 263-269 (2001)
• [Publications] Naka, T., Kishimoto, T., et al.: "SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN γ and IL-4 signaling in vivo"Immunnity. 14. 535-545 (2001)
• [Publications] Sakakibara, S., Yamanishi, K., et al.: "Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expression"J. Virol.. 75(in press). (2002)
• [Publications] Kondo, K., Yamanishi, K., et al.: "Identification of human herpesvirus 6 latency-associated transcripts"J. Virol. 76(8):in press 2002. 78(in press). (2002)
• [Publications] Maeda, Y., Kinoshita, T.et al.: "PIG-M transfers the first mannose to glycosyl phosphatidylinositol on the lumenal side of the ER"EMBO J.. 20. 250-261 (2001)
• [Publications] Ohishi, K., Kinoshita, T.: "PIG-S and PIG-T, essential for GPI-anchor attachment to proteins, form a complex with GAA1 and GPI8"EMBO J.. 20. 4088-4098 (2001)
• [Publications] Hiroi, T., Kiyono, H., et al.: "HIV mucosal vaccine : nasal immunization with rBCG-V3J1 induces a long-term V3J1-peptide-specifi neutralizing immunity in Th1 and Th2 deficient conditions"J. Immunol.. 167. 5682-5867 (2001)
• [Publications] Kunisawa, J., Kiyono, H., et al.: "Novel antigen delivery system using Fusogenic liposome for the induction of mucosal and systemic immune responses"J. Immunol.. 167. 1406-1412 (2001)
• [Publications] Kumanogoh, A., H.Kikutani: "The CD100/Seffla4D-CD72 interactions: a novel mechanism of immune regulation"Trends in Immunology (formerly known as Immunology Today). 22. 670-676 (2001)
• [Publications] Watanabe, C., Kikutani, H.et al.: "Enhanced immune responses in transgenic mice expressing a truncated form of the lymphocyte semaphorin CD100"J. Immunol.. 167. 4321-4328 (2001)
• [Publications] Kawai T, Akira S., et al.: "Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes"J. Immunol.. 167. 5887-5894 (2001)
• [Publications] Hemmi H, Akira S., et al.: "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway"Nat Immunol.. 3. 196-200 (2002)
• [Publications] Kawazoe,M. et.al.: "SST-1/SICS-1 family proteins inhibit insulin signal transduction pathway through modulating IRS-1phosphorylation."J.Exp.Med.. 193. 263-269 (2001)
• [Publications] Baba,Y. et.al.: "BLNK mediates Syk-dependent Btk activation."Proc.Natl.Acad.Sci.USA. in press. (2001)
• [Publications] Fujimoto,M. et.al.: "Defective thymocyte development and perturbed homeostasis of T cells in SST-1/SOCS-1 transgenic mice."J.Immunol.. 165. 1799-1806 (2000)
• [Publications] Morita,Y. et.al.: "SSI/SOCS-1 suppresscs TNF-α-induced cell death by regulation of p38 MAP kinase signal in fibroblast."Proc.Natl.Acad.Sci.USA. 97. 5405-5410 (2000)
• [Publications] Saito,H. et.al.: "Interferon regulatory factor-1 mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by interferon-gamma."J.Immunol.. 164. 5833-5843 (2000)
• [Publications] Nomura,K. et.al.: "The genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into later stage of pre-B cells in B cell differentiation pathway."Blood.. 96. 610-617 (2000)
• [Publications] Nagasawa,T. et.al.: "A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of Hematopoiesis."Inter.J.Hematol.. 72. 408-411 (2000)
• [Publications] Kosuge,H. et.al.: "Epidemiological study of human herpesvirus-6 and human herpesvirus-7 in pityriasis rosea."Br.J.Dermatol.. 143(4). 795-798 (2000)
• [Publications] Chen,J. et.al.: "Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene."J Virol.. 74(6). 2867-2875 (2000)
• [Publications] Gomi,Y. et.al.: "Oka varicella vaccine is distinguishable from its parental virus in DNA sequence of open reading frame 62 and its transactivation activity."J.Med.Virol.. 61(4). 497-503 (2000)
• [Publications] Haque,M. et.al.: "Identification and analysis of the K5 gene of Kaposi's sarcoma- associated herpesvirus."J.Virol.. 74(6). 2867-2875 (2000)
• [Publications] Mori,Y. et.al.: "Expression of human herpesvirus 6B rep within infected cells and binding of its gene product to the TATA-binding protein in vitro and in vivo."J.Virol.. 74(13). 6096-6104 (2000)
• [Publications] Mori,Y. et.al.: "Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion."J.Med.Virol.. 61(3). 332-335 (2000)
• [Publications] Takeda,K. et.al.: "Characterization of human herpesvirus 7 U27 gene product and identification of its nuclear localization signal."Virology. 272(2). 394-401 (2000)
• [Publications] Tanaka-Taya,K. et.al.: "Reactivation of human herpesvirus 6 by infection of human herpesvirus 7."J.Med.Virol.. 60(3). 284-289 (2000)
• [Publications] Taguchi,T. et.al.: "Structure of transcripts and proteins encoded by U79-80 of human herpesvirus 6 and its subcellular localization in infected cells."Virology. 271(2). 307-320 (2000)
• [Publications] Chen,J. et.al.: "Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator."Proc.Natl.Acad.Sci.USA. (in press). (2001)
• [Publications] Haque,M. et.al.: "Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus /human herpesvirus-8."J.Gen.Virol.. (in press). (2001)
• [Publications] Maeda,Y. et.al.: "Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3."EMBO J.. 19. 2475-2482 (2000)
• [Publications] Nagamune,K. et.al.: "Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei."Proc.Natl.Acad.Sci.USA. 97. 10336-10341 (2000)
• [Publications] Ohishi,K. et.al.: "Gaa1p and Gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins."Mol.Biol.Cell.. 11. 1523-1533 (2000)
• [Publications] Watanabe,R. et.al.: "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2."EMBO J.. 19. 4402-4411 (2000)
• [Publications] Hong,Y. et.al.: "Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol."J.Biol.Chem.. 275. 20911-20919 (2000)
• [Publications] Kinoshita,T. et al.: "Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis."Current Opinion in Chem.Biol.. 4. 632-638 (2000)
• [Publications] Murakami,H. et al.: "Porcine MCP gene promoter directs high level expression of human DAF (CD55) in transgenic mice."Immunobiology. 201. 583-597 (2000)
• [Publications] Kadota,Y. et al.: "Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma)."Clin.Exp.Immunol.. 121. 59-68 (2000)
• [Publications] Begum,N.A. et al.: "Molecular remodelling of human CD46 for xenotransplantation : designing a potent complement regulator without measles virus receptor activity."Immunology. 100. 131-139 (2000)
• [Publications] Maeda,Y. et al.: "PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER."EMBO J.. 20. 250-261 (2000)
• [Publications] Nishimura,J. et al.: "Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype."Blood. (in press). (2001)
• [Publications] Yada,T. et al.: "Its8, a fission yeast homologue of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis."J Biol.Chem.. (in press). (2001)
• [Publications] Yamamoto,M. et.al: "Alternate mucosal immune system : Organized Peyer's patches are not required for mucosal IgA antibody responses in the gastrointestinal tract."J.Immunol. 164. 5184-5191 (2000)
• [Publications] Hiroi,T. et.al: "Interleukin 15 and IL-15R selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses."J.Immunol. 165. 4329-4337 (2000)
• [Publications] Kweon,M-N. et.al: "Systemically derived large intestinal CD4^+ Th2 cells play a central role for the development of STAT6-mediated allergic diarrhea."J.Clin.Invest. 106. 199-206 (2000)
• [Publications] Kishi,D. et.al: "Alteration of Vβ usage and cytokine production of CD4^+ ββT cells by elimination of Bacteroides vulgatus prevents the development of colitis in TCRα-chain deficient mice."J.Immunol. 165. 5891-5899 (2000)
• [Publications] Dohi,T. et.al: "Mice Dificient in Th1 and Th2-type cytokines develop distinct forms of hapten-induced colitis."Gastroenrology. 119. 724-733 (2000)
• [Publications] Yamamoto,M. et.al: "Enterotoxin adjuvants have direct effects on T cells and APC which result in either IL-4 dependent or-intdependent immune responses."J.Infect.Dis. 182. 180-190 (2000)
• [Publications] Koga,T. et.al.: "Evidence for early aging in the mucosal immune system."J.Immunol. 165. 5352-5359 (2000)
• [Publications] Boyaka,P.N. et.al.: "Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils."Am.J.Pathol.. 157. 2023-2035 (2000)
• [Publications] Kunisawa,J. et.al.: "Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses."Vaccine. 19. 589-594 (2000)
• [Publications] Higuchi,K. et.al.: "Comparison of inhibitory effects of intranasal and oral administration of bovine type II collagen on collagen induced arthritis in DBA1/J mice."J.Rheumatol.. 27(4). 1038-1044 (2000)
• [Publications] Saitoh-Inagawa,W. et.al.: "Immunological characterization of lacrimal glands as a part of mucosal immune network."Invest.Ophthalmol.Visual.Sci.. 41. 138-144 (2000)
• [Publications] Simecka,J.W. et.al: "Mucosally-induced immunoglobulin E associated inflammation in the respiratory tract."Infect.Immun.. 68. 672-679 (2000)
• [Publications] Byun,Y. et.al.: "Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizin antibodies."Vaccine. (in press). (2001)
• [Publications] Saito,M. et.al.: "Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant."J.Infect.Dis. (in press). (2001)
• [Publications] Simecka,J.W. et.al.: "IgA responses and IgE associated inflammation along the repiratory tract after mucosal but not systemic immunization."Infect.Immun. (in press). (2001)
• [Publications] Yuki,Y. et.al.: "Nasal treatment of experimental encephalomyelitis with a recombinant hybrid molecule of cholera toxin-β-subunit and proteolipid-protein-peptide."Biotech. Bioengi. (in press). (2001)
• [Publications] Yoshida,Ke. et.al.: "Genetics and immunological basis of autoimmune diabetes in the NOD mouse."Rev.in Immunogenetics. 2. 140-146 (2000)
• [Publications] Wakayama,H. et.al.: "Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRγ-deficient mice."Eur.J.Immunol.. 30. 118-112 (2000)
• [Publications] Haczku,A. et.al.: "CD23 exhibits negative regulatory effects on allergic sensitization and a hyperresponsiveness."Am.J.Respir.Crit.Care Med.. 161. 952-960 (2000)
• [Publications] Kumanogoh,A. et.al.: "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD1OO : A novel mechanism for regulating B cell signaling."Immunity. 13. 621-631 (2000)
• [Publications] Shi,W. et.al.: "The class TV semaphorin CD1OO plays a nonredundant role in the immune system : Defective B and T cell activation in CD1OO-deficient mice."Immunity. 13. 633-642 (2000)
• [Publications] Kumanogoh,A. et.al.: "Increased T-cell autoreactivity in the absence of CD40-CD40 ligand interactions : A role of CD40 in regulatory T cell development."J.Immunol.. 166. 353-360 (2001)
• [Publications] Wang,X-O. et.al.: "Functional soluble CD1OO/Sema4D released from activated lymphocytes : Possible role in normal and pathological immune responses."Blood. (in press). (2001)
• [Publications] Naka,T. et.al.: "Cytokine inhibitors : Negative feedback reglations of cytokine signals"IRBM. 20 (2001)
• [Publications] Baba,Y. et al.: "WASP is involved in the tyrosine kinase pathway in B-lineage cells."Blood. 93. 2003-2012 (1999)
• [Publications] Kamiya,A. et al.: "Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer."EMBO J.. 18. 2127-2136 (1999)
• [Publications] Sui,X. et al.: "Soluble interleukin-6(IL-6) receptor with IL-6 stimulates megakaryopoiesis from human CD34+cells through glycoprotein (gp)130 signaling."Blood. 93. 2525-2532 (1999)
• [Publications] Nakashima,K. et al.: "Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation."J.Neurosci.. 19. 5429-5434 (1999)
• [Publications] Kawabata,K. et al.: "A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution"Proc.Natl.Acad.Sci.USA. 96. 5663-5667 (1999)
• [Publications] Sasai,M. et al.: "Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice"Arthritis Rheum. 42. 1635-1643 (1999)
• [Publications] Matsui,H. et al.: "Induction of interleukin-6(IL-6) by hypoxia is mediated by nuclear factor (NF)-KB and NF-IL6 in cardiac myocytes."Cardiovasc. Res.. 42. 104-112 (1999)
• [Publications] Yamadori,T. et al.: "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."Proc.Natl.Acad.Sci.USA.. 96. 6341-6346 (1999)
• [Publications] Hashimoto,S. et al.: "A typical X-linked agammaglobulinemia (XLA) patients diagnosed in their adult ages."Internal Medicine. 38. 722-725 (1999)
• [Publications] Kuroda,T. et al.: "Hepatoma-derived growth factor-related protein (HRP)-1 gene in spermatogenesis in mice. "Biochem.Biophys.Res.Commun.. 262. 433-437 (1999)
• [Publications] Gage,J.R. et al.: "Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the Ul monocytic cell line."AIDS. 13. 1851-1855 (1999)
• [Publications] Breen,E.C, et al.: "The development of AIDS-associated burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6"Clin.Immunol.. 92. 293-299 (1999)
• [Publications] Hashimoto,S. et al: "Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK-functional significance of Btk-SH2 domain in B cell antigen receptor-coupled calcium signaling."Blood. 94. 2357-2364 (1999)
• [Publications] Baba,Y. et al.: "Assignment of Sab gene, the SH3 domain-binding protein which preferentially assocites with bruton's tyrosine kinase, to human chromosome lq43 and mouse chromosome 14B by in situ hybridization."Cytogenet and Cell Genet.. 87. 221-222 (1999)
• [Publications] Naka,T. et al.: "SSI-1 (STAT-Induced STAT Inhibitor-1); negative regulation of cytokine signaling."TiBS. 24. 394-398 (1999)
• [Publications] Okuda,Y. et al.: "IL-6 plays a crucial role in the inductionphase of myelin ligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis."J.Neuroimmunol.. 101. 188-196 (1999)
• [Publications] Kunisada,K. et al.: "Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy."Proc.Natl.Acad.Sci.USA.. 97. 315-319 (2000)
• [Publications] Deguchi,K. et al.: "Excessive extramedullary hematopoiesis in Cbfal-deficient mice with a congenital lack of bone marrow."Biochem.Biophys.Res.Commun.. 255. 352-359 (1999)
• [Publications] Oji,Y. et al.: "Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth."Jpn.J.Cancer Res.. 90. 194-204 (1999)
• [Publications] Tamaki,H. et al.: "The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes."Leukemia. 13(3). 393-399 (1999)
• [Publications] Inada,M. et al.: "Maturational disturbance of chondrocytes in Cbfa1-deficient mice."Dev Dyn.. 214(4). 279-290 (1999)
• [Publications] Ohshima,S. et al.: "Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy."J.Clin.Immunol.. 19. 305-313 (1999)
• [Publications] Mima,T. et al.: "Dominant and shared T cell receptor beta chain variable regions of T cells induceing synovial hyperplasia in rheumatoid arthritis."Biochem.Biophys.Res.Commun,. 263. 172-180 (1999)
• [Publications] Ikegame,K. et al.: "A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus."Biochem.Biophys.Res.Commun.. 266. 81-87 (1999)
• [Publications] Nakashima,K. et al.: "Development requirement of gp130 signaling in neuronal survival and astrocyte differentiation."J.Neurosci.. 19. 5429-5434 (1999)
• [Publications] Tsuboi,A. et al.: "Constitutive expression of the wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)."Leuk.Res.. 23(5). 499-505 (1999)
• [Publications] Nishimoto,N. et al.: "Anticytokine therapy in autoimmune diseases."Intern Med. 38. 178-182 (1999)
• [Publications] Yu,P. et al.: "CD40-deficient mice infected with the defective murine leukemia virus LP-BM5 def do not develop murine AIDS but produce IgE and IgG1 in vivo."Eur.J.Immunol.. 29(2). 615-625 (1999)
• [Publications] Oka,Y. et al.: "Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor genes (WT1) product."Immunogenetics. 51(2). 99-107 (2000)
• [Publications] Oka,Y. et al.: "Cancer Immunotherapy targeting Wilms' tumor gene WT1 product."J.Immunol.. 164(4). 1873-1880 (2000)
• [Publications] Nishimoto,N. et al.: "Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy."Blood. 95. 56-61 (2000)
• [Publications] Ohshima,S. et al.: "Tumor necrosis factor alpha (TNF-alpha) interferes with Fas-Mediated apoptotic cell death on rheumatoid arthritis (RA) synovial cells : A possible mechanism of rheumatoid synovial hyperplasia and a clinical benefit of anti-TNF-alpha therapy for RA"Cytokine. 12. 281-288 (2000)
• [Publications] Tanaka,T. et al.: "Enhancement of T helper 2 response in the absence of interleukin (IL)-6; An inhibition of IL-4 mediated T helper 2 cell differentiation by IL-6."Cytokine. (in press).
• [Publications] Tanaka,T. et al.: "Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis-model mice, NC/Nga."J.Allergy Clin.Immunol.. (in press).
• [Publications] Kotani,M. et al.: "Persimmon leaf extract and astragalin inhibits development of dermatitis and IgE elevation in NC/Nga."J.Allergy Clin.Immunol.. (in press).
• [Publications] Funamoto,M.: "Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes."J.Biol.Chem.. (in press).
• [Publications] Yamauchi-Takihara,K. et al.: "Cytokines and their receptors in cardiovascular diseases-Role of gp130 signalling pathway in cardiac myocytes growth and maintenance."Int.J.Exp.Path. (in press).
• [Publications] Funamoto,M. et al.: "Isolation and characterization of the murine cardiotrophin-1 gene.-Expression and norepinephrine induced transcriptional activation-"J.Mol.Cell.Cardiol.. (in press).
• [Publications] Nishioka,K. et al.: "Enhanced expression and DNA binding activity of the two C/EBP isoforms, C/EBPβ and -δ, in the rheumatoid synovim."Arthritis Rheum.. (in press).
• [Publications] Naka,T. et al.: "Negative feedback regulations of cytokine signals."IRBM. (in press).
• [Publications] Nomura,K. et al.: "The genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into later stage of pre-B cells in B cell differentiation pathway."Blood. (in press).
• [Publications] T.Taniguchi, et al.: "Structure of transcripts and proteins encoded by U79/80 of HHV-6 and its subcellular localization in infected cells."Virology. (in press). (2000)
• [Publications] M.Haque, et al.: "Identification and analysis of the K5 gene of Kaposi's sarcoma-associated herpesvirus."J.Virol.. 74・6. 2867-75 (2000)
• [Publications] R.Inagi, et al.: "Identification and characterization of human herpesvirus 8 open reading frame K9 viral interferon regulatory factor by a monoclonal antibody."J.Hum.Virol.. 2・2. 63-71 (1999)
• [Publications] Y.Isegawa, et al.: "Comparison of the Complete DNA Sequences of Human Herpesvirus 6 Variants A and B."J.Virol.. 73・10. 8053-63 (1999)
• [Publications] U.Kositanont, et al.: "Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type1."J.Infect.Dis.. 180・1. 50-5 (1999)
• [Publications] P.Zou, et al.: "Human herpesvirus 6 open reading frame U83 encodes a functional chemokine."J.Virol.. 73・7. 5926-33 (1999)
• [Publications] Azenishi,Y. et al.: "CD59-deficient blood cells and PIG-A gene abnormalities in Japanese patients with aplastic anaemia."Br.J.Haematol. 104. 523-529 (1999)
• [Publications] Nozaki,M. et.al.: "Developmental abnormalities of glycosylphosphatidylinositol-anchor deficient embryos revealed by Cre/loxP system."Lab.Invest.. 79. 293-299 (1999)
• [Publications] Watanabe,R. et.al.: "Mammalian PIG-L and its yeast homologue Gpil2p are N-acetylglucosaminyl-phosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis."Biochem.J.. 339. 185-192 (1999)
• [Publications] Suzuki,K. et.al.: "A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes ; A possible role for regulation of neutrophil adherence and migration."J.Immunol. 162. 4277-84 (1999)
• [Publications] Pramoonjago,P.: "Genotypic, immunophenotypic and clinical features of Thai patients with paroxysmal nocturnal haemoglobinuria."Br.J.Haematol.. 105. 497-504 (1999)
• [Publications] Inoue,N. et.al.: "Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes : genomic structures, chromosome loci and the presence of a minor class intron."Cytogenet. Cell Genet.. 84. 199-205 (1999)
• [Publications] Hong,Y. et.al.: "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis."J.Biol.Chem.. 274:. 18582-88 (1999)
• [Publications] Murakami,Y.: "Different roles of glycosylphosphatidylinositol in various hematopoietic cells as revealed by model mice of paroxysmal nocturnal hemoglobinuria."Blood. 94. 2963-70 (1999)
• [Publications] Hong,Y. et.al.: "PIG-N, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol."J.Biol.Chem.. 274:. 35099-105 (1999)
• [Publications] Begum,N.A. et.al.: "Molecular remodeling of human CD46 for xenotransplantation : designing a potent complement regulator without measles virus receptor activity."Immunology. (in press).
• [Publications] Murakami,H. et.al.: "Porcine MCP gene promoter directs high level expression of human DAF (CD55) in transgenic mice."Immunobiology. (in press).
• [Publications] Ohishi,K. et.al.: "Gaa1p and Gpi8p are components of a GPI transamidase that mediates attachment of glycosylphosphatidylinositol to proteins."Mol.Biol.Cell.. (in press).
• [Publications] Iijima,H. et al.: "Alteration of interleukin 4 production results in the inhibition of Th2 dominated inflammatory bowel disease in T cell receptor α chain-deficient mice."J.Exp.Med.. 190. 607-16 (1999)
• [Publications] Takahashi,I. et al.: "Clonal expansion of ββT cells in intestinal inflammatory resions of T cell receptor α-chain deficient mice."J.Immunol.. 162. 1843-50 (1999)
• [Publications] Hiroi,T. et al.: "Deficiency of IL-5 receptor α chain selectively influences on the development of the commun mucosal immune system independent IgA producing B-1 cells in mucosal-associated tissues."J.Immunol.. 162. 821-88 (1999)
• [Publications] Yanagita,M. et al.: "Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity : fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cylokine production."J.Immunol.. 162. 3559-65 (1999)
• [Publications] Kweon,M-N. et al.: "Mucosally-induced systemic T cell unresponsiveness to ovalbumin requires CD40L-CD40 interactions."J.Immunol.. 162. 1904-09 (1999)
• [Publications] Dohi,T. et al.: "Hapten-induced colitis is associated with colonic patch hypertrophy and Th2 helper-type responses."J.Exp.Med.. 189. 1169-79 (1999)
• [Publications] Boyaka,P.N. et al.: "Interleukin 12 is an effective adjuvant for induction of mucosal immunity."J.Immunol.. 162. 122-28 (1999)
• [Publications] Marinaro,M. et al.: "Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin."J.Immunol.. 162. 114-21 (1999)
• [Publications] Yamamoto,M. et al.: "Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant."J.Immunol.. 162. 7015-21 (1999)
• [Publications] Kurono,Y. et al.: "Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity."J.Infect.Disc.. 180. 122-32 (1999)
• [Publications] van Ginkel, et al.: "IgA-deficiency with increased Th2-type cytokines in TGF-β1 knockout mice."J.Immunol.. 163. 1951-57 (1999)
• [Publications] Mbawike,I.N, et al.: "IL-12 modulate 1FN-γ synthesis and influenza-specific cytotoxic activity by human CD45RO+ but not CD45RA, CD8+ T cells."J.Infect.Dis.. 180. 1477-86 (1999)
• [Publications] Fujihashi,K. et al.: "γδT cells are not essential for oral tolerance induced by large dose of ovalbumin, while regulate IL-10-mediatec small dose systemic unreponsiveness."Int.Immunol.. 11. 1907-16 (1999)
• [Publications] Pascual,D.W. et al.: "Extracellular expression of recombinant enterotoxigenic colonization factor antigen I by Salmonella elicits distinct T helper 2 followed by T helper 1 cell responses."Infect.Immun.. 67. 6249-56 (1999)
• [Publications] McGhee,J.R. et al.: "Mucosal Th1-versus Th2-type responses for antibody or cell mediated immunity to SIV rhesus macaques."J.Infect.Dise.. 179. 5480-84 (1999)
• [Publications] Tori,M. et al.: "IL-4 production in IDDM-nonrecurrent pancreas-transplanted BB rats with donor-derived NKR-P1+TCRαβ+(NKT) cells but not in IDDM-recurrent BB rats."Transplanation Procceding.. 31. 1940-41 (1999)
• [Publications] Sugimoto,M. et al.: "Lymphocyte activation is attenuated by stellate ganglion block."Regional Anethesia and Pain Medicine.. 24. 30-35 (1999)
• [Publications] Tori,M. et al.: "Significant role of intragaft lymphoid tissues in preventing insulin-dependent diabetes mellitus recurrence in whole pancreaticoduedenal transplantation."Micro Surgory.. 19. 338-43 (1999)
• [Publications] Host,D.F. et al.: "A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guerin vaccination."J.Lab.Clin.Med.. 134. 244-52 (1999)
• [Publications] Saitoh-Inagawa,W. et al.: "Immunological characterization of lacrimal glands as a part of mucosal immune network."Invest. Ophthaimol. Visual Sci.. 41. 138-44 (2000)
• [Publications] Higuchi,K. et al.: "Comparison of inhibitory effects of intranasal and oral administration of bovine type II collagen on collagen induced arthritis in DBA1/J mice."J.Rheumato.. (in press).
• [Publications] Simeka,J.W. et al.: "Nasal immunization with protein and cholera toxin as adjuvant results in an IgE-associated inflammatory response in lugs."Infect.Immun.. (in press).
• [Publications] Host,D.F. et al.: "A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guerin vaccination."J.Lab.Clin.Med.. 134. 244-52 (1999)
• [Publications] Saitoh-Inagawa,W. et al.: "Immunological characterization of lacrimal glands as a part of mucosal immune network."Invest. Ophthaimol. Visual Sci.. 41. 138-44 (2000)
• [Publications] Higuchi,K. et al.: "Comparison of inhibitory effects of intranasal and oral administration of bovine type II collagen on collagen induced arthritis in DBA1/J mice."J.Rheumato.. (in press).
• [Publications] Simeka,J.W. et al.: "Nasal immunization with protein and cholera toxin as adjuvant results in an IgE-associated inflammatory response in lugs."Infect.Immun.. (in press).
• [Publications] Uchida,J., et al.: "Mimicry of CD40 signals by Eptein-Barr virus LMP1 in B lymphocyte responses."Science. 286. 300-303 (1999)
• [Publications] Yu,P., et al.: "CD40-deficient mice infected with the defective murine leukemia virus LP-BM5 def do not develop murine AIDS but produce IgE and IgG1 in vivo."Eur.J.Immunol.. 29. 615-625 (1999)
• [Publications] Yoshida,K., et al.: "Genetics and immunological basis of autoimmune diabetes in the NOD mouse."Rev.in Immunogenetics. 2. 140-146 (2000)
• [Publications] Korganow.,A.-S.: "From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins."Immunity. 10. 451-461 (1999)
• [Publications] Cernandas,M., et al.: "CD23 and allergic pulmonary inflammation : potential role as an inhibitor."Am.J.Respir.Cell Mol.Biol.. 20. 1-8 (1999)
• [Publications] Ozaki,M.E., et al.: "CD40+ T cell responses to CD40-deficient APCs : defects in proliferaion and negative selection apply only with B cells as APCs."J.Immunol.. 163. 5250-6 (1999)
• [Publications] Futatani,T.: "Deficient expression of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection." Blood. 91. 595-602 (1998)
• [Publications] Takeda,K.: "Defective NK cell activity and Th 1 response in IL-18-dificient mice." Immunity. 8. 383-390 (1998)
• [Publications] Oh,H.: "Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphrylation in cardiac myocytes." J.Biol.Chem.273. 9703-9710 (1998)
• [Publications] Matsushita,M: "Identification and characterization of a novel SH3-domain binding protein,Sab,which perferntially associates with bruton's tyrosine kinase(Btk)." Biochem,Biophys.Res.Comm.245. 337-343 (1998)
• [Publications] Wang,X-J.: "gp130,the cytokine common singal-transducer of interleukin-6 cytokine family.is downregulated in T cells in vivo by interleukin-6." Blood. 191. 3308-3314 (1998)
• [Publications] Okuda,Y.: "IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein." Int.Immunol.10. 703-708 (1998)
• [Publications] Kunisada,K.: "Activation of gp130 transduces hypertrophic singnals via STAT3 in cardiac myocytes." Circulation. 98. 346-352 (19998)
• [Publications] Oshima,S.: "Interleukin 6 plays a key role in the development antigen-induced arthritis." Proc.Natl.Acad.Sci.USA. 95. 8222-8226 (1998)
• [Publications] Yagi,H.: "Growth disturbance in fetel liver hematopoiesis of MII-mutant mice." Blood. 92. 108-117 (1998)
• [Publications] Tachibana,K.: "The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract." Nature. 393. 591-594 (1998)
• [Publications] Nagasawa,T.: "A novel CXC chemokine PBSF/SDF-1 and its receptor XCR4:their funcitons n development,hematopoiesis and HIV infection." Seminars in Immunol.10. 179-185 (1998)
• [Publications] Takeda,K.: "Stat3 activation is responsible for ILΞ6-dependent T cell proliferation through preventing apoptosis:generation and characterization of T cell-spedific Stat3-deficient mice." J,Immunol.161. 4652-4660 (1998)
• [Publications] Motomura.T.: "Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein." J.Bone Miner.Res.13. 1084-1091 (1998)
• [Publications] Betz,U,A,K.: "Postnatally induced inactibation of gp130 in mice results in neurological, cardiac,hematopoietic,immunological,hepatic,and pulmonary defects." J.Exp.Med.188. 1955-1065 (1998)
• [Publications] Yoshizaki,K.: "Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody." Springer Semin.Immunopathol.20. 247-259 (1998)
• [Publications] Tajagi,N.: "Blockage of Interleukin-6 receptor ameliorates ioint disease in murine collagen-induced arthritis." Arthritis Rheum.41. 2117-2121 (1998)
• [Publications] Ma,Q.: "Impaired B-lymphopoiesis,myelipoiesis,and derailed cerebellar neuron migration in CXCR4-and SDF-1-deficient mice." Proc.Natl.Acad.Sci,USA. 95. 9448-9453 (1998)
• [Publications] Narazaki,M.: "Three distinct domains of SSI-I/SOCS-1/JAB protein are required for its suppression of interleukin 6 singnaling." Proc.Natl.Acad.Sci,USA. 95. 13130-13134 (1998)
• [Publications] Naka,T.: "Accelerated apoptosis of lymphocytes by augmented indcution of Bax in SSI-1 (STAT-induced STAT inhibitor-1)deficient mice." Proc.Natl.Acad.Sci.USA. 95. 15577-15582 (1998)
• [Publications] Yamamoto,H.: "NF-κB activation in CD27 singnaling : involovement of TNF receptor associated factors in its signaling and identification of functinal region of CD27." J.Immunol.161. 4753-4759 (1998)
• [Publications] Nonoyama,S.: "Functional analysis of the peripheral B cells patients with X-linked agammaglobulinemia" J.Immunol.161. 3925-3929 (1998)
• [Publications] Nagasawa,T.: "A CXC chemoking SDF-1/PBSF:A ligand for a HIV coreceptor CXCR4." Adv.Immunol.71. 211-228 (1998)
• [Publications] Hashimoto,S.: "A typical X-linked agammaglobulinemia(XLA)patients diagnosed in their adult ages." Internarl Medicine. in press. (1999)
• [Publications] Baba,Y.: "WASP is involved in the tyrosine kinase pathway in B-lineage cells." Blood. 93. 2003-2013 (1999)
• [Publications] Maeda,A.: "Paired immunoglobulin-like receptor B(PIR-B)inhibits BCR-induced activation of Sky and Btk by SHP-1." Oncogene. in press. (1999)
• [Publications] Na Ayuthaya PI: "The association of skin disease with human herpsevirus 8 infection in HIV carriers" Arch Virol.143. 1881-1891 (1998)
• [Publications] Fujisaki,H.: "Detection of human herpesvirus 7(HHV-7)DNA in breast milk by polymerase chain reaction and prevalence of HHV-7 antibody in breast-fed and bottle-fed children." J.Med.Virol.56. 275-279 (1998)
• [Publications] Aono,T.: "MOnitoring of human cytomegalovirus infections in pediatric bone marrow transplant recipients by nucleic acid sequence-based amplification." J Infect Dis.178. 1244-1249 (1998)
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• [Publications] Zou P: "Human herpesvirus 6 open reading frame U83 encodes a functional chemokine." J Virol.in press. (1999)
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• [Publications] Watanabe,R.: "The first step of glycosylphoshatidylinositol biosynthesis is mediated by a complex of PIG-A,PIG-H,PIG-C and GPII." EMBO J.17. 877-885 (1998)
• [Publications] Tomita,S.: "A homologue of Sachiaromyces cerevisiae Dpm 1 p is not sufficienct for synthesis of dolichol-phosphate-mannose in mammalian cells." J.Biol.Chem.275. 9249-9254 (1998)
• [Publications] Matsuki,M: "Defective atratum comeum early neonatal death in mice lacking the gene for transglutaminase 1(keratinocyte transglutaminase)." Proc.Natl.Acad.Sci.USA. 95. 1044-1049 (1998)
• [Publications] Sutterlin ,C: "Saccharomyces cerevisiae GP100,the functional homolog glycosyphouspahatidy linositol95" Biochem.J. 332. 153-159 (1998)
• [Publications] Takahama,Y.: "Functional competence of T cells in the absene of glycosylphosphatidylinositol-anchored proteins caused by T cell-specifice disruption of the Pig-a gene." Eur.J.Immunol.28. 2159-2166 (1998)
• [Publications] Maeda,Y.: "DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells:correct subcellular localization and stabilizaiton of DPM 1,and binding of dolichol phosphate." EMBO J.17. 4920-4949 (1998)
• [Publications] Azenichi,Y.: "CD5-deficient blood cells and PIG-A gene abnormalities in Japanese patients with aplastic abaemia." Br,J.Haematol. in press. (1999)
• [Publications] Nozaki,M.: "Developmental abnormalities of glycosylphospatidylinositol-anchor deficient embyros revealed by Cre/loxP system." Lab.Invest. in press. (1999)
• [Publications] Watanabe,R.: "Mammalian PIG-L and its yeast homologue Gpi12p are N-acetyglucosaminy-phosphatidylinositol de-N-acetylases essential in glycosyliphosphatidylinositol biosynthesis." Biochemi.J.in press. (1999)
• [Publications] Hiro.T.: "Nasal immune system : Distinctive Th0 and Th1/Yh2 type enviroments in murine nasal associated lymphoid tissues and nasal passage,respectively." Eur,J.Immunol.28. 3346-3353 (1998)
• [Publications] Iijima,H.: "Orally-administered cholea toxin rescues murine gastrointestinal T cells from staphylococcal enterotoxin B-induced anergy" gastroenterology.115. 1197-1204 (1998)
• [Publications] Yamamoto,M.: "Mucosal intranet : epithelial cells down regulate intraepithelial but not peripheral T lymphocytes." J.Immunol.160. 2188-2196 (1998)
• [Publications] Imaoka,K.: "Nasal immunization of non-human primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for anti-viral immunity." J,Immunol. 161. 5952-5958 (1998)
• [Publications] Yamamoto,M.: "A nontoxic adjuvant for mucosal immunity to pneumucoccal surface protein A" J,Immunol.161. 4115-4121 (1998)
• [Publications] Itoh,M.: "Deletion of BST-1(CD157)gene impaired systemic TI-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses." J.Immunol.161. 3974-3983 (1998)
• [Publications] Kawabata,S.: "Unique characteristics of intraepithlial lymphocytes from villi tip and cript portions of the small intestine." Gastroenterology. 115. 866-873 (1998)
• [Publications] Kweon,M-N: "Lack of orally-induced systemic unrespobsuveness in IFN-γknockout mice." J,Immunol.160. 1687-1693 (1998)
• [Publications] Wikox,P R.,: "High mucosal levels of tumor necrosis factor-α mRNA are associated with cytomegalovirus esphagitis" Gastroenterology. 114. 77-82 (1998)
• [Publications] Lu,X: "Targeted lymph node immunization with whole-inactivated SIV or envelope and core subunit antigen vaccines does not rekuably protect rhesus macaques from vaginal challenge with SIV" AIDS. 12. 1-10 (1998)
• [Publications] Kawabata,S.: "Induction of polarized Th2 cytokine expression for p27-sepcific IgA B cell responses after immunization with antigen in rhesus macaques." J,Infect Dise.177. 26-33 (1998)
• [Publications] Nguyen,H.: "Influenza virus-infected epithelial cells present viral antigen to antigen-specific CD8+ cytotoxic T lymphocytes(CTL)." J,Virology. 72. 4534-4536 (1998)
• [Publications] Harris,P.R.: "RecombinantHelicobacter pyloriurease activates primary mucosal macrophages" J.Infect.Dis.178. 1516-1520 (1998)
• [Publications] Yuki,Y.: "Human milk proteins including secretory IgA fail to elicit to lerance after feeding." Intern.Immunol.10. 537-545 (1998)
• [Publications] Sugimoto,M.: "Upregulation of fas ligand(FasL)mRNA expression in peripheral blood mononuclear cells (PBMC)after major surgery." Clin.Exp,Immunol.112. 120-125 (1998)
• [Publications] Shimaoka,M.: "High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury." Crit Care. 2. 35-39 (1998)
• [Publications] Salbi,G.E.: "Inflammatory mediators of the termuinal dentition in aduult and early onset periodontitis" J.Periodontal Res.33. 212-215 (1998)
• [Publications] Shimaoka,M.: "The influence of surgical stress on T cells : enhancement of early phase llymphocyte activation." Aneth,Analg. 87. 1431-1345 (1998)
• [Publications] Tatahashi, I: "T cells:Bodyguards and/or seepers in the gut" Chemical immunol.71. 77-78 (1998)
• [Publications] VanCott,J.L.: "Regulation of host immune responses by modification of Salmonella virule gene" Nature Medicine. 4. 147-1252 (1998)
• [Publications] Boyaka,P,N: "Interleukin 12 is an effective adjuvant for inductor of mucosal immunity" J,Immunol.162. 122-128 (1998)
• [Publications] Marinaro,M: "Use of intranasal IL-12 to target predominatly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin" J.Immunol. 162. 114-121 (1998)
• [Publications] Hiro,T: "Deficiency of IL-5 receptor α chain selectively influences on the development of the comman mcosal immune system independent IgA producing B-1 cells in mucosal associated tisses." J.Immunol.162. 821-828 (1998)
• [Publications] Takahashi,I.: "Clonal expansion of CD4+TCR_<ββ>+T cells in T cellreceptor β-chain deficient mice by gut-derived antigens." J,Immunol.162. 1843-1850 (1999)
• [Publications] Kweon,M-N,: "Mucosally-induced systemic T cell unresponsiveness to ovalbumin requires CD40 interactions." J.Immunol.in press. (1999)
• [Publications] Tori,M: "The significant role of intragaftlymphoid tissues in preventing IDDM(insulin-dependent diabetes mellitus)recurrence in whole pancreaticoduodenal transplantation." J.Micro Surgery. in press. (1999)
• [Publications] McGhee,J.R.: "Mucosal Th1-versus Th-2-type respinses for antibody or cell mediated immunity to SIV rhesus macaques" J.Infect.Dise. in press. (1999)
• [Publications] Yanagita,M: "Nasopharyngeal-associated lymphoreticular tissue(NALT)immunity : fimbriac-specific Th1 and Th2 cells and subswquent inflammatory cytokine produciton." J.Immunol. in press. (1999)
• [Publications] Mackey,M.F.: "Dendritic cells require maturation via CD40 to generate protective antitumor immunity." J.Immunol.161. 2094-2098 (1998)
• [Publications] Moritani,M.: "Abrogation of autoimmune diabetes in nonobese deabetic mice and protection against effector lymphocytes by transgenic TGF-b1." J.Clin.Invest.102. 499-506 (1998)
• [Publications] Yoshida,K.: "Cytokie Knockouts" Humana Press Inc, 26 (1998)
• [Publications] Kinoshita,T.: "The Complement System" Springer-Verlag,Berlin, 8 (1998)
• [Publications] James,S.P.: "Mucosal Immunology" Academic Press, 16 (1998)
• [Publications] Kurono,Y: "Mucosal Solutions,Advances in Mucosal Immunology" SMI,Maryland, 5 (1998)
• [Publications] McGhee,J.R.,: "Fundamental Immunology 4th Edition" Lippincott-Raven Press,Philadelphia, 47 (1998)
• [Publications] Takahashi,I.: "Induction and Modulation of Gastrointestinal Inflammation" FALK Proceeding, 5 (1998)
• [Publications] VanCott,J.L.: "Recent Advances in Otitis Media(in press)" Academic Press, (1999)
• [Publications] Boyaka,P.N.: "Strategies for mucosal vaccine development(in press)" Tropical Medicine, (1999)
• [Publications] Yamamoto,M.: "γδT cells in mucosal intranet(in press)" Allergol.Intern, (1999)
• [Publications] Yamamoto,M,: "Immunoregulatory function of mucosal γδ T cells(in press)" Annu,Inst.Pasture, (1999)
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• [Publications] Nishimoto N.et al.: "Myeloma biology and therapy." Hematol./Oncol.Clin.NA. 11. 159-72 (1997)
• [Publications] Komori T.et al.: "Targeted disruption of CBFA1/PEBP2aA gene results in complete lack of bone formation due to the maturational arrest of osteoblasts." Cell. 89. 755-64 (1997)
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• [Publications] Mackey M.F.et al.: "Protective immunity induced by tumor vaccines requires interaction between CD40 ad its ligand,CD154." Cancer Res.57. 2569-74 (1997)
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