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Takayasu Arteritis in Asian and South American countries.

Research Project

Project/Area Number 10041192
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NUMANO Fujio  Tokyo Medical and Dental Univ.Professor, 医学部, 教授 (40013958)

Co-Investigator(Kenkyū-buntansha) SUNAMORI Makoto  Tokyo Medical and Dental University, Prof., 医学部, 教授 (90138280)
NISHIMURA Yasuharu  Kumamoto University, Professor, 医学部, 教授 (10156119)
YASUKOCHI Yukio  Tokyo Medical dental University Professor, 難治疾患研究所, 教授 (60037398)
NOSE Masato  Ehime University, Professor, 医学部, 教授 (70030913)
KIMURA Akinori  Tokyo Medical and Dental University, Professor, 難治疾患研究所, 教授 (60161551)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 1999: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1998: ¥7,200,000 (Direct Cost: ¥7,200,000)
KeywordsTakayasu Arteritis / Aortitis syndrome / HLA
Research Abstract

Takayasu Arteritis is one of the large vessel vasculitis and is prevalent in young women in Japan. The etiology of this disease is still in mist. In past, several committee for intractable vasculitis was organized by the Ministry of Welfare and the Ministry of Education, Science, Sports and Culture and did many studies on Takayasu Arteritis. But so far there are few studies on Takayasu Arteritis in other Asian and South American countries.
To analyze the pathogenesis of Takayasu Arteritis, we focus on the role of HLA with Takayasu Arteritis. We found HLA-B52 and B39 are significantly associated with Takayasu Arteritis. We also found the inflammation of Takayasu patients with HLA-B52 would often be more fluminant and Takayasu patients with HLA-B39 have more renal vessels obstruction significantly. And we also showed there are common mechanism of HLA with Takayasu Arteritis in the Takayasu patients in India, China and Korea. MICA gene, which locates very close to HLA is found to be signif … More icantly associated with Takayasu Arteritis. MICA polymorphism 1-2 and 1-4 are significantly associated with Takayasu Arteritis in Japan.
The comparison of clinical symptom revealed that Japanese Takayasu patients have significantly high pulseless and aortic valve problem coming fro the involvement of aortic arch and related large vessels. In contrast, Takayasu patients in south Asian countries, especially in India, have more hypertension significantly because Takayasu arteritis would often involve the renal arteries in these countries. The etiology of these difference between East Asia and South Asia are still unknown. We now propose new classification of Takayasu Arteritis based on these findings to show these findings.
Due to kind support of this grant by the Ministry of Education, Sports and Culture, we hold two Internatinal Conference on Takayasu Arteritis and discussed many problems with the scientist and doctors from these area. And finally we published the proceedings of these congress from International Journal of Cardiology in December, 2000. Less

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] Numano F., Kobayashi: "Takayasu Arteritis -beyond pulselessness-"Internal Medicine. 38. 226-232 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Moncada GA, Hashimoto Y et al: "Usefulness of b blocker therapy in patients with Takayasu arteritis and moderate or savere aortic regurgitation"Jpn Heart J. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Numano F: "Overview Vasa Vasoritis, Vasculitis and Atherosclerosi"International Journal of cardiology. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura A et al: "Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis"International Journal of cardiology. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Dal Canto AJ et al: "Animal models of infection-mediated vasculitis : Implications for human disease"International Journal of cardiology. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nose M et al: "Genome analysis of collagen disease in MRL/lpr mice : polygenic inheritance resulting in the complex pathological manifestations."International Journal of cardiology. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小林靖,金子英司,沼野藤夫: "外来診療のすべて(分担)"メディカルビュー社. 910 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Numano F.Overview Vasa Vasoritis, Vasculitis and Atherosclerosis Salazar M, Varela A,Ramierz LA, Uribe O,Vasquez G, Egea E, YunisEJ, Iglesias-Gamarra A.: "Association of HLA-DRB1^*1602 and DRB1^*1001 with Takayasu Arteritis in Colombian Mestizos as Markers of Amerindian Ancestry."International Journal of cardiology supplement. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nose M, Terada M, Nishihara M, Kamogawa J, Mlyazakl T, Qu W M, Mori S, Nakatsuru S.: "Genome analysis of collagen disease in MRL/lpr mice : polygenic inheritance resulting in the complex pathological manifestations."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F.: "Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Dal Canto AJ, Virgin IV HW.: "Animal models of infection-mediated vasculitis : Implications of human disease."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shrama BK, Jain S, Vasishta K.: "Outcome of Pregnancy in Takayasu Arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakabayashi K, Kamiya Y, Nagasawa T.: "Aortitis syndrome associated with positive perinuclear antineutrophil cytoplasmic antibody : Report of three cases."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Vargas-Alarcon G, Zuniga J, Gamboa R, Hernandez-Pacheo G, Hesiquio R, Cruz D, Martinez-Banos D, Portal-Celhay C, Granados J, Reyes P.: "DNA-sequencing of HLA-B alleles in Mexican patients with takayasu Arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sasaki S, Kubota S, Kunihara T, Shiiya N, Yasuda K.: "Surgical experience of the thoracic aortic aneurysm due to Takayasu's arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishikimi N.: "Fate of limbs with failed vascular reconstruction in Buerger's disease patients."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwai T, Inoue Y, Matsukura I, Sugano N, Numano F.: "Surgical technique for management of Takayasu's arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Adar R, Papa MZ, Schneiderman J.: "Thromboangitis Obliterans : An old disease in need of a new look."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zheng D.Liu Guozhang.: "Clinical study of aortic regurgitation in patients with aortoarteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sasaki S, Sakuma M, Yasuda K.: "Current status of thromboangitis obliterans (Buerger's disease) in Japan."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Seko Y, Takahashi N, Tada Y, Yagita H, Okumura K, Nagai R.: "Restricted usage of T-cell eceptor Vg-Vd genes and expression of costimulatory molecules in Takayasu's arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyazawa M, Tabata N, Fujisawa R, Hashimoto K, Shiwaku H, Takei YA.: "Roles of endogeneous retroviruses and platelets in the development of vascular injury in spontaneous mouse models of autoimmune diseases."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nava A, senecal JL, Banales JL, Raymond I, Reyes.: "Abscence of antiphospholipid/co factor antibodies in takayasu Arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Giordano JM.: "Surgical treatment of Takayasu's arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Gravanis MB.: "Giant cell arteritis anf Takayasu aortitis : Morphologic, pathogeneic and Etiologic factors."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sharma BK, Jain S, Bali HK, Jain A, Kumari, S.: "A follow-up study of baloon angioplasty and de-novo stenting in Takayasu arteritis."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jain S, Shrma N, Singh S, Bali HK, Kumar L, Sharma BK.: "Takayasu arteritis in children and young adults."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 沼野藤夫: "高安動脈炎"治療学. 33・2. 59-62 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 沼野、小林靖、原口剛、金子英司: "高安動脈炎"診断と治療. 87・5. 831-834 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 沼野藤夫: "血管炎における外膜の役割"血管と内皮. 9・3. 256-261 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] O Ueda, K. Kohchi, Y. Kishi, F Numano: "Long lasting spasticity controlled vasospastic angina"Heart. 81.5. 528-532 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N. Tagami, K. Ikeda, K. Yamagata, Y. Hara, H. Fujino, A. Kubota, F. Numano, Y. Yamori: "Vitamin E prevents Apoptosis in Hippocampal Neurons caused by Cerebral"Laboratory Investigation. 79.5. 609-615 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] F. Numano, M. Gimbrone: "Inflammation and Atherosclerosis"Atherosclerosis V. (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujio Numano: "Vasovasoritis,Vasculitis and Atherosclerosis"Int. J. Card. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] T. Baba, K. Itakura, R. Tanaka, T. Kawasaki, M. Kiyosawa & F. Numano: "Importance of Fluoresce in Angiographic Study in Evaluating Eorly Rental Cances in Takayasu Disease"Japanese Ophthalmo logical Society/Jpn Ophamol (Elsevier Science Inc.). 43. 546-552 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T. Ashikaga, MD, M. Hishizaki, MD, M. Arita, MD, N. Yamawake, MD, M. Suzuki, MD, Y. Hashimoto, MD, Y. Kishi, MD, F. Numano, MD, M. Hiraoka, MD: "Effect of Dipyridamole on QT Dispersion in Vasaspastic Angina Pectoris"The American Journal of Cardiology. 84・7. 807-810 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujio Numano: "Takayasu Arteritis, Inflammatory Disease of Blood Vessel"edited by G. Hoffman. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujio Numano: "Takayasu Arteritis, Vascular Manifestation of Systemic Autoimmune Disease"edited by Atherson R. Cervara et al CRC Press. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujio Numano: "Takayasu Arteritis Fourth edition of the Oxford Textbook of Medicine"edited by Warrell, T.M. Cox. J.D. Firth. Oxford Univ. Press. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kimura A,Kobayashi Y,et al: "MICA gene polymorhism in Takayasu's arteritis and Bueger's disease." International Journal of Cardiology. 66,sup 1. 107-113 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numano F: "Takayasu arteritis,Bueger Disease and inflammatory abdominal aortic aneurysm is there a commmon pathway in their pathogenesis?" International Journal of Cardiology. 66,sup 1. 3-10 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Noguchi S.,et al: "Increased level of soluble forms of adhesion moiecule in Takayasu Arteritis" International Journal of Cardiology. 66,sup 1. 23-34 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Watanabe T.,et al: "Atherosclerosis and Inflammation : Molecular cell recruitment and adhesion molecules with reference to the implication of ICAM/LFA-1 pathway in atherogenesis." International Journal of Cardiology. 66,sup 1. 45-54 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishimura Y at al: "Molecular analysis of HLA Class II-associated susceptibility to subtypes of autoimmune disease unique to Asians." International Journal of Cardiology. 66,sup 1. 93-104 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nose M at al: "Vasculitis-susceptibility genes in mice with a deficit in Fas-mediated apoptosi" International Journal of Cardiology. 66,sup 1. 37-42 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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