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Anthhropological and genetic studies on ocular inflammatory diseases in Mongoloids

Research Project

Project/Area Number 10041203
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionYokohama City University

Principal Investigator

OHNO Shigeaki  School of Medicine, Yokohama City University, Professor, 医学部, 教授 (50002382)

Co-Investigator(Kenkyū-buntansha) SUGITA Miyuki  School of Medicine, Yokohama City University, Associate Professor, 医学部, 助教授 (90235888)
ONOUE Kazunori  Hokkaido Univ Institute of Immun Sci Professor, 免疫科学研究所・免疫病理部, 所長(教授) (40002117)
INOKO Hidetoshi  Tokai Univ Sch of Med Professor, 医学部・分子生命科学, 教授 (10101932)
UCHIO Eiichi  Medical Center, Yokohama City University, Associate Professor, 医学部・附属病院・市民総合医療センター, 助教授 (70232840)
NAKAMURA Satoshi  School of Medicine, Yokohama City University, Assistant Professor, 医学部, 講師 (00237398)
KHALID F Tab  king Saud大学, 医学部・眼科学, 教授
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 1999: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1998: ¥5,800,000 (Direct Cost: ¥5,800,000)
KeywordsMongoloid / Intractable ocular diseases / Uveitis / Human genetics / Molecular genetics / Behcet's disease / Vogt-Koyanagi-Harada disease / HLA
Research Abstract

It is well known that certain intractable inflammatory ocular diseases occur only in Mongoloid population. We have been studying the epidemiology, clinical feature, medical anthropology, and molecular genetics in mainly Vogt-Koyanagi-Harada disease and Behcet's disease.
It was revealed that Vogt-Koyanagi-Harada disease was found in East Asian countries, Central Asian countries, North America and South America. In contrast, in Caucasians, this disease was rarely found. Vogt-Koyanagi-Harada disease was frequently seen in Australian Aborigini people, and possibly, in Papua New Guinean population. Since this disease is strongly associated with HLA-DRB1ィイD1*ィエD104 in East Asian patients, it is important to further study if the same HLA association is found in other populations.
In Behcet's disease, no patients were found in East Asian countries. This disease was mainly found along the Silk Road, such as Korea, China, Iran, Turkey, and Morocco. In these countries, the number of new cases is still increasing and further epidemiological studies are needed to investigate the possible cause for this. In 1998's investigation we saw patients with Behcet's disease in Mongolia. This is the first report of the world. We have finished analyzing the molecular genetics of Greek patients with Behcet's disease. The frequency of HLA-BィイD1*ィエD15101 was 81.1 %, significantly higher than the healthy normal Greek controls. MICA-A6, one of the microsatellite alleles near the HLA region, was also significantly associated with this disease. It was interesting to find the same HLA association between Japanese and Greek patients with Behcet's disease.
We have successfully gotten the blood samples from typical patients with Behcet's disease in Iran and Turkey. And it is expected that we could also get the samples from Morocco. Further HLA-DNA analyses will be performed in the near future.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (81 results)

All Other

All Publications (81 results)

  • [Publications] 竹内聡: "アジア諸国のウイルス性結膜炎ー国際サーベイランス"臨眼. 52. 513-516 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nanba K.: "Identification of a peptide inducing experimental autommune uveoretinitis (EAU) in H-2Ak- carrying mice"Clin Exp Immunol. 111. 442-449 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugi-Ikai N.: "Increased frequencies of interleukin-2 and interferon-γーproducing T cells in patients with active Behcet's disease"Invest Ophthalmol Vis Sci. 39. 996-1004 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石原麻美: "サルコイドーシスとライム病"日本の眼科. 69. 23-26 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura T.: "Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease"Hum Immunol. 59. 500-502 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishida T.: "Proliferative response of CD8+gd+T cells to Streptococcus sanguis in patients with Behcet's disease"Ocular Immunology and Inflammation. 6. 139-144 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "HSP-derived peptides inducing Uveitis and IgG and IgA antibodies"Exp. Eye Res.. 67. 719-727 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishihara M.: "Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis a region of Japan where Lyme borreliosis is endemic"Grafe's Arch Clin Exp Ophthalmol. 236. 280-284 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 鈴木高佳: "難治性眼サルコイドーシスの2症例"臨眼. 52. 481-485 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石原麻美: "眼科領域における結核"日本臨牀. 56. 163-167 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 大野重昭: "ベーチェット病研究の最前線"Current Topics on Behcet Disease. 2-3 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 大野重昭: "Interview"Current Topics on Behcet Disease. 6-7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yawata N.: "High incidence of glucose intolerance in Vogt-Koyanagi-Harada disease"Br J Ophthalmol. 83. 39-42 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "Soluble intercellular adhesion molecule-1(ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with Behcet's disease and Vogt-Koyanagi-Harada's disease"Clin Exp Rheumatol. 117. 179-184 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabuki K.: "Association of MICA gene and HLA-B^*5101 with Behcet's disease in Greece"Invest Ophthalmol Vis Sci. 40. 1921-1926 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ota M.: "The critical region for Behcet's disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping"Am J Hum Genet. 64. 1406-1410 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabuki K.: "HLA class I and II typing of the patients with Behcet's disease in Saudi Arabia"Tissue Antigens. 54. 273-277 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "Ocular manifestations of systemic infections"Current Opinion in Ophthalmology. 10. 452-457 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabiki K.: "Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative Caucasian patients with ankylosing spondylitis"Hum Immunol. 60. 83-86 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizuki N.: "Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Behcet's disease"Arthritis Rheum. 42・9. 1961-1966 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujino Y.: "Ciclosporin microemulsion preconcentrate treatment of patients with Behcet's disease"Jpn J Ophthalmol. 43. 318-326 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakamura S.: "Uveitis Today"Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shindo Y.: "Uveitis Today"Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "Uveitis Today"Elsecier Scoence. 333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 大野重昭: "実践眼底疾患"メディカル葵出版. 446 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabuki K.: "Uveitis Update (Dev Ophthalmol)"Karger. 216 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Goto K.: "Ocular Inflammation (Basic and Clinical Concepts)"Martion Dunitz. 512 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi S.: "Surveillance of viral conjunctivitis in Asian countries"Jpn J Clin Ophthalmol. 52. 513-516 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nanba K.: "Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice"Cliln Exp Immunol. 111. 442-449 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugi-Ikai N.: "Increased frequencies of interleukin-2-and interferon-Ej-producing T cells in patients with active Behcet's disease"Invest Ophthalmol Vis Sci. 39. 996-1004 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishihara M.: "Association between sarcoidosis and Lyme disease"J Jpn Ophthalmologists Assoc. 69. 23-26 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura T.: "Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease"Hum Immunol. 59. 500-502 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishida T.: "Proliferative response of CD8+gd+T cells to Streptococcus sanguis in patients with Behcet's disease"Ocular Immunology and Inflammation. 6. 139-144 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "HSP-derived peptides inducing Uveitis and IgG and IgA antibodies"Exp.Eye Res.. 67. 719-727 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishihara M.: "Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic"Graefe's Arch Clin Exp Ophthalmol. 236. 280-284 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki T.: "Two cases of recalcitrant ocular sarcoidosis"Jpn J Clin Ophthalmol. 52. 481-485 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishihara M.: "Ocular tuberculosis"Nippon Rinsho. 56. 163-167 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohno S.: "Frontier in the study of Behcet's disease"Current Topics on Behcet Disease. 2-3 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohno S.: "Interview on Behcet's disease"Current Topics on Behcet Disease. 6-7 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yawata N.: "High incidence of glucose intolerance in Vogt-Koyanagi-Harada disease"Br J Ophthalmol. 83. 39-42 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "Soluble intercellular adhesion molecule-1(ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with Behcet's disease and Vogt-Koyanagi-Harada's disease"Clin Exp Rheumatol. 17. 179-184 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabuki K.: "ssociation of MICA-gene and HLA-BィイD1*ィエD1101 with Behcet's disease in Greece"Invest Ophthalmol Vis Sci. 40. 1921-1926 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ota M.: "The critical region for Behcet's disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping"Am J Hum Genet. 64. 1406-1410 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabuki K.: "HLA class I and II typing of the patients with Behcet's disease in Saudi Arabia"Tissue Antigens. 54. 273-277 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "Ocular manifestations of systemic infections"Current Opinion in Ophthalmology. 10. 452-457 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabuki K.: "Triplet repeat polymorphism in the MICA gene m HLA-B27 positive and negative Caucasian patients with ankylosing spondylitis"Hum Immunol. 60. 83-86 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizuki N.: "Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Behcet's disease"Arthritis Rheum. 42. 1961-1966 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujino Y.: "Ciclosporin microemulsion preconcentrate treatment of patients with Behcet's disease"Jpn J Ophthalmol. 43. 318-326 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakamura S.: "The resistance for apoptosis on activated T cells in Behcet's disease"Uveitis Today Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shindo Y.: "Immunogenetic studies of Vogt-Koyanagi-Harada's disease and sympathetic ophthalmia"Uveitis Today Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uchio E.: "Humoral immune response in heat shock potein (HSP)-induced rat uveitis"Uveitis Today Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohno S.: "Intermediate uveitis"Practical Book on Ocular Fundi Medical Aoi Publisher.Inc. 446 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yabuki K.: "Immunogenetics and uveitis"Uveitis Update (Dev Ophthalmol) Karger. 216 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Goto K.: "HLA and ocular diseases"Ocular Inflammation (Basic and Clinical Concepts) Martin Dunitz. 512 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yawata N.: "High incidence of glucose intolerance in Vogt-Koyanagi-Harada disease."Br J Ophthalmol. 83・1. 39-42 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Uchio E.: "Soluble intercellular adhesion molecule-1 (ICAM-1),CD4,CD8 and interleukin-2 receptor in patiens with Behcet's disease and Vogt-Koyanagi-Harada's disease."Clin Exp Rheumatol. 117. 179-184 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yabuki K.: "Association of MICA gene and HLA-B^*5101 woth Behcet's disease in Greece."Invest Ophthalmol Vis Sci. 40・9. 1921-1926 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ota M.: "The critical region for Behcet's disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B,by association analysis using refined microsatellite mapping."Am J Hum Genet. 64. 1406-1410 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yabuki K.: "HLA class I and II typing of the patients with Behcet's disease in Saudi Arabia"Tissue Antigens. 54. 273-277 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Uchio E.: "Ocular manifestations of systemic infections"Current Opinion Ophthalmology. 10. 452-457 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yabuki K.: "Triplet repeat polymorphism in theMICA gene in HLA-B27 positive and negative Caucasian patients with ankylosing spondylitis"Hum Immunol. 60. 83-86 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizuki N.: "Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Behcet's disease"Arthritis Rheum. 42. 1961-1966 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujino Y.: "Cisclosporin microemulsion preconcentrate treatment of patients with Behcet's disease"Jpn J Ophthalmol. 43. 318-326 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yabuki.K.: "Uveitis Update (Dev Ophthalmol)"Karger. 216 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Goto K.: "Ocular Inflammation (Basic and Clinical Concepts)"Martin Dunitz. 512 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹内 聡: "アジア諸国のウイルス性結膜炎・国際サーベイランス" 臨眼. 52・4. 513-516 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nanba K.: "Identification of a peptide inducing experimental autoimmune uveoretinitis(EAU)in H-2Ak-carrying mice" Clin Exp Immunol. 111. 442-449 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sugi-Ikai N.: "Increased frequencies of interleukin-2 and interferon-γ-producing T cells in patients with active Behcet's disease" Invest Ophthalmol Vis Sci. 39・6. 996-1004 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 石原麻美: "サルコイドーシスとライム病" 日本の眼科. 69・1. 23-26 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura T.: "Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease" Hum Immunol. 59. 500-502 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishida T.: "Proliferative response of CD8+gd+T cells to Streptococcus sanguis in patients with Behcet's disease" Ocular Immunology and Inflammation. 6・3. 139-144 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Uchio E.: "HSP-derived peptides inducing Uveitis and IgG and IgA antibodies" Exp.Eye Res.67. 719-727 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ishihara M.: "Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic" Graefe's Arch Clin Exp Ophthalmol. 236. 280-284 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 鈴木高佳: "難治性眼サルコイドーシスの2症例" 臨眼. 52・4. 481-485 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 石原麻美: "眼科領域における結核" 日本臨牀. 56・12. 163-167 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大野重昭: "ベーチェット病研究の最前線" Current Topics on Behcet Disease. 2-3 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大野重昭: "Interview" Current Topics on Behcet Disease. 6-7 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakamura S.: "Uveitis Today" Elsevier Science, 333 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shindo Y.: "Uveitis Today" Elsevier Science, 333 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Uchio E.: "Uveitis Today" Elsevier Science, 333 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大野重昭: "実践眼底疾患" メディカル葵出版, 446 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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