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STUDY ON MOLECULAR EPIDEMIOLOGY OF HIV AND HEPATITIS VIRUS INFECTIONS IN ASIA

Research Project

Project/Area Number 10041212
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionNATIONAL INSTITUTE OF INFECTIOUS DISEASES

Principal Investigator

TAKEBE Yutaka  NATIONAL INSTITUTE OF INFECTIOUS DISEASES, AIDS RESEARCH CENTER, CHIEF, エイズ研究センター, 室長 (50126116)

Co-Investigator(Kenkyū-buntansha) ABE Kenji  NATIONAL INSTITUTE OF INFECTIOUS DISEASES, SENIOR INVESTIGATOR, 感染病理部, 主任研究官 (60130415)
YAMAMOTO Naohiko  NAGOYA UNIV., ASSOCIATE PROFESSOR, 医学部, 助教授 (40220488)
SHIOTA Tatsuo  OSAKA UNIV., PROFESSOR, 微研免疫・ウイルス感染制御分野, 教授 (00187329)
TAKIMOTO Masafumi  KUMAMOTO UNIV., PROFESSOR, 医学部エイズ学研究センター, 教授 (00183450)
YASUTOMI Yasuhiro  MIE UNIV., ASSOCIATE PROFESSOR, 医学部, 助教授 (90281724)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥18,800,000 (Direct Cost: ¥18,800,000)
Fiscal Year 2000: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1999: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1998: ¥7,000,000 (Direct Cost: ¥7,000,000)
KeywordsASIA / AIDS / HIV / HBV / HCV / HGV / MOLECULAR EPIDEMIOLOGY / SURVEILLANCE / HVB
Research Abstract

(A)Molecular epidemiology of HIV in Asia
1)HIV outbreaks in northern Vietnam : We have investigated the nature of recent HIV outbreaks among injecting drug users (IDUs) near Vietnam-China border. HIV-1 subtype E was a principal strain distributed throughout country, regardless of risk factor. We found that the majority of HIV-1 subtype E among IDUs in northern Vietnam showed the significant clustering with those found in nearby Pingxiang city of China's Guangxi Province, sharing a unique valine substitution at 12 amino acids downstream of the V3 loop. The data indicated that HIV outbreaks among IDUs in northern Vietnam was caused by the recent introduction of a highly homogeneous subtype E variant(EV) of close origin of that prevailing in nearby southern China.
2)Emergence of various forms of HIV-1 intersubtype recombinants in Central Myanmar : In addition to two HIV-1 subtypes B' and E previously detected in our study, we have identified HIV-1 subtype C for the first time in Central Mya … More nmar. Moreover, approximately 1/4 of specimens showed the discordance in gag (p17) and env (C2/V3) subtypes. The recombination breakpoint analyses revealed the presence of new forms of HIV-1 intersubtype C/B' and C/B'/E recombinants. The data suggest that multiple subtypes of B', C and E are co-circulating in Central Myanmar, leading to the evolution of new forms of intersubtype recombinants.
3)The genetic polymorphism influencing the susceptibility to HIV-1 and disease progression in Thai population : Cross-section study using discordant couples in Thailand revealed that CCR5 927T mutation is an important genetic predisposition related to resistance to HIV-1 infection in Thai population. This is one of the first reports done in Asian population. Theses results would provide the information crucial to future vaccine strategies for this particular areas in Asia.
B)Molecular epidemiology of hepatitis viruses in Asia
1)Identification of novel genotype of HGV in Southeast Asia : We recently identified a novel genotype of hepatitis G virus(HGV) in Southeast Asian countries. To characterize the viral genome in more detail, we cloned the full-length nucleotide sequence of the two different HGV isolates belonging to the novel genotype. These isolates were recovered from serum of Myanmarese (designated HGV-MY14) and Vietnamese (designated HGV-VT48) subjects, respectively. Both HGV isolates were composed of 9228 nucleotides (nt) and had a single open reading frame spanning 8529 nt and encoding 2843 amino acid residues.
2)HBV and HGV genotyping by PCR : A simple and precise genotyping system based on PCR using the type-specific primers was developed in order to allow for the determination of genotypes A through F of HBV and genotypes 1 through 4 of HGV. By this new method, the prevalence of genotypes of HBV and HGV was investigated in Southeast Asia. The results revealed that the most common viral genotypes were type C of HBV and type 4 of HGV in Myanmar and Vietnam. Interestingly, type B of HBV was also prevalent in Vietnam. This assay system is considered to be useful tool for molecular diagnosis of HBV infection and large-scale surveys. Less

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (70 results)

All 2001 2000 1999 1998 Other

All Journal Article (24 results) Publications (46 results)

  • [Journal Article] Closely related HIV-1 CRF01_AE variants among injecting drug users in northern Vietnam : Evidence of HIV spread across the Vietnam-China border2001

    • Author(s)
      Kato, K., Sato, H., Takebe, Y.et al.
    • Journal Title

      AIDS Research and Human Retroviruses 17

      Pages: 113-123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by polymerase chain reaction using type-specific primers.2001

    • Author(s)
      Naito, H., Hayashi, S., Abe, K.
    • Journal Title

      J.Clinical Microbiology 39

      Pages: 362-364

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Genotyping system of GBV-C/HGV type 1 through type4 by polymerase chain reaction using type-specific primers and geographic distribution of viral genotypes.2001

    • Author(s)
      Naito, H., Abe, K.
    • Journal Title

      J.Virological Methods 91

      Pages: 3-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Closely related HIV-1 CRF01 AE variants among injecting drug users in northern Vietnam : Evidence of HIV spread across the Vietnam-China border2001

    • Author(s)
      Kato, K., Sato, H., Takebe, Y., et al.
    • Journal Title

      AIDS Research and Human Retroviruses 17

      Pages: 113-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Genotyping system of GBV-C/HGV type 1 through type 4 by polymerase chain reaction using type-specific primers and geographic distribution of viral genotypes.2001

    • Author(s)
      Naito, H., Abe, K.
    • Journal Title

      J.Virological Methods 91

      Pages: 3-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Emergence of new forms of human immunodeficiency virus type 1 recombinants in Central Myanmar.2000

    • Author(s)
      Motomura, K., Zaw, M., Long, H.T., Takebe, Y.et al.
    • Journal Title

      AIDS Research and Human Retroviruses 16

      Pages: 1831-1843

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] The entire nucleotide sequence of two hepatitis G virus isolates belonging to a novel genotype : Isolation in Myanmar and Vietnam.2000

    • Author(s)
      Naito, H., Hayashi, S., Abe, K.
    • Journal Title

      J.General Virology 81

      Pages: 189-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Emergence of new forms of human immunodeficiency virus type 1 recombinants in Central Myanmar.2000

    • Author(s)
      Motomura, K., Zaw, M., Long, H.T., Takebe, Y., et al.
    • Journal Title

      AIDS Research and Human Retroviruses. 16

      Pages: 1831-1843

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] HIV-1 env subtype E in Cambodia.1999

    • Author(s)
      Kusagawa, S., Long, H., Takebe, Y., et al.
    • Journal Title

      AIDS Research & Human Retroviruses 15

      Pages: 91-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Sendai virus based production of HIV-1 subtype B and subtype E gp120 antigens and their use for highly sensitive detection of subtype-specific serum antibodies.1999

    • Author(s)
      Toriyoshi, H., Shioda, T., Wasi, C., Takebe, Y., et al.
    • Journal Title

      AIDS Research and Human Retroviruses 15

      Pages: 1109-1120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Genetic similarity of HIV-1 subtype E in a recent outbreak among IDUs in northern Vietnam to strains in Guangxi province of southern China.1999

    • Author(s)
      Kato, K., Shiino, T., Honda, M., Long, H.T., Takebe, Y., et al.
    • Journal Title

      AIDS Research and Human Retroviruses 15

      Pages: 1157-1168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] An infectious DNA clone of HIV type 1 subtype C.1999

    • Author(s)
      Mochizuki, N., Takebe, Y., Tatsumi, M.et al.
    • Journal Title

      AIDS Research and Human Retroviruses 14

      Pages: 1321-1324

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] TT virus infection is widespread in the general populations from different geographic regions.1999

    • Author(s)
      Abe, K., Takebe, Y., Zang, D.Y., et al.
    • Journal Title

      J.Clin.Microbiology 37

      Pages: 2703-2705

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Distribution of HIV-1 disease modifying regulated on activation normal T cell expressed and secreted haplotypes in Asian, African and Caucasia individuals.1999

    • Author(s)
      Liu, H., Shioda, T., Takebe, Y., et al.
    • Journal Title

      AIDS 13

      Pages: 2602-2603

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Identification of a novel genotype of hepatitis G virus in Southeast Asia.1999

    • Author(s)
      Naito, H., Win, H.M., Abe, K.
    • Journal Title

      J.Clinical Microbiology 37

      Pages: 1217-1220

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] HIV-1 env subtype E in Cambodia.1999

    • Author(s)
      Kusagawa, S., Long, H., Takebe, Y., et al.
    • Journal Title

      AIDS Research & Human Retroviruses. 15

      Pages: 91-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Sendai virus based production of HIV-1 subtype B and subtype E gp120 antigens and their use for highly sensitive detection of subtype-specific serum antibodies.1999

    • Author(s)
      Toriyoshi, H., Shioda, T., Wasi, C., Takebe, Y., et al.
    • Journal Title

      AIDS Research & Human Retroviruses. 15

      Pages: 1109-1120

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Genetic similarity of HIV-1 subtype E in a recent outbreak among IDUs in northern Vietnam to strains in Guangxi province of southern China.1999

    • Author(s)
      Kato, K., Shiino, T., Honda, M., Long, H.T., Takebe, Y., et al.
    • Journal Title

      AIDS Research and Human Retroviruses. 15

      Pages: 1157-1168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] An infectious DNA clone of HIV type 1 subtype C.1999

    • Author(s)
      Mochizuki, N., Takebe, Y., Tatsumi, M., et al.
    • Journal Title

      AIDS Research and Human Retroviruses. 14

      Pages: 1321-1324

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] TT virus infection is widespread in the general populations from different geographic regions.1999

    • Author(s)
      Abe, K., Takebe, Y., Zang, D.Y., et al.
    • Journal Title

      J.Clin.Microbiology. 37

      Pages: 2703-2705

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Genetic and serologic characterization of HIV type 1 prevailing in Myanmar (Burma).1998

    • Author(s)
      Kusagawa, S., Mra, R., Takebe, Y., et al.
    • Journal Title

      AIDS Research & Human Retroviruses 14

      Pages: 1379-1385

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Identification and molecular characterization of human T lymphotropic virus type II infections in intravenous drug abusers in the former South Vietnam.1998

    • Author(s)
      Fukushima, Y., Takebe, Y., Long, H.T., Honda, M., et al.
    • Journal Title

      AIDS Research & Human Retroviruses 14

      Pages: 537-540

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Genetic and serologic characterization of HIV type 1 prevailing in Myanmar (Burma).1998

    • Author(s)
      Kusagawa, S., Mra, R., Takebe, Y.et al.
    • Journal Title

      AIDS Research & Human Retroviruses. 14

      Pages: 1379-1385

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Journal Article] Identification and molecular characterzition of human T lymphotropic virus type II infections in intravenous drug abusers in the former South Vietnam.1998

    • Author(s)
      Fukushima, Y., Takebe, Y., Long, H.T., Honda, M., et al.
    • Journal Title

      AIDS Research & Human Retroviruses. 14

      Pages: 537-540

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toda,M.,Sato,H.,Takebe,Y., et al.: "Inhibition of Immunoglobulin E response to Japanese cedar pollen allergen (Cry j 1) in mice by DNA immunization : Different outcomes dependent on the plasmid DNA inoculation method."Immunology. 99. 179-186 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shiino,T.,Takebe,Y., et al.: "A group of V3 sequences of human immunodeficiency virus type 1 subtype E nonsyncytium-inducing, CCR-using variants are resistant to positive selection pressure."J.Virol.. 74. 1069-1078 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sato,H.,Tomita,Y.,Takebe,Y., et al.: "Convergent evolution of reverse transcriptase (RT) genes between human immunodeficiency virus type 1 subtypes E and B following nucleoside analogue RT inhibitor therapies."J.Virol.. 74. 5357-5362 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakayama,E.,Takebe,Y.,Shioda,T. et al.: "Polymorphism in the Interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype."J.Virol.. 74. 5452-5459 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Motomura,K.,Kusagawa,Takebe,Y., et al.: "Emergence of new forms of human immunodeficiency virus type 1 intersubtype recombinants in Central Myanmar."AIDS Research and Human Retroviruses.. 16. 1831-1843 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kato,K.,Kusagawa,S.,Motomura,K.,Takebe.Y., et al.: "Closely related HIV-1 CRF01_AE variants among injecting drug users in northern Vietnam : Evidence of HIV spread across the Vietnam-China border"AIDS Research and Human Retroviruses. 17. 113-123 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Uno-Furuta,S.,Tamaki,S.,Takebe,Y., et al.: "Induction of virus-specific cytotoxic T lymphocytes by in vivo electric administration of pepetides."Vaccine. (in press).. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kusagawa,S.,Takebe,Y.,Yang,R., et al.: "Isolation and characterization of full-length molecular DNA clones of Ghanaian HIV-1 intersubtype A/G recombinant (CRF02_AG) which is replication-competent in restricted host-range."AIDS Research and Human Retroviruses. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Naito,H.,Hayashi,H.,and Abe,K.: "The entire nucleotide sequence of two hepatitis G virus isolates belonging to a novel genotype : Isolation in Myanmar and Vietnam"Journal of General Virolog. 81. 189-194 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shibahara,,N.,Moriyama,M.,Abe,K., et al.: "Biochemical and virological response to interferon therapy in patients with chronic hepatitis C, co-infected with hepatitis G virus."Journal of Viral Hepatitis. 7. 43-50 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Konomi,N.,Yamaguchi,M.,Naito,H.,Abe K., et al.: "Simultaneous detection of hepatitis B, C and G viral genomes by multiplex PCR method"Japanese Journal of Infectious Diseases. 53. 70-72 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Naito,H.,Hayashi,S.,and Abe,K.: "Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by polymerase chain reaction using type-specific primers."Journal of Clinical Microbiology. 39. 362-364 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Naito,H.,and Abe,K.: "Genotyping system of GBV-C/HGV type 1 through type 4 by polymerase chain reaction using type-specific primers and geographic distribution of viral genotypes."Journal of Virological Methods. 91. 3-9 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kusagawa S.,Y.Takebe et al.: "HIV-1 env subtype E in Cambodia"AIDS Research & Human Retroviruses. 15. 91-94 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sato H.,Y.Takebe et al.: "Evolution and biological characterization of human immunodeficiency virus type 1 subtype E gp120 V3 sequences following horizontal and vertical virus transmission in a single family"AIDS Research & Human Retroviruses. 73. 3551-3559 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sato H.,Y.Takebe et al.: "Functional complementation of the envelope hypervariable V3 loop of human immunodeficiency virus type 1 subtype B by subtype E V3 loop"Virology. 257. 491-501 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Liu H.,Takabe Y.,Shioda T.et al.: "Polymorphism in RANTES chemokine promotor affects HIV-1 disease progression"Proc.Natl.Acad.Sci.USA.. 96. 4581-4585 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kato K.,Y.Takabe et al.: "Role of naturally-occurring basic amino acid substitutions on viral coreceptor usage and cell tropism in the immunodeficiency virus type 1 subtype E envelope V3 loop"J.Virol.. 73. 5520-5526 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toriyoshi H.,Shioda T.,Takebe Y.et al.: "Sendai virus based production of HIV-1 subtype B and subtype E gp120 antigens and their use for highly sensitive detection of subtype-specific serum antibodies"AIDS Research and Human Retroviruses. 15. 1109-1120 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kato K.,Y.Takabe et al.: "Genetic similarity of HIV-1 subtype E in a recent outbreak among IDUs in northern Vietnam to strains in Guangxi province of southern China"AIDS Research and Human Retroviruses. 15. 1157-1168 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mochizuki N.,Takebe Y.et al.: "An infectious DNA clone of HIV type 1 subtype C"AIDS Research and Human Retroviruses. 14. 1321-1324 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toda M.,Takabe Y.et al.: "Inhibition of IgE response to Japanese cedar pollen allergen(Cry j 1)in mice by DNA immunization : Different outcomes dependent on the plasmid DNA inoculation method"Vaccine. (accepted).

    • Related Report
      1999 Annual Research Report
  • [Publications] Liu H.,Shioda T.,Takebe Y.et al.: "Distribution of HIV-1 disease modifying regulated on activation normal T cell expressed and secreted haplotypes in Asian,African and Caucasia individuals"AIDS. 13. 2602-2603 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shiino T.,Takebe Y.et al.: "IA group of V3 sequences of human immunodeficiency virus type 1 subtype E nonsyncytium-inducing,CCR-using variants are resistant to positive selection pressure"J.Virol.. 74(3). 1069-1078 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sato H.,Takebe Y.et al.: "Convergent evolution of reverse transcriptase(RT)gene between human immunodeficiency virus type 1 subtypes E and B following nucleoside analogue RT inhibitor therapies"J.Virol.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Abe K.,Takebe Y.et al.: "TT virus infection is widespread in the general populations from different geographic regions"Clin.Microbiology.. 37. 2703-2705 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Naito K.,Abe K.et al.: "Identification of a novel genotype of hepatitis G virus in Southeast Asia"Journal of Clinical Microbiology. 37. 1217-1220 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Naito K.,Abe K.et al.: "The entire nucleotide sequence of two hepatitis G virus isolates belonging to a novel genotype : Isolation in Myanmar and Vietnam"Journal of General Virology. 81. 189-219 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Kusagawa., Y,Takebe., et al.: "Genitic and serologic characterization of HIV type 1 prevailing in Myanmar(Burma)." AIDS Research & Human Retroviruses. 15. 91-94 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Kusagawa., Y,Takebe., et al.: "HIV-1 env subtype E in Cambodia." AIDS Research & Human Retroviruses.

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Fukushima., Y.Takebe., et al.: "Indentifcation and molecular characterzition of human T lymphotropic virus type II infections in intravenous drug abusers in the former South Vietnam." AIDS Research and human letroviruses.14. 537-540 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Sato., Y.Takebe., et al.: "Evolution and biological characterization of human immunodificiency virus type 1 subtype E gp120 V3 sequences following horizontal and vetrical virus transmission in a single family." J.Virol.accepted.(1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Sato., Y.Takebe., et al.: "Functional complementation of the envelope hypervariable V3 loop of human immunodeficiency virus type 1 subtype B by subtype E V3 loop. Virology." Virology.(submitted.). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Abe, et al.: "Hepatitis C virus RNA in dried serum spotted onto filter paper is stable at room temperature." J.of Clinical Microbiology. 36. 3070-3072 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Kaneko., K.Abe., et al.: "Molecular cloning of full-lenght sequence of hepatitis G virus genome isolated from a Japanese patient with chronic liver disease" Hepatology Research. 12. 207-216 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Tanaka., M.Mizokami., et al.: "GB virus C/hepatitis G virus infection among Colombian native Indians." Journal of Tropical Medicine & Hygiene.59(3). 462-7 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Cao., M.Mizokami., et al.: "GB virus C/hepatitis G virus infection among patients with hepatocellular carcinoma in the inshore area of Yangtze river, China." Journal of Gastroenterology & Hepatology.(In press).

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Kakumu., S.Isomura., et al.: "Prevalence of hepatitis B, hepatitis C, and GB virus C/Hepatitis G virus infections in liver disease patients and inhabitanats in Ho Chi Minh, Vietnam." J.Med.Virol.54. 243-248 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Ikeda., M.Takiguchi., et al.: "Identification of a novel HLA-A24-restricted CTL epitope dirived from HIV-1 Gag protein." AIDS. 12. 2073-2074 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] D.Kimieciak., M.Takiguchi., et al.: "The effect of peptide variation on the profile of cytotoxic T lymphocyte responses to the HIV envelope glycoprotein." Internatioal Immunology. 10. 1789-1799 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Chujoh., M.Takiguchi., et al.: "The role of anchor residues in the binding of peptides to HLA-A1101 molecules." Tissue Antigens. 52. 501-509 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Tomiyama., M.takiguchi., et al.: "Cytotoxic T-lymphocyte recognition of HLA-B5101-resticted HIV-1 Revepitope which is naturelly processed in HIV-1 infected cells." AIDS. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] H.tomiyama., M.Takiguchi., et al.: "Identification of multiple HIV-1 epitopes presented by HLA-B5101 molecules." Human Immunology. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] X.Xin., T.Sioda., et al.: "Facilitation of HIV-1 isolation from patjentes by neuraminidase." Arch.Virol.143. 85-95 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Kurotani., T.Shioda., et al.: "The paramyxovirus, Sendai virus, C proteins are categorically nonesential gene products but silencing their expression critically impairs viral replication and pathogenecity." Genes Cells. 3. 111-124 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Shioda., et al.: "Anti-HIV-1 and chemotactic activities of human SDF-1α and SDF-1β are abolished by CD26/dipeptidyl peptidase IV mediated cleavage." Proc.Natl.Acad.Sci.USA.95. 6331-6336 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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