| Project/Area Number |
10044073
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B).
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
機能・物性・材料
|
|---|
| Research Institution | KYOTO UNIVERSITY |
|---|
Principal Investigator |
YOSHIKAWA Kenichi Dept. of Phys., Kyoto University, Professor, 大学院・理学研究科, 教授 (80110823)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OANA Hidehiro Dept. of Phys., KYOTO UNIVERSITY, Assistant, 大学院・理学研究科, 助手 (20314172)
KUMAZAWA Noriyuki Dep. of Common Chair, Ibaraki University, Associate Professor, 工学部, 助教授 (70137256)
LINDEMAN B.O ルンド大学, 物理化学科, 教授
KABANOV V.A. モスクワ大学, 化学学部, 教授
VASILEVSKAYA バレンチナ ロシア科学アカデミー, ネスメヤノフ有機素子化合物研究所, 上級研究員
KHOKHLOV A.R ロシア科学アカデミー, ネスメヤノフ有機素子化合物研究所, 教授
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
|
|---|
| Keywords | Giant DNA / Coil-Globule Trancition / Single Chain Observation / Flurescente Microscopy / Single-Chain Folding / Melting Transitions / Surfactant / Folding Transition / コイルーグロビュール転移 / コイル-グロビュール転移 / 単分子観察 / ミセル |
|---|
| Research Abstract |
The main purpose of the present research project was to study the folding transitions of long polymer chain, especially of giant DNA molecules. We have found that the conformation of giant DNAs is controlled by the addition of various kinds of surfactant. With the adjustment of alcohol concentrations, both the conformation and solvability are controlled (see e. g.; J. Am. Chem. Soc., 121, 1780-1785, 1999). It has been also found that the melting, or helix-coil transition, and the folding transition exhibit the cross-talk each other. When DNA is folded, melting transition is tendid to be prevented. When melting transition is generated, the unfolding of DNA is accelerated.
|
