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Molecular mechanisms of sex determination in birds

Research Project

Project/Area Number 10044201
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionNAGOYA UNIVERSITY

Principal Investigator

SHIMADA Kiyoshi  Nagoya University, Graduate School of Bioagricultural Sciences, Professor, 大学院・生命農学研究科, 教授 (40065579)

Co-Investigator(Kenkyū-buntansha) HARADA Nobuhiro  Fujita Health University, School of Medicine, Professor, 医学部, 教授 (00189705)
PARK Min kyun  University of Tokyo, Graduate School of Science, Assistant Professor, 大学院・理学系研究科, 助教授 (00228694)
TOMOGANE Hiroshi  Nippon Veterinary and Animal Science University, Department of Animal Sciences, Professor, 獣医畜産学部, 教授 (30023493)
SAITO Noboru  Nagoya University, Graduate School of Bioagricultural Sciences, Assistant Professor, 大学院・生命農学研究科, 助教授 (40211924)
ONO Tamao  Shinshu University, School of Agriculture, Assistant Professor, 農学部, 助教授 (10177264)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 2000: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1999: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1998: ¥6,800,000 (Direct Cost: ¥6,800,000)
Keywordschicken embryo / mRNA / sexual differentiation / Dmrt-1 / AMH / Sf-1 / Dax-1 / Sox-9 / ニワトリ胚 / 性決定 / mRNA / Dmert-1 / Dax-1 / Z性染色体 / ニワトリ / SRC-1 / RT-PCR / アロマターゼ / クローニング / アンチセンスオリゴヌクレオチド / 生殖腺 / SOX9 / in situ hybridization / PCR / 抗ミュラー管ホルモン / アンドロジェンレセプター / 性分化
Research Abstract

Since sex determination and differentiation mechanisms remain unsolved in birds, this project was conducted to elucidate the molecular mechanisms of sexual differentiation of the chicken gonad. The testis produces anti-Mullerian hormone (AMH) and androgen, whereas the ovary produces little AMH but produces estrogen predominantly. Our in situ hybridization study demonstrated that AMH mRNA was expressed as early as day 5 of incubation followed by a sharp increase on day 6 of incubation in males, which was subsequently maintained. In contrast, the female showed minimum levels of expression. Conversely, aromatase mRNA was expressed in the gonad as early as day 6 of incubation in female but little in the male. Possible transcription factors affecting the AMH and aromatase genes include Sox 9, Sf-1, Dax-1, and Dmrt-1. Sox 9 mRNA is predominantly expressed in male gonad, although it is expressed after the expression of AMH.The Sf-1 mRNA expression is sexually dimorphic after day 7.5 of incubation and expression is higher in the female gonad than in the male gonad. In the chicken Dax-1 mRNA is expressed in the chicken gonad in both sexes. Chicken Dmrt-1 gene on the Z chromosome was expressed in the genital ridge and Wolffian duct prior to sexual differentiation and is expressed at higher levels in male than in female embryos. Furthermore, this is expressed prior to AMH expression in male. This sex- and time-specific expression makes this gene an especially good candidate to be involved in avian sex determination.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (333 results)

All Other

All Publications (333 results)

  • [Publications] Abinawanto,Zhang C.,Saito N.,Matsuda Y.and Shimada K.: "Identification of sperm bearing female-specific chromosome in the sex-reversed chicken."Journal of Experimental Zoology. 280. 65-72 (1998)

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  • [Publications] Kansaku N.,Shimada K.,Saito N.and Hidaka H.: "Effects of protein kinase A inhibitor (H-89) on VIP- and GRF-induced release and mRNA expression of prolactin and growth hormone in the chicken pituitary gland."Comparative Biochemistry and Physiology. 119C. 89-95 (1998)

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  • [Publications] Matsumoto K.,Ieda T.,Saito N.,Ono T.and Shimada K.: "Role of retinoic acid in regulation of mRNA expression of CaBP-D28K in the cerebellum of the chicken."Comparative Biochemistry and Physiology. 120A. 237-242 (1998)

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  • [Publications] Kita K.,Shibata T.,Aman Yaman M.,Conlon M.A.,Sasaki T.,Saito N.and Okumura J.: "Relationship of insulin-like growth factor-I to muscle protein synthesis in fasted chicks."Japanese Poultry Science. 35. 263-270 (1998)

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  • [Publications] Kita K.,Hangsanet K.,Shibata T.,Conlon M.A.,Sasaki T.,Saito N.and Okumura J.: "Refeeding increases hepatic insuline-like growth factor-I (IGF-I) gene expression and plasma IGF-I concentration in fasted chicks."British Poultry Science. 39. 679-682 (1998)

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  • [Publications] Sasaki T.,Shimada K.and Saito N.: "Changes of AVT levels in plasma, neurohypophysis and hypothalamus in relation to oviposition in the laying hen."Comparative Biochemistry and Physiology. 121A. 149-153 (1998)

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  • [Publications] Saito N.and Grossmann R.: "Effects of short-term dehydration on plasma osmolality, levels of arginine vastocin and its hypothalamic gene expression in the laying hen."Comparative Biochemistry and Physiology. 121A. 235-239 (1998)

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  • [Publications] Furuse M.,Bungo T.,Shimojo M.,Masuda Y.,Saito N.,Hasegawa S.and Sugahara K.: "Effects of various N-terminal fragments of glucagon-like peptide-1 (7-36) on food intake in the neonatal chick."Brain Research. 807. 214-217 (1998)

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  • [Publications] Ieda T.,Saito N.and Shimada K.: "Effects of aminoglutethimide on levels of messenger ribonucleic acid of CaBP-D28K and of vitamin D3 receptor in the shell gland of laying hen."Japanese Poultry Science. 35. 346-355 (1998)

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  • [Publications] Furuse M.,Bungo T.,Shimojo M.,Masuda Y.,Saito N.,Hasegawa S.and Sugahara K.: "Influence of intracerebroventricular administration of exendin (9-39) on food intake of the newly-hatched chick."Japanese Poultry Science. 35. 376-380 (1998)

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  • [Publications] Barua A.,Yoshimura Y.and Tamura T.: "The effects of age and sex steroids on the macrophage population in the ovary of chicken, Gallus domesticus."Journal of Reproduction and Fertility. 114. 253-258 (1998)

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  • [Publications] Barua A.,Yoshimura Y.and Tamura T.: "Effects of aging and oestrogen on the localization of immunoglobulin containing cells in the ovary of chicken, Gallus domesticus."Journal of Reproduction and Fertility. 114. 11-16 (1998)

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  • [Publications] Zheng W.M.,Yoshimura Y.and Tamura T.: "Effects of gonadal steroids on the localization of antigen-presenting cells, T and B cells in the chicken oviduct."Journal of Reproduction and Fertility. 114. 45-54 (1998)

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  • [Publications] Barua A.,Yoshimura Y.and Tamura T.: "Localization of macrophages in the ovarian follicles during the follicular growth and postovulatory regression in chicken, Gallus domesticus."Poultry Science. 77. 1417-1421 (1998)

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  • [Publications] Barua A.,Howlider M.A.R.and Yoshimura Y.: "A study on the performance of Fayoumi, Rode island red and Fayoumi X Rode island red chickens under rural condiction of Bangladesh."Asian-Australasian Journal of Animal Science. 11. 635-641 (1998)

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  • [Publications] Yoshimura Y.and Okamoto H.: "Phagocytosis of carbon particles by theca interna fibroblasts in hen ovary."Japanese Poultry Science. 35. 314-318 (1998)

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  • [Publications] Yoshimura Y.and Ogawa H.: "Histological characterization of the oviducal structures in Guinea fowl (Numida meleagris)."Japanese Poultry Science. 35. 149-156 (1998)

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  • [Publications] Ohira H.,Yoshimura Y.and Tamura T.: "Increase of calcium binding protein-D28K contents in the shell gland by an injection with 1,25-dihydroxyvitamin D3 into shell gland lumen in laying hens."Japanese Poultry Science. 35. 99-107 (1998)

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  • [Publications] Barua A.,Howlider M.A.R.and Yoshimura Y.: "Indigenous Naked neck fowl of Bandladesh."Worlds Poultry Science Journal,,. 54. 279-286 (1998)

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  • [Publications] Solovei I.Joffe B.,Hori,T.,Thomsor P.,Mizuno S.and Macgregor H.: "Unordered arrangement of chromosomes in the nuclei of chicken apermatozoa."Chromosoma. 107. 184-188 (1998)

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  • [Publications] Yamaguchi K.,Hidema S.and Mizuno S.: "Chicken chromobox proteins : CHCB1, -2, -3 and their relation to Wheterochromatin."Experiomental Cell Research. 242. 303-314 (1999)

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  • [Publications] Mizuno S.and Macgregor H.: "The ZW lampbrush chromosomes of birds : a unique opportunity to look at the molecular cytoenetics of sex chromosomes."Cytogenetics Cell Genetics. 80. 149-157 (1998)

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  • [Publications] Solovei I.,Ogawa A.,Naito M.,Mizuno S.and Macgregor H.: "Specific chromomeres on the chicken W lampbrush chromosome contain specific, repetitive DNA sequence families."Chromosome Research. 6. 323-327 (1998)

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  • [Publications] Ogawa A.,Murata K.and Mizuno S.: "The location of Z- and W-linked marker genes and sequence on the homomorphic sex chromosomes of the ostrich and the emu."Proceedings of National Academy of Science USA. 95. 4415-4418 (1998)

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  • [Publications] Nakabayashi O.,Kikuchi H.,Kikuchi T.and Mizuno S.: "Differential expression of genes for aromatase and estrogen receptor during the gonadal development in chicken embryos."Journal of Molecular Endocrinology. 20. 193-202 (1998)

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  • [Publications] Mochii M.,Ono T.,Matsubara Y.and Eguchi G.: "Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by an Mitf mutation."Developmental Biology. 196. 145-159 (1998)

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  • [Publications] Ono T.,Yokoi R.,Maeda S.,Nishida T.and Aoyama H.: "Settlement of quail primordial germ cells in chicken gonads."Animal Science and Technology. 69. 546-555 (1998)

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  • [Publications] Ono T.,Matsumoto T.and Arisawa Y.: "Production of donor-derived offspring by transfer of primordial germ cells in Japanese quail."Experimental Animals. 47. 215-219 (1998)

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  • [Publications] Ono T.,Yokoi R.,Maeda S.,Nishida T.and Aoyama H.: "Transfusion of chick primordial germ cells into quail embryos and their settlement in gonads."Animal Science and Technology. 69. 911-915 (1998)

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  • [Publications] Kino K.,Noda K.,Miyakawa H.,Ohtsuka K.,Ono T.,Mochii M.,Eguchi G.and Agata K.: "A low frequency of chromosomal integration of the cloned DNA after micro-injection into the cytoplasm of the fertilized eggs of chickens."Japanese Poultry Science. 35. 356-366 (1998)

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  • [Publications] Harada N.and Hatano O.: "Inhibitors of aromatase prevent degaradation of the enzyme in cultured human tumour cells."British Journal of Cancer. 77. 567-572 (1998)

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  • [Publications] Harada N.,Ota H.,Yoshimura N.,Katsuyama T.and Takagi Y.: "Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver."Journal of Clinical Endocrinology and Metabolite. 83. 697-702 (1998)

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  • [Publications] Sasano H.,Takahashi K.,Sato F.,Nagura H.and Harada N.: "Aromatase in human central nervous system."Clinical Endocrinology. 48. 325-329 (1998)

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  • [Publications] Balthazart J.,Foidart A.,Baillien M.,Harada N.and Ball G.F.: "Anatomical relationships between aromatase and tyrosine hydroxylase in the quail brain : Double-label immunocytochemical studies."Journal of Comparative Neurology. 391. 214-226 (1998)

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  • [Publications] Aste N.,Panzica G.C.,Viglietti-Panzica C.,Harada N.and Balthazart J.: "Distribution and effects of testosterone on aromatase mRNA in the quail forebrain : a non-radioactive in situ hybridization study."Jornal of Chemical Neuroanatomy. 14. 103-115 (1998)

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  • [Publications] Sasano H.,Suzuki T.and Harada N.: "From endocrinology to incrinology."Endocrine Pathology. 9. 9-20 (1998)

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  • [Publications] Foidart A.,Silverin B.,Baillien M.,Harada N.and Balthazart J.: "Neuroanatomical distribution and variations across the reproductive cycle of aromatase activity and aromatase-immunoreactive cells in the pied flycatcher (Ficedula hypoleuca)."Hormone and Behavior. 33. 180-196 (1998)

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  • [Publications] Nomura M,Kawabe K,Matsushita S,Oka S,Hatano O,Harada N,Nawata H.…: "Adrenocortical and gonadal expression of the mammalian Fts-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control."Journal of Biochemistry. 124. 217-224 (1998)

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  • [Publications] Harada N.and Honda S.: "Molecular analysis of aberrant expression of aromatase in breast cancer tissue."Breast Cancer Research and Treatment. 49. 15-21 (1998)

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  • [Publications] Santen RJ,Martel J,Hoagland M,Naftolin F,Roa L,Harada N,Hafer L,Zaino R.…: "Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts."Breast Cancer Research and Treatment. 49. 93-99 (1998)

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  • [Publications] Mor G,Yue W,Santen RJ,Gutierrez L,Eliza M,Berstein LM,Harada N,Wang J,…: "Macrophages, estrogen and the microemvironment of breast cancer."Journal of Steroid Biochememistry and Molecular Biology. 67. 403-411 (1998)

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  • [Publications] Honda S.,Harada N.,Ito S.,Takagi Y and Maeda S.: "Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene."Biochemistry and Biophysics Research Communication. 252. 445-449 (1998)

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  • [Publications] Kohchi C.,Ukena K.and Tsutsui K.: "Age-and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes P450scc, P450c17, 3β-HSD in the postnatal rat brain."Brain Research. 801. 233-238 (1998)

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  • [Publications] Tsutsui K.,Li D.,Ukena K.,Kikuchi M.and Ishii S.: "Developmental changes in galanin receptors and the effect of sex steroids on galani receptor induction."Endocrinology. 139. 4230-4236 (1998)

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  • [Publications] Ukena K.,Usui M.,Kohchi C.and Tsutsui K.: "Cytochrome P450scc side-chain cleavage enzyme (P450scc) in the cerebellar Purkinje neuron and its neonatal change in rats."Endocrinology. 139. 137-147 (1998)

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  • [Publications] Azumaya Y.,Kominami S.and Tsutsui K.: "Existence and localization of a protein in zebra finch brain with similar structural features as the large subunit of the splicing factor U2AF."Journal of Experimental Zoology. 281. 90-96 (1998)

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  • [Publications] Ohboshi S.,Fujihara N.,Yoshida T.and Tomogane H.: "Effects of glucose and amino acids on in-vitro development of rat preimplantation embryos, and morphological features of the developed blastocysts."Animal Science and Technology. 69. 637-645 (1998)

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  • [Publications] Ohoboshi S.,Fujihara N.,Yoshida T.and Tomogane H.: "Ultrastructure of bovine in vitro-produced blastocysts cryopreserved by vitrification."Zygote. 6. 17-26 (1998)

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  • [Publications] Ohkubo T.,Tanaka M.,Nakashima K.,Talbot R.T.and Sharp P.J.: "Prolactin receptor gene expression in the brain and peripheral tissues in broody and nonbroody breeds of domestic hen."General and Comparative Endocrinology. 109. 60-68 (1998)

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  • [Publications] Tanaka M.,Taniguchi T.Ohkubo T.and Nakashima K.: "cDNA cloning and characterization of neuron-specific enolase from chicken."Biochim Biophys Acta. 1395. 28-33 (1998)

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  • [Publications] Ohkubo T.,Tanaka M.,Nakashima K.and Sharp P.J.: "Relationship between prolactin receptor mRNA in the anterior pituitary gland and hypothalamus and reproductive state in male and female bantams (Gallus domesticus)."General and Comparative Endocrinology. 111. 167-176 (1998)

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  • [Publications] Ohkubo T.,Tsukada A.,Tanaka M.and Nakashima K.: "Cloning and expression of pigeon growth hormone receptor cDNA in COS-7 monkey kidney cells."Comparative Biochemistry and Physiology. 120B. 449-455 (1998)

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  • [Publications] Tsukada A,Ohkubo T,Sakaguchi K,Tanaka M,Nakashima K,Hayashida Y,Wakita M,…: "Thyroid hormones are involved in insulin-like growth factor-I (IGF-I) production by stimulating hepatic growth hormone receptor (GHR) gene expression in the chicken."Growth Hormone and IGF Research. 8. 235-242 (1998)

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  • [Publications] Sakaguchi K,Tanaka M,Ohkubo T,Yoshizato H,Hanai Y,Fujikawa T,Kaneko H,……: "Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat."Endocrine Journal. 45(Suppl). S105-S107 (1998)

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  • [Publications] Tanaka M,Taniguchi T,Yamamoto I,Sakaguchi K,Yoshizato H,Ohkubo T,…: "Gene and cDNA structures of flounder insulin-like growth factor-I (IGF-I) : Multiple mRNA species encode a single short mature IGF-1."DNA Cell Biology. 17. 859-868 (1998)

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  • [Publications] Mochizuki Y.,Park M.K.,Mori T.,Ogura A.and Kawashima S.: "Formation of lipofusion-like autofluorescent materials in NG108-15 cells : involement of lysosomal protein degradsation."Gernotology. 44. 1-8 (1998)

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  • [Publications] Iizuka A.,Park M.K.and Mori T.: "Changes in the expression pattern of luteinizing hormone receptor mRNA expression in the rat testis during degeneration os seminiferous epithelium."Zoological Science. 15. 255-261 (1998)

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  • [Publications] Kansaku N.,Tsuji Y.,Saito N.and Shimada K.: "Expression of messenger ribonucleic acids of luteinizing hormone receptor, P450 17α-hydroxylase and P450 aromatase in isolate granulosa, theca interna and theca externa lavers of chicken ovarian follicles during follicular growth."Animal Science Journal. 70. 12-17 (1999)

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  • [Publications] Bungo T.,Shimojo M.,Masuda Y.,Saito N.,Sugahara K.,Hasegawa S.and Furuse M.: "Effects of naloxone on the anorexic action by glucagon-like peptide-1 (7-36) in the neonatal chick."Japanese Poultry Science. 36. 109-115 (1999)

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  • [Publications] Furuse M.,Ao R.,Bungo T.,Ando R.,Shimojo M.,Masuda Y.and Saito N.: "Central gastrin inhibits feeding behavior and food passage in neonatal chicks."Life Sciences. 65. 305-311 (1999)

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  • [Publications] Furuse M.,Matsumoto M.,Pinotoan R.,Saito N.,Sugahara K.and Hasegawa S.: "Intraventricular injection of glucagon-like peptide-1 inhibits water intake of the neonatal chick."Japanese Poultry Science. 36. 229-335 (1999)

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  • [Publications] Saito N.and Grossmann R.: "Gene expression of arginin vasotocin in ovarian and uterine tisseus of the chicken."Asian-Ausralasian Journal of Animal Science. 12. 695-701 (1999)

    • Description
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      2000 Final Research Report Summary
  • [Publications] Saito N.,Furuse M.,Sasaki T.,Arakawa K.and Shimada K.: "Effects of naloxone on neurohypophysial peptides release by hypertonic stimulation in chicks."General and Comparative Endocrinology. 115. 228-235 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Bungo T.,Ando R.,Ao R.,Shimojo M.,Masuda Y.,Choi Y.-H.,Saito N.and Furuse M.: "Influence of intracerebroventricular administration of morphine and kyotrophin on food intake of the neonatal chick."Japanese Poultry Science. 36. 319-324 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Ieda T.,Saito N.,and Shimada K.: "Effect of low calcium diet on messenger ribonucleic acid levels of calbindin-D28K of intestine and shell gland in laying hens in relation to egg shell quality."Japanese Poultry Science. 36. 295-303 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Bungo T.,Shimojo M.,Masuda Y.,Saito N.,Sugahara K.,Hasegawa S.and Furuse M.: "Effects of substitution of N-terminal amino acid of glucagon-like peptide-1 (7-36) amide on food intake of the neonatal chick."Life Sciences. 25. PL295-PL299 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Bungo T,Kawakami SI,Ohgushi A,Shimojo M,Masuda Y,Saito N,Sugahara K,……: "Intracerebroventricularly administration of glucagon-like peptide-1 induces sleep-like behavior in the neonatal chick."Japanese Poultry Science. 36. 377-381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Hirabayashi N.,Matsuki Y.,Suzuki E.,Usami M.,Ohno Y.and Shimada K.: "Toxicokinetic study of Fadrozole, an aromatase inhibitor, in the chicken eggs by the injection on the shell membrane."Japanese Poultry Science. 36. 382-387 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Suzuki T,Kansaku N,Kurosaki T,Shimada K,Zadworny D,Kuhnlein U,Koide M,……: "Comparative FISH mapping on Z chromosomes of chicken and Japanese quail."Cytogenetics Cell Genet. 87. 22-26 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Suzuki T.,Kurosaki T.,Shimada K.,Kansaku N.,Li S.,Zadworny D.,Hashimoto A.,……: "Cytogenetical mapping of 31 functional genes on chicken chromosomes by the direct R-banding FISH."Cytogenetics Cell Genet.. 87. 32-40 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Barua A.and Yoshimura Y.: "mmunolocalization of MHC+ cells in the ovary of immature, young laying and ollaying hens, Gallus domesticus."Journal of Reproduction and Fertility. 116. 385-389 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Barua A.and Yoshimura Y.: "Effects of aging and sex steroids on the localization of T cell subsets in the ovary of chicken, Gallus domesticus."General and Comparative Endocrinology. 114. 28-35 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Zheng W.M.and Yoshimura Y.: "Localization of macrophages in the chicken oviduct : effects of age and gonadal steroids."Poultry Science. 78. 1014-1018 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Nishida-Umehara C.,Fujisawa A.,Ogawa A.,Mizuno S.,Abe S.and Yoshida M.C.: "Differentiation of Z and W chromosomes revealed by replication banding and FISH mapping of sex-chromosome-linked DNA markers in the cassowary (Aves, Ratitae)."Chromosome Research. 7. 635-640 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Wajima Y,Frusawa T,Kawauchi S,Wakabayashi N,Nakabayashi O,Nishimori K.……: "The cDNA cloning and transient expression of an ovary-specific 17α-hydroxysteroid hehydrogenase of chickens."Gene. 233. 75-82 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Nanda I,Shan Z,Schartl M,Burt DW,Koehle M,Nothwang HG,Grutzner F,……: "300 million years of conserved synteny between chicken Z and human chromosom 9."Nature Genetics. 21. 258-259 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Ono T.and Machida Y.: "Immunomagnetic purification of viable primordial germ cells of Japanese quail (Coturnix japonica)."Comparative Biochemistry and Physiology. 122A. 255-259 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Diano S.,Horvath T.L.,Register T.,Adams M.,Harada N.and Naftolin F.: "Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects."Menopause. 6. 21-28 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Utsumi T.,Yoshimura N.,Takeuchi S.,Ando J.,Maruta M.,Maeda K.and Harada N.: "Steroid sulfatase expression is an independent predictor of reccurrence in human breast cancer."Cancer Research. 59. 377-381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Harada N.,Honda S.and Hatano O.: "Aromatase inhibitors and enzyme stability."Endocrine-Related Cancer. 6. 211-218 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Honda S.,Harada N.,Abe-Dohmae S.and Takagi Y.: "Identification of cis-acting elements in the proximal promoter region for the brain specific exon 1 of the mouse aromatase gene."Molecular Brain Research. 66. 122-132 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Sasano H.,Murakami H.,Shizawa S.,Satomi S.,Nagura H.and Harada N.: "Aromatase and sex steroid receptors in human vena cava."Endocrine Journal,,.. 46. 233-242 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Harada N.,Sasano H.,Murakami H.,Ohkuma T.,Nagura H.and Takagi Y.: "Localized expression of aromatase in human vascular tissues."Circulation Research. 84. 1285-1291 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Kongo M.,Ohta Y.Nishida K.,Harada N.,Ishiguro I.: "An association between lipid peroxidation and a-naphthylisothiocyanate-induced liver injury in rats."Toxicology Letter. 105. 103-110 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Utsumi T.,Toshimura N.,Maruta M.,Takeuchi S.,Ando J.,Maeda K.and Harada N.: "Significance of steroid sulfatase expression in human breast cancer."Breast Cancer. 6. 298-300 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Yamada K.,Ogawa H.,Honda S.,Harada N.and Okazaki T.: "A GCM motif protein is involved in placenta-specific expression of human aromatase gene."Journal of Biological Chemistry,,.. 274. 32279-32286 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Ohta Y.,Kongo M.,Sasaki E.and Harada N.: "Change in hepatic antioxidant defense system with liver injury development in rats with a single α-naphthylisothiocyanate intoxication."Toxicology. 139. 265-275 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Deladocy J.,Fluck C.,Bex M.,Yoshimura N.,Harada N.and Mullis P.E.: "Aromatase deficiency caused by a novel P450arom gene mutation : Impact of absenestrogen production on serum gonadotropin concentration in a boy."Journal of Clinical Endocreinology and Metablosims. 84. 4050-4054 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Mano T,Mori K,Sawai Y,Oda N,Tugawa T,Nakano I,Watanabe F,Hamada M,……: "Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus."Endocrine Research. 25. 371-380 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Akazome Y.and Mori T.: "Evidence of sex reversal in the gonads of chicken embryos after oestrogen treatmen as detected by expression of lutropin receptor."Journal of Reproduction and Fertility. 115. 9-14 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Ukena K.,Honda Y.,Inai Y.,Kohchi C.,Lea R.W.and Tsutsui K.: "Expression and activity of of 3β-hydroxysteroid dehydrogenase/Δ^5-Δ^4-isomerase in different regions of the avian brain."Brain Research. 818. 536-542 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Takase M.,Ukena K.,Yamazaki T.,Kominami S.and Tsutsui K.: "Pregnenolone, pregnenolone sulfate and cytochrome P450 side-chain cleavage (P450scc) in the amphibian brain and their seasonal changes."Endocrinology. 140. 1936-1944 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Ukena K.,Kohchi C.and Tsutsui K.: "Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ^5-Δ^4-isomerase in the rat Purkinje neuron during neonatal life."Endocrinology. 140. 805-813 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Tanaka M.,Yamamoto I.,Ohkubo T.,Wakita M.,Hoshino S.and Nakashima K.: "cDNA cloning and developmental alterations in gene expression of the two Pit-1/GHF-1 transcription factors in the chicken pituitary."General and Comparative Endocrinology. 114. 441-448 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Tsukada A.,Ohkubo T.,Tanaka M.,Nakashima K.,Wakita M.and Hoshino S.: "Effects of thyroid hormone on serum insulin like growth factor binding proteins (IGFBPs) and IGFBP-2 mRNA expression in chickens."Japanese Poultry Science. 36. 155-166 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Koga H.,Fujimoto T.,Park M.K.and Mori T.: "Gonadotropin-releasing hormone receptro mRNA expression in the ovaries of neonatal and adult rats."Cell Tissues Organs. 164. 14-22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Tan FI,Lolait SJ,Brownstein MJ,Saito N,MacLeod V,Baeyens DA,Mayeaux PR,……: "Molecular cloning and functional characterization of a vasotocin receptor subtype that is expressed in the shell gland and brain of the domestic chicken."Biology of Reproduction. 62. 8-15 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Nishikimi H.,Kansaku N.,Saito N.,Usami M.,Ohno Y.and Shimada K.: "Sex differentiation and mRNA expression of P450c17, P450arom and AMH in gonads of the chicken."Molecular Reproduction and Development. 55. 20-30 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Suzuki T,Kurosaki T,Agata T,Koide M,Shimada K,Kansaku N,Koide M,…: "Cytogenetical assignment of 29 functional genes on chicken microchromosomes by FISH."Cytogenetics Cell Genetics. 87. 232-237 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Abinawanto, Zhang C., Saito N., Matsuda Y.and Shimada K.: "Identification of sperm bearing female-specific chromosome in the sex-reversed chicken."Journal of Experimental Zoology. 280. 65-72 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kansaku N., Shimada K., Saito N.and Hidaka H.: "Effects of protein kinase A inhibitor (H-89) on VIP- and GRF-induced release and mRNA expression of prolactin and growth hormone in the chicken pituitary gland."Comparative Biochemistry and Physiology. 119C. 89-95 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Matsumoto K., Ieda T., Saito N., Ono T.and Shimada K.: "Role of retinoic acid in regulation of mRNA expression of CaBP-D28K in the cerebellum of the chicken."Comparative Biochemistry and Physiology. 120A. 237-242 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kita K., Shibata T., Aman Yaman M., Conlon M.A., Sasaki T., Saito N.and Okumura J.: "Relationship of insulin-like growth factor-I to muscle protein synthesis in fasted chicks."Japanese Poultry Science. 35. 263-270 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kita K., Hangsanet K., Shibata T., Conlon M.A., Sasaki T., Saito N.and Okumura J.: "Refeeding increases hepatic insuline-like growth factor-I (IGF-I) gene expression and plasma IGF-I concentration in fasted chicks."British Poultry Science. 39. 679-682 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Sasaki T., Shimada K.and Saito N.: "Changes of AVT levels in plasma, neurohypophysis and hypothalamus in relation to oviposition in the laying hen."Comparative Biochemistry and Physiology. 121A. 149-153 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Saito N.and Grossmann R.: "Effects of short-term dehydration on plasma osmolality, levels of arginine vastocin and its hypothalamic gene expression in the laying hen."Comparative Biochemistry and Physiology. 121A. 235-239 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Furuse M., Bungo T., Shimojo M., Masuda Y., Saito N., Hasegawa S.and Sugahara K.: "Effects of various N-terminal fragments of glucagon-like peptide-1 (7-36) on food intake in the neonatal chick."Brain Research. 807. 214-217 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ieda T., Saito N.and Shimada K.: "Effects of aminoglutethimide on levels of messenger ribonucleic acid of CaBP-D28K and of vitamin D3 receptor in the shell gland of laying hen."Japanese Poultry Science. 35. 346-355 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Furuse M., Bungo T., Shimojo M., Masuda Y., Saito N., Hasegawa S.and Sugahara K.: "Influence of intracerebroventricular administration of exendin (9-39) on food intake of the newly-hatched chick."Japanese Poultry Science. 35. 376-380 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Barua A., Yoshimura Y.and Tamura T.: "The effects of age and sex steroids on the macrophage population in the ovary of chicken, Gallus domesticus."Journal of Reproduction and Fertility. 114. 253-258 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Barua A., Yoshimura Y.and Tamura T.: "Effects of aging and oestrogen on the localization of immunoglobulin containing cells in the ovary of chicken, Gallus domesticus."Journal of Reproduction and Fertility. 114. 11-16 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Zheng W.M., Yoshimura Y.and Tamura T.: "Effects of gonadal steroids on the localization of antigen-presenting cells, T and B cells in the chicken oviduct."Journal of Reproduction and Fertility. 114. 45-54 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Barua A., Yoshimura Y.and Tamura T.: "Localization of macrophages in the ovarian follicles during the follicular growth and postovulatory regression in chicken, Gallus domesticus."Poultry Science. 77. 1417-1421 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Barua A., Howlider M.A.R.and Yoshimura Y.: "A study on the performance of Fayoumi, Rode island red and Fayoumi X Rode island red chickens under rural condiction of Bangladesh."Asian-Australasian Journal of Animal Science. 11. 635-641 (1998)

    • Description
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  • [Publications] Yoshimura Y.and Okamoto H.: "Phagocytosis of carbon particles by theca interna fibroblasts in hen ovary."Japanese Poultry Science. 35. 314-318 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Yoshimura Y.and Ogawa H.: "Histological characterization of the oviducal structures in Guinea fowl (Numida meleagris)."Japanese Poultry Science. 35. 149-156 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ohira H., Yoshimura Y.and Tamura T.: "Increase of calcium binding protein-D28K contents in the shell gland by an injection with 1,25-dihydroxyvitamin D3 into shell gland lumen in laying hens."Japanese Poultry Science. 35. 99-107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Barua A., Howlider M.A.R.and Yoshimura Y.: "Indigenous Naked neck fowl of Bandladesh."World's Poultry Science Journal. 54. 279-286 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Solovei I.Joffe B., Hori, T., Thomson P., Mizuno S.and Macgregor H.: "Unordered arrangement of chromosomes in the nuclei of chicken apermatozoa."Chromosoma. 107. 184-188 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Yamaguchi K., Hidema S.and Mizuno S.: "Chicken chromobox proteins : CHCB1, -2, -3 and their relation to W-heterochromatin."Experiomental Cell Research. 242. 303-314 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Mizuno S.and Macgregor H.: "The ZW lampbrush chromosomes of birds : a unique opportunity to look at the molecular cytogenetics of sex chromosomes."Cytogenetics Cell Genetics. 80. 149-157 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Solovei I., Ogawa A., Naito M., Mizuno S.and Macgregor H.: "Specific chromomeres on the chicken W lampbrush chromosome contain specific, repetitive DNA sequence families."Chromosome Research. 6. 323-327 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ogawa A., Murata K.and Mizuno S.: "The location of Z-and W-linked marker genes and sequence on the homomorphic sex chromosomes of the ostrich and the emu."Proceedings of National Academy of Science USA. 95. 4415-4418 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Nakabayashi O., Kikuchi H., Kikuchi T.and Mizuno S.: "Differential expression of genes for aromatase and estrogen receptor during the gonadal development in chicken embryos."Journal of Molecular Endocrinology. 20. 193-202 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Mochii M., Ono T., Matsubara Y.and Eguchi G.: "Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by an Mitf mutation."Developmental Biology. 196. 145-159 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ono T., Yokoi R., Maeda S., Nishida T.and Aoyama H.: "Settlement of quail primordial germ cells in chicken gonads."Animal Science and Technology. 69. 546-555 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ono T., Matsumoto T.and Arisawa Y.: "Production of donor-derived offspring by transfer of primordial germ cells in Japanese quail."Experimental Animals. 47. 215-219 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] OnoT., Yokoi R., Maeda S., Nishida T.and Aoyama H.: "Transfusion of chick primordial germ cells into quail embryos and their settlement in gonads."Animal Science and Technology. 69. 911-915 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kino K., Noda K., Miyakawa H., Ohtsuka K., Ono T., Mochii M., Eguchi G.and Agata K.: "A low frequency of chromosomal integration of the cloned DNA after micro- injection into the cytoplasm of the fertilized eggs of chickens."Japanese Poultry Science. 35. 356-366 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Harada N.and Hatano O.: "Inhibitors of aromatase prevent degaradation of the enzyme in cultured human tumour cells."British Journal of Cancer. 77. 567-572 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Harada N., Ota H., Yoshimura N., Katsuyama T.and Takagi Y.: "Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver."Journal of Clinical Endocrinology and Metabolite. 83. 697-702 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Sasano H., Takahashi K., Sato F., Nagura H.and Harada N.: "Aromatase in human central nervous system."Clinical Endocrinology. 48. 325-329 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Balthazart J., Foidart A., Baillien M., Harada N.and Ball G.F.: "Anatomical relationships between aromatase and tyrosine hydroxylase in the quail brain : Double-label immunocytochemical studies."Journal of Comparative Neurology. 391. 214-226 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aste N., Panzica G.C., Viglietti-Panzica C., Harada N.and Balthazart J.: "Distribution and effects of testosterone on aromatase mRNA in the quail forebrain : a non-radioactive in situ hybridization study."Jornal of Chemical Neuroanatomy. 14. 103-115 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Sasano H., Suzuki T.and Harada N.: "From endocrinology to incrinology."Endocrine Pathology. 9. 9-20 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Foidart A., Silverin B., Baillien M., Harada N.and Balthazart J.: "Neuroanatomical distribution and variations across the reproductive cycle of aromatase activity and aromatase-immunoreactive cells in the pied flycatcher (Ficedula hypoleuca)."Hormone and Behavior. 33. 180-196 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Nomura M., Kawabe K., Matsushita S., Oka S., Hatano O., Harada N., Nawata H.and Morohashi K.: "Adrenocortical and gonadal expression of the mammalian Fts-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control."Journal of Biochemistry. 124. 217-224 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Harada N.and Honda S.: "Molecular analysis of aberrant expression of aromatase in breast cancer tissue."Breast Cancer Research and Treatment. 49. 15-21 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Santen R.J., Martel J., Hoagland M., Naftolin F., Roa L., Harada N., Hafer L., Zaino R., Pauley R., and Santner S.: "Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts."Breast Cancer Research and Treatment. 49. 93-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Mor G., Yue W., Santen R.J., Gutierrez L., Eliza M., Berstein L.M., Harada N., Wang J., Lysiak J., Diano S.and Naftolin F.: "Macrophages, estrogen and the microemvironment of breast cancer."Journal of Steroid Biochememistry and Molecular Biology. 67. 403-411 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Honda S., Harada N., Ito S., Takagi Y.and Maeda S.: "Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene."Biochemistry and Biophysics Research Communication. 252. 445-449 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Kohchi C., Ukena K.and Tsutsui K.: "Age-and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes P450scc, P450c17, 3β-HSD in the postnatal rat brain."Brain Research. 801. 233-238 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Tsutsui K., Li D., Ukena K., Kikuchi M.and Ishii S.: "Developmental changes in galanin receptors and the effect of sex steroids on galanin receptor induction."Endocrinology. 139. 4230-4236 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Ukena K., Usui M., Kohchi C.and Tsutsui K.: "Cytochrome P450scc side-chain cleavage enzyme (P450scc) in the cerebellar Purkinje neuron and its neonatal change in rats."Endocrinology. 139. 137-147 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Azumaya Y., Kominami S.and Tsutsui K.: "Existence and localization of a protein in zebra finch brain with similar structural features as the large subunit of the splicing factor U2AF."Journal of Experimental Zoology. 281. 90-96 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Ohboshi S., Fujihara N., Yoshida T.and Tomogane H.: "Effects of glucose and amino acids on in-vitro development of rat preim plantation embryos, and morphological features of the developed blastocysts."Animal Science and Technology. 69. 637-645 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ohoboshi S., Fujihara N., Yoshida T.and Tomogane H.: "Ultrastructure of bovine in vitro-produced blastocysts cryopreserved by vitrification."Zygote. 6. 17-26 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ohkubo T., Tanaka M., Nakashima K., Talbot R.T.and Sharp P.J.: "Prolactin receptor gene expression in the brain and peripheral tissues in broody and nonbroody breeds of domestic hen."General and Comparative Endocrinology. 109. 60-68 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Tanaka M., Taniguchi T, Ohkubo T.and Nakashima K.: "cDNA cloning and characterization of neuron-specific enolase from chicken."Biochim Biophys Acta. 1395. 28-33 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ohkubo T., Tanaka M., Nakashima K.and Sharp P.J.: "Relationship between prolactin receptor mRNA in the anterior pituitary gland and hypothalamus and reproductive state in male and female bantams (Gallus domesticus)."General and Comparative Endocrinology. 111. 167-176 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Ohkubo T., Tsukada A., Tanaka M.and Nakashima K.: "Cloning and expression of pigeon growth hormone receptor cDNA in COS-7 monkey kidney cells."Comparative Biochemistry and Physiology. 120B. 449-455 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Tsukada A., Ohkubo T., Sakaguchi K., Tanaka M., Nakashima K., Hayashida Y., Wakita M.and Hoshino S.: "Thyroid hormones are involved in insulin-like growth factor-I (IGF-I) production by stimulating hepatic growth hormone receptor (GHR) gene expression in the chicken."Growth Hormone and IGF Research. 8. 235-242 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Sakaguchi K., Tanaka M., Ohkubo T., Yoshizato H., Hanai Y., Fujikawa T., Kaneko H.and Nakashima K.: "Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat."Endocrine Journal. 45 (Suppl). S105-S107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Tanaka M., Taniguchi T., Yamamoto I., Sakaguchi K, Yoshizato H., Ohkubo T.and Nakashima K.: "Gene and cDNA structures of flounder insulin-like growth factor-I (IGF-I) : Multiple mRNA species encode a single short mature IGF-I."DNA Cell Biology. 17. 859-868 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Mochizuki Y., Park M.K., Mori T., Ogura A.and Kawashima S.: "Formation of lipofusion-like autofluorescent materials in NG108-15 cells : involvement of lysosomal protein degradation."Gernotology. 44. 1-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Iizuka A., Park M.K.and Mori T.: "Changes in the expression pattern of luteinizing hormone receptor mRNA expression in the rat testis during degeneration of seminiferous epithelium."Zoological Science. 15. 255-261 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Kansaku N., Tsuji Y., Saito N.and Shimada K.: "Expression of messenger ribonucleic acids of luteinizing hormone receptor, P450 17α-hydroxylase and P450 aromatase in isolated granulosa, theca interna and theca externa layers of chicken ovarian follicles during follicular growth."Animal Science Journal. 70. 12-17 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Bungo T., Shimojo M., Masuda Y., Saito N., Sugahara K., Hasegawa S.and Furuse M.: "Effects of naloxone on the anorexic action by glucagon-like peptide-1 (7-36) in the neonatal chick."Japanese Poultry Science. 36. 109-115 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Furuse M., Ao R., Bungo T., Ando R., Shimojo M., Masuda Y.and Saito N.: "Central gastrin inhibits feeding behavior and food passage in neonatal chicks."Life Sciences. 65. 305-311 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Furuse M., Matsumoto M., Pinotoan R., Saito N., Sugahara K.and Hasegawa S.: "Intraventricular injection of glucagon-like peptide-1 inhibits water intake of the neonatal chick."Japanese Poultry Science. 36. 229-235 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Saito N.and Grossmann R.: "Gene expression of arginin vasotocin in ovarian and uterine tisseus of the chicken."Asian-Australasian Journal of Animal Science. 12. 695-701 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Saito N., Furuse M., Sasaki T., Arakawa K.and Shimada K.: "Effects of naloxone on neurohypophysial peptides release by hypertonic stimulation in chicks."General and Comparative Endocrinology. 115. 228-235 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Bungo T., Ando R., Ao R., Shimojo M., Masuda Y., Choi Y.-H., Saito N.and Furuse M.: "Influence of intracerebroventricular administration of morphine and kyotrophin on food intake of the neonatal chick."Japanese Poultry Science. 36. 319-324 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Ieda T., Saito N., and Shimada K.: "Effect of low calcium diet on messenger ribonucleic acid levels of calbindin-D28K of intestine and shell gland in laying hens in relation to egg shell quality."Japanese Poultry Science. 36. 295-303 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Bungo T., Shimojo M., Masuda Y., Saito N., Sugahara K., Hasegawa S.and Furuse M.: "Effects of substitution of N-terminal amino acid of glucagon-like peptide-1 (7-36) amide on food intake of the neonatal chick."Life Sciences. 25. PL295-PL299 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Bungo T., Kawakami S.-I., Ohgushi A., Shimojo M., Masuda Y., Saito N., Sugahara K., Hasegawa S.and Furuse M.: "Intracerebroventricularly administration of glucagon-like peptide-1 induces sleep-like behavior in the neonatal chick."Japanese Poultry Science. 36. 377-381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Hirabayashi N., Matsuki Y., Suzuki E., Usami M., Ohno Y.and Shimada K.: "Toxicokinetic study of Fadrozole, an aromatase inhibitor, in the chicken eggs by the injection on the shell membrane."Japanese Poultry Science. 36. 382-387 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Suzuki T., Kansaku N., Kurosaki T., Shimada K., Zadworny D., Kuhnlein U., Koide M., Koike M., Mano T,, Namikawa T.and Matsuda Y.: "Comparative FISH mapping on Z chromosomes of chicken and Japanese quail."Cytogenetics Cell Genetics. 87. 22-26 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Suzuki T., Kurosaki T., Shimada K., Kansaku N., Li S., Zadworny D., Hashimoto A., Koide M., Koike M., Takata M., Kuroiwa A., Minai S., Namikawa T.and Matsuda Y.: "Cytogenetical mapping of 31 functional genes on chicken chromosomes by the direct R-banding FISH."Cytogenetics Cell Genetics. 87. 32-40 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Barua A.and Yoshimura Y.: "Immunolocalization of MHC+ cells in the ovary of immature, young laying and old laying hens, Gallus domesticus."Journal of Reproduction and Fertility. 116. 385-389 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Barua A.and Yoshimura Y.: "Effects of aging and sex steroids on the localization of T cell subsets in the ovary of chicken, Gallus domesticus."General and Comparative Endocrinology. 114. 28-35 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Zheng W.M.and Yoshimura Y.: "Localization of macrophages in the chicken oviduct : effects of age and gonadal steroids."Poultry Science. 78. 1014-1018 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Nishida-Umehara C., Fujisawa A., Ogawa A., Mizuno S., Abe S.and Yoshida M.C.: "Differentiation of Z and W chromosomes revealed by replication banding and FISH mapping of sex-chromosome-linked DNA markers in the cassowary (Aves, Ratitac)."Chromosome Research. 7. 635-640 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Wajima Y., Frusawa T., Kawauchi S., Wakabayashi N., Nakabayashi O., Nishimori K.and Mizuno S.: "The cDNA cloning and transient expression of an ovary-specific 17α-hydroxysteroid dehydrogenase of chickens."Gene. 233. 75-82 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Nanda I., Shan Z., Schartl M., Burt D.W., Koehler M., Nothwang H.-G., Grutzner F., Paton I.R., Windsor D., Dunn I., Engel W., Staeheli P., Mizuno S., Haaf T.and Schmid M.: "300 million years of conserved synteny between chicken Z and human chromosome 9."Nature Genetics. 21. 258-259 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ono T.and Machida Y.: "Immunomagnetic purification of viable primordial germ cells of Japanese quail (Coturnix japonica)."Comparative Biochemistry and Physiology. 122A. 255-259 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Diano S., Horvath T.L., Register T., Adams M., Harada N.and Naftolin F.: "Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects."Menopause. 6. 21-28 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Utsumi T., Yoshimura N., Takeuchi S., Ando J., Maruta M., Maeda K.and Harada N.: "Steroid sulfatase expression is an independent predictor of reccurrence in human breast cancer."Cancer Research. 59. 377-381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Harada N., Honda S.and Hatano O.: "Aromatase inhibitors and enzyme stability."Endocrine-Related Cancer. 6. 211-218 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Honda S., Harada N., Abe-Dohmae S.and Takagi Y.: "Identification of cis-acting elements in the proximal promoter region for the brain specific exon 1 of the mouse aromatase gene."Molecular Brain Research. 66. 122-132 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Sasano H., Murakami H., Shizawa S., Satomi S., Nagura H.and Harada N.: "Aromatase and sex steroid receptors in human vena cava."Endocrine Journal. 46. 233-242 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Harada N., Sasano H., Murakami H., Ohkuma T., Nagura H.and Takagi Y.: "Localized expression of aromatase in human vascular tissues."Circulation Research. 84. 1285-1291 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Kongo M., Ohta Y., Nishida K., Harada N., Ishiguro I.: "An association between lipid peroxidation and α-naphthylisothiocyanate-induced liver injury in rats."Toxicology Letter. 105. 103-110 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Utsumi T., Toshimura N., Maruta M., Takeuchi S., Ando J., Maeda K.and Harada N.: "Significance of steroid sulfatase expression in human breast cancer."Breast Cancer. 6. 298-300 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Yamada K., Ogawa H., Honda S., Harada N.and Okazaki T.: "A GCM motif protein is involved in placenta-specific expression of human aromatase gene."Journal of Biological Chemistry. 274. 32279-32286 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Ohta Y., Kongo M., Sasaki E.and Harada N.: "Change in hepatic antioxidant defense system with liver injury development in rats with a single α-naphthylisothiocyanate intoxication."Toxicology. 139. 265-275 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Deladocy J., Fluck C., Bex M., Yoshimura N., Harada N.and Mullis P.E.: "Aromatase deficiency caused by a novel P450arom gene mutation : Impact of absent estrogen production on serum gonadotropin concentration in a boy."Journal of Clinical Endocreinology and Metablosims. 84. 4050-4054 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Mano T., Mori K., Sawai Y., Oda N., Tugawa T., Nakano I., Watanabe F., Hamada M., Nakai A., Yamamoto H., Harada N., Nagasaka A.and Itoh M.: "Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus."Endocrine Research. 25. 371-380 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Akazome Y.and Mori T.: "Evidence of sex reversal in the gonads of chicken embryos after oestrogen treatment as detected by expression of lutropin receptor."Journal of Reproduction and Fertility. 115. 9-14 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Ukena K., Honda Y., Inai Y., Kohchi C., Lea R.W.and Tsutsui K.: "Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ^5-Δ^4-isomerase in different regions of the avian brain."Brain Research. 818. 536-542 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Takase M., Ukena K., Yamazaki T., Kominami S.and Tsutsui K.: "Pregnenolone, pregnenolone sulfate and cytochrome P450 side-chain cleavage (P450scc) in the amphibian brain and their seasonal changes."Endocrinology. 140. 1936-1944 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Ukena K., Kohchi C.and Tsutsui K.: "Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ^5-Δ^4-isomerase in the rat Purkinje neuron during neonatal life."Endocrinology. 140. 805-813 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Tanaka M., Yamamoto I., Ohkubo T., Wakita M., Hoshino S.and Nakashima K.: "cDNA cloning and developmental alterations in gene expression of the two Pit-1/GHF-1 transcription factors in the chicken pituitary."General and Comparative Endocrinology. 114. 441-448 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Tsukada A., Ohkubo T., Tanaka M., Nakashima K., Wakita M.and Hoshino S.: "Effects of thyroid hormone on serum insulin like growth factor binding proteins (IGFBPs) and IGFBP-2 mRNA expression inchickens."Japanese Poultry Science. 36. 155-166 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Koga H., Fujimoto T., Park M.K.and Mori T.: "Gonadotropin-releasing hormone receptro mRNA expression in the ovaries of neonatal and adult rats."Cell Tissues Organs. 164. 14-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Tan F.-I., Lolait S.J., Brownstein M.J., Saito N., MacLeod V., Baeyens D.A., Mayeaux P.R., Jones S.M.and Cornett L.E.: "Molecular cloning and functional characterization of a vasotocin receptor subtype that is expressed in the shell gland and brain of the domestic chicken."Biology of Reproduction. 62. 8-15 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] Nishikimi H., Kansaku N., Saito N., Usami M., Ohno Y.and Shimada K.: "Sex differentiation and mRNA expression of P450c17, P450arom and AMH in gonads of the chicken."Molecular Reproduction and Development. 55. 20-30 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki T., Kurosaki T., Agata T., Koide M., Shimada K., Kansaku N., Koide M., Namikawa T.and Matsuda Y.: "Cytogenetical assignment of 29 functional genes on chicken microchromosomes by FISH."Cytogenetics Cell Genetics. 87. 232-237 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tan FI,Lolait SJ,Brownstein MJ,Saito N,MacLeod V,Baeyens DA,Mayeaux PR,.....: "Molecular cloning and functional characterization of a vasotocin receptor subtype that is expressed in the shell gland and brain of the domestic chicken."Biology of Reproduction . 62. 8-15 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishikimi H.,Kansaku N.,Saito N.,Usami M.,Ohno Y.and Shimada K.: "Sex differentiation and mRNA expression of P450c17, P450arom and AMH in gonads of the chicken."Molecular Reproduction and Development . 55. 20-30 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Suzuki T,Kurosaki T,Agata T,Koide M,Shimada K,Kansaku N,Koide M,.....: "Cytogenetical assignment of 29 functional genes on chicken microchromosomes by FISH."Cytogenetics Cell Genetics. 87. 232-237 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ieda T.,Takahashi T.,Saito N.,Yasuoka T.,Kawashima M.,and Shimada K.: "Changes in parathyroid hormone related peptide receptor binding in the shell gland of laying hens (Gallus domesticus) during the oviposition cycle."General and Comparative Endocrinology. 117. 182-188 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sasaki T.,Shimada K.and Saito N.: "Regulation of opioid peptides on the release of arginine vasotocin in the hen."Journal of Experimental Zoology. 286. 481-486 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sasaki T.,Arakawa K.,Shimada K.and Saito N.: "The effcts of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injeciton."General and Comparative Endocrinology. 118. 365-372. (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mao X.,Zhang C.,Saito N.,Shimada K.: "Expression of messenger ribinucleic acids of luteinizing hormone and follicle-stimulating hormone receptors in the embryonic and posthatch gonads of the chicken."Japanese Poultry Science. 37. 212-220 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Zheng W.M.,Izaki J.,Furusawa S.and Yoshimura Y.: "Localization of immunoglobulin Gγ-chain mRNA-expressing cells in the oviduct of laying and diethylstilbestrol-treated immature hens."General and Comparative Endocrinology. (in press). (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Barua A.and Yoshimura Y.: "Ovarian autoimmunity and its relation to egg production in laying hens."Reproduction . 121. 117-122 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Zheng W.M.and Yoshimura Y.: "Organ-specificity of estrogen effects on the induction of immunocompetent cells in the chicken."Journal of Poultry Science . (in press). (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshimura Y.,Tamura Y.,Nishikoori M.and Okamoto T.: "Effects of diethylstilbestrol intake during growing phase on the reproductive organs in Japanese quail (Coturnix coturnix)."Japanese Poultry Science . (in press). (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Isobe N.and Yoshimura Y.: "Immunocytochemical study of cell proliferation in the cystic ovarian follicles in cows."Theriogenology. 54. 1159-1169 (2000)

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      2000 Annual Research Report
  • [Publications] Barua A.,Furusawa S.and Yoshimura Y.: "Influence of aging and estrogen treatment on the IgY concentration in the egg yolk of chicken,"Japanese Poultry Science. 37. 280-288 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Isobe N.and Yoshimura Y.: "Localization of apoptotic cells in the cystic ovarian follicles of cows : a DNA-end labeling histochemical study."Theriogenology. 53. 897-904 (2000)

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      2000 Annual Research Report
  • [Publications] Yoshimura Y.,Koike K.and Okamoto T.: "Immunolocalization of progesterone and estrogen receptors in the sperm storage tubules of laying and diethylstilbestrol-injected immature hens."Poultry Science. 78. 94-98 (2000)

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      2000 Annual Research Report
  • [Publications] Hori T.,Asakawa S.,Itoh Y.,Shimizu N.and Mizuno S.: "Wpkci,encoding an altered form of PKCI, is conserved widely on the avian W chromosome and expressed in early female embryos : Implication of its role in female sex determination."Molecular Biology and Cell. 11. 3645-3660 (2000)

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      2000 Annual Research Report
  • [Publications] Takeyama J,Suzuki T,Hirasawa G,Muramatsu Y,Nagura H,Iimura K,......: "17β-Hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus."Journal of Clinincal Endocrinology and Metabolite . 85. 410-416 (2000)

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      2000 Annual Research Report
  • [Publications] Utsumi T.,Yoshimura N.,Maruta M.,Mizoguchi Y.and Harada N.: "Correlation of cyclin D1 mRNA levels with clinicopathological parameters and clinical outcome in human breast carcinoma. "International Journal of Cancer. 89. 39-43 (2000)

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      2000 Annual Research Report
  • [Publications] Kristensen VN,Harada N,Yoshimura N,Haraldsen E,Lonning PE,Erikstein B,......: "Genetic variations of Cyp19 (aromatase) and breast cancer risk."Oncogene . 19. 1329-1333 (2000)

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      2000 Annual Research Report
  • [Publications] Utsumi T.,Yoshimura N.,Takeuchi S.,Maruta M.,Maeda K.and Harada N.: "Elevated steroid sulfatase expression in breast cancers."Jorunal of Steroid Biochemisty and Molecular Biology. 73. 141-145 (2000)

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      2000 Annual Research Report
  • [Publications] Ohta Y.,Kongo M.,Sasaki E.,Ishiguro I.and Harada N.: "Protective effect of melatonin against α-naphthylisothiocyanate-induced liver injury in rats."Journal of Pineal Reserach. 29. 15-23 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Evrard H.,Baillien M.,Foidart A.,Absil P.,Harada N.and Balthazart J.: "Localization and controls of aromatase in the quail spinal cord."Journal of Comparative Neurology. 423. 552-564 (2000)

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      2000 Annual Research Report
  • [Publications] Balthazart J.,Tlemcani O.,Harada N.and Baillien M.: "Ontogeny of aromatase and tyrosine hydroxylase activity and of aromatase-immunoreactive cells in the preoptic area of male and female Japanese quail."Journal of Neuroendocrinology . 12. 853-866 (2000)

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      2000 Annual Research Report
  • [Publications] Kanda I.,Akazome Y.,Ogasawara O.and Mori T.: "Expression of cytochrome P450 cholesterol side chain cleavage and 3β-hydroxysteroid dehydrogenase during embryogenesis in chicken adrenal glands and gonads."General and Comparative Endocrinology . 118. 96-104 (2000)

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      2000 Annual Research Report
  • [Publications] Sakamoto H.,Ubuka T.,Kohchi C.,Li D.,Ukena K.and Tsutsui K.: "Existence of galanin in lumbosacral sympathetic ganglionic neurons that project to the quail uterine oviduct."Endocrinology . 141. 4402-4412 (2000)

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      2000 Annual Research Report
  • [Publications] Kawai Y.,Ohboshi S.,Yoshida T.and Tomogane H.: "Comparison of the extent of DNA damage in rat embryos developed in vivo and in vitro."Animal Science Journal . 71. 425-427 (2000)

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      2000 Annual Research Report
  • [Publications] Ohkubo T.,Tanaka M.and Nakashima K.: "Molecular cloning of the chicken prolactin gene and activation by Pit-1 and cAMP-induced factor in GH3 cells."General and Comparative Endocrinology . 199. 208-216 (2000)

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      2000 Annual Research Report
  • [Publications] Ohkubo T.,Tanaka M.and Nakashima K.: "Structure and tissue distribution of chicken leptin receptor (cOb-R) mRNA."Biochimistry and Biophysics Acta . 1491. 303-308 (2000)

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      2000 Annual Research Report
  • [Publications] Tanaka M,Yamamoto I,Hayashida Y,Nakao N,Ohkubo T,Wakita M.and Nakashima K.: "Two novel first exons in the prolactin receptor gene are transcribed in a tissue-specific and sexual maturation-dependent manner to encode multiple 5'-truncated transcripts in the testis of the chicken."Biochimistry and Biophysics Acta. 1491. 279-284 (2000)

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      2000 Annual Research Report
  • [Publications] Tsutsui K,Saigoh E,Ukena K,Teranishi H,Fujisawa Y,Kikuchi M,Ishii S.and Sharp PJ.: "A novel avian hypothalamic peptide inhibiting gonadotropin release."Biochemistry and Biophysics Research Communication. 275. 661-667 (2000)

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      2000 Annual Research Report
  • [Publications] Kohchi C.and Tsutsui K.: "Avian galanin : Cloning of complementary DNAs and characterization of transcripts in different tissues."Journal of Experimental Zoology . 287. 183-190 (2000)

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      2000 Annual Research Report
  • [Publications] Saito N.,Sasaki T.,Furuse M.,Arakawa K.and Shimada K.: "Effects of AVT antisense oliodeoxynucleotides on AVT release induced by hypertonic stimulation in chicks."Comparative Biochemistry and Physiology. 128A. 147-153 (2001)

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      2000 Annual Research Report
  • [Publications] Kawaguchi N.,Ono T.,Mochii M.and Noda M.: "Spontaneous mutation in Mitf gene causes osteopetrosis in Silver homozygote quail."Developmental Dynamics . (in press). (2001)

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      2000 Annual Research Report
  • [Publications] Li H.C.,Matsui K.and Ono T.: "Population of circulating primordial germ cells in early Japanese quail embryos."Journal of Poultry Science. (in press). (2001)

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      2000 Annual Research Report
  • [Publications] 島田清司: "雄と雌が決まる仕組み;魚から鳥、哺乳類まで"生命誌. 7. 4-9 (1999)

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      1999 Annual Research Report
  • [Publications] Bungo T.: "Effects of naloxone on the anorexic action by glucagon-like peptide-1(7-36) in the neonatal chick."Japanese Poultry Science. 36. 109-115 (1999)

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      1999 Annual Research Report
  • [Publications] Furuse M.: "Central gastrin inhibits feeding behavior and food passage in neonatal chicks."Life Sciences. 65. 305-311 (1999)

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      1999 Annual Research Report
  • [Publications] Bungo T.: "Intraventricular injection of glucagon-like peptide-1 inhibits water intake of the neonatal chick"Japanese Poultry Science. 36. 229-235 (1999)

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      1999 Annual Research Report
  • [Publications] Saito N.: "Gene expression of arginin vasotocin in ovarian and uterine tissues of the chicken."Asian-Australasian Journal of Animal Science. 12. 695-701 (1999)

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      1999 Annual Research Report
  • [Publications] Saito N.: "Effects of naloxone on neurohypophysial peptides release by hypertonic stimulation in chicks."General and Comparative Endocrinology. 115. 228-235 (1999)

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      1999 Annual Research Report
  • [Publications] Bungo T.: "Influence of intracerebroventricular administration of morphine and kyotrophin on food intake of the neonatal chick."Japanese Poultry Science. 36. 319-324 (1999)

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      1999 Annual Research Report
  • [Publications] Ieda T.: "Effect of low calcium diet on messenger ribonucleic acid levels of calbindin-D28K of intestine and shell gland in laying hens in relation to egg shell quality."Japanese Poultry Science. 36. 295-303 (1999)

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      1999 Annual Research Report
  • [Publications] Bungo T.: "Effects of substitution of N-terminal amino acid of glucagon-like peptide-1(7-36) amide on food intake of the neonatal chick"Life Sciences. 25. PL295-PL299 (1999)

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      1999 Annual Research Report
  • [Publications] Bungo T.: "Intracerebroventricularly administration of glucagon-like peptide-1 induces sleep-like behavior in the neonatal chick."Japanese Poultry Science. 36. 377-381 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kansaku N.: "Expression of messenger ribonucleic acids of luteinizing hormone receptor, P450 17α-hydroxylase and P450 aromatase in isolated granulosa, theca interna and theca externa layers of chicken ovarian follicles during follicular growth"Animal Science Journal. 70. 12-17 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Bungo T.: "Effects of substitution of N-terminal amino acid of glucagon-like peptide-1(7-36) amide on food intake of the neonatal chick"Life Sciences. 25. PL295-PL299 (1999)

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      1999 Annual Research Report
  • [Publications] Diano S.: "Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects."Menopause. 6. 21-28 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Utsumi T.: "Steroid sulfatase expression is an independent predictor of reccurrence in human breast cancer."Cancer Res.. 59. 377-381 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Harada N.: "Aromatase inhibitors and enzyme stability."Endocrine-Related Cancer. 6. 211-218 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Honda S.: "Identification of cis-acting elements in the proximal promoter region for the brain specific exon 1 of the mouse aromatase gene."Mol.Brain Res.. 66. 122-132 (1999)

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      1999 Annual Research Report
  • [Publications] Sasano H.: "Aromatase and sex steroid receptors in human vena cava."Endocr.J.. 46. 233-242 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Harada N.: "Localized expression of aromatase in human vascular tissues."Circ.Res.. 84. 1285-1291 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kongo M.: "An association between lipid peroxidation and a-naphthylisothiocyanate-induced liver injury in rats."Toxicology Lett.. 105. 103-110 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Utsumi T.: "Significance of steroid sulfatase expression in human breast cancer."Breast Cancer. 6. 298-300 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Harada, N.: "Aromatase and intracrinology of estrogen in hormone-dependent tumors."Oncology. 57. 7-15 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamada,K.: "A GCM motif protein is involved in placenta-specific expression of human aromatase gene."J.Biol.Chem.. 274. 32279-32286 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Deladoey J.: "Aromatase deficiency caused by a novel P450arom gene mutation: Impact of absent estrogen production on serum gonadotropin concentration in a body."J.Clin.Endocrinol.Metab.. 84. 4050-4054 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mano,T.: "Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus."Endocr.Res.. 25. 371-380 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanaka,M.: "cDNA cloning and developmental alterations in gene expression of the two Pit-1/GHF-1 transcription factors in the chicken pituitary."Gen.Comp.Endocrinol.. 114. 441-448 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tsukada,A.: "Effects of thyroid hormone on serum insulin like growth factor binding proteins (IGFBPs) and IGFBP-2 mRNA expression in chickens."Jpn.Poult.Sci.. 36. 155-166 (1999)

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      1999 Annual Research Report
  • [Publications] Tsutsui K.: "Neurosteroids in vertebrate brains."Comp.Biochem.Physiol.. C124. 121-129 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 筒井和義: "脳とニューステロイド"医学のあゆみ. 別冊Ver1. 75-77 (1999)

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      1999 Annual Research Report
  • [Publications] 筒井和義: "脳がステロイドを合成する"ファルマシア. 35. 112-117 (1999)

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      1999 Annual Research Report
  • [Publications] 筒井和義: "鳥類の微小脳の繁殖戦略-産卵誘起ペプチドとその作用機構"比較生理生化学. 16. 191-199 (1999)

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      1999 Annual Research Report
  • [Publications] Tsutsui K.: "Production and function of neurosteroids in the cerebellar Purkinje neuron."Internat.J.Mol.Medicine. 4. 49-56 (1999)

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      1999 Annual Research Report
  • [Publications] Ukena K.: "Expression and activity of of 3 β-hydroxysteroid dehydrogenase/△5-△4-isomerase in different regions of the avian brain."Brain.Res.. 818. 536-542 (1999)

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      1999 Annual Research Report
  • [Publications] Takase M.: "Pregnenolone, pregnenolone sulfate and cytochrome P450 side-chain cleavage (P450scc) in the amphibian brain and their seasonal changes."Endocrinology. 140. 1936-1944 (1999)

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      1999 Annual Research Report
  • [Publications] 筒井和義: "脳で新しく見出されたニューロステロイドの合成と作用"Hormone Frontier in Gynecology. 6. 1-6 (1999)

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      1999 Annual Research Report
  • [Publications] Ukena K.: "Expression and activity of 3 β-hydroxysteroid dehydrogenase/△5-△4-isomerase in the rat Purkinje neuron during neonatal life."Endocrinology. 140. 805-813 (1999)

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      1999 Annual Research Report
  • [Publications] Kogo,H.: "Gonadotropin-releasing hormone receptor mRNA expression in the ovaries of neonatal and adult rats."Cells Tissues Organs. 164. 14-22 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 友金 弘: "猫を科学する (9) III. 猫の繁殖 (1)"畜産の研究. 53. 523-527 (1999)

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      1999 Annual Research Report
  • [Publications] 友金 弘: "猫を科学する (10)III. 猫の繁殖 (2)"畜産の研究. 53. 625-629 (1999)

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      1999 Annual Research Report
  • [Publications] 友金 弘: "猫を科学する (11)III. 猫の繁殖 (3)"畜産の研究. 53. 717-720 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 友金 弘: "猫を科学する (12)III. 猫の繁殖 (4)"畜産の研究. 53. 823-826 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Utsumi T.: "Correlation of cyclin D1 mRNA levels with clinicopathological parameters and clinical outcome in human breast carcinoma."Int.J.Cancer. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tsutsi K.: "Novel brain function: biosynthesis and actions of neurosteroids in neurons."Neurosci.Res.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tan F.-I: "Molecular cloning and functional characterization of a vasotocin receptor subtype that is expressed in the shell gland and brain of the domestic chicken."Biology of Reproduction. 62. 8-15 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishikimi H.: "Sex differentiation and mRNA expression of P450c17, P450arom and AMH in gonads of the chicken."Molecular Reproduction and Development. 55. 20-30 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki T.: "Cytogenetical assignment of 29 functional genes on chicken microchromosomes by FISH."Cytogenetics Cell Genet.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki T.: "Comparative FISH mapping on Z chromosomes of chicken and Japanese quail"Cytogenetics Cell Genet.. 87. 22-26 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sasaki T.: "Regulation of opioid peptides on the release of arginine vasotocin in the hen."Journal of Experimental Zoology. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ieda T.: "Changes in parathyroid hormone related peptide receptor binding in the shell gland of laying hens (Gallus domesticus) during the oviposition cycle."General and Comparative Endocrinology. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki T.: "Cytogenetical mapping of thirty-one functional genes on chicken chromosomes by the direct R-banding FISH."Cytogenetics Cell Genet.. 87. 32-40 (1999)

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      1999 Annual Research Report
  • [Publications] Kikuchi M.: "Recent Progress in Molecular and Comparative Endocrinology"Hormone Research Center. 625 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kikuchi M.: "Recent Progress in Molecular and Comparative Endocrinology"Hormone Research Center. 625 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kikuchi M.: "Recent Progress in Molecular and Comparative Endocrinology"Hormone Research Center. 625 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ono,T.: "Developmental Biology Protocols.Vol.I"Humana Press Inc,. 616 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Park,M.K.: "Recent Progress in Molecular and Comparative Endocrinology"Hormone Research Center. (1999)

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      1999 Annual Research Report
  • [Publications] 友金 弘: "哺乳類の生殖生物学"学窓社. (1999)

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      1999 Annual Research Report
  • [Publications] Abinawanto: "Identification of sperm bearing female-specific chromosome in the sex-reversed chicken." J.Exp.Zool.280. 65-72 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kansaku N.: "Effects of protein kinase A inhibitor (H-89) on VIP-and GRF-induced release and mRNA expression of prolactin and growth hormone in the chicken pituitary gland." Comp.Biochem.Physiol.119C. 89-95 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumoto K.: "Role of retinoic acid in regulation of mRNA expression of CaBP-D28K in the cerebellum of the chicken." Comp.Biochem.Physiol.120A. 237-242 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kita K,: "Relationship of insulin-like growth factor-I to muscle protein synthesis in fasted chicks." Jpn.Poult Sci.35. 263-270 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Furuse M,: "Effects of various N-terminal fragments of glucagon-like peptide-1(7-36) on food intake in the neonatal chick." Brain Res.807. 214-217 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kita K,: "Refeeding increases hepatic insuline-like growth factor-I(IGF-I) gene expression and plasma IGF-I concentration in fasted chicks." Brit.Poult.Sci.39. 679-682 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sasaki T.: "Changes of AVT levels in plasma,neurohypophysis and hypothalamus n relation to oviposition in the laying hen." Comp.Biochem.Physiol.121A. 149-153 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Saito N.: "Effects of short-term dehydration on plasma osmolality,levels of arginine vastocin and its hypothalamic gene expression in the laying hen." Comp.Biochem.Physiol.121A. 235-239 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Furuse M.: "Influence of intracerebroventricular administration of exendin(9-39)on food intake of the newly-hatched chick" Jpn.Poult.Sci.35. 376-380 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ieda T.: "Effects of aminoglutethimide on levels of messenger ribonucleic acid of CaBP-D28K and of vitamin D3 receptor in the shell gland of laying hen" Jpn.Poult.Sci. 35. 346-355 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimada K.: "Gene expression of steroidogenic enzymes in chicken gonads." J.Exp.Zool.281. 450-456 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kansaku N.: "Expression of messenger ribonucleic acids of luteinizing bormone receptor,P450 17α-hydroxylase and P450 aromatase in isolated grnulosa,theca interna and theca externa layers of chicken ovarian follicles during follicular growth" Animal Science Journal. 70. 12-17 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Iizuka A.: "Changes in the expression pattern of luteinizing hormone receptor mRNA in rat testis during degeneration of seminiferous epithelium" Zool.Sci. 15. 255-261 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mochizuki Y.: "Formation of lipofuscin-like autofluorecent materials in NG108-15 cells:involvement of lysosomal protein degradation" Gerontology. 44. 1-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akazome Y.: "Evidence of sex reversal in the gonads of chicken embryo after oestrogen treatfment as detected by expression of lutropin receptor" J.Reprod.Fert.115. 9-14 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohboshi S: "Ultrastrucute of in-vitro blastcysts crypreserved by vitrification" Zygote. 6. 17-28 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohoboshi S.: "Effects of glucoase and amino acids on in-vitro development of rat preimplation embryos,and morphological featurtesw of the developed blastcysts." Animal Science and Technology. 69. 637-645 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Harada N.: "Inhibitors of aromatase prevent degaradation of the enzyme in cultured human tumor cells." Br.J.Cancer. 77. 567-572 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Harada N.: "Localized aberrant expression ofr cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver" J.Clin.Endocrinol.Metab.83. 697-702 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sasano H.: "Aromatase in human central nervous system" Clin.Endocrinol.48. 325-329 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Balthazart J.: "Anatom ical relationship between aromatase and tyrosine hydroxylase in the quail brain:double-label immunocytochemical studies" J.Comp.Neurol. 391. 214-226 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Aste N.,: "districution and effects of testosterone on aromatase mRNA in the quail forebrain: a non-radioactive in situ hybridization study" J.Chem.Neuroanat.14. 103-115 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sasano H.: "From endocrinology to incrinology" Endocrine Pathology. 9. 9-20 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sasano H.: "Ontratumoral aromatase in human breasent,endometrial and ovarian malignances" Endocrine Rev.19. 593-607 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Foidart A.: "Neuroanatomical distribution and variations across the reproductive cycle of aromatase activity and aromatase-immunoreactive cells in the pied flycatcher (Ficedula hypoleuca)." Horm.Behav. 83. 697-702 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nomura M,: "Adrenocortical and gonadal expression of the mammlian Fts-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control." J.Biochem. 124. 217-224 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Harada N.: "Molecular analysis w of aberrent exxpression of aromatasze in breast cancer tissue" Breast Cancer Res.Treat.49. 15-21 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Santen RJ: "Demonstration of aromatase activity and tis regulation in breast tumor and begining breast fibroblasts" Breast Cancer Res.Treat.49. 93-99 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mor G,: "Macrophages,estrogen and the microemviromental of breast cancer." J.Steroid Bicoehm.Mo.Biol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Honda S.: "Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene" Biochem.Biophys.Res.Comm.252. 445-449 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡本光弘: "動物のステロイドホルモン合成とP450" 化学と生物. 36. 612-618 (1998)

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      1998 Annual Research Report
  • [Publications] 原田信広: "幼少期より多嚢胞性卵巣や骨代謝異常を呈するアロマターゼ完全欠損症の1例" ホルモンと臨床. 46. 215-219 (1998)

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  • [Publications] 原田信広: "アロマターゼ遺伝子" 小児内科. 30. 1038-1041 (1999)

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  • [Publications] Diano S: "Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkey and human subjects." Menopause. (in press). (1998)

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  • [Publications] Utsumi T: "Steroid sulfate expression is an independent predictor of reccurrence in human breast cancer." Cancer Res.(in press). (1999)

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  • [Publications] Harada N.: "Aromatase inhibitors and enzyme stability" Endocrine-Related Cancer. (in press). (1999)

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  • [Publications] Honda S.: "Identification of cis-acting elements in the proximal promoter region for the brain specific exon 1 of the mouse aromatase gene" Mo.Brain Res.(in press). (1998)

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  • [Publications] Mochii M.: "Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by an Mitf mutation." Developmental Biology. 196. 145-159 (1998)

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  • [Publications] Ono,T.: "Settlement of quail primordial germ cells in chicken gonads." Animal Science and Technology. 69. 546-555 (1998)

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  • [Publications] Ono T.: "Production of donor-derived offspring by transfer of primordial germ cells in Japanese quail." Experimental Animals. (in press). (1998)

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  • [Publications] Kino K.: "A low frequency of chromosomal integration of the cloned DNA after microinjection into the cytoplasm of the fertilized eggs of chickens" Japanese Poultry Science. 35. 356-366 (1998)

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  • [Publications] Ono T.: "Transfusion of chick primordial germ cells into quail embryos and their settlement in gonads" Animal Science and Technology. 69. 911-915 (1998)

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  • [Publications] Shimada K.: "Reproductive Biology Update-novel tools for assessment of environmental toxicity" Shoukadoh Booksellers Company, 498 (1998)

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  • [Publications] 朴 民根: "脳と生殖-GnRH神経系の進化と適応" 学会出版センター, 24 (1998)

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  • [Publications] 小林牧人: "「ホルモンの分子生物学」第3巻、生殖とホルモン" 学会出版センター, 57 (1998)

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  • [Publications] Ono,T.: "Methods in Molecular Biology Series,Developmental Biology Protocols (in press)" Humana Press Inc., (1998)

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Published: 1998-04-01   Modified: 2016-04-21  

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