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Establishment of International Regeneration Research Network

Research Project

Project/Area Number 10044212
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionKumamoto University

Principal Investigator

EGUCHI Goro  Kumamoto University, President, 事務局, 学長 (80022581)

Co-Investigator(Kenkyū-buntansha) ABE Shinichi  Graduate School of Science and Technology, Kumamoto University, Professor, 大学院・自然科学研究科, 教授 (90109637)
AIZAWA Shinichi  Institute of Molecular Embryology and Genetics, Kumamoto University, Professor, 発生医学研究センター, 教授 (60073011)
YAMAMURA Kenichi  Institute of Molecular Embryology and Genetics, Kumamoto University, Professor, 発生医学研究センター, 教授 (90115197)
高宗 和史  熊本大学, 理学部, 助教授 (20206882)
SCHMID Vollg  バーゼル大学, 動物学研究所, 所長
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2000: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsRegeneration / Organ regeneration / Regeneration research / Regeneration medicine / Regeneration biology / Developmental biology
Research Abstract

To establish the international collaboration net-work, which can effectively promote basic approaches to the fundamental mechanism of regeneration and contribute to development of clinical technologies based on regenerative capacities of tissues and organs, this research project was planned, conducted for three years from 1998 to 2000 and resulted in the followings.
Because studies of regeneration have not been so common and less progressed in Asia and its surrounding regions including Middle East except Japan, India and Russia, it is reasonable and effective for us to set up a center in Japan to manage international collaborations in these areas, keeping close communication with leading researchers of India and Russia.
Professor Volker Schmid, University of Basel is able enough to take the responsibility as a key scientist to promote research collaborations in : Europe, keeping close communication with Professor Jeremy Brockes, University of London, who is one of international leaders in the field of regeneration.
For north and south America and Australia, Professor P.A.Tsonis, University of Dayton, USA, who has kept close relation with leading regeneration researchers in both Canada and Australia and been already conducting collaborations with Japanese researchers, can manage as a key person to direct and lubricate fruitful international collaborations in these areas.
Hereafter, setting up the main center in the Institute of Molecular Embryology and Genetics, Kumamoto University, we will effectively promote international collaborations to approach to the mechanism of regeneration through mutual cooperation with active researchers belonging to. Institute for Frontier Medical Science, Kyoto University and other relating institutions in Japan.

Report

(4 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Mochii, Makoto(餅井 真)他4名: "Role of Mift gene in differentiation and transdifferentiation of chicken pigmented epithelial cells"Developmental Biology. 193. 47-62 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mochii, Makoto(餅井 真)他3名: "Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in the Mift gene"Developmental Biology. 196. 145-159 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuno, Nobuhiko(水野信彦)他4名: "Lens regeneration in Xenopus is not a mere repeat of Lens development with respect to crystallin gene expression"Differentiation. 64. 143-149 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuno, Nobuhiko(水野信彦)他5名: "Pax-6 and Prox-1 expression during lens regeneration from Cynops iris and Xenopus camera : evidence for a genetic program common to embryonic lens development"Differentiation. 65. 141-149 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagamoto, Toshiyuki(永本敏之)他2名: "Alpha-smooth muscle actin expression in cultured lens epithelial cells"Investigative Ophthalmology and Visual Science. 41. 1122-1129 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsonis, Panagiotis A.他3名: "A unique aged human retinal pigmented epithelial cells line useful for studying lens differentiation in vitro"International Journal of Developmental Biology. 45. 753-758 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Eguchi, Goro江口 吾朗: "Cellular and Molecular Basis of Regeneration : From Invertebrate to Humans, pp.207-229(分担執筆: Eye Lens regeneration)"John Wiley and Sons Inc., Chichester (P.Ferretti and J.Geraudie eds.). 458 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Katia Del Rio-Tsonis, Goro Eguchi(江口吾朗): "Development of the Ocular Lens (分担執筆: Lens regeneration)"Cambridge University Press, Cambridge (Frank J.Levicu and Michael L. Robinson, eds.)(未定(印刷中)). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mochii, M., Mazaki, Y., Mizuno, N., Hayashi, H. and Eguchi, G.: "Role of Mift gene in differentiation and transdifferentiation of chicen pigmented epithelial cell"Developmental Biology. 193-1. 47-62 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mochii, M., Ono, T., Matsubara, Y. and Eguchi, G.: "Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in the Mift gene"Developmental Biology. 196-1. 145-149 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kosaka, M., Kodama, R. and Eguchi, G.: "In vitro culture system for iris-pigmented epithelial cells for molecular analysis of transdifferentiation"Experimental cell Research. 245-2. 245-251 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuno, N., Mochii, M., Takahashi, T. C., Eguchi, G. and Okada, T. S.: "Lens regeneration in Xenopus is not a mere repeat of lens development with respect to crystallin gene expression"Differentiation. 64-1. 143-149 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuno, N., Mochii, M., Yamamoto, T. S., Takahashi, T.C., Eguchi, G. and Okada, T.S: "Pax-6 and Prox-1 expression during regeneration from Cynops iris and Xenopus cornea : evidence for a genetic program common to embryonic lens development"Defferentiation. 65-1. 141-149 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagamo, T., Eguchi, G. and Beebe, C. D.: "Alphasmooth muscle actin expression in cultured lens epithelial cells"Investigative Ophthalmology and Visual Science. 41-5. 1122-1129 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsornis, P. A., Jang,W., Del Rio-Tsonis, K. and Eguchi, G.: "A unique aged human retinal pigmented epithelial cell line useful for studying lens differentiation in vitro"International Journal of Developmental Biology. 45-4. 753-758 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Eguchi, G.: "Transdifferentiation as the basis of eye lens regeeration. In "Cellular and Molecular Basis of Regeneration From Invertebrates to Humans" (P. Ferretti and J. Geraudie. eds.)"John Wiley & Sons Inc. Chichester. 207-228 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Del Rio-Tsonis, K., Eguchi, G.: "Lens regeneration. In "Development of the Ocular Lens" (Frank J. Lovicu and Michael L. Robinson, eds.)"Cambridge Universiy Press, Cambridge (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 江口吾郎: "発生研究を志す若者に"細胞工学. 19・7. 1086-1094 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 江口吾郎: "イモリと共に40年"遺伝子医学. 4・4. 132-138 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Katia Del.Rio-Tsonis and Goro Eguchi.: "Development of Lens(分担執筆:Lens Regeneration)"Cambridge University Press(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kosaka,Mitsuko(小坂美津子): "In vitro culture system for iris-pigmented epithelial cells for molecular analysis of transditferentiation"Experimental Cell Research. 245・2. 245-251 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizuno,Nobuhiko(水野信彦): "A critical role for the optic vesicle in lens development: a reinvestigation of free lens formation in cynops pyrthogaster"Differentiation. 63・2. 247-252 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizuno,Nobuhiko(水野信彦): "Lens regeneration in Xenopus is not a mere repeat of lens development, with respect to crystallin gene expression"Differentiation. 64・1. 143-149 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizuno,Nobuhiko(水野信彦): "Fax-b and Prox1 expression during lens regeneration from Xenopuiris andcornea: eridence for a genetic program common to embryonic lens development"Differentiation. 65・1. 141-149 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 江口吾朗: "修復・再生する"AERA MOOK. -・54. 42-45 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mochii,Makoto,餅井 眞: "Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in the Mift,gene" Developmental Biology. 196・1. 145-159 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mochii,Makoto,餅井 眞: "Role of Mift in differentiation and transdifferentiation of chicken pigmented epithelial cell." Developmental Biology. 193・1. 47-62 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Eguchi,Goro 江口 吾朗: "Cellular and Molecular Basis of Regeneration:From Inver-tebrates to Humans." John Wiley and Sons,Chichester(P.Ferretti and J.Geraudie eds.), 207-229 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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