Molecular Mechanisms Involved in Oxygen Sensing by Heme.
| Project/Area Number |
10044230
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
FUJITA Hiroyoshi Hokkaido Univ., Grad.School of Med., Prof., 大学院・医学研究科, 教授 (60142931)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Yoshiaki Tohoku Univ., Grad.School of Science, Prof., 大学院・理学研究科, 教授 (00098146)
高橋 徹 岡山大学, 医学部, 助手 (40252952)
高橋 恭子 北海道大学, 医学部, 助手 (50292008)
GASSMANN Max チューリッヒ大学, 医学部, 研究班長
FANDREY Joac リューベック医大, 医学部, 上級講師
佐々 茂 ロックフェラー大学, 研究室, 室長
SYTKOWSKI Ar ハーバード大学, 医学部, 准教授
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2000: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1999: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1998: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | Heme / Oxygen Sensing / Heme Oxygenase / Transcription / 遺伝性ヘモクロマトージス / 晩発性皮膚ポルフィリン症 / 鉄芽球性貧血患者 / HLA-B27 / ヘムオキシゲナーゼ-1 / 赤血球系 / ヘム合成系 / 環境応答 |
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| Research Abstract |
Main aim of this project is to elucidate the biological significances of heme, with special reference to the mechanisms of diseases. One of the important results of this year is the elucidation of protective effect of heme oxygenase induction against acute renal failue. In addition, heme metabolism itself controlled the onset of side effect, hepatic disorder, by halothane.
Therefore, the mechanism to regulate heme metabolism by heme itself seems to be one of the key step to elucidate the significance of the compound. Although no remarkable finding about the heme-directed gene regulation in mammals has been reported until today, we found a new transcription factor, Bach1, is the candidate. We observed the molecular mechanism of heme to regulate Bach1 fanction and revealed the Bach1-heme mediated control of
heme oxygenase-1 gene.
These findings were presented in the International Symposium on the Regulation of Hematopoiesis in response to Environmental stress, held in Sapporo, from October 17 to 18, 2000 (chaired by H.Fujita). In the symposium, our findings on Bach1 is highly evaluated, and nowadays it is going to in press in the EMBO J.
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Report
(4 results)
Research Products
(22 results)
