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Noninvasive study of sensorimotor integration in human voluntary movements

Research Project

Project/Area Number 10044269
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIBASAKI Hiroshi  Kyoto University, School of Medicine, Brain Pathophysiology, Professor, 医学研究科, 教授 (30037444)

Co-Investigator(Kenkyū-buntansha) IKEDA Akio  Kyoto University, School of Medicine, Brain Pathophysiology, Assistant Professor, 医学研究科, 助手 (90212761)
NAGAMINE Takashi  Kyoto University, School of Medicine, Brain Pathophysiology, Assistant Professor, 医学研究科, 助手 (10231490)
FUKUYAMA Hidenao  Kyoto University, School of Medicine, Brain Pathophysiology, Associate Professor, 医学研究科, 助教授 (90181297)
ハレット マーク  米国国立衛生研究所, 部長
ナイト ロバート  米国カリフォルニア大学, デービス検・医学部, 教授
バロン ジァンクロード  フランスシセロンセンター, 所長
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordsvoluntary movement / sensorimotor association / noninvasive study / event-related functional MRI / EEG / MEG / supplementary motor area / ポジトロン断層撮影 / 機能的MR画像 / 高次脳機能
Research Abstract

During the last 2 years with this financial support, we obtained the new findings with special regard to the sensorimotor association in human motor control through international collaboration as follows.
(1) Study with functional MRI (fMRI) and positron emission tomography (PET)
Hemodynamic change was measured in association with voluntary muscle relaxation by means of single trial (event-related) fMRI analysis, and the increased activity was found in both primary and supplementary motor areas before the onset of muscle relaxation. There was a significantly greater increase in the mesial frontal area in the relaxation than in the contraction task. Cutaneous pain stimuli by laser beam elicited activation in the second somatosensory area and cingulate cortex as studied by means of fMRI, and in the primary somatosensory cortex by means of magnetoencephalography (MEG) and subdural EEG analysis.
(2) Whole head magnetoencephalography (MEG) study
Central processing mechanism in the sensory perception was investigated using electrical and auditory stimuli in order to clarify the effects of selective attention. It revealed that the early magnetic responses arising from the primary sensory cortices showed the significant changes in accordance with selective attention. We also clarified the cortical generator of P300 (auditory event-related potentials) noninvasively.
(3) EEG analysis in sensorimotor association
During continuous voluntary muscle contraction in humans, subdural EEG (ECoG) recorded from the primary motor area and EMG activity showed a high coherence mainly at 17 Hz frequency. In phasic voluntary muscle contraction, ECoGs from primary motor area and supplementary motor area proper showed a high coherence before muscle contraction.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (67 results)

All Other

All Publications (67 results)

  • [Publications] Hanakawa,T., et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease"Ann. Neurol.. 45. 329-36 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terada,K. et al.: "Movement-related cortical potential associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hamano,T. et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-15 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishitani,N. et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J. Neurosci.. 19. 1647-57 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toma,K. et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study"J. Neurosci.. 19. 3527-34 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda,A. et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-31 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima,T. et al.: "Somesthetic function of supplementary motor area during voluntary movements"NeuroReport. 10. 1859-62 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa,T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study"Brain. 122. 1271-82 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa,S. et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-66 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimizu,H. et al.: "Pre-movement fating of short-latency somatosensory evoked potentials"NeuroReport. 10. 2457-60 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima,T. et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-97 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanda,M. et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Murase,N. et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa,S. et al.: "Human pre-supplementary motor area is active before voluntary movement: subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda,A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kunieda,T. et al.: "Different activation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa, T. et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease."Ann. Neurol.. 45. 329-36 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terada, K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles."Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hamano, T. et al.: "Abnormal contingent negative variation in writer's cramp."Clin. Neurophysiol.. 110. 508-15 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishitani, N. et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit."J. Neurosci.. 19. 2647-57 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toma, K., et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study."J. Neurosci. 19. 3527-34 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda, A., et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials."Brain. 122. 915-31 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima, T. et al.: "Somesthetic function of supplementary motor area during voluntary movements."NeuroReport. 10. 1859-62 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa, T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study."Brain. 122. 1271-82 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa, S. et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials."Brain. 122. 1357-66 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimazu, H. et al.: "Pre-movement gating of short-latency somatosensory evoked potentials."NeuroReport. 10. 2457-60 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima, T., et al.: "Brain structures related to active and passive finger movements in man."Brain. 122. 1989-97 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanda, M., et al.: "Primary somatosensory cortex is actively involved in pain processing in human."Brain Res.. 853. 282-289 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Murase, N., et al.: "Abnormal premovement gating of somatosensory input in writer's cramp."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa, S. et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex."Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda, A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kunieda, T. et al.: "Different activation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans."Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa T.et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease"Ann. Neurol.. 45. 329-336 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Terada K.et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hamano T.et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-515 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishitani N.et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J. Neurosci.. 19. 2647-2657 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toma K.et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study"J. Neurosci.. 19. 3527-3534 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda A.et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-931 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mima T.et al.: "Somesthetic function of supplementary motor area during voluntary movements"Neuro Report. 10. 1859-1862 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hanakawa T.et al.: "Mechanisms underlying gait disturbance in Parkinson's disease.A single photon emission computed tomography study"Brain. 122. 1271-1282 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yazawa S.et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu H.et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"Neuro Report. 10. 2457-2460 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mima T.et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-1997 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanada M.et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Murase N.et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yazawa S.et al.: "Human pre-supplementary motor area is active before voluntary movement: subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda A.et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kunieda T.et al.: "Different actibation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujiki,N.: "Influence of unilateral deafness on auditory evoked magnetic field." Neuroreport. 9. 3129-3133 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujiwara,N.: "Role of the primary auditory cortex in auditory selective attention studied by whole-head neuromagnetometer." Brain Res.Cogn.Brain Res.7. 99-109 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukuyama,H.: "Issues in measuring glucose metabolism of rat brain using PET: the effect of harderian glands on the frontal lobe." Neurosci.Lett.255. 99-102 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Honda,M.: "Comparative study of event-related potentials and positron emission tomography activation during a paired-associate memory paradigm." Exp.Brain Res.119. 103-115 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeda,A.: "Reappraisal of the effect of electrode property on recording slow potentials." Electroencephalogr.Clin.Neurophysiol.107. 59-63 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Lu,C.S.: "Electrophysiological studies of early stage corticobasal degeneration." Mov.Disord.13. 140-146 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mima,T.: "Pathogenesis of cortical myoclonus studied by magnetoencephalopathy." Ann.Neurol.43. 598-607 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mima,T.: "Attention modulates both primary and second somatosensory cortical activities in humans: a magnetoencephalographic study." J.Neurophysiol.80. 2215-2221 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mima,T.: "Cortical myoclonus: sensorimotor hyperexcitability." Neurology. 50. 933-942 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagahama,Y.: "Neural activity during attention shifts between object features." Neuroreport. 9. 2633-2638 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagahama,Y.: "Serial processing of the somesthetic information revealed by different effects of stimulus rate on the somatosensory evoked magnetic fields" Brain Res.791. 200-208 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishitani,N.: "Cortical-hippocampal auditory processing identified bymagneto-encephalography." J.Cogn.Neurosci.10. 231-247 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishitani,N.: "Modality-specific subregions in human inferior parietal lobule: a magnetoencephalographic study during cognitive tasks." Neurosci.Lett.252. 79-82 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ogawa,M.: "Cerebral blood flow and metabolism in multiple system atrophy of the Shy-Drager syndrome type: a PET study." J.Neurol.Sci.158. 173-179 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shindo,K.: "Clinical usefulness of the dipole tracing method for localizing interictal spikes in partial epilepsy." Epilepsia. 39. 371-379 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamauchi,H.: "Atrophy of the corpus callosum,cortical hypometabolism,and cognitive impairment in corticobasal degeneration." Arch.Neurol.55. 609-103 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamauchi,H.: "Cerebral hematocrit decreases with hemodynamic compromise in carotid artery occlusion: a PET study." Stroke. 29. 98-103 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yazawa,S.: "Human SMA is active in preparation for both voluntary muscle relaxation and contraction: subdural recording of BP." Neurosci Lett.244. 145-148 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamauchi,H.: "Selective cerebral hematocrit decrease in the centrum semiovale after carotid artery occlusion: A PET study." J.Cereb.Blood Flow Metab.19. 109-114 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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