SSPE in Papua New Guinea and Indonesia : comparative molecular epidemiology
| Project/Area Number |
10044322
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Field |
Virology
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| Research Institution | Nihon University |
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Principal Investigator |
TAKASU Toshiaki Nihon University, School of Medicine ; Department of Neurology ; Professor, 医学部, 教授 (90010024)
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| Co-Investigator(Kenkyū-buntansha) |
KOKUBUN Yuji Nihon University, School of Medicine, Department of Neurology ; Assistant, 医学部, 助手 (40215223)
KAMEI Satoshi Nihon University, School of Medicine, Department of Neurology ; Lecturer, 医学部, 講師 (40142509)
KOMASE Katsuhiro The Kitasato Institute, Basic Research Center, Second Laboratory of Virology ; C, 基礎研究所, 主任研究官 (80215384)
YOSHIKAWA Yasuhiro Tokyo University Graduate School, Department of Agricultural Life Sciences ; Pro, 大学院・農学生命科学研究科, 教授 (80109975)
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| Project Period (FY) |
1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1998: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Subacute sclerosing panencephalitis (SSPE) / Measles / Vaccine / Epidemiology / Virus / Genome / Phylogeny / Papua New Guinea |
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| Research Abstract |
In the highlands provinces of Papua New Guinea (PNG) a very high incidence of subacute scierosing-panencephalitis (SSPE) was reported by Karren Lucas et al. in 1993 We registered 34 new SSPE cases at Goroka Base Hospital, Eastern Highlands Province, during a period of 1 year and 7 months from 1997 through 1998. We estimated the annual incidence of SSPE per one million populations below 15 years to be 27 for the whole PNG, 78 for four highlands and two coastal provinces, and 123 for Goroka District. These incidence rates are all higher than 0.57 for Japan and 14 for Karachi, thereby confirming a continuing high incidence of SSPE in 1997 and 1998.
We came to know the following four points. (1) Ca. 80% of SSPE patients had been vaccinated against measles prior to the development of SSPE.(2) Ca. 70% of SSPE patients got measles below 2 years and Ca. 50% below 1 year. (3) The median value of incubation period for SSPE was 5 years (4) The median value of the age at SSPE onset was 6-7 years with a peak at 5 years. Therefore the SSPE in Goroka features a peculiar
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Report
(2 results)
Research Products
(12 results)
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[Publications] Takasu T,Komase K,Kokubun Y,Nishimura T,Miki K,Mgone CS,Alpers MP,Asuo P,Mgone JM,Babona DV.: "Subacute sclerosing panencepahlitis in Papua New Guinea.1.Re-confirmatory and additional evidence of very high incidence, 2.An attempt at detecting and analyzing viral genome in cerebrospinal fluid and serum by RT-PCR method." Annual Report of the Slow Virus Infection Research Committee, The Ministry of Health and Welfare of Japan 1997. 126-135 (1998)
Description
「研究成果報告書概要(欧文)」より
Related Report
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