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Mechanisms of transposition and its regulation of bacterial transposable elements (IS and Tn) and their involvement in the genomic rearrangements

Research Project

Project/Area Number 10216202
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

OHTSUBO Eichi  The University of Tokyo, Institute of Molecular and Celular Biosciences, Professor, 分子細胞生物学研究所, 教授 (10158800)

Co-Investigator(Kenkyū-buntansha) SEKINE Yasuhiko  Rikkyo University, Cdege of Science, Assistant Professor, 理学部, 助教授 (80222074)
OHTSOBO Hisako  The University of Tokyo, Institute of Molecular and Celular Biosciences, Leclurer, 分子細胞生物学研究所, 講師 (20158801)
Project Period (FY) 1998 – 2002
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥45,700,000 (Direct Cost: ¥45,700,000)
Fiscal Year 2002: ¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 2001: ¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 2000: ¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 1999: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1998: ¥9,000,000 (Direct Cost: ¥9,000,000)
KeywordsTransposon / Transposase / Genomic rearrangements / EHEC O157 / Transposition / Insertion elements / plasmid / Escherichia coli / DNAの切断・再結合 / RecQへリカーゼ / 末端逆向き配列
Research Abstract

Transposons are mobile DNA elements and encode transposases required for their transposition. These elements cause various genomic rearrangements by their ability to transpose. This study is aimed at elucidation of molecular mechanisms of transposition promoted by bacterial insertion elements IS1 and IS3 and the ampicillin-resistance transposon Tn3, which are supposed to transpose in a different mode. We have previously shown that a circular IS3 molecule is generated from the IS3-carrying plasmid and is converted to a linear molecule, which is inserted into a new target site. We showed here that the IS3 transposase binds to terminal inverted repeats (IR) and that an IR end is cleaved and transferred to the other end to give a characteristic figure-8 molecule in a complex consisting of two transposases and two IRs. complex is formed by binding of each transposase to a domain (named A) in one IR, as well as to the other domain (named B) in the other IR. As for IS1, we showed that IS1 requires a host protein H-NS unlike IS3, and that IS1 transposase has a catalytic D-D-E motif in the C-terminal region, as well as two IR-binding motifs (helix-turn-helix and Zinc-finger) in the N-terminal region unlike the IS3 transposase. As for Tn3, we showed that nicking, the first reaction of transposition, at the 3' end of IR requires acyl carrier protein from the host, which promotes the formation of a transposase-IR complex. Furthermore, we identified IS elements present in the genomes of Escherichia coli strains and their plasmids and found that they are involved in generation of mutations, such as insertions, deletions, and substitutions, and that these mutations are useful to determine phylogenetic relationships among various pathogenic E. coli strains.

Report

(6 results)
  • 2003 Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (69 results)

All Other

All Publications (69 results)

  • [Publications] Makino, K., Ishii, K., Yasunaga, T., Hattori, M., Yokoyama, K., Yutsudo, C., Kubota, Y., Yamaichi, Y., Iida, T., Yamamoto, K., Honda, T., Han, Ohtsubo, E., Kasamatsu, M., Hayashi, T., Kuhara, S., Shinagawa, H.: "Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an Enterohemorrhagic Eschenchia coli O157 : H7 derived from Sakai outbreak."DNA Res.. 5. 1-9 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sekine, Y., Aihara, K., Ohtsubo, E.: "Linearization and transposition of IS3 circles"J.Mol.Biol.. 294. 21-34 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiga, Y., Sekine, Y., Ohtsubo, E.: "Transposition of IS1 circles"Genes Cells. 4. 551-559 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tobe, T., Hayashi, T., Han, C.-G., Schoolnik, G.K., Ohtsubo, E., Sasakawa, C.: "Complete DNA sequence and structural analysis of the enteropathogenic Eschenchia coli adherence factor plasmid"Infect.Immun.. 67. 5455-5462 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Han, C.-G., Frank, M.J., Ohtsubo, H., Ohtsubo, E.: "New transposable elements identified as insertions in rice transposon Tnr1"Genes Genet.Syst.. 75. 69-77 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Cheng, C., Tsuchimoto, S., Ohtsubo, H., Ohtsubo, E.: "Tnr8, a foldback transposable element from rice"Genes Genet.Syst.. 75. 327-333 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiga, Y., Sekine, Y., Kano, Y., Ohtsubo, E.: "The involvement of H-NS in transpositional recombination mediated by IS1"J.Bacteriol.. 183. 2476-2484 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Han, C.-G., Shiga, Y., Tobe, T., Sasakawa, C., Ohtsubo, E.: "Structural and functional characterization of IS679 and IS66-family elements."J.Bactenol.. 183. 4296-4304 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C.-G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H.: "Genome sequence and comparative analysis of enterohemorrhagic E.coli O157 : H7"DNA Res.. 8. 11-22 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C.-G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda T, Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H.: "Genome sequence and comparative analysis of enterohemorrhagic E.coli O157 : H7 (Supplement)"DNA Res.. 8. 47-52 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takami, H., Han, C.-G., Takaki, Y., Ohtsubo, E.: "Identification ad distribution of new insertion sequences in the genome of Alkaliphilic Bacillus halodurans C-125"J.Bacteriol.. 183. 4345-4356 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohta, S., Tsuchida, K., S.Choi, Sekine, Y., Shiga, Y., Ohtsubo, E.: "Presence of a characteristic D-D-E motif in IS1 transposase"J.Bactenol.. 184. 6146-6154 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, T, Ohnishi, M, Ara, T., Kaneko, J., Han, C.-G., Lee, Y.-F., Takashima, K., Nojima, H., Nakayama, K, Kaji, A., Kamio, Y., Miki, T., Mori, H., Ohtsubo, E., Terawaki, Y., Hayashi, T.: "Complete nudeotide sequence of plasmid Rts1 : implication for the evolution of large plasmid"J.Bacteriol.. 184. 3194-3202 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urasaki, A., Sekine, Y., Ohtsubo, E.: "Transposition of cyanobactenum insertion element ISY100 in Escherlchia coli"J.Bacteriol.. 184. 5104-5112 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Choi, S., Shinya Ohta, Ohtsubo, E.: "A novel IS element, IS621, of the IS110/IS492 family transposes to a specific site in repetitive extragenic palindromic sequences in Escherichia coli"J.Bacteriol.. 185. 4891-4900 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, N., Yamazoe, K., Han, C.-G., Ohtsubo, E.: "New insertion sequence elements in the upstream region of cfiA in imipenem-resistant Bacteroides fragilis strains"Antimicrob.Agents Chemother.. 47. 979-985 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohtsubo, E., Minematsu, H., Tsuchida, K., Ohtsubo, H., Sekine, Y.: "Intermediate molecules generated by transposase in the pathways of transposition of bacterial insertion element IS3"Adv.Biophys.. 38(in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohta, S., Yoshimura, E., Ohtsubo, E.: "Involvement of two domains with helix-turn-helix and zinc finger motifs in the binding of IS1 transposase to terminal inverted repeats"Mol.Microbiol.. 52(in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Makino, K., Ishii, K., Yasunaga, T., Hattori, M., Yokoyama, K., Yutsudo, C., Kubota, Y., Yamaichi, Y., Iida, T., Yamamoto, K., Honda, T., Han, C.-G., Ohtsubo, E., Kasamatsu, M., Hayashi, T., Kuhara, S., Shinagawa, H.: "Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an Enterohemorrhagic Escherichia coli O157 : H7 derived from Sakai outbreak."DNA Res.. 5. 1-9 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sekine, Y., Aihara, K., Ohtsubo, E.: "Linearization and transposition of IS3 circles."J. Mol. Biol.. 294. 21-34 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiga, Y., Sekine, Y., Ohtsubo, E.: "Transposition of IS1 circles."Genes Cells. 4. 551-559 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tobe, T., Hayashi, T., Han, C.-G., Schoolnik, G.K., Ohtsubo, E., Sasakawa, C.: "Complete DNA sequence and structural analysis of the enteropathogenic Escherichia coli adherence factor plasmid."Infect. Immun.. 67. 5455-5462 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] han, C.-G., Frank, M.J., Ohtsubo, H., Ohtsubo, E.: "New transposable elements identified as insertions in rice transposon Tnr1."Genes Genet. Syst.. 75. 69-77 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Cheng, C., Tsuchimoto, S., Ohtsubo, H., Ohtsubo, E.: "Tnr8, a foldback transposable element from rice."Genes Genet. Syst.. 75. 327-333 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiga, Y., Sekine, Y., Kano, Y., Ohtsubo, E.: "The involvement of H-NS in transpositional recombination mediated by IS1."J. Bacteriol.. 183. 2476-2484 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C.-G.Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H.: "Genome sequence and comparative analysis of enterohemorrhagic E. coli O157 : H7."DNA Res.. 8. 11-22 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C.-G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H.: "Genome sequence and comparative analysis of enterohemorrhagic E. coli O157 : H7 (Supplement)."DNA Res.. 8. 47-52 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takami, H., Han, C.-G., Takaki, Y., Ohtsubo, E.: "Identification and distribution of new insertion sequences in the genome of Alkaliphilic Bacillus halodurans C-125."J. Bacteriol.. 183. 4345-4356 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohta, S., Tsuchida, K., S.Choi, Sekine, Y., Shiga, Y., Ohtsubo, E.: "Presence of a characteristic D-D-E motif in IS1 transposase."J. Bacteriol.. 184. 6146-6154 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, T., Ohnishi, M, Ara, T., Kaneko, J., Han, C.-G., Lee, Y.-F., Takashima, K., Nojima, H., Nakayama, K, Kaji, A., Kamio, Y., Miki, T., Mori, H., Ohtsubo, E., Terawaki, Y., Hayashi, T.: "Complete nucleotide sequence of plasmid Rts1 : implication for the evolution of large plasmid."J. Bacteriol.. 184. 3194-3202 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Choi, S., Ohta, S., Ohtsubo, E.: "A novel IS element, IS621, of the IS110/IS492 family transposes to a specific site in repetitive extragenic palindromic sequences in Escherichia coli."J. Bacteriol.. 185. 4891-4900 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, N., Yamazoe, K., Han, C.-G., Ohtsubo, E.: "New insertionsequence elements in the upstream region of cfiA in imipenem-resistant Bacteroides fragilis strains."Antimicrob. Agents Chemother.. 47. 979-985 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urasaki, A., Sekine, Y., Ohtsubo, E.: "Transposition of cyanobacterium insertion element ISY100 in Escherichia coli."J. Bacteriol.. 184. 5104-5112 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohtsubo, E., Minematsu, H.Tsuchida, Sekine, Y.: "Intermediate molecules generated by transposase in the pathways of transposition of bacterial insertion element IS3."Adv. Biophys.. 38. 125-139 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohta, S., Yoshimura, E., Ohtsubo, E.: "Involvement of two domains with helix-turn-helix and zinc finger motifs in the binding of IS1 transposase to terminal inverted repeats."Mol. Microbiol.. 52. (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ikeda, H., Iida, S., Ohtsubo, E.(Eds): "Novel developments on genetic recombination : DNA double-strand break and DNA end-joining"Advances in Biophysics. Vol.38. 1-234 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, T.: "Complete nucleotide sequence of plasmid Rts1 : implication for the evolution of large plasmid"J.Bacteriol.. 184. 3194-3202 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Urasaki, A.: "Transposition of cyanobacterium insertion element ISY 100 in Escherichia coli"J.Bacteriol.. 184. 5104-5112 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Obta, S.: "Presence of a characteristic D-D-E motif in IS 1 transposase"J.Bacteriol.. 184. 6146-6154 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Cheng, C.: "Evolutionary relationships among rice species with AA genome based on SINE insertion analysis"Genes Genet.Syst.. 77. 323-334 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohta, Y.: "Expression of Arabidopsis LINEs from two promoters"Plant J.. 32. 809-818 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Cheng, C.: "Polyphyletic origin of cultivated rice : based on the interspersion pattern of SINEs"Mol.Biol.Evol.. 20. 67-75 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shiga, Y.: "The involvement of H-NS in transpositional recombination mediated by IS1"J. Bacteriol.. 183. 2476-2484 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Noma, K.: "A new class of LINEs (ATLN-L) from Arabidopsis thaliana with extraordinary structural features"DNA Res.. 8. 291-299 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hayashi, T.: "Genome sequence and comparative analysis of enterohemorrhagic E. coli O157 : H7"DNA Res.. 8. 11-22 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hayashi, T.: "Genome sequence and comparative analysis of enterohemorrhagic E. coli O157 : H7 (Supplement)"DNA Res.. 8. 47-52 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kumekawa, N.: "A new gypsy-type retrotransposon RIRE7 : preferential insertion into the tandem repeat sequence TrsD in pericentromic heterochromatin regions of rice chromosomes"Mol. Gen. Genet.. 265. 480-488 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Myouga, F.: "Identification and structural analysis of SINE elements in the Arabidopsis thaliana genome"Genes Genet. Syst.. 76. 169-179 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Han et al.: "Structural and functional characterization of IS679 and IS66-family elements. :"J. Bacteriol.. 183. 4296-4304 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takami et al.: "Identification ad distribution of new insertion sequences in the genome of alkaliphilic Bacillus halodurans C-125. : (2001)"J. Bacteriol.. 183. 4345-4356 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Cheng,C.: "Tnr8, a foldback transposable element from rice"Genes Genet.Syst.. 75. 327-333 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noma,K.: "Tnat1 and Tnat2 from Arabidopsis thaliana novel transposable elements with tandem repeat sequences"DNA Res.. 7. 1-7 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Han,C.-G.: "New transposable elements identified as insertions in rice transposon Tnr1"Genes Genet.Syst.. 75. 69-77 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noma,K.: "ATLN elements, LINEs from Arabidopsis thaliana Identification and characterization"DNA Res.. 7. 291-303 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsuchimoto,S.: "The whorl-specific action of a petunia class B floral homeotic gene"Genes Cells. 5. 89-99 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hayashi,T.: "Genome sequence and comparative analysis of enterohemorrhagic E.coli O157:H7"DNA Res.. 8. 11-22 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shiga,Y.: "The involvement of H-NS in transpositional recombination mediated by IS1 "J.Bacteriol.. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kumekawa,N.: "A new gypsy-type retrotransposon RIRE7 : preferential insertion into the tandem repeat sequence TrsD in pericentromic heterochromatin regions of rice chromosomes"Mol.Gen.Genet.. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sekine, Y.: "Linearization and transposition of IS3 circles"J. Mol. Biol.. 294. 21-34 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shiga, Y.: "Transposition of IS1 circles"Genes Cells. 4. 551-559 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tobe, T.: "Complete DNA sequence and structural analysis of the enteropathogenic Escherichia coli adherence factor plasmid"Infect. Immun.. 67. 5455-5462 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Noma, K.: "Non-LTR retrotransposons (LINEs) as ubiquitous components of plant genomes"Mol. Gen. Genet.. 261. 71-79 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ohtsubo, H.: "RIRE2, a novel gypsy-type retrotransposon from rice"Genes Genet. Syst.. 74. 83-91 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kumekawa, N.: "Identification and phylogenetic analysis of gypsy-type retrotransposons in the plant kingdom"Genes Genet. Syst. in press. (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Makino, K.: "Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an Enterohemorrhagic Escherichia coli O157 : H7 derived from Sakai outbreak." DNA Research. 5. 1-9 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taki, K.: "Regulatory mechanisms in expression of the traY-I operon of sex factor plasmid R100 : Involvement of tral and tra Y gene products." Genes Cells. 3. 331-345 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Janosi, L.: "Evidence for in vivo ribosome recycling, the forth step in protein biosynthesis." EMBO J.17. 1141-1151 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kumekawa, N.: "Identification and characterization of novel retrotransposons of gypsy type in rice." Mol.Gen.Genet.260. 593-602 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Noma, K.: "Non-LTR retrotransposons (LINEs) as ubiquitous components among plant kingdom." Mol.Gen.Genet.261. 771-79 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2018-03-28  

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