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CENTARAL AND PERIPHERAL MECHANISMS IN THE HOST DEFENSE FUNCTION AGAINST NON-INFLAMMATORY ENVIRONMENTAL STRESS.

Research Project

Project/Area Number 10307001
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

HORI Tetsuro  Kyushu University, Dept.of Physiology, Professor, 大学院・医学系研究科, 教授 (00022814)

Co-Investigator(Kenkyū-buntansha) TAKAKI Atsushi  Kyushu University, Dept.of Physiology, Assistant Professor, 大学院・医学系研究科, 助手 (30243934)
KATAFUCHI Toshihiko  Kyushu University, Dept.of Physiology, Assistant Professor, 大学院・医学系研究科, 講師 (80177401)
AOU Shuji  Kyushu University, Dept.of Physiology, Assistant Professor, 大学院・医学系研究科, 助教授 (40150908)
TAKE Sachiko  Kyushu University, Dept.of Physiology, Assistant Professor, 大学院・医学系研究科, 助手 (80253425)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥31,600,000 (Direct Cost: ¥31,600,000)
Fiscal Year 1999: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1998: ¥26,800,000 (Direct Cost: ¥26,800,000)
Keywordsbrain-gut-liver-immune interaction / endotoxin / c-fos / antisense-oligo DNA / CRF / cytokines / flowcytometer / immobilization stress / 脳・免疫系連関 / 脳・腸・肝・免疫系軸 / Bacterial Translocation / インターロイキン-1β / インターロイキン6 / 脳内ノルアドレナリン / 痛覚系 / プロスタグランディンE2
Research Abstract

In this project, we intended to claryfy the central and peripheral mechanisms in terms of host defense functions under non-inflammatory environmental stress. Main results are summarized as follows.
1) Proposal of a new host-defense paradigm/the brain-gut-liver-immune axis
The non-inflammatory stress induced the change of gut membrane barrier sysytem, then gut-derived endotoxin come into the inside of the barrier sysytem (stress-induced LPS translocation). Stress-induced LPS translocation in the gut acitivate the immune network resulting in up regulation of the host=defense function againt the stress.
2) The effect of brain-derived IL-1 on the noradrenargic (NA) sysytem
The release of NA in the frontal brain during the immobilization stress is mediated by the IL-I, PGE2, NO, and Glutamate.
3) Modification of brain-derived cytokines on the mechanisms of notiception
Administration of cytokines into the brain changed the threshold the notiception.
4) Expression of cytokines and c-fos in the brain during the non-inflammatory stresses
The c-fos mRNA expression in the POA, LHA, VMH in the brain was increased by cold exposure. The CRF mRNA expression in the MPO and PVN was increased by heat exposure, and that in the POA and LHA was increased by cold exposure. The microinjection of the antisense-oligo DNA for the c-fos into the POA inhibited the expression of IFN mRNA in the brain.
5) The shift of subsets of periferal lymphocytes during the non-inflammatory stresses
The head down stress during one hour induced the CD4+ Tcell increase, CD4/8 increase. However, six hour later, CD8+ T cell decrease and B cell increase was observed.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (113 results)

All Other

All Publications (113 results)

  • [Publications] Li,A-J.: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor."Neuroscience. 85. 785-794 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T.: "Neuroimmunomodulatory actions of hypothalamic interferon-α."Neuroimmunomodulation. 5. 172-177 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "サイトカインと脳・免疫連関"Clinical Neuroscience. 16. 401-405 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳・免疫系連関における伝達物質"Clinical Neuroscience. 16. 93-97 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T: "Cell biology and the functions of thermosensitive neurons in the brain. in Brain Function in Hot Environment : Basic and Clinical Perspectives."Progress in Brain Research. 115. 9-23 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T: "Pain modulatory actions of cytokines and PGE2 in the brain."Ann.New York Acad.Sci.. 840. 269-281 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 粟生修司: "情動の脳科学"診療内科. 2. 429-434 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "発熱とサイトカイン"Clinical Neuroscience. 16・4. 73-75 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "ストレスと免疫系"感染炎症免疫. 28(2). 106-115 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 粟生修司: "食欲のしくみ"婦人之友. 92. 104-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 粟生修司: "摂食行動の基礎"心身医学. 39. 99-109 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa,H.: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Research. 846. 171-176 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa,H.: "IL-1 β increases norepinephrine level in rat frontal cortex : involvement of prostanoids, NO and glutamate."Am.J.Physiol.. 275. 803-810 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka,K.: "PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1 β-induced fever in rats."Am.J.Physiol.. 275. 1762-1765 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩"老年精神医学雑誌. 9・11. 1381-1392 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "神経系内分泌系と免疫系との相互作用"免疫・Immunology Frontier. 8・6. 333-341 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関"アレルギーの領域. 6・1. 52-61 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 粟生修司: "ここまでわかった食欲不振の病態生理"Journal of Integrated Medicine(JIM). 8. 638-641 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩(討論)"中枢神経懇話会記録. 9. 1-18 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "情動と免疫"Clinical Neuroscience. 48(7). 772-775 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T.: "Evidence for th einvolvement of AV3V in the circulating IL-β-to-brain communication."Journal of Thermal Biology. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T.: "Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2."Ann.N.Y.Acad.Sci.. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "サイトカインと神経伝達物質"日本薬理学会誌. 115. 209-218 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "無意識の世界が感情をつくる"ゑれきてる. 75(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 李学良: "OLETFラットの学習障害と[Ala]16-aFGF(1-29)による改善"OLETFラット研究会記録集. 最終巻. 101-104 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li,A-J: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils."Physiol.& Behav.. 66(4). 577-583 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosoi,M: "Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats."Pain. 82. 221-227 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Araishi,K: "Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in β-sarcoglycan-deficient mice."Human Molecular Genetics. 8. 1589-1598 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa,H: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Res.. 846. 171-176 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関"アレルギー・免疫. 6. 52-61 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka,T.: "Brain cytokines and pain."Birkhaeuser Publishing Ltd. 225 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki,A.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 粟生修司: "摂食障害"日本評論社. 156 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "内科学進歩のトピックス"九州大学出版会. 394 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi,T.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li,A,-J.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "免疫学からみた神経系と神経疾患"日本医学館. 374 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "サイトカインと疾患"羊土社(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "インターフェロン-その研究の歩みと臨床応用への可能性-"ライフサイエンス. 211 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "麻酔科医のための生理学"真興交易医書出版. 388 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aou,S.: "Thermotherapy : Principle and Practice--Application and neoplasia, Inflammation, and Pain."Springer - Verlag(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T: "Thermotherapy : Principle and Practice--Application and neoplasia, Inflammation, and Pain."Springer - Verlag(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki,A: "Control Mechanisms of Stress and Emotion : Neuroendocrine-Based Studies"Elsevier Science B.V. 359 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi,T.: "Thermotherapy : Principles and Practice-Applications in Neoplasia, Inflammation, and Pain-"Springer-Verlag Tokyo Inc.(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T.: "Psychoneuroimmunology"Academic Press Inc.(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori,T.: "Pain and Neuroimmune Interactions"Kluwer Academic/Plenum Press(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Oka, T., Hosoi, M.& Aou, S.: "Pain modulatory actions of cytokines and PGE2 in the brain."Ann.New York Acad.Sci.. 840. 269-281 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A.-J., Oomura, Y., Sasaki, K., Suzuki, K., Tooyama, I., Hanai, K., Kimura, H.and Hori, T.: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor."Neuroscience. 85. 785-794 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Take, S & Shimizu, N.: "Neuroimmunomodulatory actions of hypothalamic interferon-α."Neuroimmunomodulation. 5. 172-177 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa, H., Hori, T., Nakane, H., Aou, S.& Tashiro, N.: "IL-1β increases norepinephrine level in rat frontal cortex : involvement of prostanoids, NO and glutamate."Am.J.Physiol.. 275. R803-R810 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, K., Oka, T.& Hori, T.: "PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1β-induced fever in rats."Am.J.Physiol.. 275. R1762-R1765 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T.& Katafuchi, T.: "Cell biology and the functions of thermosensitive neurons in the brain."In : Brain Function in Hot Environment : Basic and Clinical Perspectives. (Eds.H.S.Sharma and J.Westman) Progress in Brain Research vol.115, pp.9-23, Elsevier. Amsterdam. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi, T., Kondo, T., Take, S.& Hori, T.: "Hypothalamic modulation of delayed-type hypersensitivity and splenic natural killer cell activity."In : Brain and Biodefence (Eds.Oomura, Y.& Hori, T) Japan Scientific Societies Press, Tokyo/Karger, Basel. 3-11 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki, A., Shioda, S., Ito, K., Maeda, M., Kanemitsu, Y., Yagi, S., Arimura, A.& Hori, T.: "Non-inflammatory stress and brain-gut-liver-immune axis."In : Brain and Biodefence (Eds.Oomura, Y.& Hori, T) Japan Scientific Societies Press, Tokyo/Karger, Basel. 155-160 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A,-J., Oomura, Y., Sasaki, K., Hori, N., Tooyama, I., Nomura, Y., Hanai, K., Kimura, H., Yanaihara, N., Yoshii, H., Yamazaki, Y., Take, S.& Hori, T.: "Actions of aFGF in senescence-accelerated mice : protective effects against deficits of learning and metmory, and effects on immunological functions."In : Brain and Biodefence (Eds.Oomura, Y.& Hori, T) Japan Scientific Societies Press, Tokyo/Karger, Basel. 51-61 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, T.& Hori, T.: "Brain cytokines and pain."In : Cytokines and Pain (eds.Watkins, L.R.& Maier, S.F.) Birkhaeuser Publishing Ltd, Basel, Switzerland.. 183-203 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A-J, Oomura, Y., Sasaki, K., Suzuki, K.& Hori, T.: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils."Physiol.& Behav.. 66(4). 577-583 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosoi, M., Oka, T., Abe, M., Hori, T., Yamamoto, H., Mine, K.& Kubo, C.: "Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats."Pain. 82. 221-227 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa, H., Katafuchi, T., Hosoi, M., Yamamoto, T.& Hori, T.: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Res. 846. 171-176 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Araishi, K., Sasaoka, T., Imamura, M., Noguchi, S., Hama, H., Wakabayashi, E., Yoshida, M., Hori, T.& Ozawa, E.: "Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophyin β-sarcoglycan-deficient mice."Human Molecular Genetics. 8. 1589-1598 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki, A., Hori, T., Yagi, S., Oka, K., Kanemitsu, Y., Sudo, N., Shioda, S.& Arimura, A.: "Plasma IL-6 and its pyrogenicity during noninflammatory stress."In : Control Mechanisms of Stress and Emotion : Neuroendocrine-Based Studies.(Eds.Yamashita, H., Funder, J.W., Verbalis, J.G., Ueta, Y.& Endo, Y.)Elsevier Science B.V., Amsterdam, The Netherlands.. 173-177 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Ota, K., Matsuda, T., Oka, T.& Oka, K.: "Evidence for the involvement of AV3V in the circulating IL-1β-to-brain communication."J.Thermal.Biol.. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Oka, T., Hosoi, M., Abe, M.& Oka, K.: "Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2."Ann.N.Y.Acad.Sci.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Oka, T., Hosoi, M., Abe, M.& Oka, K.: "Biphasic modulation of pain by hypothalamic cytokines."In : Pain and Neurimmune Interactions (Eds.Saade, N.E.), Kluwer Academic/Plenum Press.. 171-190 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T.& Oka, T.: "Central cytokines : effects on peripheral immunity, inflammation and nociception."In : Psychoneuroimmunology, Third Edition, (Eds.Ader, R., Felten, D.L.& Cohen, N) Academic Press.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikaw,H.: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Research. 846. 171-176 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 李学良: "OLETFラットの学習障害と[Ala]16-aFGF(1-29)による改善"OLETFラット研究会記録集. 最終巻. 101-104 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Li.A-J: "Protective effect of acidic fibroblast growth factor against ischemia-induced leaming and memory deficits in two tasks in egrbils,"Physiol/&Behav.. 66(4). 577-583 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hosoi,M: "Prostagladia E2 has antinociceptive effect through EP1 recerptor in the centromedial hypothalamus in rats."Pain. 82. 221-227 (1999)

    • Related Report
      1999 Annual Research Report
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  • [Publications] Kamikawa.H: "Hyperalgesic Response to noxious stimulation in genetically polydipsic mice"Brain Res.. 846. 171-176 (1999)

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  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関"アレルギー・免疫. 6. 52-61 (1999)

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  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩(討論)"中枢神経懇話会記録. 9. 1-18 (1999)

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  • [Publications] 堀 哲郎: "情動と免疫"Clinical Neuroscience. 48(7). 772-775 (1999)

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  • [Publications] Hori.T.: "Evidence for th einvolvement of AV3v in the circulating IL-β-to-brain communication."Joumal of Thermal Biology. 25. 29-33 (2000)

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  • [Publications] Hori,T.: "Hypothalamic Mechanisms of Pain modulatory actions of cytokines and prostaglandin E2."Ann,N,T,Acad.Sci,. (印刷中). (2000)

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  • [Publications] 堀哲郎: "サイトカインと神経伝達物質"日本薬学会誌. 115. 209-218 (2000)

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  • [Publications] 堀哲郎: "無意識の世界が感情をつくる"ゑれきてる. 75(印刷中). (2000)

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  • [Publications] Katafuchi,T.: "Themotherapy:Principles and Practice-Applications in Neoplasia,Inflammation,and Pain-"Springer-Verlag Tokyo Inc.(印刷中). (2000)

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  • [Publications] Hori,T.: "Psychoneuroimmunology"Academic Press Inc.(印刷中). (2000)

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  • [Publications] Hori,T.: "Pain and Neuroimmune Interactions"Kluwer Academic/Plenum Press(印刷中). (2000)

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  • [Publications] Aou,S,: "Thermotherapy:Principle and Practice--Application and neoplasia,Inflammation,and Pain,"Springer-Verlag(印刷中). (2000)

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  • [Publications] Hori,T.: "Thermotherapy:Principle and Practice--Application and neoplasia,Inflammation,and Pain,"Springer-Verlag(印刷中). (2000)

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  • [Publications] Hori,T: "Cell biology and the functions of thermosensitive neurons in the brain.in Brain Function in Hot Environment:Basicand Clinical Perspectives." Progress in Brain Research. 115. 9-23 (1998)

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  • [Publications] Hori,T: "Pain modulatory actions of cytokinesand PGE2 in the brain." Ann.New York Acad.Sci.840. 269-281 (1998)

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  • [Publications] Li,A.-J.: "A single pre-training glucoseinjection induces memory facilitation in rokents performing various tasks:contributionof acidic fibroblast growth factor." Neuroscience. 85. 785-794 (1998)

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  • [Publications] Hori.T: "Neuroimmunomodulatory actions of hypothalamic interferon-α." Neuroimmunomodulation. 5. 172-177 (1998)

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  • [Publications] Kamikawa,H.: "IL-1β increases norepinephrine levelin rat frontal cortex:involvement ofprostanoids,NO and glutamate." Am.J.Physiol.275. 803-810 (1998)

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  • [Publications] 堀 哲郎: "脳・免疫系連関と伝達物質" Clinical Neuroscience. 16. 93-97 (1998)

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  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩" 老年精神医学雑誌. 9・11. 1381-1392 (1998)

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  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関" アレルギーの領域. 6・1. 52-61 (1998)

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  • [Publications] 粟生修司: "ここまでわかった食欲不振の病態生理." Journal of Integrated Medicine(JIM). 8. 638-641 (1998)

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  • [Publications] 粟生修司: "情動の脳科学." 心療内科. 2. 429-434 (1998)

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  • [Publications] 粟生修司: "摂食行動の基礎." 心身医学. 39. 99-109 (1999)

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  • [Publications] 片渕俊彦: "精神神経系とNK細胞.特集II-NK細胞の新しい展開." 炎症と免疫. 5・1. 51-60 (1997)

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  • [Publications] 片渕俊彦: "ストレスと免疫系." 感染 炎症 免疫. 28-2. 106-115 (1998)

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  • [Publications] Takaki,A.: "Brain and Biodefence" Japan Scientific Societies Press, 248 (1998)

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  • [Publications] Katafuchi,t.: "Brain and Biodefence" Japan Scientific Societies Press, 248 (1998)

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  • [Publications] Li,A,-J.: "Brain and Biodefence" Japan Scientific Societies Press, 248 (1998)

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  • [Publications] Oka,T.: "Cytokines and Pain" Birkhaeuser Publishing Ltd,Basel, 225 (1998)

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  • [Publications] Hori,T.: "Psychoneuroimmunology,Third Edition" Academic Press(in press), (1999)

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  • [Publications] 堀 哲郎: "脳機能の解明-21世紀に向けて" 九州大学出版会, 615 (1998)

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  • [Publications] 粟生修司: "摂食障害" 日本評論社, 156 (1998)

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  • [Publications] 片渕俊彦: "内科学進歩のトピックス" 九州大学出版会, 394 (1998)

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  • [Publications] 片渕俊彦: "インターフェロン-その研究の歩みと臨床応用への可能性-" ライフサイエンス, 211 (1998)

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  • [Publications] 堀 哲郎: "麻酔科医のための生理学" 真興交易医書出版(印刷中), (1999)

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  • [Publications] 片渕俊彦: "免疫学からみた神経系と神経疾患" 日本医学館(印刷中), (1999)

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  • [Publications] 片渕俊彦: "ストレスの事典" 朝倉書店(印刷中), (1999)

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Published: 1998-04-01   Modified: 2016-04-21  

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