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Molecular Pathology of Solid Tumors in Childhood

Research Project

Project/Area Number 10307004
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKeio University

Principal Investigator

HATA Jun-ichi  Keio University, School of Medicine, Dept. of Pathol, Professor, 医学部, 教授 (90051614)

Co-Investigator(Kenkyū-buntansha) YAMADA Taketo  Keio University, School of Medicine, Dept. of Pathol, Assistant professor, 医学部, 専任講師 (60230463)
UMEZAWA Akihiro  Keio University, School of Medicine, Dept. of Pathol, Associate professor, 医学部, 助教授 (70213486)
菊池 春人  慶應義塾大学, 医学部, 専任講師 (10161423)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥38,500,000 (Direct Cost: ¥38,500,000)
Fiscal Year 2000: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 1998: ¥25,100,000 (Direct Cost: ¥25,100,000)
Keywordsembryonal carcinoma cell / Wilms tumor / EAT gene / apoptosis / intersex abnormalities / WT1 / Denys-Drash syndrome / gonad dysgenesis / EAT / mcl1 / トランスジェニックマウス / 膵ラ氏島 / Drash症候群 / 家族性ウイルムス腫瘍 / H19遺伝子 / ヒトEC細胞 / mcl-1 / 初期胚分化 / H19 / IGF2 / インプリンティング遺伝子 / 肝芽腫 / 多分化能 / シスプラチン / bcl2 / 初期胚 / Wilms腫瘍
Research Abstract

We performed molecular pathological analysis of embryonal tumors such as germ cell tumors, Wilms tumors and Ewing/PNET tumors which are thought to be derived from embryonal tissue during.
1, we originally isolated EAT (early gene induced by all trans retinoic acid) gene from embryonal carcinoma cell lines (NCR-G3). Sequencing analysis revealed that EAT possessed BH1 and BH2 domains suggesting a bcl family gene. This gene was shown to have antiapoptotic functions by vitro and in vivo studies. Northern analysis and immunohistochemical studies disclosed that he EAT gene distributed in a variety of fetal and adult tissues including stage of early embryogenesis. EAT gene was shown to exclusively localize in the external and internal membrane of mitochondria by using immunoelectron microscopic procedures. These findings suggested that this gene play an important role in maintenance of early embryogenesis through antiapoptotic functions.
2, Wilms tumor are a typical embryonal tumors that is der … More ived from metanephric blastoma and the most common renal tumors in childhood. Novel gene, WT1, has been isolated chromosome11p13 region as a responsible gene in oncogenesis of Wilms tumor. This gene also play an important role in normal nephrogenesis and gonadal developments, especially male genital organs. Denys-Drash syndrome characterized by association of Wilms tumor, early onset and progressive renal failure and urogenital anomalies. Recent studies showed that exonic mutations at zinc finger domains of WT1 is responsible for pathogenesis of this syndrome. We analyzed WT1 mutations in 18 clinically diagnosed "Denys-Drash"(Drash) syndrome cases. 9 cases were typical Drash syndrome. Whereas another cases showed inronic point mutations at the splicing donor site at exon9. These mutations affect alternative splicing. The isoforms retaining three amino acids, KTS, are not produced. Clinical features of the patients with the intronic mutations correlated well with those of Frasier syndrome, characterized by more slowly progressing nephropathy than Denys-Drash syndrome, associated streak gonads and no development of Wilms' tumor. Our results indicate that WT1 isoforms with or without KTS have different functions in tumorigenesis and organogenesis of kidneys and gonads. Less

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (91 results)

All Other

All Publications (91 results)

  • [Publications] Hiraoka Y, Hata J, et al.: "Isolation and expression of a human of human SRY-related cDNA, hSOX20"BBA. 1396. 132-137 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] kikuchi H, hata J, et al.: "Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?"J Med Genetics. 35. 45-48 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okita H, Hata J, et al.: "Up-regulated expression of murine Mcl1/EAT, a Bcl-2 related gene, in the early stage of differentiation of murine embryonal"BBA. 1398. 335-341 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishida S, Hata J, et al.: "The genomic breakpoint and chimeric transcripts in the EWS-E1AF gene fusion of Ewing's sarcoma"Cytogenet Cell Genet. 82. 278-283 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Urano F, Hata J, et al.: "Molecular analysis of Ewing's sarcoma : another fusion gene, EWS-E1AF, available for use in diagnosis"Jpn J Cancer Res. 89. 703-711 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Otsuki T, Hata J, et al.: "Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse"Calcif Tissue Int. 63. 167-172 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ando T, Hata J, et al.: "EAT/mcl-1,a Member of the bcl-2 Related Genes, Confers Resistance to Apoptosis Induced by cis-Diamine"Jpn J Cancer Res. 89. 1326-1333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Abe S, Hata J, et al.: "Small round-cell type of malignant peripheral nerve sheath tumor"Modern Pathol. 11. 747-753 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sasaki Y, Hata J, et al.: "Abnormalities of basal cell keratin in epidermolysis bullosa simplex do not affect the expression patters of suprabasal"Arch Dermatol Res. 290. 591-597 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki N, Hata J, et al.: "Functional expressions of c-fms and M-CSF during trophoectodermal differentiation of human embryonal carcinoma"Placenta. 20. 203-211 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimada H, Hata J, et al.: "Terminology and morphologic criteria of neuroblastic tumors : Recommendation by the International Neuroblastic Pathology"Cancer. 86. 349-363 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimada H, Hata J, et al.: "Establishments of the International Neuroblastic Pathology Classification"Cancer. 86. 364-372 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada T, Hata J, et al.: "Function of 90kDa heat shock protein in cellular differentiation of human embryonic carcinoma cells"IN Vitro and Developmental Bio. 36. 139-146 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Makino S, Hata J, et al.: "Cardiomyocytes can be generated from marrow stromal cells in vitro"J Clin Invest. 103. 697-705 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukuzawa R, Hata J, et al.: "High frequency of inactivation of the imprinted H19 gene in sporadic hepatoblastoma"Int Nat J Cancer. 82. 490-497 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Matsushita K, Hata J, et al.: "The EAT/mcl-1 gene, an inhibitor of apoptosis, is up-regulated in the early stage of acute myocardial infarction"BBA. 1472. 471-478 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamaoka T, Hata J, et al.: "Apoptosis and remodelling of beta cells by paracrine interferon-g without insulinitis in transgenic mice"Diabetologia. 42. 566-573 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukuchi Y, Hata J, et al.: "Human acute myeloblastic leukemia-ascites model using the human GN-CSF and IL-3 releasing transgenic SCID mice"Ann Hematol. 78. 223-231 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ito S, Hata J, et al.: "Nephrotic syndrome and end-stage renal disease with WT1 mutation detected at 3 years"Pediatric Nephrol. 13. 790-791 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okita H, Hata J, et al.: "Acute myeloid leukemia possessing jumping trnaslocation is related to highly elevated levels of EAT/mcl-1,a Bcl-2 related gene with anti-apoptotic functions"Leukemia Research. 24. 73-77 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki A, Hata J, et al.: "Involvement of EAT mcl1,a bcl-2 related gene in the apoptotic mechanisms underlying human placental development and"Placenta. 21. 177-183 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukushima S, Hata J, et al.: "Augmentation of human leukemic cell invasion by the activation of small GTP-binding protein Rho"Exp. Hematol. 28. 391-400 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takata A, Hata J, et al.: "Consitutional WT1 mutations correlete with clinical features in children with progressive nephropathy"J. Med. Genetics. 37. 698-701 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Zhao C, Hata J, et al.: "Two cases of ectopic hamartomatous thymoma"Verchow Arch. 437. 643-647 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sano M, Hata J, et al.: "Involvement of EAT/mcl-1, an apoptotic bcl-2 related, in murine embryogenesis and human development"J. Exp. Cell Res. 259. 127-139 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kinjo K, Hata J, et al.: "Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice"Leukemia. 14. 431-438 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kameyama K, Hata J, et al.: "Ossifying lipoma independent of bone tissue"ORL. 62. 170-172 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamaoka T, Hata J, et al.: "Diabetes and pancreatic tumors in transgenic mice expressing Pax 6"Diabetologia. 43. 332-339 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshihashi H, Hata J, et al.: "Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome"Amer J Human Genetics. 67. 476-482 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Xin Z, Hata J, et al.: "A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors"J Biochem. 128. 847-853 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamaoka T, Hata J, et al.: "Diabetes and tumor formation in transgenic mice expressing Reg I"BBRC. 278. 368-376 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamazaki Y, Hata J, et al.: "Malignant fibrous histiocytoma preceding medulloblastoma"J Pediatr Hematol Oncol. 22. 480-481 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tachibana M, Hata J, et al.: "Autocrine growth promotion by multiple hematopoietic growth factors in the established renal cell carcinoma line KU-19-20"Cell Tissue Res. 2. 353-367 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wakabayashi K, Hata J, et al.: "Bcl-2 related proteins aredramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this"Oncol Rep. 7. 285-288 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hiraoka, Y., Ogawa, M., Sakai, Y., Taniguchi, K., Fujii, T., Umezawa, A., Hata, J., Aiso, S.: "Isolation and expression of a human of human SRY-related cDNA, hSOX20"BBA. 1396. 132-137 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kikuchi, H., Takada, A., Akasaka, Y., Fukuzawa, R., Yoneyama, H., Kurosawa, Y., Honda, M., Kamiyama, Y., Hata, J.: "Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?"J Med Genetics. 35. 45-48 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okita, H., Umezawa, A., Suzuki, A., Hata, J.: "Up-regulated expression of murine Mcl1/EAT, a Bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells"BBA. 1398. 335-341 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishida, S., Yoshida, K., Kaneko, Y., Tanaka, Y., Sasaki, Y., Urano, F., Umezawa, A., Hata, J., Fujinaga, K.: "The genomic breakpoint and chimeric transcripts in the EWS-E1AF gene fusion of Ewing's sarcoma"Cytogenet Cell Genet. 82. 278-283 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Urano, F., Umezawa, A., Yabe, H., Hong, W., Yoshida, K., Fujinaga, K., Hata, J.: "Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for use in diagnosis"Jpn J Cancer Res. 89. 703-711 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Otsuki, T., Furuya, S., Yamada, T., Nomura, S., Hata, J., Yabe, Y., Hosoda, Y.: "Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse"Calcif. Tissue Int.. 63. 167-172 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ando, T., Umezawa, A., Suzuki, A., Okita, H., Sano, M., Hiraoka, Y., Aiso, S., Saruta, T., Hata, J.: "EAT/mcl-1, a Member of the bcl-2 Related Genes, Confers Resistance to Apoptosis Induced by cis-Diamine Dichloroplatinum (II) in Mouse p53-Deficient Fibroblast Cells"Jpn J Cancer Res. 89. 1326-1333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Abe, S., Imamura, T., Park, P., Nakano, H., Okita, H., Hata, J., Tateishi, A.: "Small round-cell type of malignant peripheral nerve sheath tumor"Modern Pathol. 11. 747-753 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sasaki, Y., Shimizu, H., Akiyama, M., Yoneda, K., Ishida-Yamamoto, A., Watanabe, S., Hata, J., Nishikawa, T.: "Abnormalities of basal cell keratin in epidermolysis bullosa simplex do not affect the expression patters of suprabasal keratins and cornified cell envelop proteins"Arch Dermatol Res. 290. 591-597 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki, N., Yamada, T., Matsuoka, K., Hiraoka, N., Iwamaru, Y., Hata, J.: "Functional expressions of c-fms and M-CSF during trophoectodermal differentiation of human embryonal carcinoma cell"Placenta. 20. 203-211 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimada, H., Ambros, I., Dehner, L.P., Hata, J., Joshi, V.V., Roald, B.: "Terminology and morphologic criteria of neuroblastic tumors: Recommendation by the International Neuroblastic Pathology Committee"Cancer. 86. 349-363 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimada, H., Ambros, I., Dehner, L.P., Hata, J., Joshi, V.V., Roald, B.: "Establishments of the International Neuroblastic Pathology Classification"Cincer. 86. 364-372 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada, T., Hashiguchi, A., Nakamura, A., Kuwahara, M., Kobayashi, S., Kakita, Y., Maruyama, T., Umezawa, A., Hata, J.: "Function of 90kDa heat shock protein in cellular differentiation of human embryonic carcinoma cells"IN Vitro and Developmental Bio. 36. 139-146 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Makino, S., Fukuda, K., Miyoshi, S., Konishi, F., Kdama, H., Pan, J., Ano, M., Takahashi, T., Ori, S., Abe, H., Hata, J., Umezawa, A., Ogawa, S.: "Cardiomyocytes can be generated from marrow stromal cells in vitro"J Clin Invest. 103. 697-705 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukuzawa, R., Umezawa, A., Ochi, K., Ikeda, H., Hata, J.: "High frequency of inactivation of the imprinted H19 gene in sporadic hepatoblastoma"Int Nat J Cancer 82. 82. 490-497 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Matsushita, K., Umezawa, A., Iwanaga, S., Oda, T., Okita, H., Kimura, K., Simoda, M., Tanaka, M., Sano, M., Ogawa, Hata, J.: "The EAT/mcl-1 gene, an inhibitor of apoptosis, is up-regulated in the early stage of acute myocardial infarction"BBA. 1472. 471-478 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamaoka, T., Yano, M., Idehara, C., Yamada,T., Tomonari, S., Moritani, M., Ii, S., Yoshimotro, K., Hata, J., Itakura, M.: "Apoptosis and remodelling of beta cells by paracrine interferon-g without insulinitis in transgenic mice"Diabetologia. 42. 566-573 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukuchi, Y., Miyakawa, Y,, Kizaki, M., Umezawa, A., Shimamura, K., Kobayashi, K., Kuramochi, T., Hata, J., Ikeda, Y., Tamaoki, N., Nomura, T., Ueyama, Y., Ito, M.: "Human acute myeloblastic leukemia-ascites model using the human GN-CSF and IL-3 releasing transgenic SCID mice"Ann Hematol. 78. 223-231 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ito, S., Ikeda, M, Takata, A, Kikuchi, H, Hata, J, Honda, M: "Nephrotic syndrome and end-stage renal disease with WT1 mutation detected at 3 years"Pediatric Nephrol. 13. 790-791 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okita, H., Umezawa, A., Fukuma, M., Ando, T., Urano, F., Sano, M., Nakata, Y., Mori, T., Hata, J.: "Acute myeloid leukemia possessing jumping trnaslocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions"Leukemia Research. 24. 73-77 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzuki, A., Umezawa, A, Sano, M, Nozawa, S, Hata, J: "Involvement of EAT mcl1, a bcl-2 related gene, in the apoptotic mechanisms underlying human placental development and maintenance"Placenta. 21. 177-183 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukushima, S., Yamada, T., Hata, J.: "Augmentation of human leukemia cell invasion by the activation of small GTP-binding protein"Rho. Exp. Hematol.. 28. 391-400 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takata, A., Kikuchi, H., Fukuzawa, R., Ito, S., Honda, M., Hata, J.: "Consitutional WT1 mutations correlate with clinical features in children with progressive nephropathy"J. Med. Genetics. 37. 698-701 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Zhao, C., Yamada, T., Kuramochi, S., Yamazaki, K., Mukai, M., Kameyama, K., Hata, J.: "Two cases of ectopic hamartomatous thymoma"Virchow Arch. 437. 643-647 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sano, Umezawa, Suzuki, A., Shimoda, K., Hata, J.: "Involvement of EAT/mcl-1, an apoptotic bcl-2 related, in murine embryogenesis and human development"J. Exp. Cell Res. 259. 127-139 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kinjo, K, Kaizaki, M, Muto, A, Fukuchi, Y, Umezawa, A, Yamato, K, Nishihara, T, Hata, J, Ito, M, Ueyama, Y, Ikeda, Y: "Arsenic trioxide (As203)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice"Leukemia. 14. 431-438 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kameyama, K., Akasaka, Y., Miyazaki, H., Hata, J.: "Ossifying lipoma independent of bone tissue"ORL. 62. 170-172 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamaoka, T, Yano, M, Yamada, T, Matsushita, T, Motitani, M, Li, S, Yoshimoto, K, Hata, J, Itakura, M: "Diabetes and pancreatic tumors in transgenic mice expressing Pax 6"Diabetologia. 43. 332-339 (2000)

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  • [Publications] Yoshihashi, H., Maeyama, K., Kosaki, R., Ogata, T., Tsukahara, M., Goto, Y., Hata, J., Matsuo, N., Smith, RJ, Kosaki, K: "Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome"Amer J Human Genetics. 67. 476-482 (2000)

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  • [Publications] Xin, Z., Soejima, H., Higashimoto, K., Yatsuki, H., Zhu, X., Satoh, Y., Masaki, Z., Kaneko, Y., Jinno, Y., Fukuzawa, R., Hata, J., Mukai, T.: "A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors"J Biochem. 128. 847-853 (2000)

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  • [Publications] Yamaoka T, Yoshino K, Yamada T, Idehara C, Hoque MO, Moritani M, Yoshimoto K, Hata J, Itakura M: "Diabetes and tumor formation in transgenic mice expressing Reg I"BBRC. 278. 368-376 (2000)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Yamazaki Y, Sugita K, Kurosawa H, Ozawa T, Eguchi M, Wakai S, Hata J: "Malignant fibrous histiocytoma preceding medulloblastoma"J Pediatr Hematol Oncol. 22. 480-481 (2000)

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  • [Publications] Tachibana M, Miyakawa A, Nakashima J, Murai M, Nakamura K, Kubo A, Hata J.: "Autocrine growth promotion by multiple hematopoietic growth factors in the established renal cell carcinoma line KU-19-20"Cell Tissue Res.. 2. 353-367 (2000)

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  • [Publications] Wakabayashi K, Saito H, Ebinuma H, Saito Y, Takagi T, Nakamura M, Umezawa A, Hata J, Ishii H.: "Bcl-2 related proteins aredramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period"Oncol Rep. 7. 285-288 (2000)

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  • [Publications] Okita,H.,Hata,J.: "Acute myeloid leukemia possessing jumping trnaslocationis related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions."Leukemia Research. 24. 73-77 (2000)

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  • [Publications] Takata,A.,Hata,J.. et al: "Constitutional WT1 mutations correlate with clinical features in children with progressive nephropathy."J.Med.Genetics. 37. 698-701 (2000)

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  • [Publications] Fukuzawa,R.: "High frequency of inactivation of the imprinted H19 gene in sporadic hepatoblastoma"Int Natle J Cancer. 82. 490-497 (1999)

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  • [Publications] Okita,H.: "Acute myeloid leukemia possessing jumping trnaslocation isrelated to highly elevated levels of EAT/mcl-1,a Bcl-2 relalted gene with antiapoptotic functions"Leukemia Research. (in press).

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  • [Publications] Ito,S.: "Nephrotic syndrome and end-stage renal disease with WT1 mutation detected at 3 years"Pediatr Nephrol. 13. 790-791 (1999)

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  • [Publications] Suzuki,A.: "Involvement of EATmcl1,a bcl-2 related gene,in thte apoptotic mechanisms underlying human placental development and maintenance"Placenta. 21. (2000)

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  • [Publications] Fukushima,S.: "Augmentation of human leukemic cell invasion by the activation of small GTP-binding protein Rho"Expt Hematol. (in press). (2000)

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  • [Publications] Yamada,T.: "Function of 90kDa heat shock pretein in cellular differentiation of human embryonic carcinoma cells"IN Vitro and Developmental Biol,. (in press). (2000)

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  • [Publications] Ando,T.,Hata,J.,et al: "EAT/mcl-1,a Member of the bcl-2 Related Genes,Confers Resistance to Apoptosis Induced by cis-Diamine Dichloroplatinum(II)in Mouse p53-Deficient" Jpn J Cancer Res. 89. 1326-1333 (1998)

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  • [Publications] Kikuchi,H.,Hata,J.,et al: "Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?" J Med Genetics. 35. 45-48 (1998)

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  • [Publications] Urano,F.,Hata,J.,et al: "Molecular analysis of Ewing's sarcoma : another fusion gene,EWS-E1AF available for use in dagnosis" Jpn J Cancer Res. 89. 703-711 (1998)

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  • [Publications] Ishida,S.,Hata,J.,et al: "The genomic breakpoint and chimeric transcripts in the EWS-E1AF gene fusion of Ewing's sarcoma" Cytogenet Cell Genet. 82. 278-283 (1998)

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Published: 1998-04-01   Modified: 2016-04-21  

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