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Development of hypoallergic food by ADF/Thioredoxin and its possible therapeutic implication for food allergy

Research Project

Project/Area Number 10357007
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Pediatrics
Research InstitutionFukui Medical University

Principal Investigator

MAYUMI Mitsufumi  Fukui Medical Univ.Dept.of Pediatrics, Professor, 医学部, 教授 (70135581)

Co-Investigator(Kenkyū-buntansha) MATSUO Yushi  Oriental Yeast Co.Nagahama Research Institute, Director, バイオ部, 取締役(研究職)
YODOI Junji  Kyoto Univ.Institute for Virus Research, Professor, ウイルス研究所, 教授 (80108993)
KATAMURA Kenji  Kyoto Univ.Graduate School of Medicine, Dept.of Pediatrics, Lecturer, 医学研究科, 講師 (40185806)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥24,900,000 (Direct Cost: ¥24,900,000)
Fiscal Year 2000: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1999: ¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 1998: ¥11,200,000 (Direct Cost: ¥11,200,000)
Keywordsfood allergy / egg allergy / hypoallergic food / ADF / thioredoxin / tolerance / regulation / レドックス制御
Research Abstract

In order to provide eatable eggs for egg allergy patients and a therapeutic tool for tolerance induction in them, we examined whether or not ADF/Thioredoxin(TRX)could reduce the antigenic activity of ovalbumin(OVA)and ovomucoid(OM), two major antigens of eggs which is the most common food allergen in childhood. TRX can successfully reduce the intramolecular disulfide bonds in OVA and OVM, and make them susceptible to the treatment with digestive enzymes such as pepsin and trypsin and heat. OVA and OM treated with TRX and the digestive enzymes or heat showed a hundred times decrease in the binding activity to specific IgE antibodies, showing that TRX is useful to make hypoallergic egg allergens.
To examine whether or not the TRX-treated hypoallergic eggs are useful for early intervention of food allergy through induction of oral tolerance, we established a mouse model in which eczema and OVA specific IgE were induced by skin sensitization with OVA.We found that oral administration of OVA to the mouse induced an oral tolerance ; a decrease in anti-OVA IgE level and antigen-specific IL-4 and IFN-γ secretion. We are going to examine the effect of the hypoallergic OVA on the induction of oral tolerance by using the mouse model.
We also found the followings ; TRX plays a role in signal transduction for apoptosis through maintaining the caspase 3 activity, TRX activates transcriprional factor p53 in combination with Ref-1, TRX inhibits the extravasation of granulocytes, geranylgeranylacetone enhances expression and secretion of TRX, and Thioredoxin-binding protein 2/Vitamin D3-upregulated protein-1(TBP-2/VDUP-1)is an inhibitor of TRX.All these data provide the basis for application of TRX for the treatment of allergic diseases.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (211 results)

All Other

All Publications (211 results)

  • [Publications] H.Ueno et al.: "ZAP-70 is required for calcium mobilization but is dispensable for mitogen-activated protein kinase(MAPK)superfamily activation induced via CD2 in human T cells."Eur.J.Immunol.. 30. 78-86 (2000)

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  • [Publications] H.Tsukahara et al.: "Methylenetetrahydrofolate reductase polymorphismin Kawasaki disease."Pediatr.Int.. 42. 236-240 (2000)

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  • [Publications] H.Tsukahara et al.: "Increased oxidative stress in rats with chronic nitric oxide depletion : measurement of urinary 8-hydroxy-2'-deoxyguanosine excretion."Redox rep.. 5・1. 23-28 (2000)

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  • [Publications] H.Tsukahara et al.: "Role of nitric oxide in human pulmonary micro vascular endothelial adhesion."Life Sci.. 67. 1-11 (2000)

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  • [Publications] H.Tsukahara et al.: "Endogenous nitric oxide formation in term and preterm newborns."発達腎研究会誌. 8・1. 15-19 (2000)

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  • [Publications] K.Katamura et al.: "Regulation of CD31 expression and IL-4 production by naive human cord blood CD4+ T cells with IL-4 and IL-7."Pediatr.Int.. 42. 126-133 (2000)

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  • [Publications] K.Okazaki et al.: "Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2 type cellular immune response."Gastroenterol.. 118. 573-581 (2000)

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  • [Publications] N.Isowa et al.: "Human thioredoxin attenuates hypoxia-reoxygenation injury of murine endothelial cells in a thiol-free condition."J.Cell Physiol.. 182. 33-40 (2000)

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  • [Publications] K.Shioji et al.: "Upregulation of thioredoxin expression in giant cell myocarditis in rats."FEBS Lett.. 472. 109-113 (2000)

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  • [Publications] Y.Sumita et al.: "Serumthioredoxin levels as indicators of oxidative stress and responses to interferon therapy in patients with hepatitis C virus infection."J.Hepatol.. 33. 616-622 (2000)

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  • [Publications] K.Hirota et al.: "Geranylgeranylacetone induces thioredoxin and suppresses ethanol-induced injury in cultured hepatocytes."Biophys.Biochem.Res.Commun.. 275. 825-830 (2000)

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  • [Publications] Y.Takagi et al.: "Excitotoxic hippocampal injury is attenuated in thioredoxin transgenic mice."J.Cereb.Blood Flow Metab.. 20. 829-833 (2000)

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  • [Publications] T.Koura et al.: "Expression of thioredoxin in granulomas of sarcoidosis : possible role in the development of T lymphocyte activation."Thorax.. 55. 755-761 (2000)

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  • [Publications] H.Shibuki et al.: "Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury."Invest.Ophthalmol.Vis.Sci.. 41. 3607-3614 (2000)

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  • [Publications] S.J.Wei et al.: "Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation."Cancer Res.. 60. 6688-6695 (2000)

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  • [Publications] M.Ueno et al.: "Possible association of thioredoxin and p53 in breast cancer."Immunol.Lett.. 75. 15-20 (2000)

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  • [Publications] M.Kobayashi et al.: "Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses."Antiox.Redox Singal.. (発表予定).

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  • [Publications] A.Abdiu et al.: "Thioredoxin blood level increase after severe burn injury."Antiox.Redox Singal.. (発表予定).

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  • [Publications] T.Sasada et al.: "Secretion of Thioredoxin Enhances Cellular Resistance to cis-Diamminedichloroplatinum(II)"Antiox.Redox Singal.. (発表予定).

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  • [Publications] T.Nakashima et al.: "Thioredoxin levels in the sera of untreated hepatitis patients and those treated with glycyrrhizin or ursodeoxycholic acid."Antiox.Redox Singal.. (発表予定).

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  • [Publications] J.Yarimizu et al.: "Efficiency of selenocysteine incorporation in human thioredoxin reductase."Antiox.Redox Singal.. (発表予定).

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  • [Publications] M.Ueno et al.: "TRX superfamily and p53 against oxidative stresses."Recent Research Developments in Immunpology.. (発表予定).

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  • [Publications] T.Tanaka et al.: "Redox regulation by thioredoxin superfamily ; protection against oxidative stress and aging."Free Radic.Res.. (発表予定).

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  • [Publications] H.Dekigai et al.: "Geranylgeranylacetone promotes inductionand secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes."Free Radic.Res.. (発表予定).

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  • [Publications] H.Nakamura et al.: "Chronic elevation of plasma thioredoxin : inhibition of chemotaxis and curtailment of life expectancy in AIDS."Proc.Natl.Acad.Sci.USA. (発表予定).

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  • [Publications] Y.Matsuo et al.: "Cloning and characterization of a novel thioredoxin-related transmembrane protein."J.Biol.Chem.. (発表予定).

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  • [Publications] 眞弓光文: "食物アレルギーとアトピー性疾患"兵庫県医師会医学雑誌. 43・1. 16-19 (2000)

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  • [Publications] 大嶋勇成 他: "食物アレルギーの免疫療法の展望"小児科臨床. 53・4. 617-621 (2000)

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  • [Publications] 大嶋勇成 他: "DCとOX40/OX40L"Surgery Frontier. 7・2. 191-194 (2000)

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  • [Publications] 大嶋勇成 他: "アレルギー性疾患の発症前診断-出生前診断の必要性と可能性-"喘息. 13・3. 21-26 (2000)

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  • [Publications] 中村肇 他: "第2章 レドックス制御機構:チオレドキシンスーパーファミリーの視点から"バイオサイエンスの新世紀 酸化ストレス・レドックスの生化学. 5. 12-27 (2000)

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  • [Publications] 眞弓光文: "アトピー性疾患.特集・小児における現代病の対策と治療"医薬ジャーナル. 36・12. 3338-3341 (2000)

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  • [Publications] 藤沢和郎 他: "母親が使用した塩化リゾチーム外用剤により卵白アレルギー反応を呈した乳児例"アレルギーの臨床. 258. 68-70 (2000)

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  • [Publications] 中村肇 他: "金属代謝と生体応答-レドックス制御を中心に"肝胆膵. 41. 315-322 (2000)

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  • [Publications] M.Ueno et al.: "Thioredoxin-dependent redox regulation of p53-mediated p21 activation."J.Biol.Chem.. 274. 35809-35815 (1999)

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  • [Publications] T.Sugino et al.: "Expression and distribution of redox regulatory protein, thioredoxin after metabolic impairment by 3-nitropropionic acid in rat brain."Neurosci.Lett.. 275. 145-148 (1999)

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  • [Publications] S.Hashimoto et al.: "Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha."Biochem.Biophys.Res.Commun.. 258. 443-447 (1999)

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  • [Publications] M.Ema et al.: "Molecular mechanisms of transcription activation by HLF and HIF 1 alpha in responset hypoxia : their stabilization and redox signal-induced interaction with CBP/p300."EMBO J.. 18. 1905-1914 (1999)

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  • [Publications] A.Nishiyama et al.: "Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression."J.Biol.Chem 274 : 21645-21650, 1999.. 274. 21645-21650 (1999)

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  • [Publications] Y.Makino et al.: "Direct association with thioredoxin allows redoxregulation of glucocorticoid receptor function."J.Biol.Chem. 274. 3182-3188 (1999)

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  • [Publications] Y.Takagi et al.: "Localization of glutaredoxin(thioltransferase)in the rat brain and possible functional implications during focal ischemia."Biochem.Biophys.Res.Commun.. 258. 390-394 (1999)

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  • [Publications] A.Nishiyama et al.: "Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system."Immunol.Lett.. 68. 155-159 (1999)

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  • [Publications] R.Bertini et al.: "Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells."J.Exp.Med.. 189. 1783-1789 (1999)

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  • [Publications] T.Maruyama et al.: "Activation of c-Src kinase is associated with in vitro decidualization of human endometrial stromal cells."Endocrinology. 140. 2632-2636 (1999)

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  • [Publications] Y.Takagi et al.: "Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage."Proc.Natl.Acad.Sci.U.S.A.. 96. 4131-4136 (1999)

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  • [Publications] T.Nakamura et al.: "Mouse glutaredoxin cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2."Free Radic.Res.. 31. 357-365 (1999)

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  • [Publications] Y.Takashima et al.: "Differential expression of glutaredoxin and thioredoxin during monocytic differentiation."Immunol.Lett.. 68. 397-401 (1999)

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  • [Publications] K.Hirota et al.: "Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanis of redoxregulation of transcription factor NF-kB."J.Biol.Chem.. 274. 27891-27897 (1999)

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  • [Publications] T.Kiyomasu et al.: "Hypomethylation of the proximal and intronic regulatory regions of the IFN-g gene is not essential for its transcription by naive CD4+T cells cultured with IL-4."Immunol.Lett.. 69. 239-245 (1999)

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  • [Publications] K.Katamura.: "Differentiation of naive human CD4+ T cells into Th2 cells. The role of prostaglandin E2"Allergol.Int.. 48. 7-14 (1999)

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  • [Publications] K.Katamura et al.: "Existence of activated and memory CD4^+ T cells in peripheral blood and their skin infiltration in CD8 deficiency."Clin.Exp.Immunol.. 115. 124-130 (1999)

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  • [Publications] H.Nakamura et al.: "Redox regulation by thioredoxin in host defense."Current Trends in Immunology. 1. 133-140 (1998)

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  • [Publications] S.Ueda et al.: "Redox Regulation of Caspase-3(like)Protease Activity : Regulatory Roles of Thioredoxin and Cytochrome c."J.Immunol.. 161. 6689-6695 (1998)

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  • [Publications] K.Katamura et al.: "IL-4 and Prostaglandin E2 inhibit hypomethylation of the 5' regulatory region ofIFN-gene during differentiation of naive CD4^+ T cells."Mol.Immunol.. 35. 39-45 (1998)

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  • [Publications] M.Mayumi et al.: "Development of antigen-specific IgE antibodies in atopic and non-atopic infannts : Diagnostic value of low levels of IgE against egg white in infants with atopic dermatitis."Allergol.Int.. 47. 129-136 (1998)

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  • [Publications] H.Nakamura et al.: "Thioredoxin-dependent redox regulation in biological responses. In Free Radicals in Chemistry, Biology and Medicine(分担執筆)"T.Yoshikawa, S.Toyokuni, Y.Yamamoto, Y.Naito(eds.), OICA Intemational, London. 126-133 (2000)

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  • [Publications] 大嶋勇成 他: "食物アレルギーによる皮膚症状.皮膚科診療プラクティス9 やさしい小児皮膚科学(分担執筆)"斉藤隆三、宮地良樹、瀧川雅浩編集.文光堂. 44-48 (2000)

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  • [Publications] 眞弓光文: "アレルギー疾患.標準小児科学第4版(分担執筆)"前川喜平、辻芳郎監修.医学書院. 259-267 (2000)

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  • [Publications] 眞弓光文: "食物と小児皮膚疾患.食物アレルギー、食物制限と栄養、給食など.小児の皮膚疾患生活指導マニュアル(分担執筆)"宮地良樹、森川昭廣編集.診断と治療社. 24-29 (2000)

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  • [Publications] 眞弓光文: "食物アレルギーのメカニズム.食物アレルギー.アトピー性皮膚炎コンセンサスアップデイト(分担執筆)"宮地良樹、永倉俊和編集、メディカルレビュー社. 123-130 (2000)

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  • [Publications] H.Masutani et al.: "Redox regulation of gene expression and transcription factors in ersponse to environmenta oxidants. In Environmental stressors : Effects on Lung, Skin, Eye and Immune System Function(分担執筆)"J.Fuchs and L.Packer(eds.). Marcel Dekker Inc.New York (発表予定).

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  • [Publications] H.Masutani et al.: "Role of thioredoxin family in the redox regulation of oxidative stress response and signalling. In Antioxidant and Redoxregulation of genes.(分担執筆)"C.Sen, H.Sies and P.Baeurele(eds), Academic press,. 297-310 (1999)

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  • [Publications] S.Kumagai et al.: "Thioredoxin/ADF(adult T cell leukemia-derived factor)as an indicator of oxidative stress. In XX World Congress of Pathology and Laboratory medicine.(分担執筆)"E.Melo, M.Editore(eds), Bologna,. 101-106 (1999)

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  • [Publications] A.Nishiyama et al.: "Detection of a Nuclear 60-kDa protein coimmunoprecipitated with human thioredoxin. In Oxygen Homeostasis and Its Dynamics.(分担執筆)"Y.Ishimura, H.Shimada, M.Suematsu(eds). Springer-Verlag Tokyo, Tokyo,. 464-468 (1998)

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  • [Publications] T.Ohno et al.: "Thioredoxin and its involvement in the redox regulation of transcription factors, NF-kB and AP-1. In Oxygen Homeostasis and Its Dynamics.(分担執筆)"Y.Ishimura, H.Shimada M.Suematsu(eds). Springer-Verlag Tokyo,Tokyo. 450-456 (1998)

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  • [Publications] J.Yodoi et al.: "Thioredoxin/adult T cell leukemia-derived factor as the key redox regulator of signaling. In Oxidative Stress, Cencer, AIDS and Neurodegenerative Diseases.(分担執筆)"Montagnier, Olivier, Pasquier(eds). Marcel Dekker Inc., New York. 247-250 (1998)

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  • [Publications] M.mayumi et al.: "Development of antigen-specific IgE antibodies in atopic and non-atopic infannts : Diagnostic value of low levels of IgE against egge white in infants with atopic dermatitis."Allergol.Int.. 47. 129-136 (1998)

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      「研究成果報告書概要(欧文)」より
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      2000 Final Research Report Summary
  • [Publications] K.katamura et al.: "IL-4 and Prostaglandin E2 inhibit hypomethylation of the 5' regulatory region of IFN-γ gene during differentiation of naive CD^+T cells."Mol.Immunol.. 35. 39-45 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Ueda et al.: "Redox Regulation of Caspase-3(-like)Protease Activity : Regulatory Roles of Thioredoxin and Cytochrome c."J.Immunol.. 161. 6689-6695 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Yodoi et al.: "Thioredoxin/adult T cell leukemia-derived factor as the key redox regulator of signaling."Oxidative Stress, Cancer, AIDS and Neurodegenerative Diseases. Montagnier, Olivier, Pasquier(eds). Marcel Dekker Inc., New York. 247-250 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Ohno et al.: "Thioredoxin and its involvement in the redox regulation of transcription factors, NF-kB and AP-1."Oxygen Homeostasis and Its Dynamics. Y.Ishimura, H.Shimada, M.Suematsu(eds). Springer-Verlag Tokyo, Tokyo. 450-456 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Nishiyama et al.: "Detection of a Nuclear 60-kDa protein coimmunoprecipitated with human thioredoxin."Oxygen Homeostasis and Its Dynamics. Y.Ishimura, H.Shimada, M.Suematsu(eds). Springer-Verlag Tokyo, Tokyo. 464-468 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Nakamura, J.Yodoi: "Redox regulation by thioredoxin in host defense."Current Trends in Immunology. 1. 133-140 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Katamura et al.: "Existence of activated and memory CD4^+ T cells in peripheral blood and their skin infiltration in CD8 deficiency."Clin.Exp.Immunol.. 115. 124-130 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Katamura: "Differentiation of naive human CD4+ T cells into Th2 cells. The role of prostaglandin E2."Allergol.Int.. 48. 7-14 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Kiyomasu et al.: "Hypomethylation of the proximal and intronic regulatory regions of the IFN-γ gene is not essential for its transcription by naive CD4+ T cells cultured with IL-4."Immunol.Lett.. 69. 239-245 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Hirota et al.: "Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kB."J.Biol.Chem.. 274. 27891-27897 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Takashima et al.: "Differential expression of glutaredoxin and thioredoxin during monocytic differentiation."Immunol.Lett.. 68. 397-401 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakamura et al.: "Mouse glutaredoxin cDNA cloning , high level expression in E.coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2."Free Radic.Res.. 31. 357-365 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Takagi et al.: "Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage."Proc.natl.Acad.Sci.U.S.A.. 96. 4131-4136 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Maruyama et al.: "Activation of c-Src kinase is associated with in vitro decidualization of human endometrial stromal cells."Endocrinology. 140. 2632-2636 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] R.Bertini et al.: "Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells."J.Exp.Med.. 189. 1783-1789 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Nishiyama et al.: "Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system."Immunol.Lett.. 68. 155-159 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Takagi et al.: "Localization of glutaredoxin(thioltransferase)in the rat brain and possible functional implications during focal ischemia."Biochem.Biophys.Res.Commun.. 258. 390-394 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Makino et al.: "Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function."J.Biol.Chem.. 274. 3182-3188 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Nishiyama et al.: "Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression."J.Biol.Chem.. 274. 21645-21650 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ema etal.: "Molecular mechanisms of transcription activation by HLF and HIFl alpha in response to hypoxia : their stabilization and redox signal-induced interaction with CBP/p300."EMBOJ. 18. 1905-1914 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Hashimoto et al.: "Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha."Biochem.Biophys.Res.Commun.. 258. 443-447 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Sugino et al.: "Expression and distribution of redox regulatory protein, thioredoxin after metabolic impairment by 3-nitropropionic acid in rat brain."Neurosci.Lett.. 275. 145-148 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ueno et al.: "Thioredoxin-dependent redox regulation of p53-mediated p21 activation."J.Biol.Chem.. 274. 35809-35815 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Kumagai et al.: "Thioredoxin/ADF(adult T cell leukemia-derived factor)as an indicator of oxidative stress."XX World Congress of Pathology and Laboratory medicine. E.Melo, M.Editore(eds), Bologna. 101-106 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Masutani et al.: "Role of thioredoxin family in the redox regulation of oxidative stress response and signalling."Antioxidant and Redox regulation of genes.C.Sen, H.Sies and P.Baeurele(eds), Academic press. 297-310 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukahara et al.: "Increased oxidative stress in rats with chronic nitric oxide depletion : measurement of urinary 8-hydroxy-2'-deoxyguanosine excretion."Redox rep.. 5(1). 23-28 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukahara et al.: "Role of nitric oxide in human pulmonary microvascular endothelial cell adhesion."Life Sci.. 67. 1-11 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Katamura et al.: "Regulation of CD31 expression and IL-4 production by naive human cord blood CD4+ T cells with IL-4 and IL-7."Pediatr.Int.. 42. 126-133 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Isowa et al.: "Human thioredoxin attenuates hypoxia-reoxygenation injury of murine endothelial cells in a thiol-free condition."J.Cell Physiol. 182. 33-40 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SJ.Wei et al.: "Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation."Cancer Res.. 60. 6688-95 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Kobayashi et al.: "Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses."Antiox.Redox Singal. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Abdiu et al.: "Thioredoxin blood level increase after severe burn injury."Antiox.Redox Singal. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Sasada et al.: "Secretion of Thioredoxin Enhances Cellular Resistance to cis-Diamminedichloroplatinum(II)."Antiox.Redox Singal. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Yarimizu et al.: "Efficiency of selenocysteine incorporation in human thioredoxin reductase."Antiox.Redox Singal. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Ueno et al.: "TRX superfamily and p53 against oxidative stresses."Recent Research Developments in Immunpology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Tanaka et al.: "Redox regulation by thioredoxin superfamily ; protection against oxidative stress and aging."Free Radic Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Dekigai et al.: "Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes."Free Radic Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Nakamura et al.: "Chronic elevation of plasma thioredoxin : inhibition of chemotaxis and curtailment of life expectancy in AIDS."Proc.Natl.Acad.Sci.USA. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Matsuo et al.: "Cloning and characterization of a novel thioredoxin-related transmembrane protein."J.Biol.Chem.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Nakamura et al.: "Thioredoxin-dependent redox regulation in Biological responses."Free Radicals in Chemistry, biology and Medicine. Yoshikawa T, Toyokuni S, Yamamoto Y, Naito Y(eds), OICA International, London. 172-181 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nishinaka et al.: "Redox Control of Cellular Function by Thioredoxin ; New Therapeutic Direction in Host Defence."Archivum Immunologiae and Therapeutiae experimentalis. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Masutani et al.: "Redox regulation of gene expression and transcription factors in response to environmental oxidants."Environmental stressors : Effects on Lung, Skin, Eye and Immune System Function. J.Fuchs, L.Packer(eds), Marcel Dekker Inc.New York. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Ueno et al.: "ZAP-70 is required for calcium mobilization but is dispensable for mitogen-activated protein kinase(MAPK)superfamily activation induced via CD2 in human T cells."Eur.J.Immunol.. 30. 78-86 (2000)

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      2000 Annual Research Report
  • [Publications] H.Tsukahara et al.: "Methylenetetrahy drofolate reductase polymorphismin Kawasaki disease."Pediatr.Int.. 42. 236-240 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Tsukahara et al.: "Increased oxidative stress in rats with chronic nitric oxide depletion : measurement of urinary 8-hydroxy-2'-deoxyguanosine excretion."Redox rep.. 5・1. 23-28 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Tsukahara et al.: "Role ofnitric oxide in human pulmonary microvascular end othelial cell adhesion."Life Sci.. 67. 1-11 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Tsukahara et al.: "Endogenous nitric oxide formation in term and preterm newborns."発達腎研究会誌. 8・1. 15-19 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Katamura et al.: "Regulation of CD31 expression and IL-4 production by naive human cord blood CD4+ T cells with IL-4 and IL-7."Pediatr.Int.. 42. 126-133 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Koura et al.: "Expression of thioredoxin in granulomas of sarcoidosis : possible role in the development of Tlymphocyte activation."Thorax.. 55. 755-761 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Shibuki et al.: "Lipid peroxidation and peroxynitrite in retinal is chemia-reperfusion injury."Invest.Ophthalmol.Vis.Sci.. 41. 3607-3614 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.J.Wei et al.: "Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation."Cancer Res.. 60. 6688-6695 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Ueno et al.: "Possible association of thioredoxin and p53 in breast cancer."Immunol.Lett.. 75. 15-20 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Kobayashi et al.: "Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses."Antiox.Redox Singal. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] A.Abdiu et al.: "Thioredoxin blood level increase after severe burn injury."Antiox.Redox Singal.. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Okazaki et al.: "Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2 type cellular immune response."Gastroenterol.. 118. 573-581 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Isowa et al.: "Human thioredoxin attenuates hypoxia-reoxy genation injury of murine endothelial cells in a thiol-free condition."J.Cell Physiol.. 182. 33-40 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Shioji et al.: "Upregulation of thioredoxin expression in giant cell myocarditis in rats."FEBS Lett.. 472. 109-113 (2000)

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      2000 Annual Research Report
  • [Publications] Y.Sumita et al.: "Serum thioredoxin levels as indicators of oxidative stress and responses to interferon therapy in patients with hepatitis C virus infection."J.Hepatol.. 33. 616-622 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Hirota et al.: "Geranylgeranylacetone induces thioredoxin and suppresses ethanol-induced injury in cultured hepatocytes."Biophys.Biochem.Res.Commun.. 275. 825-830 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Takagi et al.: "Excitotoxic hippocampal injury is attenuated in thioredoxin transgenic mice."J.Cereb.Blood Flow Metab.. 20. 829-833 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Nakamura et al.: "Chronic elevation of plasma thioredoxin : inhibition of chemotaxis and curtailment ofli expectancy in AIDS."Proc.Natl.Acad.Sci.USA (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Matsuo et al.: "Cloning and characterization of a novel thioredoxin-related transmembrane protein. "J.Biol.Chem. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] 眞弓光文: "食物アレルギーとアトピー性疾患"兵庫県医師会医学雑誌. 43・1. 16-19 (2000)

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      2000 Annual Research Report
  • [Publications] 大嶋勇成 他: "食物アレルギーの免疫療法の展望"小児科臨床. 53・4. 617-621 (2000)

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  • [Publications] 大嶋勇成 他: "DCとOX40/OX40L"Surgery Frontier. 7・2. 191-194 (2000)

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      2000 Annual Research Report
  • [Publications] 大嶋勇成 他: "アレルギー性疾患の発症前診断-出生前診断の必要性と可能性-"喘息. 13・3. 21-26 (2000)

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      2000 Annual Research Report
  • [Publications] T.Sasada et al.: "Secretion of Thioredoxin Enhances Cellular Resistance to cis-Diamminedichloroplatinum(II)"Antiox.Redox Singal.. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Nakashima et al.: "Thioredoxin levels in the sera of untreated hepatitis patients and those treated with glycyrrhizin or ursodeoxycholic acid."Antiox.Redox Singal.. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] J.Yarimizu et al.: "Efficiency of selenocysteine incorporation in human thioredoxin reductase."Antiox.Redox Singal.. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Ueno et al.: "TRX superfamily and p53 against oxidative stresses."Recent Research Developments in Immunpology.. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Tanaka et al.: "Redox regulation by thioredoxin superfamily ; protection against oxidative stress and aging."Free Radic.Res.. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Dekigai et al.: "Geranylgeranylacetone promotes inductionand secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes."Free Radic.Res.. (発表予定).

    • Related Report
      2000 Annual Research Report
  • [Publications] 中村肇 他: "第2章 レドックス制御機構:チオレドキシンスーパーファミリーの視点から"バイオサイエンスの新世紀 酸化ストレス・レドックスの生化学. 5. 12-27 (2000)

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      2000 Annual Research Report
  • [Publications] 眞弓光文: "アトピー性疾患.特集・小児における現代病の対策と治療"医薬ジャーナル. 36・12. 3338-3341 (2000)

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  • [Publications] 藤沢和郎 他: "母親が使用した塩化リゾチーム外用剤により卵白アレルギー反応を呈した乳児例"アレルギーの臨床. 258. 68-70 (2000)

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  • [Publications] 中村肇 他: "金属代謝と生体応答-レドックス制御を中心に"肝胆膵. 41. 315-322 (2000)

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      2000 Annual Research Report
  • [Publications] H.Nakamura et al.: "Thioredoxin-dependent redox regulation in biological responses. In Free Radicals in Chemistry, Biology and Medicine(分担執筆)"T.Yoshikawa,S.Toyokuni,Y.Yamamoto,Y.Naito (eds.), OICA International, London. 126-133 (2000)

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      2000 Annual Research Report
  • [Publications] 大嶋勇成 他: "食物アレルギーによる皮膚症状.皮膚科診療プラクティス9やさしい小児皮膚科学(分担執筆)"斉藤隆三,宮地良樹,瀧川雅浩 編集.文光堂. 44-48 (2000)

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      2000 Annual Research Report
  • [Publications] 眞弓光文: "食物アレルギーのメカニズム.食物アレルギー.アトピー性皮膚炎コンセンサスアップデイト(分担執筆)"宮地良樹,永倉俊和 編集.メディカルレビュー社. 123-130 (2000)

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      2000 Annual Research Report
  • [Publications] H.Masutani et al.: "Redox regulation of gene expression and transcription factors in response to environmenta oxidants. In Environmental stressors : Effects on Lung, Skin, Eye and Immune System Function(分担執筆)"J.Fuchs and L.Packer(eds.).(発表予定)Marcel Dekker Inc.New York.

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      2000 Annual Research Report
  • [Publications] 眞弓光文: "アレルギー疾患.標準小児科学第4版(分担執筆)"前川喜平,辻芳郎 監修.医学書院. 259-267 (2000)

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      2000 Annual Research Report
  • [Publications] 眞弓光文: "食物と小児皮膚疾患.食物アレルギー、食物制限と栄養、給食など.小児の皮膚疾患生活指導マニュアル(分担執筆)"宮地良樹,森川昭廣 編集.診断と治療社. 24-29 (2000)

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      2000 Annual Research Report
  • [Publications] Ema, M., et al.: "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300."EMBOJ.. 18. 1905-1914 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hashimoto, S., et al.: "Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha."Biochem. Biophys. Res. Commun.. 258. 443-447 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Makino, Y., et al.: "Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function."J. Biol. Chem.. 274. 3182-3188 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Maruyama, T., et al.: "Activation of c-Src kinase is associated with in vitro decidualization of human endometrial stromal cells."Endocrinology. 140. 2632-2636 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Maruyama, T., et al.: "Induction of thioredoxin, a redox-active protein, by ovarian steroid hormones during growth and differentiation of endometrial stromal cells in vitro."Endocrinology. 140. 365-372 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimane, M., et al.: "Significant expression of G-CSF-induced gene-1 (GIG-1) protein in myeloid cells and NK cells."J. Leukoc. Biol.. 65. 109-116 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sugino, T., et al.: "Expression and distribution of redox regulatory protein, thioredoxin after metabolic impairment by 3-nitropropionic acid in rat brain."Neurosci. Lett.. 275. 145-148 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takagi, Y., et al.: "Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice."Brain Res.. 831. 283-287 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takagi, Y., et al.: "Localization of glutaredoxin (thioltransferase) in the rat brain and possible functional implications during focal ischemia."Biochem. Biophys. Res. Commun.. 258. 390-394 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takagi, Y., et al.: "Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage."Proc. Natl. Acad. Sci. U S A. 96. 4131-4136 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ueno, M., et al.: "Thioredoxin-dependent redox regulation of 53-mediated p21 activation."J. Biol. Chem.. 274. 35809-35815 (1999)

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      1999 Annual Research Report
  • [Publications] Nishiyama, A., et al.: "Interaction of thioredoxin with p40phox, a phagocyte oxidase component, in yeast two-hybrid method."Immunol. Lett.. 68. 155-159 (1999)

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      1999 Annual Research Report
  • [Publications] Bertini, R., et al.: "Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes and T cells."J. Exp. Med.. 189. 1783-1789 (1999)

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      1999 Annual Research Report
  • [Publications] Takashima, Y., et al.: "Differential expression of glutaredoxin and thioredoxin during monocytic differentiation."Immunol. Lett.. 68. 397-401 (1999)

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      1999 Annual Research Report
  • [Publications] Nishiyama, A., et al.: "Identification of thioredoxin binding protein-2/vitamin D3 up-regulated protein 1 as a negative regulator of thioredoxin function and expression."J. Biol. Chem.. 274. 21645-21650 (1999)

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      1999 Annual Research Report
  • [Publications] Nakamura, T., et al.: "Mouse glutaredoxin-cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEPB2."Free Rad. Res.. 31. 357-365 (1999)

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      1999 Annual Research Report
  • [Publications] Sasada, T., et al.: "Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-Diamminedichloroplatinum (II)"Free Radic. Biol. Med.. 27. 504-514 (1999)

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      1999 Annual Research Report
  • [Publications] Hirota, K., et al.: "Distict roles of thioredoxin in the cytoplasm and in the nucleus: a two step mechanism of redox regulation of transcription factor NF-kB"J. Biol. Chem.. 274. 27891-27897 (1999)

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      1999 Annual Research Report
  • [Publications] Maurice, M., et al.: "Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritis."Arthritis Rheum.. 42. 2430-2439 (1999)

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      1999 Annual Research Report
  • [Publications] Takahashi, T., et al.: "IgM anti-ganglioside antibodies induced by melanoma cell vaccine correlate with survival of melanoma patients."J. Invest. Dermatol.. 112. 205-209 (1999)

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      1999 Annual Research Report
  • [Publications] Katamura, K., et al.: "Existence of activated CD4+ T cells in peripheral blood and their skin infiltration in ZAP-70 deficient SCID."Clin. Exp. Immunol.. 115. 124-130 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Katamura, K.: "Differentiation of naive human CD4+ T cells. The role of prostaglandin E2."Allergol. Int.. 48. 7-14 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kiyomasu, T., et al.: "Hypomethylation of the proximal and intronic regulatory regions of the IFN-γ gene is not essential for its transcription by naive CD4+ T cells cultured with IL-4."Immunol. Lett.. 69. 239-245 (1999)

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      1999 Annual Research Report
  • [Publications] Ueno, H., et al.: "Further characterization of memory T cells existing in a case of CD8 deficiency."Human Immunol.. 60. 1049-1053 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsuda, S, et al.: "Temperature-sensitive ZAP-70 mutants degrading through a proteasome-independent pathway: restration of a kinase domein mutant by Cdc37."J. Biol. Chem.. 274. 34515-34518 (1999)

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      1999 Annual Research Report
  • [Publications] Ueno, H., et al.: "ZAP-70 is required for calcium mobirization but is dispensable for MAPK superfamily activation in human T cells stimulated via CD2."Eur. J. Immunol.. 30. 78-86 (2000)

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      1999 Annual Research Report
  • [Publications] Tsukahara, H., et al.: "Gas-phase oxidation of nitric oxide: chemical kinetics and rate constant."Nitric oxide: Biology and Chemistry. 3・3. 191-198 (1999)

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      1999 Annual Research Report
  • [Publications] Tsukahara, H., et al.: "Early (4-7 days of age) dexamethasone therapy for prevention of chronic lung disease in preterm infants."Biol. Neonate. 76. 283-290 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "リンパ球とアレルギー反応.特集 小児のアレルギー疾患"小児内科. 31・3. 291-294 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "卵アレルギー対策による難治型アトピー性皮膚炎発症予防の可能性.特集 治り難いアトピー性皮膚炎"アレルギーの臨床. 19・5. 27-30 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "小児アレルギーとヘルパーT細胞"日本小児アレルギー学会誌. 13・2. 1-6 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "アトピー性皮膚炎.外来患者の素朴な疑問に応える -家庭でのケアとその指導Q&A-"小児科. 40・7. 906-914 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "アトピー性皮膚炎と食物アレルギー 乳幼児と成人の違い"アレルギー・免疫. 6・10. 44-48 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "低アレルゲン化食品 アトピー性皮膚炎の治療における最近の進歩"アレルギー科. 8・3. 181-185 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "アレルギー.特集 診断基準と治療の基本 -最近の進歩-"小児科臨床. 52・12. 2216-2224 (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓 光文: "小児アトピー性皮膚炎の免疫学的機序.特集 小児アトピー性皮膚炎"小児科診療. 63・1. 7-11 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masutani, H., et al.: "Role of thioredoxin family in the redox regulation of oxidative stress response and signalling. In Antioxidant and Redox regulation of genes. (分担執筆)"Edited by Chandan K. Sen, Helmut Sies and Patrick A. Baeurele, Academic press. 562(14) (1999)

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      1999 Annual Research Report
  • [Publications] 眞弓光文: "アレルギーとT細胞・サイトカイン" 小児科診療 特大号小児アレルギーのすべて. 61・4. 518-521 (1998)

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      1998 Annual Research Report
  • [Publications] 眞弓光文: "免疫学からみたアトピー性皮膚炎" 日本小児科学会雑誌. 10. 749-752 (1998)

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      1998 Annual Research Report
  • [Publications] 眞弓光文: "卵アレルギー患者に対する予防接種について" infoAllergy. 6. 7-7 (1998)

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      1998 Annual Research Report
  • [Publications] 眞弓光文: "食物低アレルゲン化の新しい戦略" 最新医学. 53・12. 99-103 (1998)

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      1998 Annual Research Report
  • [Publications] M.Mayumi他: "Development of antigen-specific IgE antibodies in atopic and non-atopic infannts : Diagnostic value of low levels of IgE against egg white in infants atopic dermatitis." Allergology International. 47. 129-136 (1998)

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      1998 Annual Research Report
  • [Publications] H.Tsukahara他: "Urinary excretion of aquaporin-2in term and preterm infants." Early Human Development. 51. 31-37 (1998)

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      1998 Annual Research Report
  • [Publications] H.Tsukahara他: "Renal water channel expression in newborn infants : measurement of urinary excretion of aquaporin-2." Metabolism. 47. 1344-1347 (1998)

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      1998 Annual Research Report
  • [Publications] H.Tsukahara他: "Endothelin subtype A receptor antagonist induces osteopenia in growing rats." Metabolism. 47. 1403-1407 (1998)

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      1998 Annual Research Report
  • [Publications] K.Katamura他: "IL-4 and Prostaglandin E2 inhibit hypometylation of the 5'regulatory region of IFN-γ gene during differentiation oa naive CD4_+ Tcells." Molecular Immunology. 35. 39-45 (1998)

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      1998 Annual Research Report
  • [Publications] K.Katamura: "Differentiation of naive human CD4_+ T cells into Th2 cells. The role of prostaglandin E2." Allergology International. 印刷中.

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Katamura他: "Existence of activated and memory CD4^+ T cells in peripheral blood and their skin infiltration in CD8 deficiency." Clinical and Experimental Immunology. 115. 124-130 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Takagi他: "Redox control of neuronal damage during brain ischemia after middle cerebral artery occlusion in the rat : Immunohistochemical and hybridization studies of thioredoxin." Journal of Cerebral Blood Flow and Metabolism. 18. 206-214 (1998)

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      1998 Annual Research Report
  • [Publications] Y.Takagi他: "Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries." Laboratory Investigation. 78. 957-966 (1998)

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      1998 Annual Research Report
  • [Publications] M.Asahina他: "Expression of adult T cell leukemia-derived factor in human brain and peripheral nerve tissues." Dementia and Geriatric Cognitive Disorders. 9. 181-185 (1998)

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      1998 Annual Research Report
  • [Publications] Y.Takagi他: "Expression and distribution of redox regulatory protein, thioredoxin during transient focal brain ischemia in the rat." Neuroscience Letters. 251. 25-28 (1998)

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      1998 Annual Research Report
  • [Publications] H.Shibuki他: "Protective effect of adult T-cell leukemia-derived factor on retinal ischemia-reperfusion injury in the rat." Investigative Ophthalmology and Visual Science. 39. 1470-1477 (1998)

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      1998 Annual Research Report
  • [Publications] M.Hotta他: "Pancreatic beta-cell-specific expression of thioredoxin, an anti-oxidative and anti-apoptotic protein, prevents autoimmune diabetes as well as streptozotocin-induced diabets" Journal of Exprimental Medicine. 188. 1445-1451 (1998)

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      1998 Annual Research Report
  • [Publications] K.Mansur他: "Up-regulation of thioredoxin expression in motor neurons after nerve injury." Molecular Brain Research. 62. 86-91 (1998)

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      1998 Annual Research Report
  • [Publications] S.Ueda他: "Redox regulation of caspase-3(like) protease activity : regulatory roles of thioredoxin and cytochromec." Jounal of Immunology. 161. 6689-6695 (1998)

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      1998 Annual Research Report
  • [Publications] H.Nakamura他: "Redox regulation by thioredoxin in host defense." Current Trends in Immunology. 1. 133-140 (1998)

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      1998 Annual Research Report
  • [Publications] T.Maruyama他: "Induction of thioredoxin, a redox-active protein, by ovarian steroidhormones during growth and differentiation of endometrial stromal cells in vitro." Endocrinology. 140. 365-372 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 眞弓光文: "アレルギー疾患(喘息、アトピー性皮膚炎)の病態 喘息やアトピー性皮膚炎はどのように発病するか. 小児喘息・アレルギー疾患の予防と治療に役立つ栄養・食生活 鳥居新平編." 医学書院, 234 (1998)

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      1998 Annual Research Report
  • [Publications] T.Ohno他(分担執筆): "Thioredox in and its involvement in the redox regulation of transcription factors, NF-kBand AP-1. In “Oxygen Homeostasis and Its Dynamics" edited by Y.Ishimura, H.Shimada, M.Suematsu." Springer-Verlag Tokyo, 620 (1998)

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      1998 Annual Research Report
  • [Publications] A.Nishiyama他(分担執筆): "Detection of a Nuclear 60-kDa protein coimmunoprecipitated with human thioredoxin. In “Oxygen Homeostasis and Its Dynamics" edited by Y.Ishimura, H.Shimada, M.Suematsu." Springer-Verlag Tokyo, 620 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Kato他(分担執筆): "Diagnosis of Epstein-Barrvirus lymphoma after liver transplantation. In “Epstein-Barrvirus and Human Cancer" edited by T.Osato, K.Takada, M.Tokunaga. Gann Monograph in Cancer Research" 学術出版センター(東京), 220 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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