| Project/Area Number |
10357012
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| Research Category |
Grant-in-Aid for Scientific Research (A).
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center |
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Principal Investigator |
TAENAKA Yoshiyuki National Cardiovascular Center, Department of Artificial Organs, Director, 人工臓器部, 部長 (00142183)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATANI Takeshi National Cardiovascular Center, Department of Experimental Therapy, Director, 実験治療開発部, 部長 (60155752)
TATSUMI Eisuke National Cardiovascular Center, Department of Artificial Organs, Senior Staff, 人工臓器部, 室長 (00216996)
TSUKIYA Tomonori National Cardiovascular Center, Department of Artificial Organs, Staff, 人工臓器部, 室員 (00311449)
TAKANO Hisateru National Cardiovascular Center, Vice Director, 研究所, 副所長 (60028595)
TAKEWA Yoshiaki National Cardiovascular Center, Department of Artificial Organs, Senior Staff, 人工臓器部, 室長 (20332405)
中村 真人 東京医科歯科大学, 助教授 (90301803)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥26,300,000 (Direct Cost: ¥26,300,000)
Fiscal Year 2000: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1998: ¥14,200,000 (Direct Cost: ¥14,200,000)
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| Keywords | Artificial Heart / Heat / Hemolysis / Flow visualization / Computational fluid dynamics / Thrombus / Anatomical fitting / Electromagnetic wave / 無拍動流 / 人工循環 / 循環調節 / サーカディアンリズム / 時間医学 / 血管系トーヌス / 自律神経 / 末梢血管 / 生体適合化 / 解剖学的適合性 |
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| Research Abstract |
Biocompatibility of mechanical blood pump systems was improved for artificial hearts aiming at a tether free and totally implantable system with a transcutaneous energy transmission system. Reduction of hemolysis was realized in a centrifugal blood pump system with flow visualization and computational fluid dynamic techniques. Antithrombogenicity was also improved from the standpoint of fluid dynamics and with the application of a new surface heparinization method. Anatomical fitting was improved by the investigation of three dimensional analyses of the human body with computational tomography. Influences of heat and electromagnetic wave were also studied and harmful influences were not observed in out artificial heart system.
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