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Development of a high-frequency ultrasound system with high-speed electronic scan probes for evaluating fine structures and function in vivo

Research Project

Project/Area Number 10358020
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Biomedical engineering/Biological material science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KITABATAKE Akira  Hokkaido Univ., Grad.School of Med., Prof., 大学院・医学研究科, 教授 (00124769)

Co-Investigator(Kenkyū-buntansha) MIKAMI Taisei  Hokkaido Univ., College of Medical Technology, Asso.Prof., 医療技術短期大学部, 助教授 (90250456)
YAMAMOTO Katsuyuki  Hokkaido Univ., Grad.School of Eng., Prof., 大学院・工学研究科, 教授 (10088867)
YASUDA Keisyu  Hokkaido Univ., Grad.School of Med., Prof., 大学院・医学研究科, 教授 (60125359)
OKAMOTO Hiroshi  Hokkaido Univ.Medical Hospital, Lec., 医学部・附属病院, 講師 (50260394)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥30,600,000 (Direct Cost: ¥30,600,000)
Fiscal Year 2000: ¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1999: ¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 1998: ¥13,700,000 (Direct Cost: ¥13,700,000)
Keywordshigh-frequency ultrasound / high-speed electronic scan / echocardiography in small animals / medium-sized muscular arteries / 生体微細構造 / 探触子
Research Abstract

In this research we developed a high-frequency high-speed ultrasound system with 10MHz, 13MHz and 15-MHz electronic scan probes for the in vivo visualization of fine cardiovascular structures and measurement of their function. This system provided axial resolution of less than 0.20mm and lateral resolution of less than 0.25mm which could not have been achieved by conventional electronic scanners. Time resolution of our system was as high as 656 frames/sec. Moreover, we studied the usefulness of this system in the following 3 area ;
1.Visualization and measurement of coronary artery : Human coronary arteries excised at autopsy were examined using a commercially available 7.5-MHz probe and our 10MHz-probe, and the results were compared with histological findings. When using the 10-MHz probe, the vessel structure was depicted more clearly and the lumen area and intima-media area could be more accurately measured than when using the 7.5-MHz probe.
2. Evaluation of cardiovascular lesions in m … More ice : Apolipoprotein E-knockout mice have been shown to spontaneously develop atherosclerosis as seen in humans. Transthoracic echocardiography using our 13-MHz probe could detect atherosclerotic lesions and decreased distensibility of the ascending aorta as well as secondary changes in the left ventricular geometry in the apolipoprotein E-knockout mice.
3. Measurements of medium-sized muscular arteries : We studied reproducibility of the ultrasound measurement of lumen diameter and intima-media thickness in the brachial and radial arteries using the 7.5-MHz, 10-MHz and 15-MHz probes. In every measurement the best reproducibility was obtained using 15-MHz probe. Percent flow-mediated dilatation of the brachial artery was also measured using the 3 probes and the reproducibility was also highest when using 15MHz probe.
Thus, our new high-frequency ultrasound system will provide better structural information and detailed characterization of cardiovascular lesions in humans and experimental animals. Less

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] 山田聡: "新しい広帯域15MHzリニア電子走査型探触子による筋性中動脈計測精度の検討"超音波医学. 28・2(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Keiko Nishihara: "Usefulness of Early Diastolic Flow Propagation Velocity Measured by cdor-M mode Doppler technique for the Assessment of Left Ventricular Diastolic Function in Potiouts with Hypertrophic Cardiomycpathy"Journal of the American Society of Echocardiography. 13. 801-808 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Nakajiwa: "A Study on frequency dependence of ultrasound attenuation of bidogical tissue in the frequency range of 2-40 MHz."IEEE Ultrasonics Symposium Proceedings. 1381-1384 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Atsushi Sato: "Effect of Prolonged Treatment with Amlodipine on Enhanced Vasculor Contractility in Cardiomyopathic Hamsters"Journal of Cardiovascular Pharmacology. 34. 124-131 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masashi Watanabe: "Chronic Effects of Enalapril and Amlodipire on Cardiac Remodeling in Cardiomycpathic Hamster Hearts"Journal of Cardiovasculor Pharmacology. 32. 248-259 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hitoshi Sano: "Increased mRNA expression of cardiac renin-angiotensin system and collagen synthesis in spontornecusly hypertensive rats"Moleculor and Cellalor Biochemistry. 178. 51-58 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hiroshi Okamoto: "Heart Failure -Frontiers in Cardiology-"Akim Kitabatake. 261 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Satoshi Yamada, et al.: "Measurements of medium-sized muscular arteries using a novel wideband 15-MHz linear array probe."Journal of Medical Ultrasonics. 28-2 (in print). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Keiko Nishihara, et al.: "Usefulness of early diastolic flow propagation velocity measured by color M-mode Doppler technique for the assessment of left ventricular diastolic function in patients with hypertrophic cardiomyopathy."Journal of the American Society of Echocardiography. 13-9. 801-808 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K Nakajima, et al.: "A study on frequency dependence of ultrasound attenuation of biological tissue in the frequency range of 2-40 MHz."IEEE Ultrasonics Symposium Proceedings. 1381-1384 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Atsushi Sato, et al.: "Effect of prolonged treatment with amlodipine on enhanced vascular contractility in cardiomyopathic hamsters."Journal of Cardiovascular Pharmacology. 34. 124-131 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masashi Watanabe, et al.: "Chronic effects of enalapril and amlodipine on cardiac remodeling in cardiomyopathic hamster hearts."Journal of Cardiovascular Pharmacology. 32. 248-259 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hitoshi Sano, et al.: "Increased mRNA expression of cardiac reninangiotensin system and collagen synthesis in spontaneously hypertensive rats."Molecular and Cellular Biochemistry. 178. 51-58 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hiroshi Okamoto, et al.: "Cardiac remodeling : Role of neovascularization in heart failure Heart Failure -Frontiers in Cardiology-"261 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 山田聡: "新しい広帯域15MHzリニア電子走査型探触子による筋性中動脈計測精度の検討"超音波医学. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Keiko Nishihara: "Usefulross of Early Diavolic How Propagation Velocity Measured by Color M-Made Doppler Technique for the Assessment of Left Ventricular Diasolic Function in Patients with Hypertrophic Cardiomyopathy."Journal of the American Society of Echocardiography. 13. 801-808 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroshi Okawoto: "Management of Heart Failure : Recently Advanced Strategies for Positive Inotropic Agents"Asian Medical Journal. 43. 551-559 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 菅原多恵子: "II型糖尿病ラット心微小血管再構築に対するアンギオテンシン変換酵素阻害薬の影響"血圧. 194. 103-107 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroshi Okomoto: "Heart Failure-Frontiers in Cardiology-"Akira Kitabatake. 261 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Keiko Nishihara: "Usefulness of Early Diastolic Flow Propagation Velocity Measured by Color M-mode Doppler Technique for the Assessment of Left Ventricular Diastolic Function in Patients with Hypertrophic Cardiomyopathy"Journal of American Society of Echocardiography. 印刷中.

    • Related Report
      1999 Annual Research Report
  • [Publications] Takafumi Ozaki: "Threshold-Dependent DNA Synthesis by Pure Pressure in Human Aortic Smooth Muscle Cells : Giα-Dependent and -Independent Pathways"Biochemical and Biophysical Research Communications. 256,1. 212-217 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takanori Ogawa: "Fibromuscular Dysplasia Involving Coronary Arteries"Angiology. 50,2. 153-156 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Satoshi Fujii: "Diminished Fibrinolysis and Thrombosis : Clinical Implications for Accelated Atherosclerosis"Journal of Atherosclerosis and Thrombosis. 5,2. (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Atsushi Sato: "Effect of Prolonged Treatment with Amlodipine on Enhanced Vascular Contractility in Cardiomyopathic Hamsters"Journal of Cardiovascular Pharmacology. 34. 124-131 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Tomioka: "Relaxation in Different-Sized Rat Blood Vessels Mediated by Endothelium-Derived Hyperpolarizing Factor : Importance of Processes Mediating Precontractions"Jorunal of Vascular Research. 36. 311-320 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masashi Watanabe: "Chronic Effects of Enalapril and Amlodipine on Cardiac Remodeling in Cardiomyopathic Hamster Hearts." Journal of Cardiovascular Pharmacology. 32. 248-259 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koichi Okita: "Skeletal Muscle Metabolism in Maximal Bicycle and Treadmill Excercise Distinguished by Using in Vivo Metabolic Freeze/Method and Phosphorus-31MR." The American Journal of Cardiology. 81・1. 106-109 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koichi Okita: "Skeletal Muscle Metabolism Limits Exercise Capacity in Patients With Chronic Heart Failure." Circulation. 98・18. 1886-1891 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Alisher Isharov: "Angiotension II Type 1 Receptor Gene Polymorphisms in Patients With Cardiac Hypertrophy." Japanese Heart Journal. 39・1. 87-96 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Atsushi Tamada: "Effects of β-adrenoceptor stimulation on contractility,Ca^<2+>i,and Ca^<2+> current in diabetic rat cardiomyocytes." American Journal of Physiology. 0363・6135. H1849-H1857 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Motoi Sasaki: "Tyrosin aphosphorylation as a convergent pathway of heterotrimeric G-protein- and rho protein-mediated Ca^<2+> sensetization of smooth muscle of rabbit mesenteric" British Journal of Pharmacology. 125. 1651-1660 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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