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DEVELOPMENT OF HYBRID-TYPE LANTHANIDE COMPLEXES AS EFFECTIVE RECEPTORS

Research Project

Project/Area Number 10440198
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic chemistry
Research InstitutionOsaka City University

Principal Investigator

TSUKUBE Hiroshi  OSAKA CITY UNIVERSITY, FACULTY OF SCIENCE, PROFESSOR, 理学部, 教授 (00144725)

Co-Investigator(Kenkyū-buntansha) SHINODA Satoshi  OSAKA CITY UNIVERSITY, FACULTY OF SCIENCE, LECTURER, 理学部, 講師 (00285280)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsLanthanide Complex / Amino Alcohol / Amino Acid / CD Probe / Chirality / CD Spectrum / Molecular Recognition / キラル・センシング / 不斉センシング / 液-液抽出 / レセプター / CD
Research Abstract

A series of lanthanide tris (β-diketonates) and porphyrinates were developed as effective receptors of chiral biological substrates. These lanthanide complexes are electrically neutralized by coordinating ligands but formed highly coordinated 1 : 1 complexes with various substrates. We successfully optimized the combinations of coordinating ligands and lanthanide centers to realize specific recognition and sensing of non-chromophoric chiral biological substrates. Two types of specific receptors were developed based on lanthanide coordination chemistry : (1) Lanthanide tris (fluorinated β-diketonates) provided highly efficient fluorescence and CD sensing of chiral amino alcohols ; (2) Additional functionalization of lanthanide porphyrinates gave highly sensitive CD probes for multi-functional biogenetic amine and dipeptides. Since there are wide structural variations in the design of lanthanide complexes, new aspects of lanthanide coordination chemistry revealed in this study can offer promising possibilities in developing a new series of recognition and sensing systems involving intelligent lanthanide complexes.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] H.Tsukube 他: "Chirality Probing of Amino Alcohols with Lanthanide Completes via Induced Circular Dichroism Spectroscopy"J.Chem.Soc.,Dalton Trans.. 11-13 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube 他: "Porphyrinatoerbium-Crown Ether Conjugate for synergistic Binding and Chirality Sensing of Zuitteraonic Amino Acids"Chem.Commun.. 1007-1008 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube 他: "Lanthanide Completes as Smart CD Probes for Chirality Sensing of Biological Substrates"Enantiomer. 5. 13-22 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tamiaki 他: "Induced Circular Dichroism Active Completes of Synthetic Gadolinium Porphyrinates with Chiral Amins Acids"Inorg.Chim.Acta. 300. 243-249 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube 他: "Specific Recognition of Chiral Amino Alcohols via Lanthanide Coordination Chemistry"Inorg.Chem.. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube 他: "Conjugate Strategy of Lanthanide Porphyrinate with Crown Ether Toward Synergistic Binding and Chirality Sensing of Biological Substrates"J.Alloys.Comp.. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube et al.: "Chirality Probing of Amino Alcohols with Lanthanide Complexes via Induced Circular Dichroism Spectroscopy"J.Chem.Soc., Dalton Trans.. 11-13 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube et al.: "Porphyrinatoerbium-Crown Ether Conjugate for Synergistic Binding and Chirality Sensing of Zwitterionic Amino Acids"Chem.Commun.. 1007-1008 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube et al.: "Lanthanide Complexes as Smart CD Probes for Chirality Sensing of Biological Substrates"Enantiomer. 5. 13-22 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tamiaki et al.: "Induced Circular Dichroism Active Complexes of Synthetic Gadolinium Porphyrinates with Chiral Amino Acids"Inorg.Chim.Acta. 300. 243-249 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube et al.: "Specific Recognition of Chiral Amino Alcohols via Lanthanide Coordination Chemistry : Structural Optimization of Lanthanide Tris (β-diketonates) Toward Effective CD/Fluorescence Probing"Inorg.Chem.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Tsukube et al.: ""Conjugate Strategy" of Lanthanide Porphyrinate with Crown Ether Toward Synergistic Binding and Chirality Sensing of Biological Substrates"J.Alloys.Comp.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H,Tamiaki 他: "Induced Circular Dichroism Active Complexes of Synthetic Gadolinium Porphyrinates with Chiral Amino Acids"Inorg,Chim,Acte. 300. 243-249 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H,Tsukube 他: "Specific Recognition of Chiral Amino Alrohols via Lanthamide Coordination Chemistry"Inorg,Chem.. 40(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] H,Tsukube 他: ""Conjugate Strategy "of Lgn thanide Porphyrinate with Crown Ether Toward Synergistic Binding and Chirality Sensing"J.Alloys,Comp.. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] H. Tsukube 他: "Chirality Probing of Amino Alcohols with Lanthanide Complexes via Induced Circular Dichroism Spectroscopy"J. Chem. Soc. Dalton. 11-13 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Tsukube 他: "Porphyrinato erbium-Crown Ether Conjugate for Synergistic Binding and Chirality Sensing of Zwitterionic Amino Acids"Chem. Commun.. 1007-1008 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Tsukube 他: "Lanthanide Complexes As Smart CD Probes for Chirality Sensing of Biological Substrates"Enantiomer. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Tamiaki 他: "Induced Circular Dichroism Active Complexes of gadolinium Porphyrinates with Chiral Amino Acids"Inorg.Chem.Acta. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Tsukube: "Chirality probing of amino alcohols with lanthamide compleres via induced circular dichroism spectrocopy" J.Chem.Soc.,Dalton. 11-12 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Tsukube: "Synergistic Binding of Amino Acid by Crown Ether/Lanthanide Porphyrin Hybrid" J.Chem.Soc.,Chem,Commun.(印刷中). (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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