Microevolution and genetic adaptation among Asians

• Project/Area Number: 10440254
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 人類学(含生理人類学)
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIDA Takafumi Graduate School of Sciences Univ. Tokyo, Assoc. Prof., 大学院・理学系研究科, 助教授 (20184533)
• Project Period (FY): 1998 – 1999
• Project Status: Completed (Fiscal Year 1999)
• Budget Amount: ¥10,800,000 (Direct Cost: ¥10,800,000); Fiscal Year 1999: ¥5,000,000 (Direct Cost: ¥5,000,000); Fiscal Year 1998: ¥5,800,000 (Direct Cost: ¥5,800,000)
• Keywords: Malaria / Duffy blood group / Ovalocytosis / G6PD deficiency / Southeast Asia / Genetic diversity / Adaptation / 卵型血球症 / G6PD / 遺伝的適応 / バンド3タンパク / アジア

Research Abstract

To reveal relationships between genetic adaptation and human microevolution, we have studied malaria resistant genetic traits.
1. Duffy blood group of which antigen is a receptor for vivax malaria was screened serologically and molecularly among these populations. Specimens of weakly reacted type were identified, whereas, Fy allele was not found.
2. As for the relationships between SAO (Southeast Asian ovalocytosis) and malaria species, difference in the resistance to malaria by the species was not observed.
3. In the Raute of Nepal who are suffering from malaria, their frequency of Fya was rather low among Asian populations.
4. The distribution of 27-base pair deletion in the band 3 gene can be super imposed onto the Austronesian speaking populations.
5. Screening of G6PD deficiency among untested groups was done.

Research Products

• [Publications] Kimura et al.: "Twenty seven base a parideletion in erythrocyte band 3 protein gene responsible for Southeast Asian ovalocytasis is not common amous Southeast Asian"Hum. Biol.. 70. 993-1000 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kimura et al.: "Twenty seven base pair deletion in erythrocyte band 3 protein gene responsible for Southeast Asian ovalocytosis is not common among Southeast Asians"Hum. Biol.. 70. 993-1000 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shimizu et al.: "Sero and molecular-typing of Duffy blood grou in Southeast Asian and Oceanians"Hum. Biol.. 72(in press). (2000)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shimizu et al.: "Servo- and molecular-typing of Duffy blood group in Southeast Asians and Oceanians"Hum. Biol.. 72(in press). (2000)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kimura, M. et al.: "Twenty seven base pair deletion in erythrocyte band 3 protein gene responsible for Southeast Asian ovalocytosis is not common among Southeast Asian."Human Biology. 70. 993-1000 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Shimizu, Y., Ao, H., Soemantri, Ag., Tiwawech, D., Settheetham-Ishida, W., Kayame, O.W., Nishioka, T. and Ishida, T.: "Sero- and molecular-typing of Duffy blood group in Southeast Asians and Oceaniams : demonstration of cryptic genotypes by the PCR-RFLP study."Human Biology. 72 (in press). (2000)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Takao,S.et al.: "Seroprevalence of human T-lymphotropic retrovirus type-1 in Papua New Guinea and Irian Jaya"J.Clin.Virol.. 16. 127-131 (2000)
• [Publications] Shimizu,Y.et al.: "Sero-and Molecular-typing of Duffy blood group in Southeast Asians and Oceanians"Hum.Biol.. 72. (2000)
• [Publications] Ishida,T.et al.: "Humau T-lymphotropic retrovirus type-1 in Thailand"Southeast Asian J.Trop.Med.Publ.Health. (1999)
• [Publications] Kimura,M.et al.: "Twenty-seven base pair deletion in erythrocyte band 3 protein gene responsible for Southeast Asian ovalocytosis is not comman among Southeast Asians" Human Biology. 70. 993-1000 (1998)