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A novel compounds of capsaicinoid-like substances in the capsicum fruit and their physical activities in human body.

Research Project

Project/Area Number 10460015
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field 園芸・造園学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

YAZAWA Susumu  Kyoto University, Grd.School of Agriculture Professor, 農学研究科, 教授 (90026550)

Co-Investigator(Kenkyū-buntansha) WATANABE Tatsuo  University of Shizuoka School of Food and Science Associate Professor, 食品栄養科学部, 助教授 (10210915)
FUSHIKI Tohru  Kyoto University, Grd.School of Agriculture Professor, 農学研究科, 教授 (20135544)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1999: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥8,700,000 (Direct Cost: ¥8,700,000)
KeywordsCapsicum / Capsaicinoid-like Substance / Capsinoid / Fatty Metabolism / Calorification / Oxygen Consumption / Suppress of body Fat / カプサイシン類似物質 / 体熱産生 / カプサイシン類似新規物質 / 代謝促進 / 脂肪燃焼作用
Research Abstract

The layer chromatograhy (TLC) of extracts 'CH-19Sweet' (Capsicum annuum) fruit, which had been selected and fixed from the hot cultivar 'CH-19Hot', gave two capsaicinoid-like substances. These substances are different from capsainoids in their Rf values on TLC, they show the same coloring reactiom as capsaicinoids. Also it is observed that they were formed and accumulated on the placenta of 'CH-19Sweet'. These substaces were identified by ^1H-NMR method, and they consisted of newly found compouds, as brached non-saturated fatty acid ester combined with vanilly alcohol, and other is that having a saturated fatty acid moiety. We gave a name of capsinoid to the novel compoud. The dry fruit of CH-19Sweet, which is crushed and in wrapped in amedical wafer, were eaten by a subject. The temmperature of skin rose 1.4C about 30 minutes after feeding, and the same effect of capsinoid was showed on rat. Moreover, capsinoid had an effect on mice and rat, decrease of fat, increase of adolenaline in the blood, anodyne etc. And also in the human body capsinoid influenced on increase of body temmperature and oxygen consumption. The fruit harvest of 'CH-19Sweet' is best 20〜30 days after anthesis and the fruit storage should be conducted under 5C.
It is suggested in our experiments that the fruit of 'CH-19Sweet' is available for functional food materials.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] K.M.Kim,T Fushiki et al.: "Sroimming capacity of mice is increased by oral addinistration of a nonpungent capsaicin analog, stearoyl vanillyamide"Amer.Soc.Nutr.Sci.. 128. 1978-1983 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kobata,S.Yazawa,T.Watanabe et al.: "Novel capsaicinoid-like substances, Capsiate and dihydrocapsiate, from the fruit of a nonpungent cultivar 'CH-19 sweet'"Jour.Agr.Food Chemistry. 46. 1695-1697 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Watanabe,K.Kobata,S.Yazawa et al.: "Nordihydrocapsiate, a new capsinoid from the fruit of nonpungent pepper, Capsicum annuum."Jour.Natural Products. 62. 335-336 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 矢澤進,丹羽昌二: "トウガラシに含まれるカプサイシノイド類似新規物質の果実内生成"園芸学会雑誌. 68(別1). 240 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 矢澤進,前田智: "トウガラシ'CH-19甘'の果実発育に伴う胎座組織でのカプシノイド生成ならびに収穫時期の異なる果実のカプシノイド含量"園芸学会雑誌. 69(別1). 230 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Ohnuki,S.Yazawa,T.Fushiki et al.: "A single and long-term effect of capsiate, non-pungent capsaicin analog, on thermogenesis and fat accumulation"Life Sciences. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 岩井,渡辺,矢澤,伏木 他: "トウガラシ-辛味の科学"幸書房(東京). 261 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.M.Kim, T.Fushiki and et al.: "Swimming capacity of mice is increased by oral addinistration of a nonpungent capsaicin analog, stearoyl vanillyamide."Amer.Soc, Nutr.Sci.. 128. 1978-1983 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kobata, S.Yazawa, T.Watanabe and et al.: "Novel capsaicinoid-like substances, Capsiate and dihydrocapsiate, from the fruit of a nonpungent cultivar CH-19 Sweet."Jour.Agr.Food Chemistry. 46. 1695-1697 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Watanabe, K.Kobata, S.Yazawa and et al.: "Nordihydrocapsiate, a new capsinoid from the fruit of nonpungent pepper, Capsicum annuum."Jour.Natural Products. 62. 335-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Yazawa and S.Niwa: "Biosynthesis of a new capsaicinoid-like substance in the fruit of pepper."J.Japan.Soc.Hort.Sci.. 67(10). 240 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Yazawa and S.Maeda: "Capsinoid synthesis in the placenta of CH-19 Sweet and capsinoid content in the fruit harvested at different season."J.Japan.Soc.Hort.Sci.. 69(1). 230 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Ohnuki, S.Yazawa, T.Fushiki and et al.: "A single and long-term effect of capsiate, non-pungent capsaicin analog, on thermogenesis and fat accumulation."Life Sciences. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Iwai, T.Watanabe, S.Yazawa, T.Fushiki and et al.: "Pepper-Science of pungency"Saiwai Shobou (Tokyo). 261 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Kobata,S.Yazawa,T.Watanabe et al.: "Nordihydrocapsiate, a new capsinoid from the fruit of a nonpungent papper, Capsicum annuum."J.Nat.Prod.. 62. 335-336 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大貫一郎,矢澤進,伏木亨 他: "カプシエイトの体熱産生・体脂肪減少効果"香辛料研究会(要旨). 15. 9-10 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 須藤浩三,矢澤進,渡辺達夫 他: "カプシノイドの生合成経路の解明"日本農芸化学会(要旨). 324 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 矢澤進,米田祥三 他: "トウガラシの細胞質安定型雄性不稔系統の育成とその系統の利用"園芸学会雑誌. 70(別)(発表予定). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 古旗賢二,渡辺達夫 他: "カプシノイドの酵素的合成法における最適化"日本農芸化学会(要旨). (発表予定). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大貫一郎,矢澤進,伏木亨 他: "新規トウガラシ成分カプシエイトの体脂肪減少効果"日本農芸化学会(要旨). (発表予定). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 矢澤進,前田智: "トウガラシ'CH-19甘'の果実発育に伴う胎座組織でのカプシノイド生成ならびに収穫時期の異なる果実のカプシノイド含量"園芸学会雑誌. 69(別). 230 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 大貫宏一郎,原水聡史,伏木享他: "カプシエイトの生理作用に関する研究"日本香辛料研究講演要旨. 14. 13-14 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 須藤浩三,古旗賢二,矢澤進他: "新規カプシノイドの構造と安定性"日本農芸化学会講演要旨 (1999年度). 301 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 渡辺達夫 他: "新規トウガラシ成分、カプシノイドの酵素的合成"日本栄養・食糧学会講演要旨 (1999年度). 53. 8 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.M.Kim,H.Fushiki et al.: "Swimming Capacity of Mice Is Increased by Oral Administration of a Nonpungent Capsaicin Analog,Stearoyl Vanillylamide" American Society for Nutritional Sciences. 128. 1978-1983 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Kobata,S.Yazawa,T.Watanabe et al.: "Novel Capsaicinoid-like Substances,Capsiate and Dihydrocapsiate,from the Fruits of a Nonpungent Cultion,CH-19 Sweet of pepper" Journal of Agricultural and Food Chemistry. 46. 1695-1697 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Watanabe,K.Kobata,S.Yazawa et al.: "Nondihydrocapsiate,a New Capsinoid from the Fruits of a Nonpungent pepper,Capsicum annvum" Journal of Natural Products. 62. 335-336 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 矢澤進・丹羽昌二: "トウガラシに含まれるカプサイシノイド類似新規物質の果実内生成" 園芸学会雑誌. 68(別1). 240 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 南山泰宏・矢澤進他: "'万願寺'トウガラシにおける人為的単為結果果実の辛味発現" 園芸学会雑誌. 68(別1). 241 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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