• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prevention of initiation and promotion of colon cancer by dietary fiber and design of highly functional dietary fiber.

Research Project

Project/Area Number 10460053
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionGRADUATE SCHOOL OF AGRICULTURE, HOKKAIDO UNIVERSITY

Principal Investigator

HARA Hiroshi  Hokkaido Univ. Grad. School of Agr., Asso. Prof., 大学院・農学研究科, 助教授 (70198894)

Co-Investigator(Kenkyū-buntansha) ISHIZUKA Satoshi  Hokkaido Univ. Grad. School of Agr., Inst., 大学院・農学研究科, 助手 (00271627)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1998: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsColon Cancer / Aberrant Crypt Foci / Ionizong Irradiation / Chemical Carcinogen / Dietary Fiber / Intestinal Fermentation / Oxidized Lipids / 化学発がん剤 / 酸化DNA
Research Abstract

The aims of this study were to establish a model of colon cancer by ionizing radiation in rats and to compare the effects of dietary fiber feeding on cancer development with those in a chemically-induced colon cancer model. We first succeed to develop precancerous legion, aberrant crypt foci (ACF), in rat colonic mucosa by ionizing radiation. The properties of radiation-induced ACF were low frequency, but high multiplicity compared with the chemically induced ACF Feeding of a highly fermentable dietary fibers, sugarbeet fiber, suppressed ACF in the chemical model, but not the radiation model. In the chemical model, a low fermentable, soluble fiber prevent the development of colonic ACF just feeding fiber before, but not after a challenge of carcinogen. Also, a product of the colonic fermentation, butyric acid, prevented the development of ACF in the rat colon using the chemically-induced cancer model.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Ishizuka Satishi: "Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition."Carcinogenesis. 20. 1005-1009 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagai Takumi: "Dietary suger beet fiber prevents the increase in aberrant crypt foci induced by gamma-irradiation in the colorectum of rats treated with an immunosuppressant."Journal of Nutrition. 130. 1682-1687 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishizuka Satishi: "Dietary sugar beet fiber ameliorates diarrhea as an acute gamma-radiation injury in rats."Radiation Research. 154. 261-267 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 石塚敏: "食物繊維と上皮間リンパ球"臨床免疫. 34. 248-252 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishizuka S, Ito S, Onuma M, Kasai T, Aoyama Y, Hara H.: "Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition."Carcinogenesis. 20. 1005-1009 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagai T, Ishizuka S, Hara H, Aoyama Y.: "Dietary sugar beet fiber prevents the increase in aberrant crypt foci induced by gamma-irradiationin the colorectum of rats treated with an immunosuppressant."Journal of Nutrition. 130. 1682-1687 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishizuka S, Ito S, Kasai T, Hara H.: "Dietary sugar beet fiber ameliorates diarrhea as an acute gamma-radiation injury in rats."Radiation Research. 154. 261-267 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishizuka S.: "Dietary fiber and Intraepitherial Lymphocytes.(Japanese)"Clinical Immunology. 34. 248-252 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagai Takumi: "Dietary sugar beet fiber prevents the increase in aberrant crypt foci induced by gamma-irradiation in the colorectum of rats treated with an immunosuppressant"Journal of Nutrition. 130・7. 1682-1687 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ishizuka Satishi: "Dietary sugar beet fiber ameliorates diarrhea as an acute gamma-radiation injury in rats."Radiation Research. 154・3. 261-267 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S. Ishizuka: "Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition"Carcinogenesis. 20巻6号. 1005-1009 (1999)

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi