| Project/Area Number |
10460056
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食品科学・栄養科学
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| Research Institution | THE UNIVERSITY OF TOKYO |
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Principal Investigator |
NOGUCHI Tadashi Graduate School of Agriculture and life Sciences THE UNIVERSITY OF TOKYO Professor, 大学院・農学生命科学研究科, 教授 (50011937)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1998: ¥5,900,000 (Direct Cost: ¥5,900,000)
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| Keywords | Insulin-like growth factor-1 / IGF-binding protein / insulin / translation initiation factor / transcription factor / protein deficiency / 肝臓核因子 / 翻訳開始因子結合タンパク質 |
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| Research Abstract |
Protein metabolism is regulated by many factors including hormonal and nutritional factors. The author showed that body protein gain or loss is well explained by the plasma concentrations of insulin-like growth factors (IGFs) and their specific binding proteins called IGFBPs. Particularly, plasma concentration of IGFBP-1 increases greatly under protein deficiency or under enhanced glucocortocoid secretion or under insulin deficiency. These increases in plasma IGFBP-1 concentration is correlated to the increase in the content of IGFBP-1 mRNA in liver or the increase in the transcription rate of IGFBP-1 gene. In the present investigations, the mechanism of the increase in the IGFBP-1 gene has been analyzed.
The author identified an amino acid-responsive element in the 5'upstream region of IGFBP-1 gene. Furthermore, he showed that the binding of specific transcription factors is important for the increase in the transcription rate of IGFBP-1 gene.
The above results made it possible to explain the molecular mechanisms of the regulation of whole body protein metabolism as affected by dietary and hormonal factors.
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