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Effect of Diet and Hormone on the Regulation of Body Protein Synthesis

Research Project

Project/Area Number 10460056
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionTHE UNIVERSITY OF TOKYO

Principal Investigator

NOGUCHI Tadashi  Graduate School of Agriculture and life Sciences THE UNIVERSITY OF TOKYO Professor, 大学院・農学生命科学研究科, 教授 (50011937)

Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1998: ¥5,900,000 (Direct Cost: ¥5,900,000)
KeywordsInsulin-like growth factor-1 / IGF-binding protein / insulin / translation initiation factor / transcription factor / protein deficiency / 肝臓核因子 / 翻訳開始因子結合タンパク質
Research Abstract

Protein metabolism is regulated by many factors including hormonal and nutritional factors. The author showed that body protein gain or loss is well explained by the plasma concentrations of insulin-like growth factors (IGFs) and their specific binding proteins called IGFBPs. Particularly, plasma concentration of IGFBP-1 increases greatly under protein deficiency or under enhanced glucocortocoid secretion or under insulin deficiency. These increases in plasma IGFBP-1 concentration is correlated to the increase in the content of IGFBP-1 mRNA in liver or the increase in the transcription rate of IGFBP-1 gene. In the present investigations, the mechanism of the increase in the IGFBP-1 gene has been analyzed.
The author identified an amino acid-responsive element in the 5'upstream region of IGFBP-1 gene. Furthermore, he showed that the binding of specific transcription factors is important for the increase in the transcription rate of IGFBP-1 gene.
The above results made it possible to explain the molecular mechanisms of the regulation of whole body protein metabolism as affected by dietary and hormonal factors.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Fu,Z.W.,Noguchi,T. 他: "Developmental changes in the mRNA levels of IGF-I and its related genesin the reproductive organs of Japanese quail (Coturnix coturnix japonica)."Growth Hormone and IGF Research. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takenaka,A.,Noguchi,T. 他: "Dietary restriction of a single essential amino acid reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGFBP-lin rats."J. Nutr.. 131. 2910-2914 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Imae,M.Noguchi,T. 他: "Gene expression of the three members of hepatocyte nuclear factor-3 is differentially regulated by nutritional and hormonal factors."J.Endocrinol. 167. R1-R5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takenaka,A.Noguchi,T. 他: "Amino acid regulation of gene transcription of rat insulin-like growthfactor-binding protein-1."J.Endocrinol.. 164. R11-R16 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchijima,Y.Noguchi,T. 他: "Dexamethasone stabilizes IGFBP-1 mRNA in primary cultures of rat hepatocytes."Endocrine J.. 46. 471-476 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Higashi,Y.Noguchi,T.: "Effect of protein restriction on messenger ribonucleic acid of insulin-like growth factor-I and insulin-like growth factor binding proteins in liver of ovariectomized Rats."Brit.J.Nutr.. 79. 447-453 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fu, Z.W., Kubo, T., Noguchi, T.and Kato, H.: "Developmental changes in the mRNA levels of IGF-I and its related genesin the reproductive organs of Japanese quail (Coturnix coturnix japonica)."Growth Hormone and IGF Research. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takenaka, A., Oki, N., Takahashi, S.-I., Noguchi, T.: "Dietary restriction of a single essential amino acid reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGFBP-1in rats."J.Nutr.. 131. 2910-2914 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Imae, M., Inoue, Y., Fu, Z.W., Kato, H., Noguchi, T.: "Gene expression of the three members of hepatocyte nuclear factor-3 is differentially regulated by nutritional and hormonal factors."J.Endocrinol.. 167. R1-R5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takenaka, A., Komori, K., Morishita, T., Hidaka, T., Noguchi, T.: "Amino acid regulation of gene trauscription of rat insulin-like growthfactor-binding protein-1."J.Endocrinol.. 164. R11-R16 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchijima, Y., Takenaka, A., Takahashi, S.-I., Noguchi, T.: "Dexamethasone stabilizes IGFBP-1 mRNA in primary cultures of rat hepatocytes."Endocrine J.. 46(3). 471-476 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fu,Z.W.,Noguchi,T. 他: "Developmental changes in the mRNA levels of IGF-I and its related genesin the reproductive organs of Japanese quail (Coturnix coturnix japonica)."Growth Hormone and IGF Research. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takenaka,A.,Noguchi,T. 他: "Dietary restriction of a single essential amino acid reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGFBP-1 in rats."J.Nutr.. 131. 2910-2914 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Imae,M.Noguchi,T. 他: "Gene expression of the three members of hepatocyte nuclear factor-3 is differentially regulated by nutritional and hormonal factors."J.Endocrinol.. 167. R1-R5 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Uchijima,Y.: "Dexamethasone stabilizes lGFBP-1 mRNA in primary cultures of rat hepatocytes"Endocrine J.. 46(3). 471-476 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takenaka,A.: "Amino acid regulation of gene transcription of rat insulin-like growth factor-binding protein-1"J.Endocrinol.. 164. R11-R16 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koide, T.: "Insulin-like growth factor-I potentiates protein synthesis induced by thyrotropin in FRTL-5 cells:Comparison of induction of protein synthesis and DNA synthesis." Endocrine J.45(2). 151-163 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Higashi, Y.: "Effect of protein restriction of messenger RNA of insulin-like growth factor-I and insulin-like growth factor-binding proteins in liver of overiectomized rats." Brit.J.Nutr.79. 447-453 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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