Discovery of Highly Selective Antifungal Agents from Marine Invertebrates
| Project/Area Number |
10460091
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUNAGA Shigeki Graduate School of Agric. Life Sciences, The University of Tokyo, Assoc. Prof., 大学院・農学生命科学研究科, 助教授 (60183951)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Yoichi Graduate School of Agric. Life Sciences, The University of Tokyo, Assistant., 大学院・農学生命科学研究科, 助手 (60282696)
FUSETANI Nobuhiro Graduate School of Agric. Life Sciences, The University of Tokyo, Professor, 大学院・農学生命科学研究科, 教授 (70012010)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 1999: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥11,500,000 (Direct Cost: ¥11,500,000)
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| Keywords | sponge / antifungal / marine / invertebrates / isolation / structure / elucidation |
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| Research Abstract |
From Japanese marine invertebrates, following novel compounds have been isolates as a result of bioassay-guided fractionation monitoring antifungal activity.
1. New mycalolides
From Mycale sp. collected in the Gulf of Gokasho, three novel mycalolides have been isolated as antifungal constituents. They were assigned as 30-hydroxymycalolide A, 32-hydromycalolide A, and 38-hydroxymycaloude B on the basis of spectral data.
2. Acanthosterol sulfates
From Acanthodendrilla sp. collected in the Gulf of Gokasho 10 highly hydroxylated sterol sulfates have been isolated. Their structures were determined by interpretation of spectral data.
3. Rubrosides and aurantosides
Eleven compounds that have a tetramic acid and a conjugated polyene chromophore, termed rubrosides and aurantosides, have been isolated from the Siliquariaspongeia japnica collected off Hachijo Island. Their structures were assigned on the basis of spectral data and chemical degradation.
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Report
(3 results)
Research Products
(13 results)
