| Project/Area Number |
10460139
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | THE UNIVERSITY OF TOKYO |
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Principal Investigator |
DOI Kunio GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO PROFESSOR, 大学院・農学生命科学研究科, 教授 (70155612)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Hiroyuki GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO ASSOCIATE PROFESSOR, 大学院・農学生命科学研究科, 助教授 (40155891)
ONO Ken-ichiro GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES THE UNIVERSITY OF TOKYO PROFESSOR, 大学院・農学生命科学研究科, 教授 (50111480)
KARAKI Hideaki GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO PROFESSOR, 大学院・農学生命科学研究科, 教授 (60011912)
UETSUKA Koji GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO ASSISTANT PROFESSOR, 大学院・農学生命科学研究科, 助手 (60251419)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥11,300,000 (Direct Cost: ¥11,300,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥6,300,000 (Direct Cost: ¥6,300,000)
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| Keywords | Environmental chemicals / Ultraviolet light / Skin injury / Apoptosis / Hairless dogs / Hairless rats / WBN / ILA-Ht rat / T-2 toxin / basal cell apoptosis / IQI / Jic mouse / picryl chloride / contact dermatitis / UV irradiation / Haieless dog / Skin response / Environmental Chemical / Hairless dog / Ultraviolet / Environmental chemicals / H_2O_2 / Maneb |
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| Research Abstract |
Skin reaction to ultraviolet light irradiation was examined using hairless dogs and rats. Erythema, sunburn and suntan reactions were observed as in humans. Histopathological examination for the skin revealed apoptotic cell death in the epidermal lesions. Involvement of p53 and p21 genes in the induction of apoptosis was suggested. Skin lesions were also induced by the application of an agricultural chemical, Maneb. The lesions were enhanced by ultraviolet irradiation in dogs, but not in rats. There may be a species differences in the skin reaction.
Skin reaction to topical application of formaldehyde and hydrogen peroxide was clarified using hairless rats. Skin application of a mycotoxin, T-2 toxin, was additionally performed. The results indicated apoptotic cell death of epidermal cells and endothelial injury in the dermis.
The results of the research clarified characteristics and pathogenesis of the skin injury induced by environmental chemicals and ultraviolet light.
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