• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

ANALYSIS OF CHARACTERISTICS AND PATHOGENESIS OF SKIN INJURY INDUCED BY ENVIRONMENTAL CHEMICALS AND ULTRAVIOLET LIGHT

Research Project

Project/Area Number 10460139
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionTHE UNIVERSITY OF TOKYO

Principal Investigator

DOI Kunio  GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO PROFESSOR, 大学院・農学生命科学研究科, 教授 (70155612)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Hiroyuki  GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO ASSOCIATE PROFESSOR, 大学院・農学生命科学研究科, 助教授 (40155891)
ONO Ken-ichiro  GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES THE UNIVERSITY OF TOKYO PROFESSOR, 大学院・農学生命科学研究科, 教授 (50111480)
KARAKI Hideaki  GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO PROFESSOR, 大学院・農学生命科学研究科, 教授 (60011912)
UETSUKA Koji  GRADUATE SCHOOL OF AGRICUTURAL AND LIFE SCIENCES, THE UNIVERSITY OF TOKYO ASSISTANT PROFESSOR, 大学院・農学生命科学研究科, 助手 (60251419)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥11,300,000 (Direct Cost: ¥11,300,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsEnvironmental chemicals / Ultraviolet light / Skin injury / Apoptosis / Hairless dogs / Hairless rats / WBN / ILA-Ht rat / T-2 toxin / basal cell apoptosis / IQI / Jic mouse / picryl chloride / contact dermatitis / UV irradiation / Haieless dog / Skin response / Environmental Chemical / Hairless dog / Ultraviolet / Environmental chemicals / H_2O_2 / Maneb
Research Abstract

Skin reaction to ultraviolet light irradiation was examined using hairless dogs and rats. Erythema, sunburn and suntan reactions were observed as in humans. Histopathological examination for the skin revealed apoptotic cell death in the epidermal lesions. Involvement of p53 and p21 genes in the induction of apoptosis was suggested. Skin lesions were also induced by the application of an agricultural chemical, Maneb. The lesions were enhanced by ultraviolet irradiation in dogs, but not in rats. There may be a species differences in the skin reaction.
Skin reaction to topical application of formaldehyde and hydrogen peroxide was clarified using hairless rats. Skin application of a mycotoxin, T-2 toxin, was additionally performed. The results indicated apoptotic cell death of epidermal cells and endothelial injury in the dermis.
The results of the research clarified characteristics and pathogenesis of the skin injury induced by environmental chemicals and ultraviolet light.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (53 results)

All Other

All Publications (53 results)

  • [Publications] Malcotti V.,Kuroki K.,Doi K. 他: "Effects of double UVB-irradiations with different intervals on the dorsal skin of Wistar-derived hypotrichotic WBN/ILA-Ht rats."Experimental Toxicologic Pathology. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kuroki K.,Kimura T.,Doi K. 他: "Acute dorsal skin responses to UVB-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats."Experimental Toxicologic Pathology. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albarenque S.M.,Doi K. 他: "Kinetics of apoptosis-related genes mRNAs expression in the dorsal skin of hypotrichotic WBN/ILA-Ht rats after topical application of T-2 toxin."Experimental Toxicologic Pathology. 52. 553-556 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikeda M.,Kuroki K.,Doi K. 他: "Picryl chloride-induced allergic dermatitis in IQI/Jic female mice."Experimental Toxicologic Pathology. 52. 235-240 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albarenque S.M.,Doi K. 他: "Kinetics and distribution of transforming growth factor (TGF)-β 1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical application....."Experimental Toxicologic Pathology. 52. 297-301 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Contact dermatitis induced by chemicals for hair-dyeing in hairless dogs."Journal of Toxicologic Pathology. 12. 83-90 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids."Toxicologic Pathology. 27. 528-535 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albarenque S.M.,Doi K. 他: "T-2 toxin-induced acute skin lesions in Wistar-derived hypotrichotic WBN/ILA-Ht rats."Histology and Histopathology. 14. 337-342 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.,Kuroki K.,Doi K.: "Dermatotoxicity of agricultural chemicals in the dorsal skin of hairless dogs."Toxicologic Pathology. 26. 442-447 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (Xoloitzcuintli)."Laboratory Animal Science. 48. 469-475 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K. : "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs."Histology and Histopathology. 13. 29-36 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs."Toxicologic Pathology. 26. 595-601 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwamoto S.,Doi C.,Doi K. 他: "Lectinhistochemistry of dorsal skin of Wistar-derived hypotrichotic WBN/Ila-Ht rats."Experimental Animals. 47. 183-187 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwamoto S.,Nakayama H.,Dot K.: "Morphological and morphometrical study on the dorsal skin of Wistar and WBN/ILA-Ht rats in their developing stage.Evaluation of the proliferation and ......."Histology and Histopathology. 13. 981-988 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kuroki K.,Kimura T.,Doi K. 他: "Manganese ethylene bis(Maneb)-indtuced degeneration of hair follicle epithelia in the dorsal skin of WBN/ILA-Ht rats."Journal of Toxicologic Pathology. 11. 205-207 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishii Y.,Tsutsui K.,Doi K.,Itagaki S.: "Hair follicles of young Wistar strain hairless rats : a histological study."Journal of Anatomy. 191. 99-106 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwamoto S., Nakayama H., Doi K. 他: "Hydrogen peroxide-induced dermatitis in WBN/Kob-Ht rats."Experimental Animals. 46. 147-151 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishii Y.,Kimura T.,Itagaki S.,Doi K.: "The skin injury induced by high energy dose of ultraviolet in hairless descendants of Mexican hairless dogs."Histology and Histopathology. 12. 383-389 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T. and Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of Mexican hairless dogs."Veterinary Dermatology. 8. 107-113 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Malcotti V., Kuroki K., Nakayama H.and Doi K.: "Effects of double UVB-irradiations with different intervals on the dorsal skin of Wistar-derived hypotrichotic WBN/ILA-Ht rats."Exp.Toxicol.Pathol.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kuroki K., Kimura T., Nakayama H.and Doi K.: "Acute dorsal skin responses to UVB-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats."Exp.Toxicol.Pathol.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albarenque S.M., Suzuki K., Shinozuka J., Nakayama H.and Doi K.: "Kinetics of apoptosis-related genes mRNA expression in the dorsal skin of hypotrichotic WBN/ILA-Ht rats after topical application of T-2 toxin."Exp.Toxicol. Pathol.. 52. 553-556 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikeda M., Kuroki K., Suzuki H., Nakayama H., Saegusa J.and Doi K.: "Picryl chloride-induced allergic dermatitis in IQI/Jic female mice."Exp.Toxicol.Pathol.. 52. 235-240 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albarenque S.M., Shinozuka J., Suzuki K., Nakayama H.and Doi K.: "Kinetics and distribution of transforming growth factor (TGF)-β1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical application of T-2 toxin."Exp.Toxicol.Pathol.. 52. 297-301 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Contact dermatitis induced by chemicals for hair-dyeing in hairless dogs."J.Toxicol.Pathol.. 12. 83-90 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids."Toxicol.Pathol.. 27. 528-535 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albarenque S.M., Shinozuka J., Iwamoto S., Nakayama H.and Doi K.: "T-2 toxininduced acute skin lesions in Wistar-derived hypotrichotic WBN/ILA-Ht rats."Hist.Histopathol.. 14. 337-342 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T., Kuroki K.and Doi K.: "Dermatotoxicity of agricultural chemicals in the dorsal skin of hairless dogs."Toxicol.Pathol.. 26. 442-447 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (Xoloitzcuintli)."Lab.Anim.Sci.. 48. 469-475 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs."Histol.Histopathol.. 13. 29-36 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs."Toxicol.Pathol.. 26. 595-601 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwamoto S., Doi C., Uetsuka K., Nakayama H.and Doi K.: "Lectinhistochemistry of dorsal skin of Wistar-derived hypotrichotic WBN/Ila-Ht rats."Exp.Anim.. 47. 183-187 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwamoto S., Nakayama H.and Doi K.: "Morphological and morphometrical study on the dorsal skin of Wistar and WBN/ILA-Ht rats in their developing stage. Evaluation of the proliferation and apoptotic processes."Hist.Histopathol.. 13. 981-988 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kuroki K., Kimura T., Nakayama H.and Doi K.: "Manganese ethylene bis (Maneb)-induced degeneration of hair follicle epithelia in the dorsal skin of WBN/ILA-Ht rats."J.Toxicol.Pathol.. 11. 205-207 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishii Y., Tsutsui K., Doi K.and Itagaki S.: "Hair follicles of young Wistar strain hairless rats : a histological study."J.Anat.. 191. 99-106 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwamoto S., Nakayama H., Yasoshima A.and Doi K.: "Hydrogen peroxide-induced dermatitis in WBN/Kob-Ht rats."Exp.Anim.. 46. 147-151 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishii Y., Kimura T., Itagaki S.and Doi K.: "The skin injury induced by high energy dose of ultraviolet in hairless descendants of Mexican hairless dogs."Histol.Histopathol.. 12. 383-389 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of Mexican hairless dogs."Vet.Dermatol.. 8. 107-113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Albarenque S.M. et al.: "T-2 toxin-induced acute skin hesions in Wistar-derived hypotrichotic WBN/ILA-Ht rats"Histol Histopathol. 14. 337-342 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Albarenque S.M. et al.: "Kinetics and distribution of transforming growth factor (TGF)-β1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical applicayion of T-2 toxin"Exp Toxicol Pathol. 52. 29-301 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ikeda M. et al.: "Picryl chloride-induced allergic dermatitis in IQI/Jic female mice"Exp Toxicol Pathol. 52. 235-240 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Albarenque S.M. et al.: "Kinetics of apoptosis-related genes mRNAs expression in the dorsal skin of hypotrichotic WBN/ILA-Ht rats after topical application of T-2 toxin"Exp.Toxicol.Pathol.. 53(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Malcotti V. et al.: "Effects of double-irradiations with different intervals on the dorsal skin Of Wistar-derived hypotrichotic WBN/ILA-Ht rats."Exp.Toxicol.Pathol.. 53(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kuroki K.et al.: "Acute dorsal skin responses to UVB-irradiation in wistor-derived hypotrichotic WBN/ILA-Ht rats"Exp.Toxicol.Pathol.. 52 (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Albarenque S,M,et al.: "Kinetics of transforming growth factor (TGF)-β1mRNA in the dorsal skin of WBN/ILA-Ht rats following topical application of F-2 toxin"Exp.Toxicol.Pathol.. 52 (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda.M.et al.: "Picryl,chloride-induced allergic dermatitis in IQI/Jic female mice"Exp.Toxical.Pathol.. 52 (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kimura T,and Doi K.: "Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids"Toxicol.Pathol.. 27. 528-535 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kimura T,and Doi K.: "Contact dermatitis induced by chemicals for hair-dyeing in hairless dogs"J.Toxicol.Pathol.. 12. 83-90 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Albarenque S,M,et al.: "F-2 toxin-induced acute skin lesions in wistor-derived hypotrichotic WBN/ILA-Ht rats"Histol.Histopothol.. 14. 337-342 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iwamoto S.et al.: "Hydrogen peroxide-induced dermatitis in WBN/Kob-Ht rats." Exp.Anim.46. 147-152 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Iwamoto S.et al.: "Morphological and morphometrical study on the dorsal skin of Wistivr and WBN/ILA-Ht rats in thair developing stage." Histol.Histopathol.13. 981-988 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuroki K.et al.: "Manganese ethylene bis(Maneb)-induced degeneration of hair follide epithelia in the dorsal skin of WBN/ILA-Ht rats." J.Toxicol.Pathol.11. 205-207 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Dermatotoxicity of agricultural chemicals in the dorsal skin of hairless dogs." Toxicol.Pathol.26. 442-447 (1998)

    • Related Report
      1998 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi