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Molecular and Cellular Biology in Mechanism of Body Fluid Homeostasis (Analysis of Inter- and Intra-Cellular Signalling in the Neurosecretory Cells)

Research Project

Project/Area Number 10470019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

YAMASHITA Hiroshi  University of Occupational and Environmental Health, School of Medicine Department of Physiology, Professor, 医学部, 教授 (00030841)

Co-Investigator(Kenkyū-buntansha) SERINO Ryota  University of Occupational and Environmental Health, Department of Physiology, Associate Professor, 医学部, 助手 (00309957)
UETA Yoichi  University of Occupational and Environmental Health, Department of Physiology, Lectuere, 医学部, 講師 (10232745)
SHIBUYA Izumi  University of Occupational and Environmental Health, Department of Physiology, Associate Professor, 医学部, 助教授 (50162649)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 1999: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥9,700,000 (Direct Cost: ¥9,700,000)
KeywordsNeurosecretion / Paraventricular nucleus / Supraoptic nucleus
Research Abstract

The paraventricular nucleus (PVN) and the supraoptic nucleus (SON) in the hypothalamus are known to be one of integrative sites that regulate immune, endocrine and autonomic nervous system. The magnocellular neurosecretory cells in the PVN and the SON secrete hormones into the systemic circulation. The parvocellular neurosecretory cells in the PVN secrete hormones into the portal vessels in the median eminence and also directly influence autonomic preganglionic cells in the brainstem and spinal cord. The magnocellular neurosecretory cells in the PVN and the SON synthesize arginine vasopressin and oxytocin. Their firing rate is closely related to the amount of hormones released from the axon terminals in the neurohypophysis. we examined the effects of biological substances such as PACAP, prostaglandins (PGs), nitric oxide (NO), ATP, adenosine, glutamate, gamman aminobutyric acid (GABA), propofol (anesthetic drug) on the ion channels and neuronal activities in the rat slice preparation or acute dissociated neurosecretory cells, using extracellular, intracellular and whole cell patch-clamp recordings. Our data showed that various biological substances such as excitatory and inhibitory amino acids (glutamate, GABA), peptides, NO, PGs and purinergic substances modulate the ionic currents and neuronal activities in the neurosecretory cells. We also examined the inte- and intracellular signal transduction in the neurosecretory cells, using intracellular CaィイD12+ィエD1 imaging technique and the expression of various kinds of bioactive substance genes and receptors. These results provide new insight into understanding of the characteristics of the neurosecretory cells and the physiological implication of bioactive substances in the neuroendocrine system.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (108 results)

All Other

All Publications (108 results)

  • [Publications] Yamamoto, S. et al.: "Centrally administered parathyroid hormore(PTH)-related protein(1-34) but not PTH(1-34) stimulates arginine-vasopressin secretion and its messenger RNA expression in supraoptic nucleus of conscious rats"Endocrinology. 139. 383-388 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. et al.: "PACAP increases the cytosoric Ca^<2+>. concentration and stimulates somatodendritic vasopressin release in rat supraoptic neurons"Journal of Neuroendocrinology. 10. 31-42 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inenaka, K. et al.: "Glutamatergic synaptic inputs to mouse supraoptic neurons in calcium-free medium in vitro"Journal of Neuroendocrinology. 10. 1-7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka, K. et al.: "PACAP causes Ca^<2+> release from ryanodine/caffeine stores through a novel pathway independent of both IP_3 and cAMP in bovino adrenal medullary cells"Journal of Neurochemistry. 70. 1652-1661 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hattori, Y. et al.: "Ionotropic and metabotropic glutamate receptor agonist-induced [Ca^<2+>]i increase in isolated rat supraoptic neurones"Journal of Neuroendocrinology. 10. 383-389 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Harayama, N. et al.: "Inhibition of N-and P/Q-type calcium channels by post synaptic GABA_B receptor activation in rat Supra optic neurons"Journal of Physiology. 509. 371-383 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Serino, R. et al.: "Upregulation of hypothalamic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats"Diabetologia. 41. 640-648 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueta, Y. et al.: "Hypovolemia upregulates the expression of neuronal nitric oxide synthase gene in the paraventricular and supraoptic nuclei of rats"Brain Research. 790. 25-32 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueta, Y. et al.: "Neural nitric oxide synthase gene expression in buman pituitary tumours. a possible association with somatotroph adenomas and growth normone-rerating normone gene expression"Clinical Endocrinology. 49. 29-38 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. et al.: "Patch-clamp analysis of the mechanisms of PACAP-induced excitation in rat supraoptic neurons"Journal of Neuroendocrinology. 10. 759-768 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang, Y.-F. et al.: "Inhibition of spontaneous inhibitory postsynaptic currents (IPSC) by noradrenaline in rat supraoptic neurons through presynaptic α2-adrenoceptors"Brain Research. 807. 61-69 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ibrahim, N. et al.: "GABA_B receptor-mediated inhibition of spontaneous action potential discharge in rat supraoptic neurons"Brain Research. 813. 88-96 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka, K. et al.: "Inhibition of voltage-dependent Ca^<2+> channels by prostagrandin E_2 in rat melanotrophs"Endocrinology. 139. 4801-4810 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uezono, Y. et al.: "Adrenomedullin increases intracellular Ca^<2+> and inositol 1, 4, 5triphosphate in human oligodendroglial cell line KG-IC"Brain Research. 786. 230-234 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uezono, Y. et al.: "Activation of inwardly rectifying K^+ by GABA-B receptors expressed in Xenopus oocytes"Neuroreport. 9. 583-587 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Setiadji, V. S. et al.: "Actions of prostagrandin E_2 on rat supraoptic neurons"Journal of Neuroendocrinology. 10. 927-936 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. et al.: "Evidence that multiple P2X purinoceptors are functionally expressed in rat supraoptic neurones"Journal of Physiology. 514. 351-367 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Date, Y. et al.: "Orexins, orexinergic hypothalamic peptide, interact with autonomic, neuroendocrine and neuroregulatory systems"Proc. Natl. Acad. Sci. USA. 96. 748-753 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamamoto, Y. et al.: "Down regulation of the prepro-orexin gene expression in genetically obese mice"Molecular Brain Research. 65. 14-22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueta, Y. et al.: "Adrenomedullin-like immuroreactivity in the rat hypothalamo neurophysial tract"Peptides. 20. 199-204 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nomura, M. et al.: "Effects of centrally administered pituitary adenylate cyclaseactivating polypeptide on c-fos gene expression and heteronuclear RNA for vasopressin in rat paraventricular and supraoptic nuclei"Neuroendocrinology. 69. 167-180 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Serino, R. et al.: "Centrally administered adrenomedullin increase plasma oxytocin level with induction of c-fos mRNA in the paraventricular and supraoptic nuclei of rat"Endocrinology. 140. 2334-2342 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Date, Y. et al.: "Enterochromaffin-like cells, a cellular source of uroguanylin in rat stomach"Endocrinology. 140. 2398-2404 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue, Y. et al.: "The mechanism of inhibitory actions of propofol on rat Supraoptic neurons"Anesthesiology. 91. 167-178 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishi, R. et al.: "Increase of vasopressin mRNA in the hypothalamus of inbred polydipsic mice"Brain Research Bulletin. 50. 47-51 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isse, T. et al.: "Effects of leptin on fasting-induced inhibition of neuronal nitric oxide Synthase mRNA in the paraventricular and supraoptic nuclei of rat sl"Brain Research. 846. 229-235 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. et al.: "Prostagrandin E_2 induces Ca^<2+> release from ryanodine/caffeine-sensitive stores in bovine adrenal medullary cells via EP_1-like receptors"Journal of Neurochemistry. 73. 2167-2174 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ibrahim, N. et al.: "Prostaglandin E_2 inhibits spontaneous inhibitory postsynaptic currents in rat supraoptic neurones via presynaptic EP receptors"Journal of Neuroendocrinology. 11. 879-886 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Noguchi, J. et al.: "Baclofen inhibits postsynaptic voltage-dependent calcium currents of supraoptic nucleus neurons isolated from young rats"Biomedical Research. 20. 239-247 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ozaki, M. et al.: "Preferential potentiation by nitric oxide of spontaneous inhibitory postsynaptic currents in rat supraoptic neurons"Journal of Neuroendocrinology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hara, Y. et al.: "Increase of urocortin-like immunoreactivity in the supraoptic nucleus of Dabl rats given a high Salt diet"Neuroscience Letters. 279. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamamoto, Y. et al.: "Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice"Brain Research Bulletin. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nomura, M. et al.: "Induction of pituitary adenylate cyclase-activating polypeptid mRNA in the medial parvocellular part of the paraventricular nucleus of rats following kainic acid-induced seizure"Neuroendocrinology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. et al.: "The Adrenal Chromaffin Cell"Hokkaido Univ. Press. Sapporo. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山下 博 他: "脳と循環-血圧は脳によって調節される-"共立出版,東京. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ymamoto, S. Morimoto, I. Zeki, K. Ueta, Y. Yamashita, H. Kannan, H. & Eto, S.: "Centrally administered parathyroid hormone (PTH)-related protein (1-34) but not PTH (1-34) stimulates agrginine-vasopressin secretion and its messenger ribonucleic acid expression in supraoptic nucleus of the conscious rats."Endocrinology. 139(1). 383-388 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. Noguchi, J. Tanaka, K. Harayama, N. Inoue, Y. Kabashima, N. Ueta, Y. Hattori, Y. & Yamashita, H.: "PACAP increases the cytosolic CaィイD12+ィエD1 concentration and stimulates somatodendritic vasopressin release in rat supraoptic neurons"J. Neuroendocrinol. 10. 31-42 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inenaga, K. Honda, E. Hirakawa, T. Nakamura, S. & Yamashita, H.: "Glutamatergic synaptic inputs to mouse supraoptic neurons in calcium-free medium in vitro"J. Neuroendocrinol. 10. 1-7 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka, K. Shibuya I. Uezono, Y. Toyohira, Y. Yanagihara, N. Izumi, F. Kanno, T. & Yamashita, H.: "Pituitary adenylate cyclase-activating polypeptide causes CaィイD12+ィエD1 release from ryanodine/caffeine stores through a novel pathway independent of both inositol triphosphates and cyclic AMP in bovine adrenal medullary cells."J. Neurochem.. 70. 1652-1661 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hattori, Y. Shibuya, I. Tanaka, K. Kabashima, N. Ueta, Y. & Yamashita, H.: "Inotropic and metabotropic glutamate receptor agonist-induced [CaィイD12+ィエD1] increase in isolated rat supraoptic neurons."J. Neuroendocrinol. 10. 383-389 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Harayama, N. Shibuya, I. Tanaka, K. Kabashima, N. Ueta, Y. & Yamashita, H.: "Inhibition of N- and P/Q-type calcium by postsynaptic GABAィイD2BィエD2 receptor activation in rat supraoptic neurones."J. Physiol. 509(2). 371-383 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Serino, R. Ueta, Y. Tokunaga, M. Hara, Y. Nomura, M. Kabashima, N. Shibuya, I. Hattori, Y. & Yamashita, H.: "Upregulation of hypothalamic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats."Diabetologia. 41. 640-648 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueta, Y. Levy, A. Lightman, S. L. Hara, Y. Serino, R. Nomura, M. Kabashima, M. Kabashima, N. Shibuya, I. Hattori, Y. & Yamashita, H.: "Hypovolemia upregulates the expression of neuronal nitric synthase gene in the paraventricular and supraoptic nuclei of rats."Brain Res.. 790. 25-32 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueta, Y. Levy, A. Powell, M. P. Lightman, S. L. Kinoshita, Y. Yokota, A. Shibuya, I. & Yamashita, H.: "Neuronal nitric oxide synthase gene expression in human pituitary tumor : a possible association with somatotroph adenomas and growth hormone-releasing hormone gene expression."Clinical Endocrinol. 49. 29-38 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. Kabashima, N. Tanaka, K. Setiadji, V. S. Noguchi, J. Harayama, N. Ueta, Y. & Yanashita, H.: "Patch-clamp analysis of the mechanism of PACAP-induced excitation in rat supraoptic neurones."J. Neuroendocrinol. 10. 759-768 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang, Y. F. Shibuya, I. Kabashima, N. Setiadji, V. S. Isse, T. Ueta, Y. & Yamashita, H.: "Inhibition of spontaneous inhibitory postsynaptic currents (IPSC) by noradrenaline in rat supraoptic neurons through presynaptic α2-adrenocepotors."Brain Res.. 807. 61-69 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ibrahim, N. Shibuya, I. Kabashima, N. Setiadji, V. S. Isse, T. Ueta, Y. & Yamashita, H: "GABAィイD2BィエD2 receptor-mediated inhibition of spontaneous action potential discharge in rat supraoptic neurons."Brain Res.. 813. 88-96 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka, K. Shibuya, I. Kabashima, N. Setiadji, V. S. Ueta, Y. & Yamashita, H.: "Inhibition of voltage-dependent CaィイD12+ィエD1 channels by prostaglandin EィイD22ィエD2 rat molanotrophs."Endocrinology. 139(12). 4801-4810 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uezono, Y. Shibuya, I. Ueda, Y. Tanaka, K. Oishi, Y. Yanagihara, N. Ueno, S. Toyohira, Y. Nakamura, T. Ymashita, H. & Izumi, F: "Adrenomedullin increase intracellular CaィイD12+ィエD1 and inositol, 1, 4, 5-trisphosphate in human oligodendroglial cell line KG-1C"Brain Res.. 786. 230-234 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Uezono, Y. Akihara, M. Kawano, C. Shibuya I. Ueda Y, Yanagihara, N. Toyohira, Y. Yamashita, H. & Isumi, F.: "Activation of inwardly rectifying KィイD1+ィエD1 channels by GABA-B receptors expressed in Xenopus oocytes"Neuroreport. 9. 583-587 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Setiadji, V. S. Shibuya, I. Kabashima, N. Ibrahim, N. Harayama, N. Ueta, Y. & Ymashia, H.: "Actions of prostaglandin EィイD22ィエD2 on rat supraoptic neurons"J. Neuroendocrinol. 10. 92-936 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. Tanaka K. Hattori, Y. Uezono, Y. Harayama, N. Noguchi, J. Ueta, Y. Izumi, F. & Yamashita, H.: "Evidence that multiple P2X purinoceptors are functionally expressed in rat supraoptic neurones"J. Physiol. 514. 351-367 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Date,Y. Ueta, Y. Ymashita, H.Yamguchi, H. Matsukura, S. Kangawa, K. Sakurai, T. Yanagisawa, M. & Nakazato, M.: "Orexins, orexinergic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems"Proc. Natl. Acad. Sci. USA. 96. 748-753 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamamoto, Y. Ueta, Y. Date, Y. Nakazato, M. Hara, Y. Serino, R. Nomura, M. Shibuya, I. Matsukura, S. & Yamashita, H.: "Down regulation of the prepro-orexin gene expression in genetically obese mice. Mol."Brain Res.. 65. 14-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueta, Y. Hara, Y. Setiadhi, V. S. Isse, T. Shibuya, I. Kitamuyra, K. Kanagawa, K. Matsuo, H. Eto, T. & Yamashita, H.: "Arenomedullin-like immunoreactivity in the rat hypothalamo-neorohypophysial tract"Peptides. 20. 199-204 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nomura, M. Ueta, Y. Serino, R. Yamamoto, Y. Shibuya, I. & Yamashita, H.: "Effects of centrally administered pituitary adenylate cyclase-activating polypeptide on c-fos gene expression and heteronuclear RNA for vasopressin in rat jparaventricular and supraoptic nuclei"Neurjoendocrinology. 69. 167-180 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Serino, R. Ueta, Y. Hara, Y. N, Nomura, M. Yamamoto, Y. Shibuya, I. Hattori, Y. Kitamura, K. Kangawa, K. Russell, J. A. & Yamashita, H.: "Centrally admisnistrered adrenomedullin increase plasma oxytocin level with induction of c-fos mRNA in the praventricular and supraoptic nuclei of rat"Endocrinology. 140(5). 2334-2342 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Date, Y. Nakazato, M. Yamaguchi, H. Kangawa, K. Kinoshita, Y. Chiba, T. Ueta, Y. Yamashita, H. & Matsukura, S.: "Enterchromaffin-like cells, a cellelar source of uroguanylin in rat stomach"Endocrinology. 140(5). 2398-2404 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue, Y. Shibuya, I. Kabashima, N. Noguchi, J. Harayama, N. Ueta, Y. Sata, T. Shigematsu, A. & Yamashita, H.: "The mechanism of inhibitory actions of propofol on rat supraoptic neurons"Anesthesiology. 91(1). 167-178 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishi, R. Ueta, Y. Serino, R. Nomura, M. Yamashita, Y. Shiabuya, I. Koizumi, K. & Yamashita, H.: "Increase of vasopressin mRNA in the hypothalamus of inbred polydipsic mice."Brain Res. Bull. 50(1). 47-51 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isse, T. Ueta, Y. Serino, R. Noguchi, J. Yamamoto, Y. Nomura, M. Shiabuya, I. Lightman, S. L. & Yamashita, H.: "Effects of leptin on fasting-induced inhibition of neuronal nitric oxide synthase mRNA in the praventricular and supraoptic nuclei of rats."Brain Res.. 846(2). 229-235 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. Tanaka, K. Uezono, Y. Ueta, Y. Toyohira, Y. Yanagihara, N. Izumi, F. & Yamashita, H.: "Prostaglandin EィイD22ィエD2 induces CaィイD12+ィエD1 release from ryanodine/caffeine-sensitive stores in bovine adrenal medullary cells via EPィイD21ィエD2-like receptors."J. Neurochem.. 73(5). 2167-2174 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ibrahim, N. Shibuya, I. Kabashima, N. Sutarmo, V. S. Ueta, Y. & Yamashita, H.: "Prostaglandin EィイD22ィエD2 inhibits spontaneous inhibitory postsynaptic currents in supraoptic neurones via presynaptic EP receptors."J. Neuroendocrinol. 11. 879-886 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Noguchi, J. & Yamashita, H.: "Baclofen inhibits potsynaptic voltage-dependent calcium currents of supraoptic nucleus neurons isolated from young rats."Biomedical Res.. 20(4). 239-247 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ozaki, M. Shibuya, I. Kabashima, N. Isse, T. Noguchi, J. Ueta, Y. Inoue, Y. Shigamatsu, A. & Yamashita, H.: "Preferential potentiation by nitric oxide of spontaneous inhibitory postsynaptic currents in rat supraoptic neurones."J. Neuroendocrinol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hara, Y. Ueta, Y. Isse, T. Serino, R. Shibuya, I. Hattori, Y. & Yamashita, H.: "Increase of urocortin-like immunoreactivity in the supraoptic nucleus of Dahl rats given a high salt diet."Neurosci. Lett.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamamoto, Y. et al: "Effects of food restriction on the hypothalamic prepro-orexin gene experssion on genetically obese mice."Brain. Res. Bull.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nomura, M. Ueta, Y. Hannibal, J. Scrino, R. Yamamoto, Y. Shibuya, I. Matsumoto, T. & Yamashita, H.: "Induction of pituitary adenylate cyclase-activating polypeptide mRNA in the medial parvocellular part of the paraventricular nucleus of rats following kainic acid-induced seizure."Neuroendocrinology. (accepted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, I. Tanaka, K. Nomura, M. Ueta, Y. Kanno, T. & Yamashita, H.: "Mechanisms of PACAP-induced CaィイD12+ィエD1 influx and CaィイD12+ィエD1 release in bovine adrenal chromaffin cells., The Adrenal Chromaffin Cell."Hokkaido Univ. Press. Sapporo. 43-55 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue Y et al.: "The mechanisms of inhibitory actions of propofol on rat supraopticneurons"Anesthesiology. 91・1. 167-178 (1999)

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      1999 Annual Research Report
  • [Publications] Nishi R et al: "Increase of vasopressin mRNA in the hypothalamus of inbred polydipsic mice"Brain Research Bulletin. 50・1. 47-51 (1999)

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      1999 Annual Research Report
  • [Publications] Isse T et al: "Effects of leptin on fasting-induced inhibition of neuronal nitric oxide mRNA in the paraventridular and supraoptic nuclear"Brain Research. 846・2. 229-235 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shibuya I et al: "Prostagrandin E_2 induces Ca^<2+> release from ryardin/caffeine-sensitive stores in bovine adrenal medullary cells via ER-like receptors"Journal of Neurochemistry. 73・5. 2167-2174 (1999)

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      1999 Annual Research Report
  • [Publications] Ibrahim N et al: "Prostagrandin E_2 inhibits spontaneous inhibitory postsynaptic currents in rat supraoptic neurones via presynaptic EP receptors"Journal of Neuroendocrinology. 11. 879-886 (1999)

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      1999 Annual Research Report
  • [Publications] Noguch J et al: "Badofen inhibits postsynaptic voltage-dependent calcium currents of supraoptic nucleus neurons isolated from young rats."Biomedical Research. 20・4. 239-247 (1999)

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      1999 Annual Research Report
  • [Publications] Ozaki M et al: "Preferential potentiation by nitric oxide of spontaneous inhibitory postsynatic currents in rat supraoptic neurons."Journal of Neuroendocrinology. (in press).

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      1999 Annual Research Report
  • [Publications] Hara Y et al: "Increase of Urocortin-like immunoreactivity in the supraotic nucleus of Dabl rats given a high salt diet."Neuroscience Letters. 279・1. 17-20 (2000)

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      1999 Annual Research Report
  • [Publications] Yamamoto Y et al: "Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese gene"Brain Researche Bulletin. (in press).

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      1999 Annual Research Report
  • [Publications] Nomura M et al: "Induction of pituitary adenylate cyclase-actovating polypeptide mRNA intle medial parvocellular part of the paraventricular nucleus of rats following lkainic acid-induced seizure"Neuroendocrinology. (in press).

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      1999 Annual Research Report
  • [Publications] 上田 陽一・他: "アドレノメデュリンの中枢内分布" 医学のあゆみ. 184(1). 31-33 (1998)

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  • [Publications] Shibuya,I.et al.: "PACAP increases the cytosolic Ca^<2+> concentration and stimulates somatodendritic vasopressin relaase in rat supraoptic neurons." Journal of Neuroendocrinology. 10(1). 31-42 (1998)

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  • [Publications] Inenaga,K.et al.: "Glutamatergic synaptic inputs to mouse supraoptic neurons in calcium-free medium in vitro." Journal of Neuroendocrinology. 10(1). 1-7 (1998)

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      1998 Annual Research Report
  • [Publications] Yamamoto,S.et al.: "Centrally Administered Parathyroid Hormone (PTH)-Related Protein (1-34) But Not PTH(1-34) Stimulates Arginine-Vasopressin Secretion and It's Messenger RNA Expression in SON of the Conscious Rats." Endocrinology. 138(1). 383-388 (1998)

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      1998 Annual Research Report
  • [Publications] Uezono,Y.et al.: "Activation of inwardly rectifying K^+ channels by GABA-B receptors expressed in xenopus oocytes." Neuroreport. 9(4). 583-587 (1998)

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      1998 Annual Research Report
  • [Publications] Ueta,Y.et al.: "Hypovolemia upregulates the expression of neuronal nitric oxide synthase gene in the paraventricular and supraoptic nuclei of rats." Brain Research. 790. 25-32 (1998)

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      1998 Annual Research Report
  • [Publications] Tanaka,K et al.: "Inhibition of voltage-dependent Ca^<2+> channels by prostagrandin E_2 in rat melanotrophs." Endocrinology. 139(12). 4801-4810 (1998)

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  • [Publications] Setiadji,V.S.: "Actions of prostaglandin E_2 on rat supraoptic neurons" Journal of Neuroendocrinology. 10(12). 927-936 (1998)

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      1998 Annual Research Report
  • [Publications] Shibuya,I.et al.: "Evidence that multiple P_2X purinoceptors are functionally expressed in rat supraoptic neurons." Journal of Physiology. 514. 351-367 (1999)

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  • [Publications] Date,Y.et al.: "Orexins,orexinergic hypothalamic peptides,interact with automatic,neuroendocrine and neuroregulatory systems" Proc.Natl.Acad.Sci.USA. 96. 748-753 (1998)

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  • [Publications] Ueta,Y.et al.: "Adrenomadullin-immunoreactivity in the rat hypothalamo-neurohypophysial ract." Peptides. in press.

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      1998 Annual Research Report
  • [Publications] Yamamoto,Y.et al.: "Down regulation of the prepo-orexin gene expression in genetically obese mice." Molecular Brain Research. in press.

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  • [Publications] Nomura,M.et al.: "Effects of centrally administered pituitary adenylate cyclase activating polypeptide on c-fus gene expression and heteronuclear RNA for vasopressin in rat paraventricular and supraoptic nuclei." Neuroendocrinology. in press.

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  • [Publications] Serino,R.et al.: "Centrally administered adrenomedullin increase plasma oytocin level with induction of c-fos mRNA in the paraventricular and supraoptic nuclei of rat" Endocrinology. in press.

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  • [Publications] Date,Y.et al.: "Enterochromaffin-like cells,a cellular source of uroguanylin rat stomach." Endocrinology. in press.

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  • [Publications] 渋谷 泉,他: "サイトカインによる内分泌反応" CLINICAL NEUROSCIENCE. 16(4). 60-63 (1998)

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  • [Publications] 上田 陽一 他: "一酸化窒素(NO)と神経内分泌系" 脳機能の解明-21世紀に向けて-. 31. 351-354

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  • [Publications] Hattori,Y.et al.: "Ionotropic and metabotropic glutamate receptor agonist-induced 〔Ca^<2+>〕; increase in isolated rat supraoptic neurons." Journal of Neuroendocrinology. 10(5). 383-389 (1998)

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  • [Publications] Uezono,Y.et al.: "Adrenomedullin increases intracellular Ca^<2+> and inositol 14,5-trisphosphate in human oligodendroglial cell line KG-IC." Brain Research. 786. 230-234 (1998)

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  • [Publications] Harayama,N.et al.: "Inhibition of N- and P/Q-type calcium channels by postsynaptic GANA_β receptor activation in rat supraoptic neurons." Journal of Physiology. 509(2). 371-383 (1998)

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  • [Publications] Seirno,R.et al.: "Upregulation of hypothalamic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats." Diabetologia. 41(6). 640-648 (1998)

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  • [Publications] Ueta,Y.et al.: "Neuronal nitric oxide synthase gene expression in human pituitary tumors:a possible association with somatotroph adenomas and growth nermonts-relensing hormene gene expression." Clinical Endocrinology. 49. 29-38 (1998)

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  • [Publications] 上田 陽一・他: "アドレノメデュリンと中枢神経系" Molecular Medicine特集 アドレノメデュリンの基礎とその臨床応用. 35(8). 998-1005 (1998)

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  • [Publications] Tanaka,K.et al.: "Pituitary adenylate cxiase-activating polypeptide causes Ca^<2+> release from rganodine/caffeine stores through a novel pathway independent of both inositol triphosphates and cyclic" Journal of Neurochemistry. 70. 1652-1661 (1998)

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  • [Publications] Shibuya,I.et al.: "Patch-clamp analysis of the mechanism of PACAP-induced excitation in rat supraoptic neurons." Journal of Neuroendocrinology. 10(10). 759-768 (1998)

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      1998 Annual Research Report
  • [Publications] Wang,Y.-F.et al.: "Inhibition of spontaneous inhibitory postsynaptic currents (IPSC) by noradrenaline in rat supraoptic neurons through presynaptic α2-adrenoceptors." Brain Rsearch. 807. 61-69 (1998)

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      1998 Annual Research Report
  • [Publications] Ibrahim,N.et al.: "GABA_β receptor-mediated inhibition of spontaneous action potential discharge in rat supraoptic neurons." Brain Research. 813. 88-96 (1998)

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      1998 Annual Research Report
  • [Publications] Shibuya,I.et al.: "The Adrenal Chromaffin cell." Hokkaido Univ,Press,Sapporo, 13 (1998)

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  • [Publications] 山下 博.他: "脳と循環-血圧は脳によって調節される" 共立出版,東京, (1998)

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Published: 1998-04-01   Modified: 2016-04-21  

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