| Project/Area Number |
10470092
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
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| Research Field |
Immunology
|
|---|
| Research Institution | Research Institute, Osaka Medical Center for Maternal and Child Health |
|---|
Principal Investigator |
NAGASAWA Takashi Research Institute, Osaka Medical Center for Maternal and Child Health, Department of medical immunity, Lab.head, 免疫部門, 部長 (80281690)
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥3,200,000 (Direct Cost: ¥3,200,000)
|
|---|
| Keywords | chemokine / bone marrow / B lymphocyte / hematopoiesis / homing / angiogenesis / B細胞 / 腸管 |
|---|
| Research Abstract |
Chemokines are a family of small structurally related molecules that were recognized originally for their ability to regulate cell trafficking in inflammation. We isolated a chemokine, stromal cell-derived factor/pre-B-cell growth stimulating factor (SDF-1/PBSF) as a molecule that stimulates the growth of B lymphocyte precursors and have found its multiple physiological functions in development. We have shown that SDF-1/PBSF is essential for embryonic viability, development of B lymphocyte, colonization of bone marrow by hematopoietic cells and cardiogenesis. Moreover, we identified a murine seven-transmembrane G-protein-coupled receptor for SDF-1/PBSF, termed CXCR4, that also functions as a coreceptor for strains of HIV-1. Here we generated CXCR4 deficient mice and found that CXCR4 was a primary physiologic receptor for SDF-1/PBSF.
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