Physiologic and pathologic functions of a CXC chemokine PBSF/SDF-1 and its receptor CXCR4
Project/Area Number |
10470092
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
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Research Institution | Research Institute, Osaka Medical Center for Maternal and Child Health |
Principal Investigator |
NAGASAWA Takashi Research Institute, Osaka Medical Center for Maternal and Child Health, Department of medical immunity, Lab.head, 免疫部門, 部長 (80281690)
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Project Period (FY) |
1998 – 1999
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Project Status |
Completed (Fiscal Year 1999)
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Budget Amount *help |
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥3,200,000 (Direct Cost: ¥3,200,000)
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Keywords | chemokine / bone marrow / B lymphocyte / hematopoiesis / homing / angiogenesis / B細胞 / 腸管 |
Research Abstract |
Chemokines are a family of small structurally related molecules that were recognized originally for their ability to regulate cell trafficking in inflammation. We isolated a chemokine, stromal cell-derived factor/pre-B-cell growth stimulating factor (SDF-1/PBSF) as a molecule that stimulates the growth of B lymphocyte precursors and have found its multiple physiological functions in development. We have shown that SDF-1/PBSF is essential for embryonic viability, development of B lymphocyte, colonization of bone marrow by hematopoietic cells and cardiogenesis. Moreover, we identified a murine seven-transmembrane G-protein-coupled receptor for SDF-1/PBSF, termed CXCR4, that also functions as a coreceptor for strains of HIV-1. Here we generated CXCR4 deficient mice and found that CXCR4 was a primary physiologic receptor for SDF-1/PBSF.
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Report
(3 results)
Research Products
(15 results)
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[Publications] Kawabata, K., Ujikawa, M., Egawa, T., Kawamoto, H., Tachibana, K., Iizawa, H., Katsura, Y., Kishimoto, T., Nagasawa, T.: "A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution"Proc. Natl. Acad. Sci. USA. 96. 5663-5667 (1999)
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[Publications] Tachibana, K., Hirota, S., Iizawa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S., Kishimoto, T., & NAGASAWA, T.: "The chomokinase receptor CXCR4 is essential for vascularization of the gastrointertinal tract." Nature. 393. 591-594 (1998)
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[Publications] Morita, C., Shioda, T., Tashiro, K., NAGASAWA, T., Ikegawa, M., Ohnishi, Y., Kato, A., Hu, H., Xin, X., Hasan, M.K., MaeKawa, M., Takabe, Y., Sakai, Y., Honjo, T., Nagai, Y.: "Large quantity production with extreme convenience of Human SDF-1a and SDF-1b by a Sendai Virus vector." FEBS Lett.425. 105-111 (1998)
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[Publications] Ma, Q., Jones, D., Borghesani, P.R., Segal, R.A., NAGASAWA, T., Kishimoto, T., Bronson, R.T., Springer, T.A.: "Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4-and SDF-1-deficient mice." Proc.Natl.Acad.Sci.USA. 95. 9448-9453 (1998)
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[Publications] Naka, T., Matsumoto, T., Narazaki, M., Fujimoto, M., Morita, Y., Ohsawa, Y., Saito, H., NAGASAWA, T., Uchiyama, Y.Kishimoto, T.: "Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSi-1(STAT-induced STAT inhibitor-1) deficient mice." Proc. Natl.Acad.Sci.USA. 95. 15577-15582 (1998)