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Effect of concomitant exposure of endocrine disrupting chemicals and its risk assessment

Research Project

Project/Area Number 10470096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MAKITA Yuji  Kyushu University, Faculty of Medicine Associate Professor, 大学院・医学研究院, 助教授 (30209407)

Co-Investigator(Kenkyū-buntansha) OMURA Minoru  Kyushu University, Faculty of Medicine Assistant, 大学院・医学研究院, 助手 (50243936)
HIRATA Miyuki  Kyushu University, Faculty of Medicine Assistant, 大学院・医学研究院, 助手 (30156674)
TANAKA Akiyo  Kyushu University, Faculty of Medicine Assistant Professor, 大学院・医学研究院, 講師 (10136484)
INOUE Naohide  Kyushu University, Faculty of Medicine Professor, 大学院・医学研究院, 教授 (00131904)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsEdocrine disrupter / P,p'-DDE / Tributyltin(TBT) / Combined effect / Wistar rat / アンドローゲン作用 / 抗アンドローゲン作用 / 哺乳動物 / p,p'-DDE / P,P'-DDE / アンドーゲン作用 / 生体影響 / 複合汚染 / 海産資源
Research Abstract

P,p'-DDE(DDE) and tributyltin (TBT)have been ubiquitous in the environment and are suspected to be potent endocrine disrupters. DDE and TBT are considerably taken in Japan from marine products, in which they are included through bio-concentration and food chain. Above all, fetuses and neonates are highly susceptible to endocrine disrupters and faced with concurrent exposure of DDE and TBT through the maternal environment, where these substances are much contained in increased marine product intake during pregnancy and in milk during nursing period. Therefore, the combined effects of DDE and TBT on rat offspring were investigated by simultaneous administration of DDE and/or TBT in pregnant Wistar rats. In this study, TBT did suppress the growth and reduce the prostate weight of rat offspring, whereas DDE itself scarcely affected but restored the growth suppression and prostate weight reduction by TBT. These results indicate that TBT could affect the endocrine system of rat male offspring as well as that of marine prosobranch snails and suggest that TBT may exert its actions through the androgen receptor as DDE is known to be an androgen receptor antagonist in rats.

Report

(4 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 槇田裕之, 田中昭代, 平田美由紀, 大村実, 尾方里香, 井上尚英: "P, p'-DDEとTBT(トリブチルスズ)の複合投与による影響"日本衛生学会誌. 56.1. 250-251 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 尾方里香, 大村実, 槇田裕之, 田中昭代, 平田美由紀, 井上尚英, 粟生修司他: "トリブチルスズは哺乳動物にとって内分泌攪乱物質か"日本衛生学会誌. 55.1. 125-126 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大村実, 増田義雄, 平田美由紀, 田中昭代, 尾方里香, 槇田裕之, 井上尚英: "六塩化ナフタレンの雄ラットへの胎児期暴露実験"日本衛生学会誌. 54.1. 245-246 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Romero Y.: "Effects of p, p'-DDE on male reproductive organs in peripubertal Wistar rats following a single peritoneal injection"Fukuoka Acta Medica. 89.1. 64-72 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Makita Y, Tanaka A, Hirata M, Omura M, Ogata R: "Combined effects of p, p'-DDE and tributyltin on Wistar rat offspring"Fukuoka Acta Medica. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Makita Y, Tanaka A, Hirata M, Omura M, Ogata R, Inoue N: "Effects of combined administration of p,p'-DDE and TBT"Jpn J Hygiene. 56. 250-251 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogata R, Omura M, Makita Y, Tanaka A, Hirata M, Inoue N, Aou S, Kubo K: "Is TBT an endocrine disrupter for mammals?"Jpn J Hygiene. 55. 125-126 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Omura M, Masuda Y, Hirata M, Tanaka A, Ogata R, Makita Y, Inoue N: "Effects of gestational exposure of hexachlorinated naphthalene in male rat"Jpn J Hygiene. 54. 245-246 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Romero Y: "Effects of p,p ' -DDE on male reproductive organs in peripubertal Wistar rats following a single peritoneal injection"Fukuoka Acta Med. 89. 64-72 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Makita Y, Tanaka A, Hirata M, Omura M, Ogata R: "Combine effects of p,p'-DDE and tributyltin on Wistar rat offspring"(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 槙田裕之 他: "p,p'-DDEとトリブチルスズの複合投与による影響"日本衛生学会雑誌. 56・1(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 尾方里香 他: "トリブチルスズの妊娠期/授乳期曝露による母仔ラットへの影響"日本衛生学会雑誌. 54・1. 255 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Omura et al: "Onset of spermatogenesis is accelerated by a gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring"Environ. Health Perspect. (in press). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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