| Project/Area Number |
10470103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHIMAMOTO Takashi U of Tsukuba, Institute of Community Medicine, Professor, 社会医学系, 教授 (50143178)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Akihiko Osaka Medical Center for Cancer and Cardiovascular Diseases, Chief, 成人病センター＊工部, 診療主任
TANIGAWA Takeshi U of Tsukuba, Institute of Community Medicine, Assistant Professor, 社会医学系, 講師 (80227214)
ISO Hiroyasu U of Tsukuba, Institute of Community Medicine, Associate Professor, 社会医学系, 助教授 (50223053)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 1999: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1998: ¥10,000,000 (Direct Cost: ¥10,000,000)
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| Keywords | atherosclerosis / risk factors / carotid sonography / plasma fibrinogen / platelet aggregation / adhesion molecule / immune function / homosysteine / 頚動脈硬化 / 単球 / 超音波断層検査 / 循環器疾患 |
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| Research Abstract |
To investigate new risk factors for atherosclerosis among Japanese, the examination of echocardiograms and candidate risk factors were conducted for a total of 1,648 men and women aged 60-74 years in four communities. Sonography and reading of carotid atherosclerosis were standardized according to the methods of Cardiovascular Health Study in the United States, a large cohort study of examining of atherosclerosis risk factors.
Conventional risk factors for carotid athrosclerosis (intima-media thickness >=1.1 mm for common carotid and/or >=1.5 mm for bulb and internal carotid) included age, hypertension, high total cholesterol, low HDL-cholesterol, diabetes, and smoking. Age and hypertension were common risk factors for atheorsclerosis in both common and bulb/internal carotid arteries. High total cholesterol, low HDL-cholesterol were risk factors for atherosclerosis in common arteries, but no in bulb/internal carotid arteries. Plasma fibrinogen or platelet aggregation were not associated with carotid ahthersclerosis in either common or bulb/carotid arteries. As new factors for carotid for carotid atherosclerosis, plasma E selection (one of the adhesion molecules) was associated with common carotid atherosclerosis. Counts of monocytes and lymphocyte, more specifically memory T cell lymphocytes were associated with common carotid atherosclerosis. Plasma homocysteine was associated with carotid atherosisclerosis in normotensive men.
In conclusion, the present study showed high concentraions of E selectin and homocysteine, and high counts of monocytes and memory T cell as new risk factors for atherosclerosis.
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