| Project/Area Number |
10470113
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Jichi Medical School |
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Principal Investigator |
KAYABA Kazunori MEDICINE, JICHI MEDICAL SCHOOL, LECTURER, 医学部, 講師 (10221194)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Shizukiyo MEDICINE, JICHI MEDICAL SCHOOL, ASSISTANT PROFESOR, 医学部, 助手 (70306140)
YOSHIMURA Manabu MEDICINE, JICHI MEDICAL SCHOOL, ASSISTANT PROFESOR, 医学部, 助手 (20285802)
GOTO Tadao MEDICINE, JICHI MEDICAL SCHOOL, ASSISTANT PROFESOR, 医学部, 助手 (00285800)
SIMADA Kazuyuki MEDICINE, JICHI MEDICAL SCHOOL, PROFESOR, 医学部, 教授 (90145128)
KARIO Kazuomi MEDICINE, JICHI MEDICAL SCHOOL, ASSISTANT PROFESOR, 医学部, 助手 (60285773)
柳川 洋 自治医科大学, 医学部, 教授 (30077169)
中村 好一 自治医科大学, 医学部, 助教授 (50217915)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 1999: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1998: ¥7,300,000 (Direct Cost: ¥7,300,000)
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| Keywords | STROKE / MYOCARDIALIINFARCTION / ATHEROLEROSCLEROTIC DISEASE / DEATH / COHORT STUDY / PROSPECTIVE STUDY / JAPANESE / RISK FACTOR / 動脈硬化性疾患 / 横断研究 / 社会支援 / 生活習慣 |
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| Research Abstract |
A prosepective cohort study examining the risk factors of the atheroseclerotic diseases has been conducted. As base-line data, information about life-style by questionnaires and biological information by serum sample body weight and height were obtained from 1992 to 1995 in 12 rural districts. All the subjects were 12,490 males and females, and the subjets aged 40 to 69 years were 10,608 males and females. We have followed the subjects to catch incidences of stroke and myocardial infarction, deaths and the moving outs until the end of 1999. Incidences of stroke were 188 cases, and myocardial infarction, 25 cases. Deaths were 361 and moving out were 222 at the end of 1998, and 176 out of 222 were censored. We have been cleaning the base-ilne data, and recheck data of questionnaires for all the subjects.
We examined the association between body mass index(BMI) and mortality for the subjets aged 40 to 69 males and females. The mean follow-up period was 5.5 year, and the follow-up rate was 100%. Hazard ratios were 136(BMI: <20.0k/mィイD12ィエD1 95% confidence interval(CI): 0.84-221), 0.70 (BMI: 23.0-25.9 kg/mィイD12ィエD1 95% Cl: 0.43-1.13), 0.76(BMI:>26kg/mィイD12]ィエD1 95%CI: 0.41-1.43) For the reference(BMI:20.0-22.9kg/mィイD12ィエD1in males, and were 0.91(BMI: <20.0kg/mィイD12ィエD1, 95% CI:0.42-1.96), 1.02(BMI:23.0-25.9kg/mィイD12ィエD1 95% Cl:0.58-1.81),1.86 (BMI:【greater than or equal】26 kg/mィイD12ィエD1 1.02-3.40) For the reference(BMI:20.0-22.9 kg/mィイD12ィエD1 in females adjusted for age, diastolic blood pressure, total cholesterol HDL-cholesterol and smoking habit using Cox's proportional hazard model.
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