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Development for detecting the early health effect of fiber inhalation and constructing the risk assessment system of the fiber.

Research Project

Project/Area Number 10470115
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionUniversity of Occupational Environmental Health (UOEH)

Principal Investigator

TANAKA Isamu  UOEH, lnst. of Ind. Ecol. Sci. Professor, 産業生態科学研究所, 教授 (00038035)

Co-Investigator(Kenkyū-buntansha) YAMATO Hiroshi  UOEH, lnst. of Ind. Ecol. Sci. Assoc. Professor, 産業生態科学研究所, 助教授 (90248592)
HORI Hajime  UOEH, lnst. of I School of Health Sciences Professor, 産業保健学部, 教授 (70140902)
HIGASHI Toshiaki  UOEH, lnst. of Ind. Ecol. Sci. Professor, 産業生態科学研究所, 教授 (10119000)
OHGAMI Akira  UOEH, lnst. of Ind. Ecol. Sci. Research Assoc., 産業生態科学研究所, 助手 (40301692)
MORIMOTO Yasuo  UOEH, lnst. of Ind. Ecol. Sci. Assoc. Professor, 産業生態科学研究所, 助教授 (30258628)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1999: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1998: ¥3,300,000 (Direct Cost: ¥3,300,000)
KeywordsRisk Assessment / Health Effect / Fibrous Materials / Inhalation / 吸入曝路
Research Abstract

Test, fibers used in this experiment were glass wool, rock wool, ceramic fiber and potassium octatitanate whisker. The four steps for detecting health effect were conducted.
First, Step : Identification of the physico-chemical and geometric properties of fibers.
The following properties were investigated for test fibers ; fiber diameter, fiber length, solubility in distilled water and Gamble solution, surface property (Zeta-potential), specific surface area, solid density, chemical compounds.
Second step : biopersistence in lungs for test fibers by intratracheal instillation method.
The hamsters were injected to fibers (2mg) by intratracheal instillation methods. The hamsters were sacrificed 3 days and 3 months after the injection. The amount of remained in the lungs were detected by ICP-AES. The result showed that the biopersistence was potassium octatitanate whisker = ceramic fiber > rock wool >> glass wool.
Third step : biopersistence in lungs by short-term inhalation based on the second step.
The rats were exposed to potassium octatitanate whisker by one month inhalation study (10ng/mィイD13ィエD1 ; 6hours/days, 5days/week). The biological half time was decided to 3.5 months.
Fourth step : biopersistence in lungs and histopathological findings by long-term inhalation.
The rats were exposed to potassium octatitanate whisker by one year inhalation study ( 1.9mg/m3 ; 6hours/days, 5days/week). The biological half time was decided to 15 months. For histopathological findings, there were no tumor, but the fibrotic changes were observed in au exposed rats.
The result shows that the fiber amounts in the lungs over the critical point caused the prolongation of the biopersistence of fibers in the lungs and the fibrotic changes of the lungs.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (55 results)

All Other

All Publications (55 results)

  • [Publications] HORI Hajime: "A Clearance Model of Inhaled Man-Made Fibers in Rat Lung"Industrial Health. 37. 103-107 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] MORIMOTO Yasuo: "Effects of Mineral Fibers on the Gene Expression of Proinflamatory Cytokines and Inducible Nitric-Oxide Synthase in Alveolar Macrophages"Industrial Health. 37. 329-334 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] MORIMOTO Yasuo: "Combined Effect of Cigarette Smoke and Mineral Fibers on the Gene Expression of Cytokine mRNA"Environmental Health Perspectives. 107, N06. 495-500 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] ISHIMATSU Sumiyo: "A New Digestion Method for Recovery of MMMFs from Lungs"Industrial Health. 37. 307-312 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YAMAGUCHI Raizou: "Increased 8-Hydroxyguanine in DNA Its Repair Activity in Hamster and Rat Lung After Intracheal Instillation of Crocidolite Asbestos"Japanese Journal of Cancer Research. 90. 505-509 (199*)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TANAKA Isamu: "Lung Deposiotion and Clearance of Inhaled Graphitr Whisker"J.Aerosil Sci. 29. 295-296 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YAMATO Hiroshi: "Fiber Numbers Per Unit Weight of JFM Standard Reference Samples Determined with a ScanningElectron Microscope"Industrial Health. 36. 384-387 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] HORI Hajime: "A Clearance Model of Inhaled Glass Fiber in Rat Lungs"ELSEVIER. 591-595 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YAMATO Hiroshi: "Clearance of Inhaled Potassium Octatitanate Whisker in Rat Lungs"ELSEVIER. 587-590 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] MORIMOTO Yasuo: "Risk Assessment of Man-Made Fibers by RT-PCR"ELSEVIER. 611-614 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] ISHIMATSU Sumiyo: "Clearance Time of Deposited Graphite Whisker in Rat Lungs"ELSEVIER. 583-586 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] ISHIMATSU Sumiyo: "Biopersistence of Inhaled Glass Fibers in Rat Lungs"ELSEVIER. 692-696 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] OYABU Takako: "Biopersistence and the Possibility of Fibrosis of Limestone in Rat Lung"ELSEVIER. 546-549 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TSUDA Tohru: "One-Year Inhalation Study of Man-Made Fibers"ELSEVIER. 596-600 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOSHIZUMI Kouji: "Improvements in Airborne Asbestos Concentrations in Work Places of Asbestos-Containing Products Manufacturing Plants in Japan"ELSEVIER. 1033-1036 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YAMAGUCHI Raizou: "Increased 8-Oh-Gua in DNA and Its Repair Activity in Crocidolite Treated Hamster Lung"ELSEVIER. 737-740 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Hori, S. Ishimatsu, T Oyabu, H. Yamato, Y. Morimoto, T. Tsuda, T. Higashi and I.Tanaka: "A CLEARANCE MODEL OF INHALED GLASS FIBER N RAT LUNGS"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 591-595 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Yamato, T. Seto, Y. Morimoto, T. Tsuda, T. Oyabu, S. Ishimatsu, H. Hori and I. Tanaka: "CLEARANCE OF INHALED POTASSIUM OCTATITANATE WHISKER N RAT LUNGS"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 587-590 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Morimoto, T. Tsuda, H. Yamato, H. Hori, T. Higashi and I. Tanaka: "RISK ASSESSMENT OF MAN-MADE FIBERS BY RT-PCR"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 611-614 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Ishimatsu, I. Tanaka, T. Oyabu, H. Yamato, Y. Morimoto, H. Hori, T. Tsuda, A. Ohgami and T. Higashi: "CLEARANCE TIME OF DEPOSITED GRAPHITE WHlSKER IN RAT LUNGS"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 583-586 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Ishimatsu, T. Oyabu, H. Hori, H. Yamato, Y. Morimoto, T. Tsuda, T. Higashi and I. Tanaka: "BIOPERSISTENCE OF INHALED GLASS FIBERS IN RAT LUNGS"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 691-696 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Oyabu, T. Kasai, H. Yamato, S. Ishimatsu, Y Morimoto, H. Hashimoto, T. Tsuda, H. Hori, A. Ohgami, I. Tanaka and Y Baba: "BIOPERSISTENCE AND THE POSSIBILIY OF FIBROSIS OF LIMESTONE IN RAT LUNG"ibidAdvances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 546-549 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Tsuda, H. Yamato, Y. Morimoto, T. Oyabu, S. Ishimatsu, H. Hori, T. Kasai, M. Kido, T. Higashi and I. Tanaka: "ONE-YEAR INHALATION STUDY OF MAN-MADE FIBERS"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 696-600 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Yoshizumi, H. Hori, T. Higashi, I. Tanaka, H. Hiroi and M. Tomita: "IMPROVEMENTS IN AIRBORNE ASBESTOS CONCENTRATlONS IN WORK PLACES OF ASBESTOS-CONTANING PRODUCTS MANUFACTURING PLANTS IN JAPAN"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 1033-1036 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] R. Yamaguchi, T. Hirano, Y. Ootsuyama, S. Asami, Y. Tsurudome, S. Fukada, H. Yamato, I. Tanaka and H. Kasai: "INCREASED 8-OH-GUA IN DNA AND ITS REPAIR ACTIVITY IN CROCIDOLITE TREATED HAMSTER LUNG"Advances in the Prevention of Occupational Respiratory Diseases (Edited by K. Chiyotani, et al) ELSEVIER, Amsterdam.. 734-740 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Hori, S. Ishimatsu, T. Oyabu, H. Yamato, Y. Morimoto, T. Tsuda, T. Higashi and I. Tanaka: "A CLEARANCE MODEL OF INHALED MAN-MADE FIBERS IN RAT LUNGS"Industrial Health. Vol. 37. 103-107 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Morimoto, T. Tsuda, M. Hirohashi, H. Yamato, H. Hori. A. Ohgami, K. Yatera, H. N. Kim, L. Ding, M. Kido, T. Higashi and I. Tanaka: "EFFECTS OF MINERAL FIBERS ON THE GENE EXPRESSlON OF PROINFLAMMATORY CYTOKINES AND Inducible NITRIC-OXIDE SYNTHASE IN ALVEOLAR MACROPHAGES"Industrial Health. Vol. 37. 329-334 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Morimoto, T. Tsuda, H. Hori, H. Yamato, A. Ohgami, T. Higashi, N. Nagata, M. Kido and I. Tanaka: "COMBINED EFFECT OF CIGARETTE SMOKE AND MINERAL FIBERS ON THE GENE EXPRESSION OF CYTOKINE mRNA"Environmental Health Perspectives.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Ishimatsu, T. Oyabu, H. Hori and I. Tanaka: "A NEW DIGESTION METHOD FOR RECOVERY OF MMMFs FROM LUNGS"Industrial Health. Vol. 37. 307-312 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] R. Yamaguchi, T. Hirano, Y. Ootsuyama, S. Asami, Y. Tsurudome, S. Fukada, H. Yamato, T. Tsuda, I. Tanaka and H. Kasai: "INREASED 8-HYDROXYGUANiNE IN DNA AND ITS REPAIR ACTIVITY IN HAMSTER AND RAT LUNG AFTER INTRATRACHEAL INSTILLATION OF CROCIDOLITE ASBESTOS"Japanese Journal of Cancer Research. Vol. 90. 505-509 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I. Tanaka, S. Ishimatsu, T. Oyabu, H. Yamato, A. Ohgami, Y. Morimoto, H. Hori, T. Tsuda and T. Higashi: "LUNG DEPOSlOTION AND CLEARANCE OF INHALED GRAPHITE WHISKER"J. Aerosol Sci.. Vol. 29. 295-296 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Yamato, Y. Morimoto, T. Tsuda, A. Ohgami, N. Kohyama and I. Tanaka: "FIBER NUMBERS PER UNIT WEIGHT OF JFM STANDARD REFERENCE SAMPLES DETERMINED WITH A SCANNING ELECTRON MICROSCOPE"Industrial Health. Vol. 36. 384-387 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] HORI Hajime: "A Clearance Model of Inhaled Man-Made Fibers in Rat Lungs"Industrial Health. 37. 103-107 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] MORIMOTO Yasuo: "Effects of Mineral Fibers on the Gene Expression of Proinflammatory Cytokines and Inducible Nitric-Oxide Synthase in Alveolar Macrophages"Industrial Health. 37. 329-334 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] MORIMOTO Yasuo: "Combined Effect of Cigarette Smoke and Mineral Fibers on the Gene Expression of Cytokine mRNA"Environmental Health Perspectives. 107,NO6. 495-500 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] ISHIMATSU Sumiyo: "A New Digestion Method for Recovery of MMMFs from Lungs"Industrial Health. 37. 307-312 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] YAMAGUCHI Raizou: "Increased 8-Hydroxyguanine in DNA Its Repair Activity in Hamster and Rat Lung After Intratracheal Instillation of Crocidolite Asbestos"Japanese Journal of Cancer Research. 90. 505-509 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] TANAKA Isamu: "Lung Deposiotion and Clearance of Inhaled Graphite Whisker"J.Aerosol Sci. 29. 295-296 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] YAMATO Hiroshi: "Fiber Numbers Per Unit Weight of JFM Standard Reference Samples Determined with a Scanning Electron Microscope"Industrial Health. 36. 384-387 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] HORI Hajime: "A Clearance Model of Inhaled Glass Fiber in Rat Lungs"ELSEVIER. 5 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] YAMATO Hiroshi: "Clearance of Inhaled Potassium Octatitanate Whisker in Rat Lungs"ELSEVIER. 14 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] MORIMOTO Yasuo: "Risk Assessment of Man-Made Fibers by RT-PCR"ELSEVIER. 4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] ISHIMATSU Sumiya: "Clearance Time of Deposited Graphite Wisker in Rat Lungs"ELSEVIER. 4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] ISHIMATSU Simiyo: "Biopersisitence of Inhaled Glass Fibers in Rat Lungs"ELSEVIER. 6 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Oyabu Takako: "Biopersistence and the Possibility of Fibrosis of Limestone in Rat Lung"ELSEVIER. 4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] TUDA Tohru: "One-Year Inhalation Study of Man-Made Fibers"ELSEVIER. 5 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] YOSHIZUMI Kouji: "Improvemants in Airborne Asbestos Concentrations in Work Places of Asbestos-Containing Products Manufacturing Plants in Japan"ELSEVIER. 4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamaguchi Raizou: "Increased 8-Oh-Gua in DNA and Its Repair Activity in Crocidolite Treated Hamster Lung"ELSEVIER. 4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] YAMATO Hiroshi: "Fiber Number Per Unit Weight of JMF Standerd Reference Samples Determined with a Scanning Electron Microscope" Industrial Health. 36,NO4. 384-387 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] HORI Hajime: "Advances in the Prevention of Occupational Resiratory Diseases" Elsevier, 591-595 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] YAMATO Hiroshi: "Advances in the Prevention of Occuptional Respiratory" Elsevir, 587-590 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] MORIMOTO Yasuo: "Advances in the Prevention of Occupational Respiratory Diseases" ELsevier, 611-614 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] ISHIMATSU Sumiyo: "Advances in the Prevention of Occupational Respiratory Diseases" Elsevier, 583-586 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] ISHIMATSU Sumiyo: "Advances in the Prevention of Occupational Respiratory Diseases" Elsevier, 692-696 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] TSUDA Tohru: "Advances in the Prevention of Occupational Respiratory Diseases" Elsevier, 596-600 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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