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ミクログリアに発現しマクロファージに発現しない遺伝子の同定

Research Project

Project/Area Number 10470158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNational Institute of Neuroscience, National Center of Neurology and Psychiatry

Principal Investigator

TABIRA Takeshi  National Institute of Neuroscience, NCNP, Department of Demyelinating Disease and Aging, Head, 神経研究所・疾病研究第6部, 部長 (80112332)

Co-Investigator(Kenkyū-buntansha) INOUE Haruhisa  National Institute of Neuroscience, NCNP, Department of Demyelinating Disease and Aging, Visiting Fellow, 神経研究所・疾病研究第6部, 流動研究員
SAWADA Makoto  Fujita Health University, Institute for Comprehensive Medical Science, Associate Professor, 総合医学研究所, 助教授 (10187297)
TAKAHASHI Keikichi  National Institute of Neuroscience, NCNP, Department of Demyelinating Disease and Aging, Section Chief, 神経研究所・疾病研究第6部, 室長 (40117148)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 1999: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥10,500,000 (Direct Cost: ¥10,500,000)
KeywordsMAGE / microglia / macrophage / SAGE / 遺伝子発現
Research Abstract

We used a method for analyzing the qualitative and quantitative aspects of gene expression (MAGE) to compare expressed genes between microglia and macrophage. By sequencing 10,000 clones in each, we have found several genes that were significantly different between the two cell populations. Genes expressed highly in microglia included TSC36 (TGFβ-inducible gene), while genes expressed highly in macrophage included apolipoprotein E and cathepsin L.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] H. Inoue et al.: "Serial analysis of gene expression in a microglial cell line"Glia. 28. 265-271 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue H, et al.: "Serial analysis of gene expression in a microglial cell line."Glia. 28. 265-271 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Inoue et al.: "Serial analysis of gene expression in a microglial cell line"Glia. 28. 265-271 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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