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Pathogenesis of hypertrophic cardiomyopathy associated with hepatitis C virus.

Research Project

Project/Area Number 10470164
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MATSUMORI Akira  Kyoto University, Dept.of Cardiovasc.Med.Associate Professor, 医学研究科, 助教授 (70135573)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 1999: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1998: ¥5,400,000 (Direct Cost: ¥5,400,000)
Keywordshepatitis C virus / cardiomyopathy / hypertrohic cardiomyopathy / myocarditis / HLA / viral genomes / genes / 拡張型心筋症 / PCR法 / 肝炎 / ウイルス
Research Abstract

The importance of hepatitis C virus (HCV) infection has recently been noted in patients with hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM).
In a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy, HCV antibody was found in 74 of 697 patients (10.6%) with HCM and in 42 of 663 patients (6.3%) with DCM; this prevalence was significantly higher than measured in volunteer blood donors in Japan (2.4%).
A collaborative multicenter study, chaired by Dr.B.Maisch, was performed to test the reproducibility of detection of detection of viral genomes such as enteroviruses, adenovirus, cytomegalovirus and HCV in formalin fixed tissues. Autopsy and biopsy materials were analyzed blindly. Hepatitis C virus genomes were found in the hearts of 2 out of 11 patients (18%) with dilated cardiomyopathy and myocarditis from Italy, and 4 out of 11 patients (36%) from the United States. We attempted to detect HCV genomes in paraffin sections of autopsied hearts. Among 106 hearts examined, β-actin gene was amplified in 61 hearts (52.6%). Among these, HCV RNA was detected in 13 hearts (21.3%), and negative strands in 4 hearts (6.6%). HCV RNA was found in 6 hearts (26.0%) with HCM, 3 heart (11.5%) with DCM, and 4 hearts (33.3%) with myocarditis. These HCV RNA positive samples were obtained between 1979 and 1990, indicating that HCV RNA can be amplified from paraffin-embedded hearts preserved for many years. We also analyzed autopsied hearts with DCM in a collaborative research with the University of Utah, and found HCV RNA in 8 of 23 hearts (35%) with positive actin genes. The sequences of HCV genomes recovered from these hearts were closely homologous to the standard strain of HCV.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (57 results)

All Other

All Publications (57 results)

  • [Publications] Fukukawa Y, et al.: "Anti-monocyte chemoattractant protein-I/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries"Circ Res. 84. 306-314 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono K, et al.: "Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemotactic and activating factor/monocyte chemoattractant protein-1"Leb Invest. 79. 195-203 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Okada M, et al.: "Hepatocyte growth factor is a major mediator in heparin-induced angiogenesis"Biochem Biophys Res Commun. 255. 80-87 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki A, et al.: "Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis"J Am Coll Cardiol. 33. 1400-1407 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsumori A, et al.: "Apical hypertrophic cardiomyopathy and hepatitis C virus infection"Jpn Circ J. 63. 433-438 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hwang MW, et al.: "FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery diease in murine model of cardiac transplantation"Circulation. 100. 1322-1329 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hara M, et al.: "Mast cells apoptosis of cardiomyocytes and proliferation of other intramyocardial cell in vivo"Circulation. 100. 1443-1449 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishio R, et al.: "Treatment of experimental viral myocarditis with interleukin-10"Chirculation. 100. 1102-1108 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono K, et al.: "Contribution of endothelin-1to myocardial injuruy in a murine model of myocarditis.Acute effects of bosentan, an endothelin receptor antagonist"Chirculation. 100. 1823-1829 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fukukawa Y, et al.: "Cytokine gene expression during the development of graft coronary artery disease in mice"Jpn Circ J. 63. 775-782 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsumori A, et al.: "High doses of digitalis increase the myocardial producion of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: A possible mechanism of digitalis toxicity"Jpn Circ J. 63. 934-940 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Gwathmey JK, et al.: "Cellular and molecular remodeling in an animal model of dilated cardiomyopathy treated with the b-blocker carteolol"Am J Physiol. 276. H1678-H1690 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono K, Matsumori A.: "Inflammatory heart disease."In congestibe heart failure, Second edition, edited by Jeffrey D.Hosenpud and Barry H. Grenberg. Lippincott Williams & Wilkins, Philadelphia.. 11 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Furukawa Y, Matsumori A, Ohashi N, Shioi T, Ono K, Harada A, Matsushima K, Sasayama S.: "Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries."Circ Res. 84. 306-314 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono K, Matsumori A, Furukawa Y, Igata H, Shioi T, Matsushima K, Sasayama S.: "Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1."Lab Invest. 79. 195-203 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Okada M, Matsumori A, Ono K, Miyamoto T, Sasayama S.: "Hepatocyte growth factor is a major mediator in heparin-induced angiogenesis."Biochem Biophys Res Commun. 255. 80-87 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasaki A, Matsumori A, Yamada T, Shioi T, Wang W-Z, Ono K, Nishio R, Okada M, Sasayama S.: "Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis."J Am Coll Cardiol. 33. 1400-1407 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsumori A, Ohashi N, Nishio R, Kakio T, Hara M, Furukawa Y, Ono K, Shioi T, Sasayama S.: "Apical hypertrophic cardiomyopathy and hepatitis C virus infection."Jpn Circ J. 63. 433-438 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hwang MW, Matsumori A, Furukawa Y, Ono K, Okada M, Iwasaki A, Hara M, Sasayama S.: "FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation."Circulation. 100. 1322-1329 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hara M, Matsumori A, Ono K, Kido H, Hwang MW, Miyamoto T, Iwasaki A, Okada M, Nakatani K, Sasayama S.: "Mast cells apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vivo."Circulation. 100. 1443-1449 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishio R, Matsumori A, Shioi T, Ishida H, Sasayama S.: "Treatment of experimental viral myocarditis with interleukin-10."Circulation. 100. 1102-1108 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono K, Matsumori A, Shioi T, Furukawa Y, Sasayama S.: "Contribution of endothelin-1 to myocardial injury in a murine model of myocarditis. Acute effects of bosentan, an endothelin receptor antagonist."Circulation. 100. 1823-1829 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Furukawa Y, Matsumori A, Hwang MW, Hirozane T, Ono K, Shioi T, Sasayama S.: "Cytokine gene expression during the development of graft coronary artery disease in mice."Jpn Circ J. 63. 775-782 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsumori A, Igata H, Ono K, Iwasaki A, Miyamoto T, Nishio R, Sasayama S.: "High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis : A possible mechanism of digitalis toxicity."Jpn Circ J. 63. 934-940 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Gwathmey JK, Kim CS, Hajjar RJ, Khan F, DiSalvo TG, Matsumori A, Bristow MR.: "Cellular and molecular remodeling in an animal model of dilated cardiomyopathy treated with the β-blocker carteolol."Am J Physiol. 276. H1678-H1690 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono K, Matsumori A.: "Inflammatory heart disease. In Congestive heart failure, Second Edition, edited by Jeffrey D. Hosenpud and Barry H. Grrenberg."Lippincott Williams & Wilkins Philadelphia.. 313-323 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Furukawa Y.et al.: "Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries"Circ Res. 84. 306-314 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ono K.et al.: "Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1"Lab Invest. 79. 195-203 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Okada M.et al.: "Hepatocyte growth factor is a major mediator in heparin-induced angiogenesis"Biochem Biophys Res Commun. 255. 80-87 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iwasaki A.et al.: "Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis"J Am Coll Cardiol. 33. 1400-1407 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsumori A.et al.: "Apical hypertrophic cardiomyopathy and hepatitis C virus infection"Jpn Circ J. 63. 433-438 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hwang MW.et al.: "FTY720, an new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation"Circulation. 100. 1322-1329 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hara M.et al.: "Mast cells apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vivo"Circulation. 100. 1443-1449 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishio R.et al.: "Treatment of experimental viral myocarditis with interleukin-10"Circulation. 100. 1102-1108 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ono K.et al.: "Contribution of endothelin-1 to myocardial injury in a murine model of myocarditis.Acute effects of bosentan, an endothelin receptor antagonist"Circulation. 100. 1823-1829 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Furukawa Y.et al.: "Cytokine gene expression during the development of graft coronary artery disease in mice"Jpn Circ J. 63. 775-782 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsumori A.et al.: "High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: A possible mechanism of digitalis toxicity"Jpn Circ J. 63. 934-940 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Gwathmey JK.et al.: "Cellular and molecular remodeling in an animal model of dilated cardiomyopathy treated with the b-blocker carteolol"Am J Physiol. 276. H1678-H1690 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ono K, Matsumori A.: "Inflammatory heart disease."In Congestive heart failure, second Edition, edited by Jeffrey D. Hosenpud and Barry H. Grenberg. Lippincott Williams & Wilkins, Philadelphia.. 11 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wang W-Z, et al.: "Protective effects of Mu-Fang-Ji-Tang against myocardial injury in a murine model of congestive heart failure induced by viral myocarditis." Life Sci. 62. 1139-1147 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okada M, et al.: "Cyclical stretch upregulates the prodection of interleukin-8 and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in human endothelial cells." Arterioscler Thromb Vasc Biol. 18. 894-901 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ono K, et al.: "Cytokine gene expression after myocardial infarction in rat hearts. Possible implication in left ventricular remodeling." Circulation. 98. 149-156 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A.: "Calcium channel blocker-induced protection against cardiovascular damage." Int.J.Cardiol.suppl.62. S39-S46 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A.: "The use of cytokine inhibitors A new therapeutic insight into heart failure." Int.J.Cardiol.suppl.62. S3-S12 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A, et al.: "Circulating hepatocyte growth factor as an early marker of arterial thrombus formation." Jpn Circ J. 62. 311-313 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A, et al.: "Hepatitis C virus infection and heart diseases. A multicenter study in Japan." Jpn Circ J. 62. 389-391 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sato Y, et al.: "Serum concentration of cardiac troponin T in patients with cardiomyopathy-A possible mechanism of acute heart failure-" HEART. 80. 209-210 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamada T, et al.: "Myosin light chain I trade:A simple marker for the severity and prognosis of patients with acute myocardial infarction." Am Heart J. 135. 329-334 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishio R, et al.: "Denopamine, a β1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis. Suppression of tumor necrosis factor-a production in the heart." J Am Coll Cardiol. 32. 808-815 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A, et al.: "Immediate increase in circulating hepatocyte growth factor/scatter factor by heparin." J Mol Cell Cardiol. 30. 2145-2149 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A, et al.: "Hepatitis C virus infection and hypertrophic cardiomyopathy." Ann Int Med. 129. 749-750 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Furukawa Y, et al.: "Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries." Circ Res. 84. 306-314 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ono K, et al.: "Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1." Lab Invest. 79. 195-203 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okada M, et al.: "Hepatocyte growth factor is a major mediator in heparin-induced angiogenesis." Biochem Biophys Res Commun. 225. 80-87 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Iwasaki A, et al.: "Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis." J Am Coll Cardiol. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A, et al.: "Apical hypertrophic cardiomyopathy and hepatitis C virus infection." Jpn Circ J. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumori A,et al.: "Coronary reperfusion and cytokines." Edited by Abiko Y, Karmazyn M Springer-Verlag, Tokyo, 157-177(20) (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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