| Project/Area Number |
10470198
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | TOKAI UNIVERSITY |
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Principal Investigator |
MURAYAMA Chieko (2000) TOKAI UNIV.SCHOOL OF MEDICINE, ASSISTANT RESEARCHER, 医学部, 助手 (50307295)
母里 知之 (1998-1999) 東海大学, 医学部, 教授 (70055896)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Yutaka SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (70019967)
IMAMIYA Satoshi SCHOOL OF MEDICINE, ASSISTANT RESEARCHER, 医学部, 助手 (30276844)
OHIZUMI Yukio SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (30024813)
KUTSUZAWA Tomoko SCHOOL OF HEALTH SCIENCE, ASSOCIATE PROFESSOR, 健康科学部, 助教授 (10183310)
HAIDA Munetaka SCHOOL OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (20208408)
村山 千恵子 東海大学, 医学部, 助手 (50307295)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2000: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | HYPOXIC CELLS / OXYGEN SATURATION / NEAR-INFRARED LIGHT / OXY-HEMOGLOBIN / DEOXY-HEMOGLOBIN / SPECT / ANTI-PIMONIDAZOLE ANTIBODY / 低酸素性細胞 / 近赤外分光 / 腫瘍内酸素濃度 / 非侵襲的測定法 / oxy-hemoglobin / deoxy-hemoglobin |
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| Research Abstract |
THERE ARE HYPOXIC CELLS IN THE TUMOR AS A RESISTANCE FACTOR OF TREATMENT FOR A RADIATION.IT IS IMPORTANT TO KNOW THE RATE OF HYPOXIC CELLS IN THE TUMOR, THAT IS, OXYGEN CONDITION OF THE TUMOR FOR THE DECISION OF THE TREATMENT PRINCIPLE.
BY THIS REASON, BEFORE AND DURING A RADIATION TREATMENT, A DEGREE OF OXYGEN SATURATION IN THE TUMOR OF PATIENTS IS MEASURED BY USING NEAR-INFRARED SPECTROSCOPY AND RELATION WITH EFFECT ON TREATMENT IS EXAMINED.AS A RESULT OF MEASURING A DEGREE OF OXYGEN SATURATION IN THE TUMOR WITH NON INVASIVE OXYGENATION MONITOR (OM-200, SHIMADZU) AND OMEGAOXYMETER (OMEGAMONITOR, BOM-L1), IT COULD SHOW A TENDENCY TO GET THE GOOD TUMOR REDUCTION RATE FOR A DEGREE OF OXYGEN SATURATION BEFORE THE TREATMENT WHICH TO BE RESPECTIVELY SUPERIOR IN 70%, 60% AND MORE.THE TUMOR THAT DEGREES OF OXYGEN SATURATION IN THE TUMOR INCREASE BY 10GY IRRADIATION (AFTER AN IRRADIATION START SEVERAL DAYS) SHOWS HIGH SENSITIVITY TOWARD THE RADIATION, AND SEEMS THAT IT CAN EXPECT AN EFFECTIVE TUMOR REDUCTION RATE.
RADIO-ACTIVE COMPOUNDS WHICH ACCUMULATE INTO THE HYPOXIC CELLS WERE DEVELOPED FOR THE PURPOSE OF NUN-INVASIVE MEASURING BY SPECT.A LOTS OF FUNDAMENTAL EXPERIMENTS WERE DONE TO PREPARE FOR THE PATENT APPLICATION.FOR ANOTHER METHOD TO RECOGNIZE HYPOXIC CELLS IN THE TUMOR, PIMONIDAZOLE WHICH ALSO ACCUMULATE INTO THE HYPOXIC CELLS WAS DETECTED BY IMMUNOHISTOCHEMISTRY WITH ANTI-PIMONIDAZOLE ANTIBODY.
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